Review
Urology & Nephrology
Lukasz Swiatek, Jan Jeske, Milosz Miedziaszczyk, Ilona Idasiak-Piechocka
Summary: This systematic review investigated the potential impact of a vegetarian diet on kidney function in CKD patients. The findings suggest that a vegetarian diet improves renal filtration function in CKD patients, highlighting the need for further research on the impact of diet on CKD progression.
Article
Pharmacology & Pharmacy
Rose I. M. Batista, Renato C. Nogueira, Graziele C. Ferreira, Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Jose E. Tanus-Santos
Summary: Supplementation with L-arginine has been shown to have beneficial effects in hypertension by increasing nitric oxide formation and enhancing nitrate concentrations, but these effects may be prevented by antiseptic mouthwash. Alteration of the nitrate cycle in the body by mouthwash can impact endothelial dysfunction, antihypertensive effects, and antioxidant effects of L-arginine in hypertensive rats. The findings suggest a new mechanism where antibacterial mouth rinse can affect arterial blood pressure and the development of cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Almudena Perez-Torres, Alberto Caverni-Munoz, Elena Gonzalez Garcia
Summary: Chronic kidney disease is a major public health issue and Mediterranean diet could be a suitable dietary option for patients. This review aims to provide practical guidelines on how to adapt Mediterranean diet for chronic kidney disease patients.
Article
Physiology
Michaela L. Sundqvist, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom
Summary: The study aimed to investigate potential sex differences in renal nitrate handling during low and high dietary nitrate intake. It was hypothesized that renal clearance and excretion of nitrate are higher in men compared to women. Results showed that women had lower urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance, and fractional excretion of nitrate compared to men.
Article
Nutrition & Dietetics
Ban-Hock Khor, Dina A. Tallman, Tilakavati Karupaiah, Pramod Khosla, Maria Chan, Joel D. Kopple
Summary: This study evaluated the nutrient composition of plant-based low protein diets and moderately high protein diets for chronic kidney disease patients in the Asia Pacific region. The study found that plant-based diets were deficient in essential amino acids at lower protein prescriptions, but met the Recommended Dietary Allowances at higher protein intakes. Plant-based and vegetarian diets contained higher potassium, phosphorus, and calcium content but lower long-chain n-3 polyunsaturated fatty acids and vitamin B-12 compared to conventional diets. Planning of all low protein diets, especially plant-based and vegetarian diets, should ensure the adequacy of all nutrients, particularly essential amino acids, and consider supplementing with multivitamins and trace elements.
Article
Nutrition & Dietetics
Yi-Chou Hou, Hui-Fen Huang, Wen-Hsin Tsai, Sin-Yi Huang, Hao-Wen Liu, Jia-Sin Liu, Ko-Lin Kuo
Summary: A vegetarian diet is associated with a lower occurrence of chronic kidney disease in patients with diabetes mellitus. Both lacto-ovo vegetarians and vegans have a lower risk of CKD compared to omnivores, and the risk of CKD related to high BMI and hyperuricemia is also lower for those following a vegan or lacto-ovo diet.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
John Ukeri, Michael T. Wilson, Brandon J. Reeder
Summary: Cytoglobin has physiological roles that are not clearly understood, but may include regulation of nitric oxide, oxygen sensing, and protection against oxidative stress. Specific mutations can affect the nitric oxide binding and metabolism activities of cytoglobin, helping to understand its precise role under physiological and pathophysiological conditions.
Article
Nutrition & Dietetics
Chia-Lin Wu, Wen-Hsin Tsai, Jia-Sin Liu, Hao-Wen Liu, Sin-Yi Huang, Ko-Lin Kuo
Summary: This study found that vegetarians have a lower risk of chronic kidney disease (CKD) compared to omnivores in patients with hyperuricemia. Additionally, age, diabetes, hypertension, obesity, and high uric acid levels were identified as independent risk factors for CKD in patients with hyperuricemia.
Article
Nutrition & Dietetics
Barbora Piknova, Ji Won Park, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: Nitric oxide (NO) (co)regulates physiological processes in the body and its availability is affected by aging. Aging leads to changes in nitrate and nitrite contents in tissues, with higher nitrate levels and lower nitrite levels in old rats compared to young rats. However, the nitrate reduction pathway is not affected by aging. Further investigation is needed to understand the changes in NO accessibility during aging.
