Article
Cardiac & Cardiovascular Systems
William D. Watson, Peregrine G. Green, Andrew J. M. Lewis, Per Arvidsson, Giovanni Luigi De Maria, Hakan Arheden, Einar Heiberg, William T. Clarke, Christopher T. Rodgers, Ladislav Valkovic, Stefan Neubauer, Neil Herring, Oliver J. Rider
Summary: The study shows that even in nonischemic heart failure patients with severely impaired systolic function, the heart retains significant metabolic flexibility, including the ability to change substrate use to match arterial supply and workload changes. Increasing the uptake and oxidation of long-chain fatty acids is associated with improved myocardial energetics and contractility.
Article
Physiology
Eline Lievens, Kim Van Vossel, Freek Van de Casteele, Audrey Baguet, Wim Derave
Summary: This study found a sexual dimorphism in carnosine and creatine concentrations in adult skeletal muscle, but not in carnitine. During puberty, carnosine increased more in males compared to females, while there were no significant changes in creatine and carnitine. The origin of sexual dimorphisms in carnosine partially occurred during puberty, but not for creatine.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S Bouchard, Liming Xia, Xin Zhou
Summary: The recovery process of COVID-19 patients remains unclear, with some experiencing ongoing respiratory issues. Xe-129 MRI analysis reveals higher ventilation defects and longer gas-blood exchange time in COVID-19 patients, indicating lung function impairment during recovery.
Review
Psychiatry
David E. Nichols
Summary: At first glance, the molecular structures of MDMA and MDA seem similar, but their activity stereochemistry differs. MDMA is distinct from classical hallucinogenic phenethylamines in structure and psychopharmacology. It promotes affiliative social behavior, has acute anxiolytic effects, and induces introspection and personal reflection. Its mechanism of action involves the transport and release of neuronal serotonin.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Maho Ishikawa, Reika Sawaya, Miki Hirayama, Junpei Ueda, Shigeyoshi Saito
Summary: Pelizaeus-Merzbacher disease (PMD) is an X-linked recessive disorder of the central nervous system. Using magnetic resonance imaging and proton magnetic resonance spectroscopy, abnormalities in the brain white matter structure and metabolism were observed in Tama rats, a rodent PMD model, which are similar to findings in PMD patients and other animal models.
Article
Cardiac & Cardiovascular Systems
Nickie N. Andescavage, Subechhya Pradhan, Alexis C. Gimovsky, Kushal Kapse, Mary T. Donofrio, Jenhao Jacob Cheng, Yushuf Sharker, David Wessel, Adre J. du Plessis, Catherine Limperopoulos
Summary: The study found that fetuses with complex congenital heart disease (CHD) have altered cerebral metabolites, particularly in the third trimester of pregnancy. These alterations are associated with survival to hospital discharge and warrant further study on the long-term neurodevelopmental consequences.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Elisabeth Bliemsrieder, Georgios Kaissis, Martin Grashei, Geoffrey Topping, Jennifer Altomonte, Christian Hundshammer, Fabian Lohoefer, Irina Heid, Dominik Keim, Selamawit Gebrekidan, Marija Trajkovic-Arsic, Aline Winkelkotte, Katja Steiger, Roman Nawroth, Jens Siveke, Markus Schwaiger, Marcus Makowski, Franz Schilling, Rickmer Braren
Summary: The in vivo assessment of tissue metabolism is a novel strategy for evaluating oncologic disease, particularly hepatocellular carcinoma (HCC). The study found that metabolic alterations, especially in glucose metabolism and lactate production, impact survival differences in HCC tumor tissue. In vivo imaging techniques revealed distinct tumor phenotypes corresponding to differences in glycolytic metabolism in HCC tumor tissue.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Rayner, Mark A. Peterzan, William T. Clarke, Christopher T. Rodgers, Stefan Neubauer, Oliver J. Rider
Summary: The study demonstrated that obesity cardiomyopathy and dilated cardiomyopathy have distinct differences in myocardial energy metabolism, with higher ATP demand through CK in obese DCM possibly leading to reduced energy utilization efficiency. Intentional weight loss intervention was associated with significant improvement in myocardial contractility and a decrease in ATP delivery rate, suggesting improved metabolic efficiency.
