期刊
NEW JOURNAL OF CHEMISTRY
卷 38, 期 7, 页码 2902-2910出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nj00244j
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资金
- UGC, New Delhi
In the present study, novel combinatorial libraries of substituted pyrazolines 6a-l and isoxazolines 7a-l have been synthesized via the reactions of chalcones with the hydrazine hydrate and hydroxylamine hydrochloride in ethanol. The title compounds were screened for their preliminary in vitro antibacterial activity against a panel of pathogenic strains, in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv, in vitro antimalarial activity against Plasmodium falciparum and in vitro antioxidant activity by the ferric-reducing antioxidant power method. Compounds 6k, 6l, 7h and 7k exhibited excellent antibacterial activity and a few of them exhibited moderate antituberculosis activity compared with the first line drugs. Half of the compounds exhibited terrific antimalarial activity and the majority of compounds showed highest antioxidant potency.
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