期刊
NEW JOURNAL OF PHYSICS
卷 10, 期 -, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1367-2630/10/12/125016
关键词
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资金
- National Institutes of Health [HL075515-S03, HL075515-S04, 5F32HL73604-2, P41-EB001977]
- National Science Foundation [0824399, 0800793]
- Max Planck Society
- National Science Foundation through TeraGrid resources provided by the Pittsburgh Supercomputing Center
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0800793] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0824399] Funding Source: National Science Foundation
The heart is a nonlinear biological system that can exhibit complex electrical dynamics, complete with period-doubling bifurcations and spiral and scroll waves that can lead to fibrillatory states that compromise the heart's ability to contract and pump blood efficiently. Despite the importance of understanding the range of cardiac dynamics, studying how spiral and scroll waves can initiate, evolve, and be terminated is challenging because of the complicated electrophysiology and anatomy of the heart. Nevertheless, over the last two decades advances in experimental techniques have improved access to experimental data and have made it possible to visualize the electrical state of the heart in more detail than ever before. During the same time, progress in mathematical modeling and computational techniques has facilitated using simulations as a tool for investigating cardiac dynamics. In this paper, we present data from experimental and simulated cardiac tissue and discuss visualization techniques that facilitate understanding of the behavior of electrical spiral and scroll waves in the context of the heart. The paper contains many interactive media, including movies and interactive two- and three-dimensional Java applets(1).
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