Review
Cardiac & Cardiovascular Systems
Rupak Desai, Avilash Mondal, Abhishek Prasad, Ankit Vyas, Akhil Jain, Chintan Rupareliya, Manan Shah, Timir Paul, Gautam Kumar, Rajesh Sachdeva
Summary: This study examined 12 CCI patients with confirmed or suspected COVID-19 infection. The majority of these patients were middle-aged males from the Middle East, Spain, and the USA. Among them, 6 patients tested positive for COVID-19 antibodies, with type 2 DM, hyperlipidemia, and smoking as primary risk factors. Neurological impairments and verbal impairment were common symptoms, and left MCA infarct was the most frequent neuroimaging finding. Conservative therapies such as DAPT and anticoagulants were used, and different treatments were applied for AMI and AIS patients. COVID-19-related complications were observed in some cases, and 7 patients had residual deficits upon discharge, with 1 patient unfortunately dying.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Syed Kashif Zaidi, Farid Ahmed, Heba Alkhatabi, Md Nasrul Hoda, Muhammad Al-Qahtani
Summary: The COVID-19 pandemic has heightened global occurrences of hypoxia, including thrombotic stroke, making nitric oxide therapy a promising option. Nebulized low-dose GSNO has been shown to enhance collateral microvascular perfusion in diabetic mice following stroke, indicating its potential for development as an affordable field therapy against ischemic events.
Article
Cardiac & Cardiovascular Systems
Jean-Philippe Collet, Eric Van Belle, Holger Thiele, Sergio Berti, Thibault Lhermusier, Thibault Manigold, Franz-Josef Neumann, Martine Gilard, David Attias, Farzin Beygui, Angel Cequier, Fernando Alfonso, Pierre Aubry, Flore Baronnet, Stephane Ederhy, Mohamad El Kasty, Mathieu Kerneis, Olivier Barthelemy, Thierry Lefevre, Pascal Leprince, Alban Redheuil, Patrick Henry, Jean-Jacques Portal, Eric Vicaut, Gilles Montalescot
Summary: This study aimed to compare the effectiveness of oral anticoagulation and antiplatelet therapy after TAVI surgery and found that apixaban was not superior to standard treatment, regardless of the indication for oral anticoagulation.
EUROPEAN HEART JOURNAL
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
XiaoQing Cheng, JiaQian Shi, Hang Wu, WuSheng Zhu, GuangMing Lu
Summary: This review summarizes the potential and current status of CT densitometry-based methods in quantifying net water uptake as a biomarker for ischemic stroke management. Net water uptake can predict malignant brain edema and hemorrhagic transformation, evaluate lesion age, and predict the efficacy of reperfusion therapy and long-term clinical prognosis.
EUROPEAN RADIOLOGY
(2022)
Article
Chemistry, Medicinal
Damiano Rocchi, Cristina Blazquez-Barbadillo, Mariangela Agamennone, Antonio Laghezza, Paolo Tortorella, David Vicente-Zurdo, Noelia Rosales-Conrado, Paula Moyano, Javier del Pino, Juan F. Gonzalez, J. Carlos Menendez
Summary: Matrix metalloproteinases (MMPs) play a key role in neuroinflammatory events and brain damage associated with stroke. The study revealed a new compound with inhibitory effects on MMPs and potential neuroprotective activity against oxidative stress, providing a promising lead for future drug development. The compounds showed some selectivity for specific MMP enzymes and a noncompetitive inhibition mechanism was observed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Jie Xu, Anxin Wang, Xia Meng, Gulbahram Yalkun, Anding Xu, Zhiqiang Gao, Huisheng Chen, Yong Ji, Jun Xu, Deqin Geng, Runxiu Zhu, Bo Liu, Aiqin Dong, Hua Mu, Zhihong Lu, Shuya Li, Huaguang Zheng, Xia Chen, Yilong Wang, Xingquan Zhao, Yongjun Wang
Summary: In this clinical trial, edaravone dexborneol was found to have better functional outcomes at 90 days in patients with acute ischemic stroke, especially in female patients.
