Article
Respiratory System
Michael F. Morris, Yash Pershad, Paul Kang, Lauren Ridenour, Ben Lavon, Maarten Lanclus, Rik Godon, Jan De Backer, Marilyn K. Glassberg
Summary: Evidence suggests that a decrease in BV5% on chest CT scans may predict adverse clinical outcomes in COVID-19 patients. A BV5% threshold below 25% was associated with increased odds ratios for mortality, intubation, and the composite of mortality or intubation, indicating its potential as a novel biomarker for predicting outcomes in these patients.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Rehabilitation
Rim Dridi, Nadia Dridi, Nabil Gmada, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study analyzed the effects of regular soccer training on pulmonary function in boys aged 6 to 10 years. The results showed that soccer training significantly improved alveolar-capillary membrane diffusion capacity and capillary blood volume in the lungs.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)
Article
Biochemistry & Molecular Biology
Liukun Meng, Wen Yuan, Hongjie Chi, Ruijuan Han, Yeping Zhang, Xiangbin Pan, Jian Meng, Ying Liu, Jiawei Song, Jiuchang Zhong, Xiaoyan Liu
Summary: This study revealed a significant role of CMG2 in the pathogenesis of SPS-induced PAH, where CMG2 deficiency exacerbates vascular remodeling, suggesting CMG2 as a potential target for the treatment of CHD-PAH.
Review
Cardiac & Cardiovascular Systems
Jean-Paul Richalet, Eric Hermand, Francois J. Lhuissier
Summary: Hypoxic conditions encountered at high altitude affect all physiological functions. Cardiovascular responses to hypoxia provide a remarkable model of oxygen regulation. Hypoxia can have adverse effects in patients with cardiovascular diseases, but intermittent, moderate hypoxia might be useful in managing certain cardiovascular disorders.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Karen Sanchez, Lenin Ramirez-Cando, Wilfre Machado, Anita Villafuerte, Santiago Banaz
Summary: This study analyzed the risk factors underlying high-altitude pulmonary edema (HAPE) in dwellers and travelers of the Ecuadorian Andes. The findings showed that high-altitude dwellers, particularly children and elder people, were more prone to HAPE, while women were more tolerant of HAPE than men. Additionally, elevated median corpuscular hemoglobin concentration (MCHC) was found to be strongly associated with HAPE risk.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Jacob Peter Hartmann, Rasmus H. Dahl, Stine Nymand, Gregers W. Munch, Camilla K. Ryrso, Bente K. Pedersen, Pia Thaning, Stefan P. Mortensen, Ronan M. G. Berg, Ulrik Winning Iepsen
Summary: This study aimed to compare peripheral exercise limitations in patients with COPD and CHF. The results showed that in small muscle mass exercise, the convective oxygen transport was limited in COPD patients, while muscle diffusive oxygen transport was unresponsive in CHF patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Ruijun Jiang, Tonglu Li, Zhijie Jia, Yonglu Dong
Summary: This study investigated the soil properties and groundwater resources of Hailiutu pasture in Inner Mongolia, China, and measured the soil water characteristics. The results showed that the pasture had an available water capacity of 218.0 mm and acted as a natural capillary barrier optimizing irrigation. Therefore, a drip irrigation method was designed for irrigation in dryland pastures.
Article
Cardiac & Cardiovascular Systems
Andreas Seraphim, Kristopher D. Knott, Katia Menacho, Joao B. Augusto, Rhodri Davies, Iain Pierce, George Joy, Anish N. Bhuva, Hui Xue, Thomas A. Treibel, Jackie A. Cooper, Steffen E. Petersen, Marianna Fontana, Alun D. Hughes, James C. Moon, Charlotte Manisty, Peter Kellman
Summary: This study explores the prognostic significance of PTT and PBVi using an automated method with CMR. The results show that these parameters can independently predict adverse cardiovascular outcomes, offering additional insights into cardiopulmonary function.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Anders Nelsson, Mikael Kanski, Henrik Engblom, Martin Ugander, Marcus Carlsson, Hakan Arheden
Summary: Increased pulmonary blood volume (PBV) is a measure of congestion and is associated with an increased risk of cardiovascular events. This study aimed to determine the accuracy and precision for different methods of quantifying PBV, finding that adjusting for left atrium volume (LAV) is crucial for more accurate results. Among the methods tested, CoG(FPP) had the best precision and lowest interobserver variability for measuring PBV.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Respiratory System
Marina Aiello, Laura Marchi, Luigino Calzetta, Silvia Speroni, Annalisa Frizzelli, Marianna Ghirardini, Valentina Celiberti, Nicola Sverzellati, Maria Majori, Pier Anselmo Mori, Silvia Ranzieri, Roberta Pisi, Giovanna Pela, Massimo Corradi, Alfredo Chetta
Summary: By evaluating laboratory data, lung function, and radiological changes in patients after the onset of COVID-19 interstitial pneumonia, a risk assessment score for pulmonary sequelae at high-resolution computed tomography (HRCT) was established. This score, known as the COVID-19 Sequelae Score (COSeSco), includes age, BMI, comorbidities, D-dimer levels, walking distance, and dyspnea perception to identify high-risk COVID-19 patients likely to develop pulmonary sequelae assessed by HRCT.
