Persistent Immune Responses after Ebola Virus Infection

More than a decade after infection with the Gulu strain of Sudan Ebola virus, persons in Uganda were found to have persistent immune responses. To the Editor: Ebola virus is a highly virulent emerging pathogen and a causative agent of viral hemorrhagic fever.(1) Studies of the pathogenesis of Ebola virus infection in humans have indicated that recovery is largely dependent on the development of an immune response.(1)-(3) To investigate the persistence of immune response in humans, we examined levels of cytokine expression after in vitro whole-blood stimulation in persons 12 years after infection with the Gulu strain of Sudan Ebola virus (SUDV-gul). The study was conducted in accordance with the Declaration of Helsinki and was approved by the Uganda Ministry of Health, the ...