Article
Biochemistry & Molecular Biology
Olga V. Kosmachevskaya, Elvira I. Nasybullina, Konstantin B. Shumaev, Natalia N. Novikova, Alexey F. Topunov
Summary: DNICs, a physiological form of nitric oxide in organisms, act as antioxidants and antiradical agents to protect hemoglobin from oxidative modification caused by peroxynitrite through intercepting peroxynitrite and free radicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anatoly F. Vanin
Summary: This article discusses the oxidative mechanism of M-DNICs formation and the effect of thiol-containing ligands on the stability of these complexes. The results demonstrate that thiol-containing ligands help M-DNICs maintain stability at neutral pH values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Chuan-Kuei Chiang, Yu-Chiao Liu, Kai-Ti Chu, Jing-Ting Chen, Cheng-Yeh Tsai, Gene-Hsiang Lee, Ming-Hsi Chiang, Chien-Ming Lee
Summary: In this study, a dimeric and mononuclear Fe-NO model complex were synthesized and characterized, showing the formation of a thiolate-bridged bimetallic complex during the reduction of the mononuclear complex. The electronic structure of the bimetallic complex was described as a FeII/{Fe(NO)2}9 state, providing insights into the NO scrambling behavior in the activity of flavodiiron nitric oxide reductases (FNORs).
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wen-Han Chuang, Yu-Ting Chou, Yi-Hong Chen, Ting-Han Kuo, Wen-Feng Liaw, Tsai-Te Lu, Chih-Fei Kao, Yun-Ming Wang
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment, memory loss, and behavioral deficits. The aggregation of β-amyloid(1-42) (Aβ(1-42)) is a significant cause of AD pathogenesis. Despite extensive research, current treatment efficacy for AD remains insufficient. Nitric oxide (NO) has a neuroprotective role in the central nervous system by inhibiting Aβ aggregation and rescuing memory and learning deficits through the NO signaling pathway. Targeting the NO pathway may be a therapeutic option, but the limited half-life of NO in the biological system poses a challenge. This study explored a biomimetic dinitrosyl iron complex (DNIC-COOH) that can stably deliver NO to address this issue. Adding DNIC-COOH to neuron-like cells and primary cortical neurons along with Aβ(1-42) demonstrated its ability to protect neuronal cells, enhance neuronal functions, and facilitate Aβ(1-42) degradation through the NO-sGC-cGMP-AKT-GSK3β-CREB/MMP-9 pathway.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jill B. Harland, Subhra Samanta, Nicolai Lehnert
Summary: In this study, three new synthetic model systems for NorBC were designed and characterized using spectroscopy. It was found that replacing the carboxylate ligand with a phenolate or pyridine group restored the reactivity towards NO, resulting in the formation of diiron dinitrosyl complexes. However, no N2O production was detected.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chi-Yen Tung, Wei-Chih Shih, Tzung-Wen Chiou, I-Jui Hsu, Wen-Feng Liaw
Summary: The study reveals that DNIC 1 can facilitate versatile chemical reactions associated with two-electron hydrogen evolution reaction processes, and a three-component photocatalytic system has been developed to achieve efficient hydrogen generation.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Taiming Liu, Hobe Schroeder, Gordon G. Power, Arlin B. Blood
Summary: This review proposes a classification of compounds called "nitrodilators" that dilate vessels by activating a preformed nitrodilator-activated NO store (NANOS) within the cell, despite not releasing free NO.
