Article
Physics, Fluids & Plasmas
Sergei F. Pravdin, Timur Nezlobinsky, Alexander Panfilov, Hans Dierckx
Summary: Studying the phenomenon of eliminating vortices in excitable media by stimulating them with a smaller period, even in three-dimensional scroll waves, shows promising results. However, in cases with negative filament tension, longer stimulation periods may lead to three-dimensional instabilities, making elimination impossible.
Article
Physics, Multidisciplinary
Mahesh Kumar Mulimani, Soling Zimik, Rahul Pandit
Summary: This study investigates the electrophysiological factors affecting the dynamics of spiral waves in cardiac tissue. It demonstrates that changes in cellular parameters and intercellular factors can modulate the frequency of spiral waves and provides insights into the anchoring of spiral waves in fibrotic hearts.
FRONTIERS IN PHYSICS
(2022)
Article
Physics, Multidisciplinary
Yiling Zhang, Guoyong Yuan, Jun Liu, Jifang Shi, Guangrui Wang, Shaoying Chen
Summary: In this study, the spiral dynamics in an oscillatory bilayer system with inhomogeneous inter-layer coupling and a spiral-resting initial state was investigated. It was found that depending on the proportion of coupled areas and the coupling strength, complete synchronization of two spiral waves as well as several asynchronous patterns can be observed.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Mathematics, Interdisciplinary Applications
Yipeng Hu, Qianming Ding, Yong Wu, Ya Jia
Summary: This study investigates the effect of electric fields on spiral waves in discontinuous myocardial tissue caused by cellular structures. The research finds that a constant electric field can induce the drift of spiral waves, a polarized electric field of specific intensity and angular frequency can induce linear drift of spiral waves, and the drift of spiral waves in a predictable direction can be controlled by adjusting the phase difference of the electric field and the initial phase of the spiral wave.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Physics, Multidisciplinary
M. Bataille-Gonzalez, M. G. Clerc, E. Knobloch, O. E. Omel'chenko
Summary: Systems of coupled nonlinear oscillators often exhibit states of partial synchrony, referred to as chimera states, in which some oscillators oscillate coherently while the rest remain incoherent. This study investigates stationary and moving chimera states in planar phase oscillator arrays using numerical simulations and the corresponding continuum limit. The results reveal the existence and properties of traveling spiral wave chimeras and the transition from stationary to moving chimeras, accompanied by the appearance of complex filamentary structures within the incoherent spiral wave core.
NEW JOURNAL OF PHYSICS
(2023)
Article
Mathematics, Interdisciplinary Applications
Ying Xu, Guodong Ren, Jun Ma
Summary: This paper investigates the electric activity in myocardial tissue and the impact of external electromagnetic radiation on its stability and wave propagation. A memristive cardiac tissue model is developed by incorporating magnetic flux variable and induction current. The results show that external electromagnetic radiation can control the wave propagation in cardiac tissue and generate specific spatial patterns.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Computer Science, Interdisciplinary Applications
A. K. M. Nazimuddin, M. Humayun Kabir, M. Osman Gani
Summary: This article explores the stable oscillatory periodic solutions and periodic traveling wave solutions of the Brusselator model, as well as stability analysis and stability boundary on the parameter plane. It also demonstrates rotating spiral waves and their instability in the two-dimensional spatial domain.
JOURNAL OF COMPUTATIONAL SCIENCE
(2022)
Article
Physics, Multidisciplinary
A. Molavi Tabrizi, A. Mesgarnejad, M. Bazzi, S. Luther, J. Christoph, A. Karma
Summary: Research has found that rotating excitation waves during ventricular fibrillation (VF) are associated with rotating waves of mechanical deformation. There are two types of mechanical phase singularities: paired singularities that are colocalized with electrical phase singularities, and unpaired singularities that can form independently. The formation of unpaired singularities is influenced by the anisotropy of the active force field generated by fiber anisotropy and the nonlocality of elastic interactions. These insights can potentially be used to locate electrical rotor cores from mechanical measurements.
Article
Geosciences, Multidisciplinary
Jiwon Choi, Dong-Hun Lee
Summary: Standing poloidal Alfven waves are excited by wave-particle interaction in the magnetosphere, with ultralow frequency radial oscillations. Through magnetohydrodynamic simulations, it has been shown that the long-lasting poloidal waves depend on the local Alfven frequency gradient being negligible. Two necessary conditions for the existence of persistent poloidal modes have been derived, which are consistent with statistical observations.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Article
Neurosciences
Karthikeyan Rajagopal, Janarthanan Ramadoss, Shaobo He, Prakash Duraisamy, Anitha Karthikeyan
Summary: This article discusses various dynamical properties of a four-dimensional mammalian cold receptor model, focusing on the effects of noise and temperature on collective behavior. By introducing obstacles in the network, the study shows how they affect wave reentry and proposes a new technique to identify it using individual node periods.