Review
Biology
Thomas Georges, Camille Le Blanc, Sophie Ferreol, Pierre Menu, Marc Dauty, Alban Fouasson-Chailloux
Summary: With the increasing prevalence of air travel and altitude stays, COPD patients are at higher risk of serious complications and require comprehensive care to manage potential issues.
Article
Critical Care Medicine
Marius M. Hoeper, Krit Dwivedi, Christine Pausch, Robert A. Lewis, Karen M. Olsson, Doerte Huscher, David Pittrow, Ekkehard Gruenig, Gerd Staehler, Carmine Dario Vizza, Henning Gall, Oliver Distler, Christian Opitz, John Simon R. Gibbs, Marion Delcroix, Da-Hee Park, Hossein Ardeschir Ghofrani, Ralf Ewert, Harald Kaemmerer, Hans-Joachim Kabitz, Dirk Skowasch, Juergen Behr, Katrin Milger, Tobias J. Lange, Heinrike Wilkens, Hans-Juergen Seyfarth, Matthias Held, Daniel Dumitrescu, Iraklis Tsangaris, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose, Martin Claussen, Stephan Eisenmann, Kai-Helge Schmidt, Andrew J. Swift, Alfred A. Roger Thompson, Charlie A. Elliot, Stephan Rosenkranz, Robin Condliffe, David G. Kiely, Michael Halank
Summary: This study provides a detailed characterization of patients meeting diagnostic criteria for idiopathic pulmonary arterial hypertension (IPAH) and identifies a distinct lung phenotype characterized by low diffusion capacity for carbon monoxide (DLCO) and smoking history. These patients resemble those with pulmonary hypertension due to lung disease rather than classical IPAH. These findings have important implications for understanding the pathogenesis, diagnosis, and treatment of the disease and warrant further exploration.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Physiology
Alessandra Magini, Gerald S. Zavorsky, Anna Apostolo, Mauro Contini, Simone Barbieri, Piergiuseppe Agostoni
Summary: In heart failure patients, the week-to-week variability in DMCO was lowest when using the single-step NO-CO technique, while Vcap estimation was unreliable. The DMCO derived from double diffusion most closely matched that from the RF method.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Medicine, General & Internal
Eleni Diamanti, Vasiliki Karava, Patrick Yerly, John David Aubert
Summary: This study investigated the association between DLCO and PH severity and survival, finding that DLCO is negatively associated with transplant-free survival in PH patients. The inclusion of DLCO into a PH risk stratification score shows promise and requires further investigation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Luis A. Torres, Kristine E. Lee, Gregory P. Barton, Andrew D. Hahn, Nathan Sandbo, Mark L. Schiebler, Sean B. Fain
Summary: This study aimed to evaluate lung perfusion in idiopathic pulmonary fibrosis (IPF) patients using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). The results showed regional perfusion differences between IPF patients and healthy controls, which were not evident in global analysis. Decreased first moment transit time (FMTT) may be a candidate marker for IPF progression.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Pediatrics
Jean-Benoit Martinot, Valerie Cuthbert, Nhat N. Le-Dong, Nathalie Coumans, Deborah De Marneffe, Clement Letesson, Jean L. Pepin, David Gozal
Summary: Automated analysis using mandibular movements during sleep shows promising potential for diagnosing moderate-to-severe pediatric obstructive sleep apnea.
PEDIATRIC PULMONOLOGY
(2022)
Letter
Critical Care Medicine
Nhat-Nam Le-Dong, Jean-Benoit Martinot, Nathalie Coumans, Valerie Cuthbert, Renaud Tamisier, Ebastien Bailly, Jean-Louis Pepin
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Valerie Cuthbert, Stephane Denison, David Gozal, Gilles Lavigne, Jean-Louis Pepin
Summary: This study used an artificial intelligence-based approach to automatically detect rhythmic masticatory muscles activities by identifying stereotypical mandibular jaw movements, demonstrating the reliability and quantifiability of sleep bruxism.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Medicine, General & Internal
Lulu Bravo, Igor Smolenov, Htay Htay Han, Ping Li, Ramona Hosain, Frank Rockhold, Sue Ann Costa Clemens, Camilo Roa, Charissa Borja-Tabora, Antoinette Quinsaat, Pio Lopez, Eduardo Lopez-Medina, Leonardo Brochado, Eder A. Hernandez, Humberto Reynales, Tatiana Medina, Hector Velasquez, Leonardo Bautista Toloza, Edith Johana Rodriguez, Dora Ines Molina de Salazar, Camilo A. Rodriguez, Eduardo Sprinz, Jose Cerbino-Neto, Kleber Giovanni Luz, Alexandre Vargas Schwarzbold, Maria Sanali Paiva, Josefina Carlos, May Emmeline B. Montellano, Mari Rose A. de Los Reyes, Charles Y. Yu, Edison R. Alberto, Mario M. Panaligan, Milagros Saivani-Bautista, Erik Buntinx, Maya Hites, Jean-Benoit Martinot, Qasim E. Bhorat, Aysha Badat, Carmen Baccarini, Branda Hu, Jaco Jurgens, Jan Engelbrecht, Donna Ambrosino, Peter Richmond, George Siber, Joshua Liang, Ralf Clemens
Summary: The SCB-2019 vaccine, supplemented with CpG and alum, provides significant protection against COVID-19 caused by different SAR-CoV-2 viruses, including the dominant Delta variant.