Article
Chemistry, Inorganic & Nuclear
Wen-Chieh Chang, Wan-Tin Du, Yi-Xuan Lin, Ruei-Lin Jhang, Chung-Hung Hsieh
Summary: This article describes the synthesis and characterization of cationic, neutral, and anionic DNCCs, demonstrating the interconversions and NO releasing ability akin to what is observed in DNICs.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Wen-Chieh Chang, Wan-Tin Du, Yi-Xuan Lin, Ruei-Lin Jhang, Chung-Hung Hsieh
Summary: This article describes the synthesis and characterization of cationic, neutral, and anionic DNCCs, demonstrating the interconversions and NO releasing ability akin to what is observed in DNICs.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Igrunkova, Alexey Fayzullin, Natalia Serejnikova, Tatiana Lipina, Alexandr Pekshev, Anatoly Vanin, Victoria Zaborova, Elena Budanova, Dmitry Shestakov, Igor Kastyro, Anatoly Shekhter
Summary: This study compared the wound healing effects of B-DNIC-GSH and NO-CGF. The results showed that B-DNIC-GSH had a more pronounced effect in reducing inflammation and promoting wound healing compared to NO-CGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Ibrahim Habib, Tsai-Te Lu, Amr Sabbah, Kuei-Hsien Chen, Fu-Te Tsai, Wen-Feng Liaw
Summary: This study presents a novel strategy for the efficient preparation of nanoscale zerovalent iron (NZVI) composites using a one-pot photosynthetic process. The obtained NZVI composites showed potential applications in biomedicine, catalysis, and environmental remediation.
INORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Anatoly F. Vanin
Summary: This study proposed a mechanism for the formation of dinitrosyl iron complex (DNIC) and explored its biological activity. The results showed that the release of NO molecules and nitrosonium cations from these complexes had positive and negative effects, respectively. Additionally, it was suggested to enhance the selective release of nitrosonium cations and incorporate the released NO molecules into biologically non-active mononitrosyl iron complexes using dithiocarbamate derivatives.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Biochemistry & Molecular Biology
Neha Singh, Satish C. Bhatla
Summary: Under oxidative stress conditions, plants enhance antioxidant capacity by regulating iron homeostasis through HO-1, thereby modulating ROS scavenging and antioxidant responses to maintain intracellular redox balance.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Chemistry, Inorganic & Nuclear
Kady M. Oakley, Ziyi Zhao, Ryan L. Lehane, Ji Ma, Eunsuk Kim
Summary: Iron-sulfur clusters have been identified as a target for nitric oxide in biological systems. This study explores the nitrosylation of a synthetic [4Fe-4S] cluster, revealing the production of a RBA-like intermediate and a new DNIC. Additionally, it was found that RBA reacts with thiols to release hydrogen sulfide, suggesting potential challenges in identifying nitrosylated Fe-S clusters in biological systems.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Nataliya A. Sanina, Galina Kozub, Tat'yana A. Kondrat'eva, Denis Korchagin, Gennadii Shilov, Roman B. Morgunov, Nikolai S. Ovanesyan, Alexander Kulikov, Tat'yana S. Stupina, Alexey A. Terent'ev, Sergey M. Aldoshin
Summary: This study synthesized two new anionic dinitrosyl iron complexes with S-donor ligands and investigated their structure and properties using various analytical methods. The experimental results showed that these complexes exhibited high cytotoxicity against human glioma cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Cardiac & Cardiovascular Systems
A. A. Abramov, V. L. Lakomkin, A. Prosvirnin, V. Kapelko
Article
Cardiac & Cardiovascular Systems
A. A. Abramov, V. L. Lakomkin, A. Prosvirnin, E. Lukoshkova, V. Kapelko
Article
Cardiac & Cardiovascular Systems
V. L. Lakomkin, A. A. Abramov, I. M. Studneva, A. D. Ulanova, I. M. Vikhlyantsev, A. Prosvirnin, E. Lukoshkova, V. Kapelko
Article
Acoustics
V. G. Andreev, V. V. Gramovich, M. V. Krasikova, A. I. Korolkov, O. N. Vyborov, N. M. Danilov, T. V. Martynyuk, O. V. Rodnenkov, O. V. Rudenko
