期刊
NICOTINE & TOBACCO RESEARCH
卷 11, 期 8, 页码 954-960出版社
OXFORD UNIV PRESS
DOI: 10.1093/ntr/ntp092
关键词
-
资金
- Flight Attendants Medical Research Institute
- U. S. Public Health Service [DA02277, DA12393]
- General Clinical Research Center at San Francisco General Hospital [NIH RR00083]
Introduction: Plasma or saliva cotinine concentrations are used widely as biomarkers of secondhand smoke (SHS) exposure and have been associated with the risk of SHS-related disease. Concentrations of cotinine and other nicotine metabolites are considerably higher in urine than in plasma or saliva, making chemical analysis easier. In addition, urine is often more convenient to collect in some SHS exposure studies. The optimal use of nicotine metabolites in urine, singly or in combination, with or without correction for urine creatinine concentration, to estimate plasma cotinine concentration with low-level nicotine exposure has not been determined. Methods: We dosed 36 nonsmokers with 100, 200, or 400 m g deuterium-labeled nicotine (simulating exposure to SHS) by mouth daily for 5 days and then measured plasma and urine cotinine and metabolites at various intervals over 24 hr. Results: A plasma cotinine concentration of 1 ng/ml corresponds on average to a daily intake of 100 m g nicotine. Cotinine concentrations in urine averaged four to five times those in plasma. Correction of urine cotinine for creatinine concentration improved the correlation between urine and plasma cotinine. Measuring multiple cotinine metabolites in urine did not improve the correlation with plasma cotinine, compared with the use of urine cotinine alone. Discussion: Measurement of urine cotinine corrected for creatinine concentration appears to be the best predictor of plasma cotinine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据