COGNITIVE NEURODYNAMICS
(2023)
Article
Physics, Multidisciplinary
Li Qian-Yun, Bai Jing, Tang Guo-Ning
Summary: This study investigates the formation and control of spiral waves and spatiotemporal chaos in a two-layer composite medium through M-F coupling. The results indicate that increasing the coupling strength between cells can effectively eliminate spiral waves and spatiotemporal chaos, depending on the role played by fibroblasts.
ACTA PHYSICA SINICA
(2021)
Article
Engineering, Multidisciplinary
Eduard Rohan, Vu-Hieu Nguyen, Salah Naili
Summary: This study focuses on fluid-saturated poroelastic media governed by the Biot model at a mesoscopic scale, using periodic functions to describe material properties and deriving a formulation based on Floquet-Bloch wave decomposition. The results show good correspondence between wave dispersion results obtained by the Floquet-Bloch approach and those computed using a model derived from asymptotic analysis with respect to the scale parameter.
APPLIED MATHEMATICAL MODELLING
(2021)
Article
Physics, Fluids & Plasmas
Yin-Jie He, Qi-Hao Li, Kuangshi Zhou, Ruhong Jiang, Chenyang Jiang, Jun-Ting Pan, Dafang Zheng, Bo Zheng, Hong Zhang
Summary: Spiral waves in excitable systems are key motifs of self-sustained dynamical patterns, with phase singularities capturing the complexity of their dynamics. Clinical studies have shown that ablating tissue at phase singularity locations may cure atrial fibrillation. The authors propose a method to determine phase singularity locations by calculating the topological charge at each grid point in space.
Article
Mathematics, Applied
Gabriela Jaramillo
Summary: This paper considers the more general case of oscillatory media with nonlocal coupling and proves the existence of rotating wave solutions. The method used combines a multiple-scales analysis and a construction similar to Lyapunov-Schmidt.
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES S
(2022)
Article
Engineering, Geological
Chai Hua-you, Ke Wen-hui, Chai Yang-fei, Zhu Hong-xi, Wang Xian-Da, Liu Huan
Summary: This study examines the behavior of shallow heterogeneities and Rayleigh wave scattering in homogeneous half spaces. The results show that heterogeneities significantly affect the spectral density and structure of the wave field. The location, burial depth, and type of heterogeneity can be inferred from spectral changes.
ROCK AND SOIL MECHANICS
(2022)
Article
Neurosciences
Shanna Hamilton, Iuliia Polina, Radmila Terentyeva, Peter Bronk, Tae Yun Kim, Karim Roder, Richard T. Clements, Gideon Koren, Bum-Rak Choi, Dmitry Terentyev
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Elif Sengun, Brett Baggett, Kevin Murphy, Yichun Lu, Tae-Yun Kim, Dmitry Terentyev, Bum-Rak Choi, John Sedivy, Nilufer Turan, Gideon Koren
Article
Biophysics
Peter Bronk, Tae Yun Kim, Iuliia Polina, Shanna Hamilton, Radmila Terentyeva, Karim Roder, Gideon Koren, Dmitry Terentyev, Bum-Rak Choi
BIOPHYSICAL JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Jungmin Hwang, Tae Yun Kim, Dmitry Terentyev, Mingwang Zhong, Anatoli Y. Kabakov, Peter Bronk, Karuppiah Arunachalam, Luiz Belardinelli, Sridharan Rajamani, Yukiko Kunitomo, Zachary Pfeiffer, Yichun Lu, Xuwen Peng, Katja E. Odening, Zhilin Qu, Alain Karma, Gideon Koren, Bum-Rak Choi
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2020)
Article
Cell & Tissue Engineering
Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, Kareen L. K. Coulombe
STEM CELLS INTERNATIONAL
(2020)
Article
Hematology
Akash Gupta, Yu-Dong Fei, Tae Yun Kim, An Xie, Ken Batai, Ian Greener, Haiyang Tang, Sultan Ciftci-Yilmaz, Elizabeth Juneman, Julia H. Indik, Guanbin Shi, Jared Christensen, Geetanjali Gupta, Cheryl Hillery, Mayank M. Kansal, Devang S. Parikh, Tong Zhou, Jason X-J Yuan, Yogendra Kanthi, Peter Bronk, Gideon Koren, Rick Kittles, Julio D. Duarte, Joe G. N. Garcia, Roberto F. Machado, Samuel C. Dudley, Bum-Rak Choi, Ankit A. Desai
Summary: IL-18 plays a crucial role in the development of sickle cell disease-related cardiomyopathy, and the main treatment approach is to reduce cardiac fibrosis and VT occurrence by inhibiting IL-18. The level of IL-18 in the blood is related to cardiac function, suggesting IL-18 as a potential therapeutic target for patients with SCD.