ACOUSTICAL PHYSICS
(2020)
Review
Medicine, General & Internal
A. M. Aleevskaya, O. N. Vyborov, V. V. Gramovich, T. Martynyuk
TERAPEVTICHESKII ARKHIV
(2020)
Article
Medicine, Research & Experimental
A. A. Timoshin, K. B. Shumaev, V. L. Lakomkin, A. A. Abramov, E. K. Ruuge
Summary: Transdermal administration of DNIC-Acc increased the total level of NO in lung and liver tissues of rats, accompanied by a slight decrease in mean blood pressure.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
V. I. Kapelko, A. A. Abramov, V. L. Lakomkin, E. V. Lukoshkova
Summary: This study aimed to investigate changes in the mechanical properties of rat myocardium during short-term compression of the lower vena cava. The results showed that the lower the left-ventricular end-systolic volume, the greater the changes in myocardial mechanical performance.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, General & Internal
Irina E. Chazova, Tamila V. Martynyuk, Sergey V. Gorbachevskii, Vladimir V. Gramovich, Nikolay M. Danilov, Elizaveta P. Panchenko, Aleksandr M. Chernyavskiy, Anton A. Shmalts, Igor S. Yavelov
Summary: On December 13, 2021, an expert council was held to discuss the reasons for the low level of diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) during the COVID-19 pandemic and possible ways to improve detection in patients with pulmonary embolism (PE). The main reasons identified were insufficient knowledge among specialists, especially primary care physicians, and a lack of clear regulatory documents and expert centers for managing these patients. The experts suggested strengthening the primary diagnosis of CTEPH through telemedicine consultations, utilizing echocardiography and computed tomography (CT) for differential diagnosis in patients with dyspnea, and maintaining diagnostic vigilance in patients with risk factors and previous venous thromboembolism. They also recommended creating educational materials, algorithms for monitoring patients with PE, and designated responsible specialists for long-term management. Additionally, they proposed developing educational programs and establishing expert centers for monitoring and managing patients with CTEPH, including the ability to perform various diagnostic tests and cooperate with the Ministry of Health to create specific protocols and procedures.
TERAPEVTICHESKII ARKHIV
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
V. Viktoria Gazizova, E. Vlasova, V. Gramovich, L. Ilina, A. Shiryaev, V. Vasilev, R. Akchurin
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
V. L. Lakomkin, A. A. Abramov, E. V. Lukoshkova, A. V. Prosvirnin, V. I. Kapel'ko
Article
Medicine, General & Internal
V. P. Gazizova, E. E. Vlasova, E. Dzybinskaya, V. V. Gramovich, O. Stukalova, A. A. Shiryaev, R. S. Akchurin
TERAPEVTICHESKII ARKHIV
(2020)
Article
Acoustics
V. G. Andreev, V. V. Gramovich, O. N. Vyborov, T. V. Martynyuk, O. V. Rodnenkov, O. V. Rudenko
ACOUSTICAL PHYSICS
(2019)
Article
Medicine, General & Internal
A. A. Safiullina, T. M. Uskach, I. V. Zhirov, O. A. Pogorelova, O. V. Stukalova, S. A. Gaman, V. V. Gramovich, P. I. Novikov, S. N. Tereshchenko
TERAPEVTICHESKII ARKHIV
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Elina Vlasova, V. Gazizova, E. Dzybinskaya, V. Gramovich, V. Vasilyev, A. Shiryaev, R. Akchurin
EUROPEAN JOURNAL OF HEART FAILURE
(2019)
Article
Multidisciplinary Sciences
Yuri M. Poluektov, Irina Yu Petrushanko, Nidas A. Undrovinas, Valentina A. Lakunina, Asker Y. Khapchaev, Valery Kapelko, Alexander A. Abramov, Vladimir L. Lakomkin, Mikhail S. Novikov, Vladimir P. Shirinsky, Vladimir A. Mitkevich, Alexander A. Makarov
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron
Summary: This review investigates the strategy of using nitric oxide (NO) donors to extend postharvest shelf-life and improve fruit quality, discusses the interactions between NO and ethylene or reactive oxygen species, and highlights the potential of nanotechnology in NO applications.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2024)