期刊
NEW JOURNAL OF CHEMISTRY
卷 36, 期 2, 页码 360-370出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nj20374f
关键词
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资金
- MNT-ERA NET [NAN2007-31135-E, NAN2007-31198-E]
- FIS [PI08222]
- COST Action [TD0802]
- CIBER-BBN for U.A. FIS [PI052476, PI061479]
- Fundacion para la Investigacion y la Prevencion del SIDA en Espana [FIPSE 24632/07]
- Red RIS [RD06-0006-0035]
- Fundacion Caja Navarra and Comunidad de Madrid [S-SAL-0159-2006]
- CIBER-BBN
- VI National RDi Plan
- Iniciativa Ingenio
- Consolider Program
- CIBER Actions
- Instituto de Salud Carlos III
- European Regional Development Fund
- Research Group UCM [920415 (GR58/09)]
A synthetic strategy has been carried out to prepare a new family of dendrimers containing eugenol linkers between the carbosilane scaffold and the peripheral amine or ammonium groups, of type G(n)-Si(CH2)(3)C6H3(OMe){O(CH2)(2)NMe2}](m) or G(n)-[Si(CH2)(3)C6H3(OMe)O(CH2)2NMe(3)(+)I(-)}](m) respectively. Cationic carbosilane dendrimers have shown fluorescent properties due to the presence of the aromatic rings. A preliminary study of the interaction of dendrimers with two model drugs as examples of Active Pharmaceutical Ingredients (APIs) has been performed by fluorescence and NMR methods. This study determines the ability of these dendrimers to interact with potassium phenoxymethylpenicillin (Penicillin VK) as an example of an anionic low molecular weight drug entity or bovine serum albumin (BSA) as a biopharmaceutical drug protein entity, affording an appropriate dendritic system for its use in certain biological applications like drug delivery.
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