期刊
STROKE
卷 46, 期 6, 页码 1707-1709出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.115.009090
关键词
cerebral amyloid angiopathy
资金
- Cambridge National Institute for Health Research Comprehensive Biomedical Research Centre
- Medical Research Council [G0001354, G1000183B, G0001354B] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10090] Funding Source: researchfish
Background and Purpose-We investigated the relationship between magnetic resonance imaging-visible centrum semiovale perivascular spaces (CSO-PVS), a biomarker of impaired interstitial fluid drainage, and positron emission tomography-based amyloid-beta burden across a wide range of cerebrovascular amyloid deposition. Methods-Thirty-one nondemented subjects (11 probable cerebral amyloid angiopathy patients and 10 healthy subjects >= 60 years; 10 older individuals, <60 years) had brain magnetic resonance imaging and Pittsburgh compound B-positron emission tomography. CSO-PVS was evaluated on T2-magnetic resonance imaging using a 4-point scale. The association between Pittsburgh compound B and CSO-PVS was assessed in linear regression. Results-In multivariable analyses adjusted for age, microbleeds and white matter hyperintensities, whole cortex Pittsburgh compound B binding was associated with CSO-PVS degree both as continuous (coefficient, 0.11; 95% confidence interval, 0.01-0.22; P=0.040) and as dichotomous variable (coefficient, 0.27; 95% confidence interval, 0.11-0.44; P=0.002). The median Pittsburgh compound B retention was higher in high versus low CSO-PVS degree (P=0.0007). Conclusions-This pilot study suggests a possible association between cerebrovascular amyloid deposition and CSO-PVS, with potential pathophysiological implications.
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