Review
Clinical Neurology
Yifan Zhou, Huimin Jiang, Huimin Wei, Lu Liu, Chen Zhou, Xunming Ji
Summary: This article reviews the pathophysiological mechanisms and clinical features of stroke, focusing on arterial stroke and cerebral venous thrombosis. It provides guidance for further research on cerebral venous thrombosis and summarizes the etiology, epidemiology, symptomatology, diagnosis, and treatment heterogeneity of this condition.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Zhang, Weiqiang Dou, Shu Jiang, Dong Dong, Xinyi Wang
Summary: This study investigated the feasibility of using 3D isotropic high-resolution T1w-CUBE imaging to detect and measure intraluminal thrombus in stroke patients. The results showed that T1w-CUBE imaging had higher clinical efficacy in thrombus diagnosis and measurement compared to SWI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Medicine, General & Internal
Hyung Jun Kim, Jong-Won Chung, Oh Young Bang, Yeon Hee Cho, Yun Jeong Lim, Jaechun Hwang, Woo-Keun Seo, Gyeong-Moon Kim, Hee-Jin Kim, Myung-Ju Ahn
Summary: The mechanisms of coagulopathy and the effects of anticoagulants were compared in patients with active cancer and atrial fibrillation (AF). The results showed that the anticoagulation effects of factor Xa inhibitors differed between cancer stroke and AF stroke patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Sport Sciences
Shu-Chun Huang, Chih-Chin Hsu, Tieh-Cheng Fu, Carl P. C. Chen, Ming-Feng Liao, Chien-Ya Hsu, Jong-Shyan Wang
Summary: The study found that stepper-based exercise training can improve cardiopulmonary fitness in nonambulatory hemiplegic patients with ischemic stroke and reduce heteroaggregation of monocytes with platelets. This research provides new possibilities for the rehabilitation of nonambulatory hemiplegic patients.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingxuan Jiang, Jianyong Wei, Yueqi Zhu, Liming Wei, Xiaoer Wei, Hao Tian, Lei Zhang, Tianle Wang, Yue Cheng, Qianqian Zhao, Zheng Sun, Haiyan Du, Yu Huang, Hui Liu, Yuehua Li
Summary: The study aims to develop a clot-based radiomics model using CT imaging radiomic features and machine learning to identify cardioembolic (CE) stroke before mechanical thrombectomy (MTB) in patients with acute ischemic stroke (AIS). The results show that the radiomics model performs better than the routine radiological method in predicting CE stroke.
EUROPEAN RADIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yulong Li, Guang Xin, Shiyi Li, Yuman Dong, Yuda Zhu, Xiuxian Yu, Chengyu Wan, Fan Li, Zeliang Wei, Yilan Wang, Kun Zhang, Qingqiu Chen, Hai Niu, Wen Huang
Summary: This study reveals the regulatory role of PD-L1 in platelet activation and thrombosis. PD-L1 knockout inhibits platelet activation and thrombus formation, and improves the severity of ischemic stroke and survival rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Rong Zhou, Kuan Lin, Changlong Leng, Mei Zhou, Jing Zhang, Youwei Li, Yujing Liu, Xiansheng Ye, Xiaoli Xu, Binlian Sun, Xiji Shu, Wei Liu
Summary: Chebulic acid (CA) has a neuroprotective effect against hypoxia by upregulating Nrf2 nuclear translocation, reducing oxidative damage, and improving motor ability in mice after stroke.