EUROPEAN HEART JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Physics, Multidisciplinary
C. Munuera-Javaloy, A. Tobalina, J. Casanova
Summary: Ensembles of nitrogen-vacancy centers are used to detect nuclear magnetic resonance signals from micron-sized samples. The large magnetic field regime is of particular interest due to the high thermal polarization and accessibility of chemical shifts and J couplings. However, coupling NV-based sensors with high-frequency nuclear signals has been challenging. This Letter presents a method that overcomes this obstacle and achieves high spectral resolutions, limited only by the coherence of the nuclear spin signal.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
A. J. Healey, S. C. Scholten, T. Yang, J. A. Scott, G. J. Abrahams, I. O. Robertson, X. F. Hou, Y. F. Guo, S. Rahman, Y. Lu, M. Kianinia, I Aharonovich, J-P Tetienne
Summary: A versatile quantum microscope is demonstrated using point defects embedded in a thin layer of hexagonal boron nitride, allowing for real-time observation of temperature and magnetic field near the Curie temperature of a van der Waals ferromagnet, as well as mapping of charge currents and Joule heating in a graphene device. The integration of hexagonal boron nitride quantum sensor with other van der Waals materials will have significant practical benefits for the design and measurement of 2D devices.
Article
Cardiac & Cardiovascular Systems
Moritz J. Hundertmark, Amanda Adler, Charalambos Antoniades, Ruth Coleman, Julian L. Griffin, Rury R. Holman, Hanan Lamlum, Jisoo Lee, Daniel Massey, Jack J. J. J. Miller, Joanne E. Milton, Shveta Monga, Ferenc E. Mozes, Areesha Nazeer, Betty Raman, Oliver Rider, Christopher T. Rodgers, Ladislav Valkovic, Eleanor Wicks, Masliza Mahmod, Stefan Neubauer
Summary: This study found that treatment with 10 mg of empagliflozin once daily for 12 weeks did not improve cardiac energetics or change circulating serum metabolites associated with energy metabolism in patients with heart failure. Therefore, enhancing cardiac energy metabolism does not likely mediate the beneficial effects of SGLT2i in heart failure.
Article
Physics, Multidisciplinary
Ainitze Biteri-Uribarren, Pol Alsina-Bolivar, Carlos Munuera-Javaloy, Ricardo Puebla, Jorge Casanova
Summary: This study tackles the detection of individual molecules by combining a hybrid sensor-a nitrogen vacancy center (NV) and a dangling bond on the diamond surface-with a multi-tone dynamical decoupling sequence. Via numerical simulations, the authors prove that the sequence minimizes the impact of decoherence, which allows using the dangling-bond as a signal amplifier.
