Article
Oncology
Reza Fardanesh, Sunitha B. Thakur, Varadan Sevilimedu, Joao V. Horvat, Roberto Lo Gullo, Jeffrey S. Reiner, Sarah Eskreis-Winkler, Nikita Thakur, Katja Pinker
Summary: The study aimed to determine the effectiveness of different ADC parameters in differentiating between benign and malignant axillary lymph nodes, with mean ADC being identified as the most useful parameter.
FRONTIERS IN ONCOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Maja Bruvo, Faisal Mahmood
Summary: There is discrepancy in reported ADC values of the parotid gland, with factors such as gustatory stimulation, diffusion weighting factors, and timing of follow-up after radiotherapy influencing the measurements. Interestingly, the choice of regions of interest may not affect the ADC measurements.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Review
Oncology
Xianwen Hu, Zhigang Liang, Chuanqin Zhang, Guanlian Wang, Jiong Cai, Pan Wang
Summary: This meta-analysis provides evidence that maximum uptake value (SUVmax) and apparent diffusion coefficient (ADC) have good diagnostic performance in quantitatively differentiating benign and malignant ovarian or adnexal masses, with SUVmax showing higher accuracy than ADC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Vitus Gosch, Kersten Villringer, Ivana Galinovic, Ramanan Ganeshan, Sophie K. K. Piper, Jochen B. B. Fiebach, Ahmed Khalil
Summary: This study explored the performance of ADC thresholding for delineating baseline DWI lesions in acute ischemic stroke MRI. The results showed substantial variability in the performance of ADC thresholds between patients, influenced by factors such as lesion size and lesion and parenchymal ADC values. Due to the inherent noisiness of ADC maps, automated delineation of very small lesions based on ADC thresholds is not reliable.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Chao-Chun Chang, Chia-Ying Lin, Li-Ting Huang, Ming-Tsung Chuang, Ying-Hung Lu, Wei-Li Huang, Ying-Yuan Chen, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen
Summary: This study evaluated the diagnostic capacity of apparent diffusion coefficient (ADC) in predicting pathological Masaoka and T stages in patients with thymic epithelial tumors (TETs). The results showed that ADC values were negatively correlated with pathological stages and more accurately predicted pathological T stages. ADC values can be used to preoperatively predict the T stages of TETs.
Article
Oncology
Renwei Liu, Ruifeng Li, Jinzhi Fang, Kan Deng, Cuimei Chen, Jianhua Li, Zhiqing Wu, Xiaoxu Zeng
Summary: This study evaluated the utility of ADC histogram analysis in differentiating between three types of solid ovarian tumors: granulosa cell tumors (GCTs) of the ovary, ovarian fibromas, and high-grade serous ovarian carcinomas (HGSOCs). The results showed that ADC parameters can accurately differentiate different types of ovarian tumors before surgery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunfei Zhang, Chun Yang, Liang Liang, Zhang Shi, Shuo Zhu, Caizhong Chen, Yongming Dai, Mengsu Zeng
Summary: This study evaluated the feasibility of 5.0 T high-field DWI in the upper abdomen and assessed the agreement of the ADC values with that from 3.0 T abdominal DWI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takahiro Ueda, Yoshiharu Ohno, Maiko Shinohara, Kaori Yamamoto, Masato Ikedo, Masao Yui, Takeshi Yoshikawa, Daisuke Takenaka, Sayuri Ishida, Minami Furuta, Takahiro Matsuyama, Hiroyuki Nagata, Hirotaka Ikeda, Yoshiyuki Ozawa, Hiroshi Toyama
Summary: The purpose of this study was to determine the influence of reverse encoding distortion correction (RDC) on ADC measurement and its efficacy for improving image quality and diagnostic performance for differentiating malignant from benign prostatic areas on prostatic DWI. The results showed that RDC DWI had significantly better SNR and overall image quality compared to DWI. ROC analysis also demonstrated that the diagnostic performance of ADC in RDC DWI was better than in DWI. Therefore, RDC technique has the potential to improve image quality and ability to differentiate malignant from benign prostatic areas on DWIs.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Baohong Wen, Zanxia Zhang, Jing Zhu, Liang Liu, Yinhua Li, Haoyu Huang, Yong Zhang, Jingliang Cheng
Summary: The study utilized radiomics features based on ADC maps to accurately stratify parotid gland tumors, aiding clinicians in distinguishing PA and WT from MTs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cheng Hong Toh, Tiing Yee Siow, Alex Mun-Ching Wong, Mauricio Castillo
Summary: This retrospective study aimed to investigate the relationship between microbial culture yields and ADC values of brain abscesses, finding that mean ADC was the only significant factor related to culture yields. The study concluded that ADC could be used to discriminate between culture-positive and culture-negative abscesses with high sensitivity, specificity, and accuracy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mehmet Ali Gultekin, Hac Mehmet Turk, Ismail Yurtsever, Dilek Hacer Cesme, Mesut Seker, Mehmet Besiroglu, Alpay Alkan
