Article
Chemistry, Physical
Yanyan Li, Guichen Li, Qian Zhang, Yuxia Li, Qifan Jia, Wenyuan Zhang, Xiaoxia Feng, Weibing Xu, Jiacheng Liu
Summary: Three water-soluble porphyrins containing halogen atoms (F, Cl, Br) were synthesized, with P3 showing the highest singlet oxygen generation capacity. MTT assay confirmed good phototoxicity and high selectivity of P1-P3, while fluorescence imaging and intracellular reactive oxygen species demonstrated cell apoptosis and ROS production. The high ROS production and excellent phototoxicity make the photosensitizers potential candidates for PDT drugs.
CHEMICAL PHYSICS LETTERS
(2021)
Review
Pharmacology & Pharmacy
Ana Maria Udrea, Adriana Smarandache, Andra Dinache, Catalina Mares, Simona Nistorescu, Speranta Avram, Angela Staicu
Summary: Malignant melanoma is a severe form of skin cancer with various risk factors, and photodynamic therapy using photosensitizers has shown promise in its treatment. However, the presence of melanin and its antioxidant properties can hinder the effectiveness of this therapy, leading to the exploration of new photosensitizing platforms. The use of nanotechnology has advanced the development of photosensitizers, enhancing solubility, optical absorption, and tumor targeting.
Article
Medicine, Research & Experimental
Han Sun, Ruihua Guo, Yanhui Guo, Jitao Song, Zhiliang Li, Fengling Song
Summary: Porphyrins have been widely used in photodynamic therapy for cancer treatment, but their poor water solubility, self-quenching on ROS generation, and low tolerance for hypoxic conditions hinder their therapeutic efficacy. In this study, a water-soluble porphyrin with cationic side chains was developed, which exhibited enhanced ROS generation and effective tumor ablation capability. This research demonstrates the potential of side-chain chemistry in improving the photodynamic properties of porphyrins for cancer therapy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Natalia Plekhova, Olga Shevchenko, Oksana Korshunova, Aleksandra Stepanyugina, Ivan Tananaev, Vladimir Apanasevich
Summary: The effectiveness of photodynamic therapy depends on the triad effects of photosensitizers, molecular oxygen, and visible light on malignant tumors. Porphyrin PS are widely used in PDT due to their unique diagnostic and therapeutic functions. The development of second-generation photosensitizers provides possibilities for targeted tumor PDT. The properties of photosensitizers, selectivity, light absorption, and drug delivery strategies are crucial for the effectiveness of PDT.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Lingxiu Liu, Chunbin Li, Jianye Gong, Ying Zhang, Weiwei Ji, Lina Feng, Guoyu Jiang, Jianguo Wang, Ben Zhong Tang
Summary: By utilizing the distinctive structural characteristics of anion-p(+) interactions, a highly water-soluble type I photosensitizer (DPBC-Br) with aggregation-induced emission (AIE) and near-infrared (NIR) emission is developed. DPBC-Br displays remarkable water solubility, outstanding photobleaching resistance, and enables efficient differentiation between tumor cells and normal cells via NIR-I imaging. Additionally, DPBC-Br produces superior type I reactive oxygen species (ROS), showing specific killing of cancer cells and inhibition of tumor growth with negligible systemic toxicity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Xuwen Da, Fei-Hu Yu, Chao Zhang, Zhanhua Wang, Yao Jian, Yuanjun Hou, Yong Chen, Xuesong Wang, Qianxiong Zhou
Summary: This work proposes a bioorthogonal assembly based on d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions for precise cancer cell imaging and photodynamic therapy (PDT). The assembly exhibits luminescence turn-on and singlet oxygen generation upon irradiation, demonstrating the potential of using supramolecular interaction for bioorthogonal chemistry.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas-Roper, Vincent Chaleix, Vincent Sol
Summary: This study presents a synthesis method for light-triggered antibacterial hydrogels based on xylan chains chemically bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). TCPP not only acts as an efficient photosensitizer against Gram-positive bacteria, but also serves as a cross-linking agent for the hydrogels. The hydrogels were characterized using infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and swelling and rheological tests. Under visible light irradiation, the hydrogels showed interesting antimicrobial activity against Staphylococcus aureus and Bacillus cereus, suggesting their potential for the treatment of skin bacterial infections through photodynamic antimicrobial chemotherapy (PACT).