Article
Multidisciplinary Sciences
Celinda M. Kofron, Tae Yun Kim, Fabiola Munarin, Arvin H. Soepriatna, Rajeev J. Kant, Ulrike Mende, Bum-Rak Choi, Kareen L. K. Coulombe
Summary: This study presents a novel human 3D in vitro pro-arrhythmic risk assessment platform using human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3-dimensional microtissues, which effectively differentiates between high-risk and low-risk compounds and evaluates the impact of environmental toxicants such as bisphenol-A.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Arvin H. Soepriatna, Tae Yun Kim, Mark C. Daley, Elena Song, Bum-Rak Choi, Kareen L. K. Coulombe
Summary: An in vitro model of 3D atrial microtissue was developed using hiPSC-derived cardiomyocytes to study chamber-specific chemical responses experimentally. The results showed that atrial microtissues have faster spontaneous beating rates, slower AP rise time, and shorter AP duration compared to ventricular microtissues, and exhibit different responses to specific drugs like 4-AP and Ivabradine.
CELLULAR AND MOLECULAR BIOENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Shanna Hamilton, Radmila Terentyeva, Vladimir Bogdanov, Tae Yun Kim, Fruzsina Perger, Jiajie Yan, Xun Ai, Cynthia A. Carnes, Andriy E. Belevych, Christopher H. George, Jonathan P. Davis, Sandor Gyorke, Bum-Rak Choi, Dmitry Terentyev
Summary: This study demonstrates that oxidative stress in cardiac disease impairs the regulation of Ca2+ release channel RyR2, leading to proarrhythmic disturbances. The researchers discovered a new intraluminal interaction axis involving RyR2, ERp44, and Ero1 alpha. Inhibition of Ero1 alpha has the potential to stabilize the RyR2-ERp44 complex and reduce spontaneous Ca2+ release and tachyarrhythmias.
CIRCULATION RESEARCH
(2022)
Article
Physiology
Ilija Uzelac, Christopher J. Crowley, Shahriar Iravanian, Tae Yun Kim, Hee Cheol Cho, Flavio H. Fenton
Summary: Most cardiac arrhythmias result from changes in cell membrane channels and intracellular calcium concentration. This study presents an optical-mapping methodology that allows simultaneous measurements of transmembrane voltage and calcium signals without cross-talk. This has important implications for understanding the effects of heart failure and drug treatments on cellular and tissue dynamics.
FRONTIERS IN PHYSIOLOGY
(2022)
Meeting Abstract
Biophysics
Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Benjamin Martin, Vladimir Bogdanov, Andriy E. Belevych, Christopher H. George, Sandor Gyorke, Bum-Rak Choi, Jonathan P. Davis, Dmitry A. Terentyev
BIOPHYSICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Hong Liu, Yang Zhao, An Xie, Tae-Yun Kim, Radmila Terentyeva, Man Liu, Guangbin Shi, Feng Feng, Bum-Rak Choi, Dmitry Terentyev, Shanna Hamilton, Samuel C. Dudley
Summary: The study demonstrates that type 2 diabetes mice have an increased risk of arrhythmia, mainly due to the increased SR Ca2+ leak caused by cardiac IL-1β-mediated mitoROS generation. Inhibiting IL-1β and mitoROS can reduce the risk of arrhythmias. Reversing diabetic arrhythmia can be achieved by stabilizing the RyR2 channel.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Meeting Abstract
Biophysics
Radmila Terentieva, Shanna Hamilton, Tae Yun Kim, Iulia Polina, Peter Bronk, Karim Roder, Jin O-Uchi, Gideon Koren, Sandor Gyorke, Andriy E. Belevych, Bum-Rak Choi, Dmitry A. Terentyev
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biophysics
Tae Yun Kim, Anatoli Kabakov, Radmila Terentyeva, Dmitry A. Terentyev, YiChun Lu, Katja E. Odening, Andras Varro, Zsuzsanna Bosze, Gideon Koren, Bum-Rak Choi
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biophysics
Peter Bronk, Tae Yun Kim, Iuliia Polina, Shanna Hamilton, Radmila Terentieva, Karim Roder, Gideon Koren, Dmitry A. Terentyev, Bum-Rak Choi
BIOPHYSICAL JOURNAL
(2020)