Article
Multidisciplinary Sciences
Priyantha Wijayatunga, Lars-Owe D. Koskinen, Nina Sundstrom
Summary: This study aimed to develop a model that could predict future intracranial pressure (ICP) levels of individual patients in the intensive care unit (ICU) in order to warn treating clinicians. The model, based on a probabilistic Markov model and a prediction enhancement method, was able to reliably predict increases in ICP and had a straightforward expandability.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Joseph D. D. Krocker, Madeline E. E. Cotton, Jacob B. B. Schriner, Baron K. K. Osborn, Michael M. M. Talanker, Yao-Wei W. Wang, Charles S. S. Cox Jr, Charles E. E. Wade
Summary: The TRPM4 gene is associated with inflammation in the central nervous system, and certain variants of this gene (rs8104571 and rs150391806) are linked to increased intracranial pressure following traumatic brain injury (TBI). In this study, the influence of these variants on clinical outcomes and intracranial pressure was assessed in 292 TBI patients. The rs8104571 variant allele was associated with poor clinical outcomes and increased intracranial pressure, particularly in the African American subpopulation.
SCIENTIFIC REPORTS
(2023)
Review
Critical Care Medicine
Robert McNamara, Shiv Meka, James Anstey, Daniel Fatovich, Luke Haseler, Toby Jeffcote, Andrew Udy, Rinaldo Bellomo, Melinda Fitzgerald
Summary: Traumatic intracranial hypertension (tIH) is a common complication of moderate to severe traumatic brain injury (m-sTBI) that can be lethal. The development of technology to predict tIH and administer interventions prior to the rise in intracranial pressure (ICP) has been a focus of research. In 2022, the first operationalizable tIH prediction system was developed, allowing for proactive management and protection of patients from potential harm. This review discusses the approaches to ICP forecasting and tIH prediction algorithms that form the foundation for this operational system, offering valuable insights for clinicians and researchers interested in this technology.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Computer Science, Information Systems
Tariq Shahzad, Saqib Saleem, Tshilidzi Marwala, Khmaies Ouahada
Summary: The study proposes quantitative measures for early assessment of intracranial hypertensive episodes in traumatic brain injured patients and explores the association between intra-individual variability and those events. The results show specific changes in information flow patterns during intracranial hypertension episodes, with traumatic brain injury patients exhibiting more inconsistency during intracranial pressure elevations.
Article
Computer Science, Information Systems
Hack-Jin Lee, Hakseung Kim, Young-Tak Kim, Kanghee Won, Marek Czosnyka, Dong-Joo Kim
Summary: The study proposed a novel parameter for predicting potentially life-threatening IH events and developed a machine learning model for predicting LTH events. By analyzing the association between LTH parameters and mortality, the model demonstrated reasonable predictive capacity for mortality. The CatBoost model was able to anticipate whether an IH event would progress into an LTH event.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Clinical Neurology
Ahmed Ismail Kashkoush, Tamia Potter, Jordan C. Petitt, Song Hu, Kyle Hunter, Michael L. Kelly
Summary: This study investigated the clinical and radiological factors that predict intracranial hypertension (ICHTN) in patients with severe traumatic brain injury (TBI). The study found that the Rotterdam CT score (RS) can predict the occurrence of ICHTN, and the diagnostic accuracy of the model was improved with the inclusion of sulcal effacement at the vertex on CT of the head.
JOURNAL OF NEUROSURGERY
(2022)
Review
Clinical Neurology
Jetan Badhiwala, Angela Lumba-Brown, Gregory W. J. Hawryluk, Jamshid Ghajar
Summary: External lumbar drainage (ELD) has an immediate significant effect on intracranial pressure (ICP) in patients with traumatic brain injury (TBI), but the durable effect and impact on neurological outcomes are uncertain. ELD appears to be safe with low risk of complications, warranting further high-quality investigation into its potential application in severe TBI with refractory intracranial hypertension.
Article
Medicine, General & Internal
Debbie Y. Madhok, Robert M. Rodriguez, Jason Barber, Nancy R. Temkin, Amy J. Markowitz, Natalie Kreitzer, Geoffrey T. Manley
Summary: This study found that most patients with mild TBI, with a GCS score of 15 and a negative head CT scan, did not fully recover at 2 weeks and 6 months after the injury. Emergency department clinicians should recommend 2-week follow-up visits to identify patients with incomplete recovery and facilitate rehabilitation.