Article
Chemistry, Multidisciplinary
Claire Donohoe, Fabio A. Schaberle, Fabio M. S. Rodrigues, Nuno P. F. Goncalves, Christopher J. Kingsbury, Mariette M. Pereira, Mathias O. Senge, Ligia C. Gomes-da-Silva, Luis G. Arnaut
Summary: The challenge of large molecules crossing cell membranes has hindered the development of new medicines. However, this study shows that altering the atropisomers of a drug can improve cell uptake and therapeutic efficacy. The most effective atropisomer is able to optimize hydrogen bonding with membrane phospholipids, leading to increased cellular uptake and phototoxicity. These findings highlight the importance of atropisomerism in drug development and provide new insights for designing efficient cell-penetrating drugs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Zilin Zhu, Li Wei, Ashish Kumar Yadav, Zhongxian Fan, Ashish Kumar, Mengzhao Miao, Samya Banerjee, Huaiyi Huang
Summary: Recently, there has been interest in developing photo catalytic anticancer drugs, mainly in the form of metal complexes. In this study, we introduce lysosome/mitochondria targeting cyanine appended bipyridine compounds as potential organic photocatalytic anticancer agents. The organocatalyst (bpyPCN) not only induces light-induced NADH oxidation but also generates intracellular ROS, showcasing its anticancer activity. This is the first example of an organic compound inducing catalytic NADH photo-oxidation in both aqueous solutions and cancer cells.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Maxwell I. Martin, Trong-Nhan Pham, Kaytlin N. Ward, Anthony T. Rice, Phoebe R. Hertler, Glenn P. A. Yap, Philip H. Gilmartin, Joel Rosenthal
Summary: Photodynamic therapy (PDT) is a promising treatment for certain cancers, but traditional macrocyclic tetrapyrrole ligands have limitat
ions due to adverse biological side effects. However, non-traditional oligotetrapyrrole ligands metalated with palladium (Pd[DMBil1]) have shown excellent biocompatibility. In this study, a new family of Pd[DMBil2-R] complexes with extended conjugation was synthesized and characterized, indicating their potential for PDT applications. The electronic nature of the phenylalkynyl appendages greatly influenced the photophysics of the Pd-II biladiene.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Patricia Santos, Ana T. P. C. Gomes, Leandro M. O. Lourenco, Maria A. F. Faustino, Maria G. P. M. S. Neves, Adelaide Almeida
Summary: The photodynamic action of three cationic porphyrins towards viruses was evaluated and compared with methylene blue. The study found that these porphyrins were more effective than methylene blue in the photoinactivation of viruses in plasma, and also had a moderate inactivation effect in whole blood. Therefore, these porphyrin compounds are promising and safe photosensitizers for photoinactivation of viruses in blood plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Qiang Wang, Chunbin Li, Yuchen Song, Qiankun Shi, Heng Li, Hua Zhong, Jianguo Wang, Fang Hu
Summary: In this study, a new donor was developed to improve the overall performance of aggregation-induced emission photosensitizers. By expanding the pi extension of aromatic rings, the new photosensitizer exhibited red-shifted absorption and fluorescence peaks, enhanced photosensitization efficiency, and demonstrated excellent imaging and cancer cell ablation capabilities.
Article
Chemistry, Multidisciplinary
Shuang Chao, Ziyan Shen, Jiaming Ren, Zhilin Zhang, Xiaolin Chen, Yuxin Pei, Zhichao Pei
Summary: A three-in-one self-assembled metallo-nanophotosensitizer system (NLCD) was constructed by cooperative coordination of amphiphilic l-arginine-modified photosensitizer NBS-l-Arg and DOX in the presence of Cu(2+)via the synergy of coordination, hydrophobic, and pi-pi stacking interactions. The resulting NLCD NPs possessed uniform size, well-defined nanosphere structure, and GSH-responsive ability. In vitro studies exhibited that NLCD NPs integrating photodynamic/chemodynamic/chemo multimodal therapy achieved an enhanced therapeutic effect.