Article
Hematology
Frederik Denorme, Irina Portier, Yasuhiro Kosaka, Robert A. Campbell
Summary: Hyperglycemia exacerbates ischemic stroke outcomes regardless of platelet glucose uptake. Additionally, hyperglycemia primes procoagulant platelet formation, highlighting the therapeutic potential of targeting procoagulant platelet formation in the treatment of acute ischemic stroke.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Babak B. Navi, Cenai Zhang, Carla P. Sherman, Richard Genova, Natalie M. LeMoss, Hooman Kamel, Scott T. Tagawa, Ashish Saxena, Allyson J. Ocean, Scott E. Kasner, Mary Cushman, Mitchell S. Elkind, Ellinor Peerschke, Lisa M. DeAngelis
Summary: Hematologic and embolic biomarkers soon after AIS in cancer patients may be associated with subsequent adverse clinical outcomes, particularly recurrent thromboembolism or death.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Hong-Ru Chen, Yu-Yo Sun, Ching-Wen Chen, Yi-Min Kuo, Irena S. Kuan, Zheng-Rong Tiger Li, Jonah C. Short-Miller, Marchelle R. Smucker, Chia-Yi Kuan
Article
Neurosciences
Chia-Yi Kuan, Hong-Ru Chen, Ning Gao, Yi-Min Kuo, Ching-Wen Chen, Dianer Yang, Melissa M. Kinkaid, Erding Hu, Yu-Yo Sun
Summary: The study suggests that brain-targeted stabilization of HIF1 alpha may be an effective treatment for neonatal hypoxic-ischemic brain injury, while systemic P4H inhibition could potentially lead to unwanted adverse effects.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Lori N. Eidson, Qingzeng Gao, Hongyan Qu, Daniel S. Kikuchi, Ana Carolina P. Campos, Elizabeth A. Faidley, Yu-Yo Sun, Chia-Yi Kuan, Rosana L. Pagano, Bernard Lassegue, Malu G. Tansey, Kathy K. Griendling, Marina S. Hernandes
Summary: The study elucidated the role of Poldip2 in vascular inflammation and leukocyte recruitment following cerebral ischemia, showing that Poldip2 depletion attenuated the infiltration of inflammatory cells and decreased the induction of adhesion molecules. Mechanistically, it was demonstrated that FAK activation was a critical intermediary in Poldip2-mediated VCAM-1 induction.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Tzenge-Lien Shih, Kuan-Hung Lin, Ray-Jade Chen, Ting-Yu Chen, Wei-Ting Kao, Jen-Wei Liu, Hsueh-Hsiao Wang, Hsien-Yu Peng, Yu-Yo Sun, Wan-Jung Lu
Summary: The naphthalimide derivative compound 5 exhibits antiplatelet and antithrombotic effects, preventing thrombus formation while potentially increasing bleeding risk. Development of more potent and efficient antiplatelet agents from compound 5 while minimizing bleeding risk may offer therapeutic potential for cardiovascular diseases.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Vincent M. Sciortino, Angela Tran, Naidi Sun, Rui Cao, Tao Sun, Yu-Yo Sun, Ping Yan, Fenghe Zhong, Yifeng Zhou, Chia-Yi Kuan, Jin-Moo Lee, Song Hu
Summary: This study demonstrates the potential of multi-parametric photoacoustic microscopy in quantifying hemodynamics and oxygen metabolism in the mouse brain, allowing longitudinal, cortex-wide, awake-brain imaging. The use of a long-lifetime, wide-field, light-weight, dual-transparency cranial window enabled observation of cerebrovascular responses, which showed complete recovery in 18 days post-installation. Monitoring over 22 weeks post-recovery revealed no adverse changes, indicating the technique's promise for studying chronic progression and therapeutic responses of neurovascular diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Kanchan Bisht, Kenneth A. Okojie, Kaushik Sharma, Dennis H. Lentferink, Yu-Yo Sun, Hong-Ru Chen, Joseph O. Uweru, Saipranusha Amancherla, Zainab Calcuttawala, Antony Brayan Campos-Salazar, Bruce Corliss, Lara Jabbour, Jordan Benderoth, Bria Friestad, William A. Mills, Brant E. Isakson, Marie-Eve Tremblay, Chia-Yi Kuan, Ukpong B. Eyo
Summary: Microglia play a role in regulating vascular tone through PANX1-P2RY12 signaling, with interactions between microglia and brain capillaries crucial for neurovascular structure and function. The study highlights the importance of purines released through PANX1 channels in activating microglial P2RY12 receptors, leading to the regulation of vasodilation and blood flow in the brain.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yi-Min Kuo, Yu-Yo Sun, Chia-Yi Kuan
Summary: An innovative thromboembolic stroke model was developed by combining dye and thrombin, producing clots that are sensitive to fibrinolytic treatment. The model demonstrates high stability, favorable clot composition, and the ability to effectively reduce infarct size.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Medicine, Research & Experimental
Hong-Ru Chen, Xiaohui Zhang-Brotzge, Yury M. Morozov, Yuancheng Li, Siming Wang, Helen Heju Zhang, Irena S. Kuan, Elizabeth M. Fugate, Hui Mao, Yu-Yo Sun, Pasko Rakic, Diana M. Lindquist, Ton DeGrauw, Chia-Yi Kuan
Summary: Deficiency in the creatine transporter (CrT) can lead to synaptic dysgenesis and signaling imbalances in the brain, particularly under stress conditions. Intranasal creatine supplementation may be an effective treatment for congenital CrT deficiency and acute brain injuries, showing potential in preserving brain energetics homeostasis and reducing infarct size.