Summary: The study found significantly lower ADC and ADC(mean) values in liver metastases of GEP-NET group, with ROC curve analysis showing a significant difference, indicating that ADC and ADC(mean) values can be used to differentiate GEP-NET metastases from adenocarcinoma metastases.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue Li, Hong Wang, Jiayin Gao, Lei Jiang, Min Chen
Summary: Quantitative ADC metrics generally outperformed BI-RADS parameters in distinguishing MRI-only suspicious lesions, with ADCmean being the best ADC parameter for differentiating MRI-only lesions.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaixuan Zhao, Sheng Li, Yan Liu, Qiuling Li, Huan Lin, Zhigang Wu, Erdmann Seeliger, Thoralf Niendorf, Zaiyi Liu, Wenjian Wang
Summary: This study examines the diagnostic and prognostic value of magnetic resonance (MR) markers for mild, moderate, and severe DKD. The results show that ADCcortex is a valuable imaging marker for the diagnosis and prediction of renal function decline in DKD.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lauren K. Fang, Kathryn E. Keenan, Michael Carl, Haydee Ojeda-Fournier, Ana E. Rodriguez-Soto, Rebecca A. Rakow-Penner
Summary: This study aimed to evaluate the reproducibility of DW-MRI estimates across multiple scanners and protocols, and compare the effects of using 8-channel versus 16-channel breast coils. The results showed that normalization by an internal reference improved interscanner ADC reproducibility, and high-resolution protocols yielded comparably accurate and less variable ADCs.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jian Wang, Chao Ma, Panpan Yang, Zhen Wang, Yufei Chen, Yun Bian, Chengwei Shao, Jianping Lu
Summary: This study investigated the effects of gradient nonlinearity (GNL) in abdominal apparent diffusion coefficient (ADC) measurements and developed a bias correction procedure. The results showed the presence of ADC bias and successfully corrected it using the proposed method. This study highlights the importance of considering GNL in ADC measurements in the abdomen.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Shefali Chaudhary, S. Senthil Kumaran, Vinay Goyal, M. Kalaivani, Gauri Shanker Kaloiya, Rajesh Sagar, Nalin Mehta, Achal Kumar Srivastava, N. R. Jagannathan
Summary: Through multi-voxel proton magnetic resonance spectroscopic imaging, it was found that metabolic alterations in the frontal lobe of cognitively impaired PD patients could be potential biomarkers for PD cognitive impairment, involving neuronal function loss, altered energy metabolism, and cholinergic neural transmission. These findings may serve as promising indicators for early diagnosis and monitoring of PD cognitive impairment.
NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
K. Gupta, Shivabalan, V Kumar, S. Vyas, R. M. Pandey, N. R. Jagannathan, S. Sinha
Summary: This study conducted in a tertiary care center in India found a high prevalence of cognitive impairment in ART naive patients with HIV, with a particular impact on simple motor skills and memory. However, there was no significant difference in brain metabolites concentration between patients with cognitive impairment and those without cognitive impairment. Further longitudinal studies are needed to understand the underlying pathophysiological mechanisms.
CURRENT HIV RESEARCH
(2021)
Editorial Material
Chemistry, Multidisciplinary
Haribabu Arthanari, Kandala V. R. Chary, Thomas Szyperski, Krishna V. Ramanathan, Ramakrishna V. Hosur, Nagarajarao Suryaprakash, Srinivasarao Raghothama, Naranamangalam R. Jagannathan, Raymond S. Norton, Erode N. Prabhakaran, Paturu Kondaish, Sulakshana P. Mukherjee, Satish Kumar Adiga, RamaKrishna Vadrevu, Anirban Bhunia, David Joseph
MAGNETIC RESONANCE IN CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mylathal Sivasamy Naveen Kumar, Gaurav Gupta, Virendra Kumar, Naranamangalam R. Jagannathan, Sanjeev Sinha, Sujeeth Mewar, Pradeep Kumar
Summary: This study used NMR spectroscopy to analyze the metabolic profiles of serum samples from patients with sepsis, and discovered differences between non-survivors and survivors. The findings suggest that the metabolic alterations at day zero may predict the survival of patients with sepsis.
MAGNETIC RESONANCE IMAGING
(2022)
Review
Biophysics
Richa Dubey, Neeraj Sinha, Naranamangalam R. Jagannathan
Summary: Body fluids, cells, and tissues contain a variety of metabolites, making comprehensive analysis difficult. Quantitative nuclear magnetic resonance (NMR) spectroscopy is an established analytical technique that enables fast and comprehensive detection and quantification of metabolites. NMR-based metabolomics has been widely utilized in various medical fields, especially in clinical studies.