CHEMICAL COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Xuehong Min, Fan Yi, Xiao-Le Han, Ming Li, Qianci Gao, Xiaocui Liang, Zhao Chen, Yue Sun, Yi Liu
Summary: This study presents an effective synthetic strategy for preparing water-soluble AIE photosensitizers with high targeted capacity mediated by supramolecular assembly. The reversible control of singlet oxygen generation and photodynamic targeting of cancer cells in an acidic environment is achieved.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Zihan Ma, Lishuang Wang, Tingting Chen, Guangning Wang
Summary: In this study, two kinds of 3D self-doped (N/O) lilac-based and coriander-based porous carbons with high performance have been prepared.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qin Wang, Yun-Fan Yan, Jiao-Lin Weng, Ying Huang, Fu Yang, Hao-Hui Xie, Fei Tan, Fa-Kun Zheng, Jian-Gang Xu
Summary: Balancing energy and mechanical sensitivities is a challenging issue in the field of energetic materials. This study constructed a 3D energetic metal-organic framework with nitrogen-rich ligand and NO3- anions. The framework demonstrated high stability, energy density, and excellent mechanical sensitivities, making it a potential insensitive energetic material.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Marrium Saeed, Urooj Kamran, Amina Khan, Md Irfanul Haque Siddiqui, Hasan Jamal, Haq Nawaz Bhatti
Summary: In this study, magnesium-aluminum layered double hydroxides (Mg-Al-LDH) were synthesized using an environmentally friendly hydrothermal technique for adsorbing the dye reactive green 5 (RG5). To improve the adsorption capability, composites were prepared by combining Mg-Al-LDH with low-cost Mangifera indica stone biomass (MISB). The results showed that the composites had high adsorption capacities for RG5 dye and could be regenerated.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Xuanlin Zhan, Xiaojie Li, Yunyan Zeng, Siyan Jiang, Chao Pan, Shiyu Pan, Jiaquan Huang, Heqian Zhang, Zhiwei Qin
Summary: This study reports on the potential prospects of natural products derived from the rhizosphere for the development of antibiotics and herbicides, as well as the advancements in cultivating a mutant strain that produces a substantial quantity of lydicamycins, a potent family for herbicide development.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jie Zhu, Jiangtao Yu, Linhua Zhu, Xiaoxiao Yu, Jixing Liu, Yanhong Chao, Jingzhou Yin, Peiwen Wu, Jian Liu, Wenshuai Zhu
Summary: This study successfully demonstrates the 3D printing of attapulgite monoliths and investigates the influence of thermal treatment on their properties. The thermal treated monoliths show superior catalytic performance at low temperatures.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yanzhu Ye, Yixiang Ye, Jiannan Cai, Zhongshui Li, Shen Lin
Summary: In this paper, a novel Pt/CoP/C photo-electro synergistic catalyst was successfully synthesized and its performance was investigated. The catalyst exhibited excellent photo-electro catalytic performance, with significantly higher hydrogen production compared to a commercial catalyst. The introduction of cobalt phosphide and the existence of Co3O4 were identified as key factors for enhancing the catalytic activity.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nurul Hidayah Abu Bakar, Wan Norfazilah Wan Ismail, Hartina Mohd Yusop, Noreen Farzuhana Mohd Zulkifli
Summary: Hydrophobic coatings inspired by the lotus effect have gained popularity for their ability to solve various problems. The sol-gel method, utilizing silica, alumina, and titania, is explored as an environmentally friendly approach to produce water-based hydrophobic coatings. This study focuses on producing water-based hydrophobic coatings for cotton and polyester fabrics using a one-step sol-gel method. The coated fabrics exhibited improved hydrophobic properties, altered surface morphologies, and lower air permeability compared to uncoated fabrics. TEOS-PDMS coating provides a promising approach for enhancing the hydrophobic and surface properties of cotton and polyester fabrics.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nikita Belko, Hanna Maltanava, Anatol Lugovski, Polina Shabunya, Sviatlana Fatykhava, Evgeny Bondarenko, Pavel Chulkin, Sergey Poznyak, Michael Samtsov
