期刊
NEW JOURNAL OF CHEMISTRY
卷 32, 期 2, 页码 323-332出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b712896g
关键词
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An amphoteric bio-compatible and stealth-like poly ( amidoamine) named ISA23 was obtained from 2,2-bis(acrylamido) acetic acid (BAC) and 2-methylpiperazine. The partial substitution of 4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl (Amino-TEMPO) for 2-methylpiperazine as co-monomer gave two new PAA-TEMPO conjugates based on ISA23: ISA23-TEMPO1 and ISA23-TEMPO2 with 10 and 40% TEMPO-carrying units per polymer chain, respectively. In this study, a thorough NMR characterization of ISA23 polymer together with NMR and ESR characterizations of the ISA23-TEMPO derivatives and a preliminary evaluation of their potential as NMR labels for imaging applications are reported. Relaxivity measurements performed on ISA23-TEMPO1 and ISA23-TEMPO2 showed relaxivities of 0.4 and 1.8 mM(-1) s(-1), respectively, indicating that the PAA-TEMPO adducts have a definite potential as NMR imaging contrast agents. This was confirmed by preliminary magnetic resonance imaging (MRI) determinations.
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