Article
Clinical Neurology
Linda D'Antona, Hasan Asif, Claudia Louise Craven, James Alexander McHugh, Anna Vassiliou, Lewis Thorne, Manjit Singh Matharu, Laurence Dale Watkins, Fion Bremner, Ahmed Kassem Toma
Summary: The study found that brain MRI and ophthalmic biomarkers can predict intracranial hypertension, with concave pituitary gland shape associated with moderately elevated median 24-hour ICP, and optic disc protrusion (MRI), papilledema, and absence of SVP related to the highest median ICP values. A combination of at least one abnormal biomarker in MRI and ophthalmic assessments was highly suggestive of intracranial hypertension.
Article
Multidisciplinary Sciences
Kassi Ackerman, Akram Mohammed, Lokesh Chinthala, Robert L. Davis, Rishikesan Kamaleswaran, Nadeem Shafi
Summary: A machine learning approach was used to identify novel features associated with elevated intracranial pressure events in children with severe brain injuries. The study found that hemodynamic changes can be observed up to 4 hours prior to elevated intracranial pressure events, with blood pressure and intracranial pressure data being the most significant indicators.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Andrew R. Stevens, Helen Gilbody, Julian Greig, John Usuah, Basit Alagbe, Anne Preece, Wai Cheong Soon, Yasir A. Chowdhury, Emma Toman, Ramesh Chelvarajah, Tonny Veenith, Antonio Belli, David J. Davies
Summary: A retrospective service evaluation was conducted to compare the effectiveness of external ventricular drain (EVD) and external lumbar drain (ELD) in controlling intracranial pressure (ICP) after traumatic brain injury (TBI). The results showed that both methods were successful in ICP control, but ELD should be limited to carefully selected patients and strict drainage protocols should be followed.
WORLD NEUROSURGERY
(2023)
Article
Critical Care Medicine
Hansen Deng, Benjamin E. Zusman, Enyinna L. Nwachuku, John K. Yue, Yue-Fang Chang, Yvette P. Conley, David O. Okonkwo, Ava M. Puccio
Summary: Research indicates that variations in the Bcl-2 gene can affect intracranial pressure and prognosis of severe traumatic brain injury patients, with the GG genotype being associated with higher ICP, cerebral edema, and the need for surgical intervention.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
William Robert Kwapong, Le Cao, Ruosu Pan, Hang Wang, Chen Ye, Wendan Tao, Junfeng Liu, Bo Wu
Summary: This study aimed to evaluate retinal microvascular and structural changes in intracranial hypertension (IH) patients compared with controls, and to investigate the association between clinical parameters and retinal changes in IH patients. The results showed that IH patients had reduced microvascular densities and thinner retinal thicknesses compared with controls. There was also a correlation between clinical parameters and retinal changes in IH patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Harri Isokuortti, Grant L. Iverson, Jussi P. Posti, Jori O. Ruuskanen, Antti Brander, Anneli Kataja, Milaja Nikula, Juha Ohman, Teemu M. Luoto
Summary: The study found that the use of serotonergic antidepressants was not associated with an increased risk of traumatic intracranial hemorrhage.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Per Kristian Eide
Summary: This study found that abnormal pulsatile intracranial pressure (ICP) persists in patients with idiopathic intracranial hypertension (IIH) refractory to conservative medical therapy, despite normalized static ICP. The abnormal pulsatile ICP may reflect changes at the glia-neurovascular interface resulting in impaired astrocytic pulsation absorber mechanisms.