Article
Medicine, General & Internal
Monica Dinu, Barbara Colombini, Giuditta Pagliai, Ilaria Giangrandi, Francesca Cesari, Annamaria Gori, Betti Giusti, Rossella Marcucci, Francesco Sofi
Summary: In a group of subjects with medium-to-low cardiovascular risk profile, a 3-month lacto-ovo-vegetarian diet resulted in significant improvements in kidney function markers, while no significant changes were observed in the Mediterranean diet group. The effects of the two diets on kidney function markers showed opposite trends. More trials are needed to confirm these results.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Nutrition & Dietetics
Aljazi Bin Zarah, Mary Carissa Feraudo, Jeanette Mary Andrade
Summary: Limited instruments to determine diet quality among US adults with chronic kidney disease were addressed in this study by developing a food frequency questionnaire (CKD SFFQ) and validating it against two 24-hour recalls. The CKD SFFQ showed good agreement with the recalls in assessing overall diet quality, with a systematic trend towards higher estimates in certain components. The majority of participants reported rarely or never consuming certain food groups, such as grains, fruits, vegetables, seafood, and plant proteins.
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. Ward
Summary: Endothelial dysfunction may lead to atherosclerosis, while dietary nitrate/nitrite shows significant benefits on cardiovascular homeostasis. Research suggests that nitrate/nitrite may enhance eNOS activation by stimulating AMPK signaling pathway, potentially contributing to vascular protective effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Transplantation
Hirofumi Hamano, Yasumasa Ikeda, Hiroaki Watanabe, Yuya Horinouchi, Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Kenshi Takechi, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya, Toshiaki Tamaki
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Article
Pharmacology & Pharmacy
Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki, Koichiro Tsuchiya
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Peripheral Vascular Disease
Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Hiroki Toya, Tomoko Nagao, Marin Morishita, Koichi Tsuneyama, Yuya Horinouchi, Yoshitaka Kihira, Kenshi Takechi, Yasumasa Ikeda, Koichiro Tsuchiya, Masanori Yoshizumi, Toshiaki Tamaki, Keisuke Ishizawa
JOURNAL OF HYPERTENSION
(2019)
Article
Pharmacology & Pharmacy
Masaki Imanishi, Yuki Izawa-Ishizawa, Takumi Sakurada, Yusuke Kohara, Yuya Horinouchi, Eriko Sairyo, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Keijo Fukushima, Yasumasa Ikeda, Hiromichi Fujino, Masanori Yoshizumi, Koichiro Tsuchiya, Toshiaki Tamaki, Keisuke Ishizawa
Review
Oncology
Hirofumi Hamano, Marin Mitsui, Yoshito Zamami, Kenshi Takechi, Takahiro Nimura, Naoto Okada, Keijo Fukushima, Masaki Imanishi, Masayuki Chuma, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yasushi Kirino, Toshimi Nakamura, Kazuhiko Teraoka, Yasumasa Ikeda, Hiromichi Fujino, Hiroaki Yanagawa, Toshiaki Tamaki, Keisuke Ishizawa
SUPPORTIVE CARE IN CANCER
(2019)
Article
Peripheral Vascular Disease
Masateru Kondo, Masaki Imanishi, Keijo Fukushima, Raiki Ikuto, Yoichi Murai, Yuya Horinouchi, Yuki Izawa-Ishizawa, Mitsuhiro Goda, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Yasumasa Ikeda, Hiromichi Fujino, Koichiro Tsuchiya, Keisuke Ishizawa
AMERICAN JOURNAL OF HYPERTENSION
(2019)
Article
Biochemistry & Molecular Biology
Yasumasa Ikeda, Akiho Satoh, Yuya Horinouchi, Hirofumi Hamano, Hiroaki Watanabe, Mizuki Imao, Masaki Imanishi, Yoshito Zamami, Kenshi Takechi, Yuki Izawa-Ishizawa, Licht Miyamoto, Tasuku Hirayama, Hideko Nagasawa, Keisuke Ishizawa, Ken-Ichi Aihara, Koichiro Tsuchiya, Toshiaki Tamaki
