Article
Environmental Sciences
Guo-Shou Wang, Ji-Ying Chen, Wei-Cheng Chen, I-Chin Wei, Szu-Wei Lin, Kuang-Wen Liao, Tzu-Sen Yang, Ju-Fang Liu
Summary: This study demonstrates that surfactin can induce apoptosis in osteosarcoma cells while having no effect on normal cells. Surfactin triggers ER stress and mitochondrial dysfunction, leading to programmed cell apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang
Summary: This study reveals that excessive ER Ca2+ can directly activate the IRE1a-XBP1 pathway, and inhibition of over-activated IRE1a-XBP1 signaling in TMCO1-deficient cells can lead to significant cell death.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ling Chen, Xuejie Huan, Fengju Jia, Zhen Zhang, Mingxia Bi, Lin Fu, Xixun Du, Xi Chen, Chunling Yan, Qian Jiao, Hong Jiang
Summary: OTUD3 knockout mice exhibited loss of nigral dopaminergic neurons and Parkinsonian symptoms, and the underlying mechanism involves the activation of IRE1a-induced ER stress. The ER stress inhibitor TUDCA can alleviate the observed phenotypes. Additionally, OTUD3 regulates the ubiquitination level of Fortilin, affecting the interaction ability of IRE1a with Fortilin and ultimately enhancing the activity of IRE1a.
Article
Biochemistry & Molecular Biology
Roberta Gonnella, Maria Saveria Gilardini Montani, Luisa Guttieri, Maria Anele Romeo, Roberta Santarelli, Mara Cirone
Summary: This study demonstrates the crucial role of the IRE1α/XBP1 axis in the survival of PEL cells, with minor influence from PERK and ATF6, and the ability of the IRE1α/XBP1 axis to induce the release of IL-6, IL-10, and VEGF. Additionally, IRE1α/XBP1 inhibition reduces STAT3 phosphorylation and induces pro-survival autophagy in PEL cells, suggesting that targeting this axis may be a promising strategy against PEL cells.
Article
Immunology
Xi Chen, Chao Li, Jiali Liu, Yangyang He, Yungeng Wei, Jie Chen
Summary: Inhibition of ER stress alleviated crystalline silica-induced pulmonary fibrosis, with TXNDC5 playing a key role in fibroblast activation and being closely related to IRE1 alpha-XBP-1 signaling. Pharmacological inhibition of IRE1 alpha improved pulmonary function and delayed crystalline silica-induced lung fibrosis, demonstrating potential as novel therapeutic targets for silicosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tsung-Lang Chiu, Hsin-Yi Huang, Hui-Fen Chang, Hsin-Rong Wu, Mei-Jen Wang
Summary: This study reveals that mutations in the parkin gene contribute to the degeneration of dopaminergic neurons under nitrosative stress, while the normal parkin gene can protect the neurons from cell apoptosis induced by nitric oxide exposure. Furthermore, parkin enhances the protective function through the IRE1oc/XBP1 signaling pathway, while mutant parkin disrupts this function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yue An, Changyong Xu, Wenmin Liu, Ji Jiang, Pengfei Ye, Mei Yang, Weihua Zhu, Jingjing Yu, Manman Yu, Wuyi Sun, Jian Hong, Huan Qiu, Wei Wei, Shihao Zhang
Summary: This study found that AT2R is highly expressed during the progression of liver fibrosis and suppresses the IRE1 alpha-XBP1 pathway, thereby attenuating liver fibrosis. AT2R inhibits the activation and proliferation of hepatic stellate cells and acts as a potential therapeutic target for treating liver fibrosis.
CELLULAR SIGNALLING
(2024)
Review
Cell Biology
Ling Chen, Mingxia Bi, Zhen Zhang, Xixun Du, Xi Chen, Qian Jiao, Hong Jiang
Summary: IRE1 alpha is a protein that resides in the endoplasmic reticulum and acts as a sensor for ER stress. It plays important roles in maintaining protein homeostasis and regulating various cellular processes. In addition, IRE1 alpha is crucial in neurodegenerative diseases, making it a potential target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell Biology
Wei-Bin Shen, Bingbing Wang, Ruofan Yao, Katherine R. Goetzinger, Sheng Wu, Haijun Gao, Peixin Yang
Summary: Maternal obesity is associated with adverse obstetrical outcomes and increased risk of congenital heart defects in fetuses. This study examines the activation of endoplasmic reticulum stress pathways in obese placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hakim Manghwar, Jianming Li
Summary: Plants are sensitive to various stresses that can lead to diseases, but they have defense mechanisms to cope with these stresses. The endoplasmic reticulum (ER) plays a crucial role in protein folding, but this process can be disrupted by stresses, causing ER stress. We discuss ER stress, the unfolded protein response (UPR) and strategies for reducing ER stress in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zheng-kun Zhang, Yan Zhou, Jun Cao, Dan-yang Liu, Li-hong Wan
Summary: The study found that rosmarinic acid has a protective effect on septic-associated mortality and lung injury by inhibiting lung cell apoptosis to alleviate inflammation.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Aparajita Madhavan, Bernard P. Kok, Bibiana Rius, Julia M. D. Grandjean, Adekunle Alabi, Verena Albert, Ara Sukiasyan, Evan T. Powers, Andrea Galmozzi, Enrique Saez, R. Luke Wiseman
Summary: Signaling through the IRE1 arm of the unfolded protein response has both protective and harmful effects in obesity. A selective pharmacological activator of IRE1/XBP1s signaling can stimulate adaptive remodeling in the liver and pancreas, and mitigate obesity-linked metabolic dysfunction. The activator improves systemic glucose metabolism, liver insulin action, and enhances pancreatic function.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Xiaoyang Zhao, Min Wang, Jingjing Liu, Xiong Su
Summary: The study suggests that stearoyl-CoA desaturase 1 (SCD1) and oleic acid can effectively reverse silica nanoparticle (SiNP)-induced endoplasmic reticulum stress and insulin resistance, while the effects of thapsigargin treatment cannot be restored. Moreover, downregulation of SCD1 and excessive accumulation of IRE1 alpha protein prevent the beneficial effects of exogenous oleic acid on insulin resistance induced by endoplasmic reticulum stress.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Food Science & Technology
Su Been Park, Gun Hee Cho, Young Eun Park, Hyang Sook Chun
Summary: Emodin induces endoplasmic reticulum stress and apoptosis in HepG2 cells, suggesting its potential hepatotoxicity.
Review
Medicine, Research & Experimental
Yi Kong, Jian Jiang, Yuqiong Huang, Li Li, Xin Liu, Zilin Jin, Fen Wei, Xinxin Liu, Song Zhang, Xiaoru Duan, Yonghui Zhang, Qingyi Tong, Hongxiang Chen
Summary: This review summarizes the research progress on endoplasmic reticulum stress in melanoma and discusses the mechanisms of melanoma pathogenesis and resistance, as well as the potential of targeting endoplasmic reticulum stress or the unfolded protein response process for melanoma therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron
Summary: This review investigates the strategy of using nitric oxide (NO) donors to extend postharvest shelf-life and improve fruit quality, discusses the interactions between NO and ethylene or reactive oxygen species, and highlights the potential of nanotechnology in NO applications.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2024)