Article
Medicine, Research & Experimental
Hong-Ru Chen, Ching-Wen Chen, Yi-Min Kuo, Brandon Chen, Irena S. Kuan, Henry Huang, Jolly Lee, Neil Anthony, Chia-Yi Kuan, Yu-Yo Sun
Summary: Monocytes play a significant role in neonatal brain injury, promoting acute inflammatory responses and transforming into pathological microglia. Blocking the influx of monocytes may be a potential therapy for neonatal brain injury.
Article
Biochemistry & Molecular Biology
Changjun Yang, Bianca P. Lavayen, Lei Liu, Brian D. Sanz, Kelly M. DeMars, Jonathan Larochelle, Marjory Pompilus, Marcelo Febo, Yu-Yo Sun, Yi-Min Kuo, Mansour Mohamadzadeh, Susan A. Farr, Chia-Yi Kuan, Andrew A. Butler, Eduardo Candelario-Jalil
Summary: The study demonstrates that adropin can protect the nervous system by maintaining the integrity of the blood-brain barrier, thereby improving brain damage caused by cerebral ischemia and enhancing sensorimotor and cognitive functions. In mouse experiments, adropin treatment or overexpression significantly reduces brain injury, while genetic deletion exacerbates it.
Editorial Material
Clinical Neurology
Yu-Yo Sun, Horacio Soto, Chung-Feng Kao, Cui Mei, Muh-Shi Lin
BEHAVIOURAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Woon-Man Kung, Chai-Ching Lin, Wei-Jung Chen, Li-Lin Jiang, Yu-Yo Sun, Kuang-Hui Hsieh, Muh-Shi Lin
Summary: The levels of CISD2 are decreased in patients with central nervous system (CNS) insult and are negatively correlated with disease severity. Inhibition of CISD2 exacerbates inflammation caused by spinal cord and brain injury, while enhancement of CISD2's anti-inflammatory properties may serve as a potential therapeutic strategy for CNS insult.
Article
Medicine, Research & Experimental
Wan-Jung Lu, Chung-Hsin Tsai, Ray-Jade Chen, Li-Ting Huang, Ting-Yu Chen, Lih-Chyang Chen, Hsueh-Hsiao Wang, Hsien-Yu Peng, Yu-Yo Sun, Kuan-Hung Lin
Summary: Artesunate acts as a GPVI antagonist and effectively prevents platelet activation and thrombus formation with minimal risk of bleeding.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Yu-Yo Sun, Hui-Wen Yao, Hong-Ru Chen, Ching-Wen Chen, Melissa M. Kinkaid, Chia-Yi Kuan
Summary: This study compares the physiological properties and responses to cerebral hypoxia-ischemia in a β-thalassemia mouse model and wildtype mice. The results show that the β-thalassemia mice exhibit clinical features and a propensity to thromboembolism similar to patients. These findings provide insight into the pathological mechanisms and potential stroke treatments for β-thalassemia patients.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Hong-ru Chen, Ching-wen Chen, Nandita Mandhani, Jonah C. Short-miller, Marchelle R. Smucker, Yu-yo Sun, Chia-yi Kuan
JOURNAL OF NEUROSCIENCE
(2020)