Meeting Abstract
Immunology
Daiana De Blasio, Stefano Fumagalli, Luca Longhi, Franca Orsini, Fabrizio Ortolano, Elisa R. Zanier, Silvia Ferrari, Giulio Goti, Peter Garred, Edoardo Picetti, Marco Locatelli, Anna Bernardi, Marco Gobbi, Nino Stocchetti, Maria-Grazia De Simoni
Article
Immunology
R. Zangari, E. R. Zanier, G. Torgano, A. Bersano, S. Beretta, E. Beghi, B. Casolla, N. Checcarelli, S. Lanfranconi, A. Maino, C. Mandelli, G. Micieli, F. Orzi, E. Picetti, M. Silvestrini, N. Stocchetti, B. Zecca, P. Garred, M. G. De Simoni
JOURNAL OF NEUROINFLAMMATION
(2016)
Article
Critical Care Medicine
Priscilla Di Deo, Hester Lingsma, Daan Nieboer, Bob Roozenbeek, Giuseppe Citerio, Luigi Beretta, Sandra Magnoni, Elisa R. Zanier, Nino Stocchetti
JOURNAL OF NEUROTRAUMA
(2016)
Article
Critical Care Medicine
Karim Asehnoune, Zsolt Balogh, Giuseppe Citerio, Andre Cap, Timothy Billiar, Nino Stocchetti, Mitchell J. Cohen, Paolo Pelosi, Nicola Curry, Christine Gaarder, Russell Gruen, John Holcomb, Beverley J. Hunt, Nicole P. Juffermans, Mark Maegele, Mark Midwinter, Frederick A. Moore, Michael O'Dwyer, Jean-Francois Pittet, Herbert Schoechl, Martin Schreiber, Philip C. Spinella, Simon Stanworth, Robert Winfield, Karim Brohi
INTENSIVE CARE MEDICINE
(2017)
Article
Clinical Neurology
Nino Stocchetti, Marco Carbonara, Giuseppe Citerio, Ari Ercole, Markus B. Skrifvars, Peter Smielewski, Tommaso Zoerle, David K. Menon
Review
Clinical Neurology
Tommaso Zoerle, Marco Carbonara, Elisa R. Zanier, Fabrizio Ortolano, Giulio Bertani, Sandra Magnoni, Nino Stocchetti
FRONTIERS IN NEUROLOGY
(2017)
Editorial Material
Critical Care Medicine
Nino Stocchetti, Daniele Poole, David O. Okonkwo
INTENSIVE CARE MEDICINE
(2018)
Article
Plant Sciences
Marcin Feltynowski, Jakub Kronenberg, Tomasz Bergier, Nadja Kabisch, Edyta Laszkiewicz, Michael W. Strohbach
URBAN FORESTRY & URBAN GREENING
(2018)
Article
Critical Care Medicine
Victor Volovici, Ari Ercole, Giuseppe Citerio, Nino Stocchetti, Lain K. Haitsma, Jilske A. Huijben, Clemens M. F. Dirven, Mathieu van der Jagt, Ewout W. Steyerberg, David Nelson, Maryse C. Cnossen, Andrew I. R. Maas, Suzanne Polinder, David K. Menon, Hester F. Lingsma
JOURNAL OF CRITICAL CARE
(2019)
Article
Anesthesiology
Frederick A. Zeiler, Manuel Cabeleira, Peter J. Hutchinson, Nino Stocchetti, Marek Czosnyka, Peter Smielewski, Ari Ercole
Summary: The study investigated the relationship between slow-wave fluctuations of intracranial pressure (ICP), mean arterial pressure (MAP) and brain tissue oxygen (PbtO(2)) over time in traumatic brain injury (TBI) patients. While ICP and MAP showed similar structures in time, PbtO(2) displayed a different optimal structure. PbtO(2) did not reliably respond to slow-wave fluctuations in MAP.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Critical Care Medicine
Chiara Robba, Paola Rebora, Erika Banzato, Eveline J. A. Wiegers, Nino Stocchetti, David K. Menon, Giuseppe Citerio
Article
Clinical Neurology
Frederick A. Zeiler, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter J. Hutchinson, Peter Smielewski, Marek Czosnyka, Audny Anke, Ronny Beer, Bo Michael Bellander, Erta Beqiri, Andras Buki, Marco Carbonara, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Endre Czeiter, Bart Depreitere, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Danile Kondziella, Lars-Owe Koskinen, Ana Kowark, David K. Menon, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Oliver Sakowitz, Nina Sundstroem, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf, Alexander Younsi
ACTA NEUROCHIRURGICA
(2020)
Article
Medicine, General & Internal
Fiona E. Lecky, Olubukola Otesile, Carl Marincowitz, Marek Majdan, Daan Nieboer, Hester F. Lingsma, Marc Maegele, Giuseppe Citerio, Nino Stocchetti, Ewout W. Steyerberg, David K. Menon, Andrew I. R. Maas, Caitlin Moyer, Caitlin Moyer, Caitlin Moyer, Caitlin Moyer, Caitlin Moyer
Summary: Low-energy falls contribute significantly to the burden of TBI and their prevalence will increase with the aging population. In older individuals, the severity of brain injury and risk to life may not be accurately predicted by energy transfer, suggesting that other factors may be more relevant for triage and care in this population.
Article
Clinical Neurology
Fabrizio Ortolano, Marco Carbonara, Antonella Stanco, Vittorio Civelli, Giorgio Carrabba, Tommaso Zoerle, Nino Stocchetti
ACTA NEUROCHIRURGICA
(2017)
Review
Critical Care Medicine
Nino Stocchetti, Tommaso Zoerle, Marco Carbonara
CURRENT OPINION IN CRITICAL CARE
(2017)