Article
Pharmacology & Pharmacy
Tatsuya Tsuda, Masaki Imanishi, Mizuho Oogoshi, Mitsuhiro Goda, Yoshitaka Kihira, Yuya Horinouchi, Yoshito Zamami, Keisuke Ishizawa, Yasumasa Ikeda, Ichiro Hashimoto, Toshiaki Tamaki, Yuki Izawa-Ishizawa
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2020)
Article
Medicine, Research & Experimental
Yuki Tsuchihashi, Shinji Abe, Licht Miyamoto, Honoka Tsunematsu, Toshihiro Izumi, Aya Hatano, Hiroko Okuno, Megumi Yamane, Takashi Yasuoka, Yasumasa Ikeda, Koichiro Tsuchiya
MOLECULAR PHARMACEUTICS
(2020)
Article
Toxicology
Hirofumi Hamano, Takahiro Niimura, Yuya Horinouchi, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Masaki Imanishi, Masayuki Chuma, Yuki Izawa-Ishizawa, Licht Miyamoto, Keijo Fukushima, Hiromichi Fujino, Koichiro Tsuchiya, Keisuke Ishizawa, Toshiaki Tamaki, Yasumasa Ikeda
TOXICOLOGY LETTERS
(2020)
Article
Endocrinology & Metabolism
Yasumasa Ikeda, Hiroaki Watanabe, Tetsuya Shiuchi, Hirofumi Hamano, Yuya Horinouchi, Masaki Imanishi, Mitsuhiro Goda, Yoshito Zamami, Kenshi Takechi, Yuki Izawa-Ishizawa, Licht Miyamoto, Keisuke Ishizawa, Ken-ichi Aihara, Koichiro Tsuchiya, Toshiaki Tamaki
Article
Pharmacology & Pharmacy
Masaki Imanishi, Yusuke Yamakawa, Keijo Fukushima, Raiki Ikuto, Akiko Maegawa, Yuki Izawa-Ishizawa, Yuya Horinouchi, Masateru Kondo, Masatoshi Kishuku, Mitsuhiro Goda, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Yasumasa Ikeda, Koichiro Tsuchiya, Hiromichi Fujino, Koichi Tsuneyama, Keisuke Ishizawa
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Article
Urology & Nephrology
Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Yuki Izawa-Ishizawa, Licht Miyamoto, Keisuke Ishizawa, Hiromichi Fujino, Toshiaki Tamaki, Ken-ichi Aihara, Koichiro Tsuchiya
Summary: Research suggests that diphenhydramine may serve as a novel treatment for cisplatin-induced kidney toxicity by inhibiting cell death and reducing oxidative stress to alleviate kidney injury, with clinical evidence from patients supporting this finding.
KIDNEY INTERNATIONAL
(2021)
Article
Oncology
Kenta Yagi, Marin Mitstui, Yoshito Zamami, Takahiro Niimura, Yuki Izawa-Ishizawa, Mitsuhiro Goda, Masayuki Chuma, Kimiko Fukunaga, Takahiro Shibata, Shunsuke Ishida, Takumi Sakurada, Naoto Okada, Hirofumi Hamano, Yuya Horinouchi, Yasumasa Ikeda, Hiroaki Yanagawa, Keisuke Ishizawa
Summary: In this study, it was found that the use of proton pump inhibitors in bevacizumab-treated patients is associated with a lower treatment response, possibly due to PPIs inducing VEGF gene expression. Therefore, while PPIs may prevent hypertension in patients, they may reduce the anti-tumoral effects of bevacizumab.
Article
Pharmacology & Pharmacy
Aoi Suenaga, Yasuyuki Seto, Masafumi Funamoto, Masaki Imanishi, Koichiro Tsuchiya, Yasumasa Ikeda
Summary: This study investigated the effects of TJ-17, a traditional Japanese Kampo medicine, on chronic kidney disease (CKD). The results showed that TJ-17 could alleviate renal injury, inflammation, and fibrosis in a mouse model of CKD induced by folic acid. It has a potential preventive effect on CKD.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron
Summary: This review investigates the strategy of using nitric oxide (NO) donors to extend postharvest shelf-life and improve fruit quality, discusses the interactions between NO and ethylene or reactive oxygen species, and highlights the potential of nanotechnology in NO applications.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2024)