NMR IN BIOMEDICINE
(2023)
Article
Medical Laboratory Technology
Deepti Upadhyay, Prasenjit Das, Siddhartha Dattagupta, Govind K. Makharia, Naranamangalam R. Jagannathan, Uma Sharma
Summary: This study compared the metabolome of potential celiac disease (PCeD) patients with celiac disease (CeD) and control groups, and found altered metabolic profiles in PCeD patients, indicating gluten intolerance at the metabolic level before intestinal damage. The changes in metabolites also suggested the vulnerability of PCeD patients to develop intestinal inflammation over time.
CLINICA CHIMICA ACTA
(2022)
Review
Cardiac & Cardiovascular Systems
Cathy Qin, Sanjana Murali, Elsa Lee, Vaishnavi Supramaniam, Derek J. Hausenloy, Johnes Obungoloch, Joanna Brecher, Rongyu Lin, Hao Ding, Theophilus N. Akudjedu, Udunna C. Anazodo, Naranamangalam R. Jagannathan, Ntobeko A. B. Ntusi, Orlando P. Simonetti, Adrienne E. Campbell-Washburn, Thoralf Niendorf, Regina Mammen, Sola Adeleke
Summary: Cardiovascular disease is a major burden for healthcare systems worldwide, and cardiovascular magnetic resonance (CMR) is a well-established diagnostic technology. However, global inequality in availability and access to CMR exists due to cost and technical demands. There is renewed interest in low-field CMR to provide sustainable imaging technology tailored to local needs.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Uma Sharma, Naranamangalam R. Jagannathan
Summary: This article reviews the application of NMR, MRS, and MRI methods in understanding breast cancer biology, as well as in the diagnosis and therapeutic monitoring of breast cancer.
Editorial Material
Biophysics
Gopala Krishna Aradhyam, Naranamangalam R. Jagannathan
BIOPHYSICAL REVIEWS
(2022)
Article
Psychiatry
Rishi Gupta, Mamta Sood, Uma Sharma, Rachna Bhargava, N. R. Jagannathan, R. K. Chadda
Summary: Neurochemical dysfunction in select brain areas directly correlates with impairment in cognitive functions seen in patients with bipolar disorder in euthymic phase.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Biophysics
Nupur Sharma, Deepti Upadhyay, Hitender Gautam, Uma Sharma, Rakesh Lodha, Sushil Kumar Kabra, Bimal Kumar Das, Arti Kapil, Anant Mohan, Naranamangalam Raghunathan Jagannathan, Randeep Guleria, Urvashi Balbir Singh
Summary: The serum metabolic profile of children with intra-thoracic tuberculosis (TB) was investigated using proton NMR spectroscopy-based targeted and untargeted metabolomics approaches. Significant differences in metabolites were observed between TB children and non-TB controls, and six metabolic pathways were found to be altered. The findings provide new tools for the diagnosis of pediatric TB, but further validation is needed.
NMR IN BIOMEDICINE
(2023)
Editorial Material
Biophysics
Gopala Krishna Aradhyam, Naranamangalam R. Jagannathan
Summary: Gobind Khorana's distinguished career in biochemistry led to significant achievements, including the synthesis of coenzyme A and the genetic code. He also accomplished the complete synthesis of a gene and conducted groundbreaking studies on visual rhodopsin. This Editorial introduces articles celebrating the 100th anniversary of his birth.
BIOPHYSICAL REVIEWS
(2023)
Review
Urology & Nephrology
R. Ravikanth Reddy, Naranamangalam R. Jagannathan
Summary: Nuclear magnetic resonance (NMR) metabolomics is a powerful analytical technique for evaluating biochemicals/metabolites associated with cancer and other diseases. It can aid in the diagnosis and understanding of dysregulated metabolic pathways in prostate cancer by detecting metabolites in biofluids and tissues.
INDIAN JOURNAL OF UROLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Durgesh Kumar Dwivedi, Naranamangalam R. Jagannathan
Summary: Integrating advanced multiparametric MR imaging (mpMRI) approaches into the diagnostic workup of prostate cancer (PCa) can address the current challenges of serum PSA level-based screening. mpMRI not only increases the detection of clinically significant PCa but also reduces unnecessary biopsies. It also helps in PCa grading and biopsy guidance.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Audiology & Speech-Language Pathology
A. Ankeeta, S. Senthil Kumaran, Rohit Saxena, Sada Nand Dwivedi, N. R. Jagannathan, Vaishna Narang
Summary: This study investigated the role of visual and auditory cortical networks in auditory perception using functional mapping and brain imaging techniques. The results showed increased functional connectivity and cross-modal reorganization in early blind children, with the degree of connectivity positively correlated with duration of education.
BRAIN AND LANGUAGE
(2022)