Article
Cardiac & Cardiovascular Systems
Claire de Bisschop, Fabrice Caron, Pierre Ingrand, Quentin Bretonneau, Olivier Dupuy, Jean-Claude Meurice
Summary: The study showed that a 4-week pulmonary rehabilitation program, with or without BCAA supplementation, can improve muscle function, quality of life, and dyspnea in COPD patients. However, the effect of BCAA supplementation on muscle oxygenation may not be significant.
RESPIRATORY MEDICINE
(2021)
Letter
Clinical Neurology
Bruno Revol, Christel Castelli, Raoua Ben Messaoud, Amandine Coffy, Sebastien Bailly, Ingrid Jullian-Desayes, Jean-Benoit Martinot, Pierre Martinot, Marie Joyeux-Faure, Jean-Louis Pepin
Article
Neurosciences
Julia L. Kelly, Raoua Ben Messaoud, Marie Joyeux-Faure, Robin Terrail, Renaud Tamisier, Jean-Benoit Martinot, Nhat-Nam Le-Dong, Mary J. Morrell, Jean-Louis Pepin
Summary: This study evaluated the diagnostic capability of using measurements of mandibular movement (MM) combined with automated machine learning analysis for obstructive sleep apnoea (OSA) diagnosis. The results showed that this method is comparable to manually scored in-home polysomnography (PSG), making it a convenient diagnostic tool that can be used in the patients' own home.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jean-Louis Pepin, Nhat-Nam Le-Dong, Valerie Cuthbert, Nathalie Coumans, Renaud Tamisier, Atul Malhotra, Jean-Benoit Martinot
Summary: This study investigated the similarity between sleep mandibular movements (MM) signal and esophageal pressure (PES) signal, and found that MM signals can be a reliable surrogate for measuring respiratory effort in patients with suspected obstructive sleep apnea (OSA).
NATURE AND SCIENCE OF SLEEP
(2022)
Letter
Clinical Neurology
Jean-Benoit Martinot, Jean-Louis Pepin, Atul Malhotra, Nhat-Nam Le-Dong
Article
Critical Care Medicine
Guillaume Bottaz-Bosson, Alphanie Midelet, Monique Mendelson, Jean -Christian Borel, Jean -Benoit Martinot, Ronan Le Hy, Marie -Caroline Schaeffer, Adeline Samson, Agnes Hamon, Renaud Tamisier, Atul Malhotra, Jean-Louis Pepin, Sebastien Bailly
Summary: PAP remote monitoring has revolutionized the management of OSA by providing valuable and objective information about patient treatment adherence and efficiency. However, current studies often oversimplify data analysis, lacking standardized indicators and not considering missing values or treatment interruptions. To ensure fair comparison and avoid biases, rigorous data cleaning and processing are necessary. Improving data quality and standardization could facilitate data sharing and the application of AI strategies in sleep apnea research.CHEST 2023; 163(5):1279-1291
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
J. B. Martinot, S. Bailly, R. Tamisier, N. Le-Dong, J. L. Pepin
Article
Respiratory System
Iwein Gyselinck, Laurens Liesenborghs, Ann Belmans, Matthias M. Engelen, Albrecht Betrains, Quentin Van Thillo, Pham Anh Hong Nguyen, Pieter Goeminne, Ann-Catherine Soenen, Nikolaas De Maeyer, Charles Pilette, Emmanuelle Papleux, Eef Vanderhelst, Aurelie Derweduwen, Patrick Alexander, Bernard Bouckaert, Jean-Benoit Martinot, Lynn Decoster, Kurt Vandeurzen, Rob Schildermans, Peter Verhamme, Wim Janssens, Robin Vos
Summary: This study evaluated the efficacy of azithromycin in hospitalized COVID-19 patients and found that it did not affect the time to clinical improvement.
Meeting Abstract
Critical Care Medicine
J. P. Martinot, N. Le-Dong, V. Cuthbert, J. Pepin
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Health Care Sciences & Services
Jean-Louis Pepin, Sebastien Bailly, Jean-Christian Borel, Sophie Logerot, Marc Sapene, Jean-Benoit Martinot, Patrick Levy, Renaud Tamisier
Summary: Patterns of continuous positive airway pressure device use by obstructive sleep apnoea patients collected through telemonitoring can indicate the onset of COVID-19 symptoms. Existing telemonitoring platforms could be immediately used to screen for COVID-19, and for other respiratory infections, in this large at-risk population.
Article
Biochemistry & Molecular Biology
Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron
Summary: This review investigates the strategy of using nitric oxide (NO) donors to extend postharvest shelf-life and improve fruit quality, discusses the interactions between NO and ethylene or reactive oxygen species, and highlights the potential of nanotechnology in NO applications.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2024)