Summary: This study investigates the difference in electrochemical behavior between rhodamine B hydrazide and rhodamine B acylhydrazone, and finds that rhodamine B acylhydrazone exhibits higher reversibility in electrooxidation. These results can be applied for developing new sensors with desired electrochemical properties.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Showket Ahmad Bhat, Mohd Ikram
Summary: In this study, 0-3 particulate multiferroic composites were synthesized and characterized. The composites exhibited excellent ferroelectric and ferromagnetic properties, as well as high piezoelectric strain and magnetoelectric coupling effects.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Carla Gomes, Mariana Costa, Susana M. M. Lopes, Bernardo Albuquerque Nogueira, Rui Fausto, Jose A. Paixao, Teresa M. V. D. e Melo, Luisa M. D. R. S. Martins, Marta Pineiro
Summary: The development of sustainable processes requires the integration of green chemistry principles. In this study, a solvent-free synthesis method was developed to prepare new copper catalysts, which efficiently catalyze cycloaddition reactions under solvent-free mechanochemical conditions. Through this process, the principles of atom economy, reduction of solvents and auxiliaries, design for energy efficiency, and reduction of derivatives and catalysis are combined.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Zhihua Liu, Jinzhe Li, Jianguo Zhou
Summary: This study demonstrates the enhancement of photoelectrochemical activity of BiFeO3 photoelectrodes through ion modification, which increases visible light absorption and active area, leading to improved PEC water splitting performance.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yisheng Zhang, Wensong Li, Jing Li, Fang Li, Wei Xue, Xinqiang Zhao, Yanji Wang
Summary: Pt/C and SO42-/ZrO2 were used as catalysts for the synthesis of p-aminophenol through the catalytic transfer hydrogenation of nitrobenzene in water with formic acid as the hydrogen source. The optimal Pt loading for PAP selectivity was found to be 1 wt%. The presence of different valence states of Pt affected both the nitrobenzene hydrogenation and formic acid decomposition. Among different solid acid catalysts tested, SO42-/ZrO2 exhibited the highest catalytic activity for p-aminophenol formation. Under the optimized reaction conditions, the conversion of nitrobenzene reached 80.0%, with a selectivity of 47.6% for p-aminophenol.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Pradyota Kumar Behera, Papita Behera, Amlan Swain, Santosh Kumar Sahu, Ajeena Sahoo, Laxmidhar Rout
Summary: We have developed a simple and direct method for the synthesis of diaryl ether using an oxygen bridged bimetallic CuMoO4 nanocatalyst under mild reaction conditions. The catalyst exhibited tolerance towards a wide range of substrates with various functional groups. It is efficient and recyclable. This methodology allows easy access to nitrofen derivatives (herbicides) from unactivated 2,4-dichlorophenol, which are important for agriculture and pharmaceuticals.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yihua Fu, Yan Zhang, Changwei Hu, Zhishan Su
Summary: The mechanism of the reaction between CO2 and styrene oxide for cyclic carbonate was revealed using density functional theory calculations. The noncatalytic reaction occurred via a concerted mechanism, while in the presence of guanidine and tetrabutylammonium iodide (TBAI) co-catalysts, the epoxide ring-opening by nucleophilic attack of an iodide anion was predicted to be the rate-determining step. Guanidine acted as the H-bond donor to activate styrene oxide, facilitating the reaction with a lower activation barrier.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Saikat Khamarui, Sirshendu Ghosh
Summary: Copper nanorods (Cu-NRs) exhibit significant plasmonic behavior and can act as efficient catalysts in redox processes and coupling. A benign decarboxylative approach, utilizing localized surface plasmon resonance (LSPR) assisted catalysis with Cu-NRs, has been developed for the production of alkane analogues from alkyl carboxylic acids under visible light. The catalyst shows a broad substrate scope and high functional group tolerance, without the need for an external oxidant or proton source. A plausible mechanism for this recyclable nano-catalyst has also been proposed based on control experiments.
NEW JOURNAL OF CHEMISTRY
(2024)