COMMUNICATIONS PHYSICS
(2023)
Review
Cardiac & Cardiovascular Systems
Salva R. Yurista, Robert A. Eder, Deborah H. Kwon, Christian T. Farrar, Yi Fen Yen, W. H. Wilson Tang, Christopher T. Nguyen
Summary: As one of the highest energy consuming organs in the body, the heart relies on various fuel sources to generate ATP for its continuous work. Magnetic resonance imaging (MRI) plays a crucial role in understanding the metabolic changes in the failing heart, and noninvasive quantification of metabolic changes has potential clinical applications. Novel MRI techniques, such as magnetic resonance spectroscopy (MRS), hyperpolarized MRS, and chemical exchange saturation transfer, provide detailed investigation of cardiac metabolism in heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Psychiatry
Xiaoting Wu, Mingqi Tu, Nisang Chen, Jiajia Yang, Junyan Jin, Siying Qu, Sangsang Xiong, Zhijian Cao, Maosheng Xu, Shuangyi Pei, Hantong Hu, Yinyan Ge, Jianqiao Fang, Xiaomei Shao
Summary: This study aims to explore the efficacy and cerebral mechanism of intradermal acupuncture for moderate depressive disorder (MDD). Participants will be randomly assigned to a waiting list group, sham intradermal acupuncture group, and active intradermal acupuncture group. Multiple assessment methods will be used to measure the effectiveness after a 6-week intervention and 4-week follow-up. Additionally, selected participants will undergo MRI analysis. If proven effective, intradermal acupuncture may become a routine treatment for MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Behavioral Sciences
Brittney M. Cox, Fares Alsawah, Peter C. McNeill, Matthew P. Galloway, Shane A. Perrine
BEHAVIOURAL BRAIN RESEARCH
(2011)
Article
Substance Abuse
Shane A. Perrine, Shonagh K. O'Leary-Moore, Matthew P. Galloway, John H. Hannigan, Scott E. Bowen
DRUG AND ALCOHOL DEPENDENCE
(2011)
Review
Psychiatry
Nash N. Boutros, Samiran Ghosh, Aminah Khan, Susan M. Bowyer, Matthew P. Galloway
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2014)
Article
Neurosciences
Venkata Siva Sai Sujith Sajja, Matthew Galloway, Farhad Ghoddoussi, Andrea Kepsel, Pamela VandeVord
JOURNAL OF NEUROSCIENCE RESEARCH
(2013)
Article
Clinical Neurology
Farhad Ghoddoussi, Matthew P. Galloway, Amruta Jambekar, Monica Bame, Richard Needleman, William S. A. Brusilow
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2010)
Article
Neurosciences
Venkata Siva Sai Sujith Sajja, Shane A. Perrine, Farhad Ghoddoussi, Christina S. Hall, Matthew P. Galloway, Pamela J. VandeVord
MOLECULAR AND CELLULAR NEUROSCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Juan Bustillo, Matthew P. Galloway, Farhad Ghoddoussi, Federico Bolognani, Nora Perrone-Bizzozero
NEUROCHEMISTRY INTERNATIONAL
(2012)
Article
Neurosciences
Dayan Knox, Shane A. Perrine, Sophie A. George, Matthew P. Galloway, Israel Liberzon
NEUROSCIENCE LETTERS
(2010)
Article
Neurosciences
Andrew L. Eagle, Dayan Knox, Megan M. Roberts, Kostika Mulo, Israel Liberzon, Matthew P. Galloway, Shane A. Perrine
NEUROSCIENCE RESEARCH
(2013)
Article
Neurosciences
Shane A. Perrine, Farhad Ghoddoussi, Mark S. Michaels, Elisabeth M. Hyde, Donald M. Kuhn, Matthew P. Galloway
Article
Biophysics
Venkata Siva Sai Sujith Sajja, Matthew P. Galloway, Farhad Ghoddoussi, Dhananjeyan Thiruthalinathan, Andrea Kepsel, Kathryn Hay, Cynthia A. Bir, Pamela J. VandeVord
NMR IN BIOMEDICINE
(2012)
Article
Clinical Neurology
Brittney M. Cox, Mrudang M. Shah, Teri Cichon, Manuel E. Tancer, Matthew P. Galloway, David M. Thomas, Shane A. Perrine
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2014)
Article
Clinical Neurology
Shane A. Perrine, Farhad Ghoddoussi, Mark S. Michaels, Imran S. Sheikh, George McKelvey, Matthew P. Galloway
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2014)
Article
Oncology
Chaim B. Colen, Yimin Shen, Farhad Ghoddoussi, Pingyang Yu, Todd B. Francis, Brandon J. Koch, Michael D. Monterey, Matthew P. Galloway, Andrew E. Sloan, Saroj P. Mathupala
Editorial Material
Neurosciences
Matthew P. Galloway
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)