Article
Biochemistry & Molecular Biology
Lvmei Li, Qiang Wang, Xiangping Sun, ZeLong Li, Shuwei Liu, Xian Zhang, Jinyu Zhou, Rui Zhang, Kunmei Liu, Peng Wang, Jianguo Niu, Yujun Wen, Lianxiang Zhang
Summary: Neuropsychiatric diseases are associated with early life stress (ELS) and patients often exhibit abnormal learning, memory, and emotion. The regulatory mechanism underlying these conditions remains unclear. Hippocampal synaptic plasticity (HSP) changes play an important role, and the RhoA pathway is known to regulate HSP through the modulation of dendritic spines (DS). However, the involvement of RhoA in HSP changes in ELS has not been reported. In this study, we investigated the participation and mechanisms of RhoA in HSP regulation in ELS.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Anagh Sinha Ravi, Menglong Zeng, Xudong Chen, Gerardo Sandoval, Javier Diaz-Alonso, Mingjie Zhang, Roger A. Nicoll
Summary: Recent research suggests that the TARP/PSD-95 complex is an essential interaction underlying AMPAR trafficking and LTP. The interaction between PSD-95 and AMPAR auxiliary subunits TARPs can capture AMPARs and enhance synaptic transmission and LTP.
Article
Neurosciences
Xiaoxu Zeng, Yingying Niu, Guangcheng Qin, Dunke Zhang, Lixue Chen
Summary: According to previous study, the loss of inhibitory interneuron function contributes to central sensitization in chronic migraine. This study aimed to explore the role of interneuron-mediated inhibition in the development of synaptic plasticity in chronic migraine. The results showed that dysfunction of inhibitory interneurons contributed to central sensitization by regulating synaptic plasticity through the GABABR/PKA/Fyn/pNR2B pathway in the periaqueductal gray of chronic migraine rats.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Santosh Pothula, Rong-Jian Liu, Min Wu, Alexa-Nicole Sliby, Marina R. Picciotto, Pradeep Banerjee, Ronald S. Duman
Summary: The NMDAR PAM AGN-241751 exhibits antidepressant-like effects in mice, with GluN2B on excitatory neurons in the mPFC being identified as the key mediator of these behavioral effects.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Cell Biology
Zhao-Hui Yao, Jing Wang, Jing-Ping Yuan, Kai Xiao, Shao-Feng Zhang, Yan-Chun Xie, Jun-Hua Mei
Summary: EGB761 treatment may improve cognitive function impairment induced by CCH by affecting synaptic plasticity, synaptic degeneration, and axon demyelination.
Article
Multidisciplinary Sciences
Leonardo Oliveira Bittencourt, Aline Dionizio, Maria Karolina Martins Ferreira, Walessa Alana Braganca Aragao, Sabrina de Carvalho Cartagenes, Bruna Puty, Cristiane do Socorro Ferraz Maia, Fatemeh Vida Zohoori, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima
Summary: This study investigated the association between prolonged fluoride exposure and memory and learning impairments in mice. The results showed that high levels of fluoride could trigger memory impairments, which were associated with changes in the proteomic profile of the hippocampus and neurodegeneration. However, exposure to low concentrations of fluoride was found to be safe.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Louise Laursen, Raviteja Inturi, Soren Ostergaard, Per Jemth
Summary: This study investigated the interaction between the PSG supramodule and other proteins in the post-synaptic density using bioinformatics and biophysical methods. The results showed that the PDZ3 domain had specific binding with peptides, and mutations in PDZ3 could affect the affinity and specificity of the interaction. Additionally, the study found that the ADGRB1 protein formed liquid droplets with the PSG supramodule, providing new insights into PSD formation.
Article
Biochemistry & Molecular Biology
Katarzyna Glombik, Jan Detka, Bartosz Bobula, Joanna Bak, Magdalena Kusek, Krzysztof Tokarski, Boguslawa Budziszewska
Summary: This study analyzed the possible link between depression and hypothyroidism, finding that WKY rats showed weakened memory processes and reduced long-term potentiation, while PTU administration in Wistar rats decreased LTP and increased basal excitatory transmission. Differences in synaptic plasticity between strains were observed, suggesting a lower sensitivity of the hippocampus to thyroid hormones in depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Batoul Mirbolouk, Kambiz Rohampour, Mohammad Rostampour, Adele Jafari, Behrooz Khakpour-Taleghani
Summary: This study evaluated the role of Orx1R in depressive behaviors using the CMS model, showing that chronic Orx1R antagonism alleviates depressive behaviors induced by CMS and improves PSD-95 expression in PFC.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Stachowicz
Summary: PSD-95 is a crucial component of excitatory synapses and plays a role in synaptic plasticity. Its involvement in the side effects of antidepressants related to cognitive function and psychosis is being explored. Understanding the mechanisms of action of compounds with antidepressant potential, such as PSD-95, can aid in the development of safer drugs.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Neurosciences
Zu-Cheng Shen, Zhi-Xuan Xia, Jian-Min Liu, Jie-Yan Zheng, Yu-Fei Luo, Han Yang, Meng-Die Li, Ting Cao, Hai-Ping Liu, Gui-Lin Jin, Hui-Hui Huang, Chang-Xi Yu, Jun Zhou
Summary: Palmitoylation has been found to be relevant to learning, memory, and disorders such as post-traumatic stress disorder and aging-related cognitive decline. However, the mechanisms underlying palmitoylation in these processes are not well understood. This study investigated the role of palmitoylation in hippocampal synaptic transmission and fear memory formation and identified the involvement of APT1-mediated depalmitoylation in the regulation of glutamatergic synaptic plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Yan He, Daxiang Xu, Ziyi Yan, Yongshuai Wu, Yongsheng Zhang, Xiaokang Tian, Jinhang Zhu, Zhuanzhuan Liu, Wanpeng Cheng, Kuiyang Zheng, Xiaoying Yang, Yinghua Yu, Wei Pan
Summary: In this study, the researchers found that chronic infection of Toxoplasma gondii impairs cognitive function and activates microglia while disrupting the Acod1/itaconate axis. However, administration of dimethyl itaconate can significantly improve cognitive deficits and synaptic impairment caused by the parasitic infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Li-Jie Yang, Wei Wu, Wan-Rong Jiang, Cheng-Liang Zhu, Zhao -Hui Yao
Summary: Chronic cerebral hypoperfusion (CCH)-mediated cognitive impairment is a global problem. In this study, we found that RasGRF1 expression levels decreased after CCH, while the inhibition of miRNA-323-3p upregulated RasGRF1 expression and improved cognitive impairments such as spatial learning and memory.
Article
Neurosciences
Shweta Gupta, Arturo J. Moreno, Dan Wang, Julio Leon, Chen Chen, Oliver Hahn, Yan Poon, Kenneth Greenberg, Nathaniel David, Tony Wyss-Coray, Daniel Raftery, Daniel E. L. Promislow, Dena B. Dubal
Summary: The study reveals that cognitive stimulation and KL1 treatment induce metabolic remodeling in the mouse hippocampus, which is closely associated with individual cognitive performance. Furthermore, KL1 treatment enhances synaptic plasticity and improves cognition in both young and old mice.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Chuan Liu, Ruidie Shi, Yuting Liu, Xiangwei Zhao, Xiujun Zhang, Haitao Wang, Lei Wu, Xueliang Shang
Summary: This study confirmed the effectiveness of low-frequency transcranial magnetic stimulation (LF-TMS) in protecting cognitive function, which can provide reference for future clinical treatment.
BEHAVIOURAL BRAIN RESEARCH
(2023)