Article
Surgery
Samik H. Patel, Barry Smith, Robert Polak, Morgan Pomeranz, Punam V. Patel, Richard Englehardt
Summary: The study evaluated the efficacy of MSA device placement in patients with persistent or de novo GERD after sleeve gastrectomy. The results showed that MSA device placement significantly improved GERD symptoms, reduced anti-reflux medication usage, and resulted in high patient satisfaction. Further studies are needed to validate the use of MSA in patients who have undergone sleeve gastrectomy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
George N. Baison, Anee S. Jackson, Candice L. Wilshire, Reginald C. W. Bell, Veronica Lazzari, Luigi Bonavina, Shahin Ayazi, Blair A. Jobe, Sebastian F. Schoppmann, Colin P. Dunn, John C. Lipham, Christy M. Dunst, Alexander S. Farivar, Adam J. Bograd, Brian E. Louie
Summary: Objective: To evaluate and characterize outcomes of MSA in patients with IEM. The study found that although MSA improves patients with gastroesophageal reflux and normal motility, many patients with IEM have lower rates of objective GERD resolution, lower resolution of existing dysphagia, higher rates of new onset dysphagia and need for dilation, which should be counseled to the patients before surgery.
Article
Surgery
Akira Dobashi, Jodie L. Deters, Charles A. Miller, Crystal J. Lavey, Elizabeth Rajan
Summary: This study investigated the feasibility and safety of a newly developed endotherapy for GERD using intraluminal magnets referred to as a magnet closure device (MCD). The results showed successful deployment of MCDs, increased LES pressures, and no clinically significant adverse events, suggesting a promising reversible technique for GERD therapy. Future studies are needed to improve durability and explore its potential as an attractive alternative to endoluminal GERD therapy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Rena Yadlapati, John E. Pandolfino, Madeline Greytak, Jonathon Cahoon, Mary Clarke, Matthew Clary, Daniel Fink, Paul Menard-Katcher, Andrew M. Vahabzadeh-Hagh, Philip Weissbrod, Samir Gupta, Alexander Kaizer, Sachin Wani
Summary: The study found that the external upper esophageal sphincter compression device as an adjunct to proton pump inhibitor therapy in patients with laryngopharyngeal reflux has potential efficacy in significantly improving symptoms.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Surgery
Shahin Ayazi, Katrin Schwameis, Ping Zheng, Kirsten Newhams, Brittney M. Myers, Andrew D. Grubic, Toshitaka Hoppo, Blair A. Jobe
Summary: This study evaluated the impact of MSA on the lower esophageal sphincter (LES) and esophageal body using high resolution impedance manometry. The findings showed that MSA improved LES characteristics without affecting esophageal peristaltic progression and bolus clearance.
Article
Veterinary Sciences
Giselle L. Hosgood, Carla Appelgrein, Candice Gelmi
Summary: The study presented a technique for circumferential esophageal hiatal rim reconstruction in 29 brachycephalic dogs with persistent regurgitation. Short-term follow-up showed a significant reduction in regurgitation frequency post surgery. It is recommended to consider this procedure for brachycephalic dogs with a history of regurgitation unresponsive to medical management.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2021)
Article
Surgery
Sven Eriksson, Katrin Schwameis, Shahin Ayazi, Toshitaka Hoppo, Ping Zheng, Blair A. Jobe
Summary: This retrospective study analyzed 777 patients who underwent magnetic sphincter augmentation (MSA) and found that 5.1% of patients required device removal. Most of the removals were performed due to dysphagia, and removal for dysphagia showed better outcomes compared to removal for gastroesophageal reflux disease (GERD). Tailored approach should be adopted for MSA removal based on the indication.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biochemistry & Molecular Biology
Tina L. Samuels, Simon Blaine-Sauer, Ke Yan, Kate Plehhova, Cathal Coyle, Nikki Johnston
Summary: Epithelial barrier dysfunction is a major characteristic of GERD, which is associated with symptom origination, inflammatory remodeling, and carcinogenesis. Alginate-based antireflux medications have been found to protect against peptic barrier disruption, and this study reveals the molecular mechanisms behind the injury and protection. The findings highlight the potential of targeting regulated intramembrane proteolysis and molecular mechanisms induced by weakly acidic reflux to treat GERD and prevent carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yung-An Tsou, Sheng-Hwa Chen, Wen-Chieh Wu, Ming-Hsui Tsai, David Bassa, Liang-Chun Shih, Wen-Dien Chang
Summary: This study investigated the clinical assessments and extent of esophageal pressure changes in LRPD patients with varying severities of GERD. It found that patients with more severe GERD had lower esophageal sphincter pressures, with the lowest pressures observed in patients with grade D GERD. No significant differences in esophageal pressures were noted based on age, gender, or BMI among the patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Pietro Familiari, Federica Borrelli de Andreis, Rosario Landi, Francesca Mangiola, Ivo Boskoski, Andrea Tringali, Vincenzo Perri, Guido Costamagna
Summary: This study demonstrated that there was no difference in the efficacy of POEM with a shorter cut length of 8 cm compared to the standard treatment of 13 cm. The shorter cut length also reduced the procedure time significantly. However, reducing the cutting length did not reduce the rate of GORD.
Article
Multidisciplinary Sciences
Chong Zhang, Chengfeng Pan, Kai Fung Chan, Jinyang Gao, Zhengxin Yang, Kevin Kai Chung Leung, Dongdong Jin, Yuqiong Wang, Neng Xia, Zhipeng Ning, Xin Wang, Shuai Jiang, Zifeng Zhang, Qinglong Wang, Bo Hao, Philip Wai Yan Chiu, Li Zhang
Summary: This article reports a battery-free and deformable electronic esophageal stent for wireless stimulation of the lower esophageal sphincter without the need for open surgery. The stent is capable of adapting to the dynamic environment of the esophagus and wirelessly harvesting energy through deep tissue. In vivo experiments using pig models demonstrated that continuous electrical stimulations delivered by the stent significantly increased the pressure of the lower esophageal sphincter.
Review
Surgery
Pedro Norton, Fernando A. M. Herbella, Francisco Schlottmann, Marco G. Patti
Summary: This study reviewed the evaluation of the upper esophageal sphincter (UES) using high-resolution manometry (HRM) and found that HRM allows for more precise measurements compared to conventional manometry, but the clinical significance of these parameters still needs confirmation. Various diseases can affect UES function, including achalasia, gastroesophageal reflux disease, globus, neurologic diseases, and Zenker's diverticulum.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Gu Cihang, Timothy Olszewski, Karen L. King, Michael F. Vaezi, Kevin D. Niswender, Heidi J. Silver
Summary: This study is the first randomized controlled diet intervention trial to investigate the impact of both the amount and type of carbohydrate on symptomatic gastroesophageal reflux disease (GERD). The results showed that reducing the intake of simple sugars improved pH monitoring outcomes and symptoms of GERD. These findings provide feasible and clinically applicable dietary recommendations for the treatment and management of GERD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Tayler J. James, Jocelyn F. Burke, Luke R. Putnam, Jennifer Pan, Nikolai A. Bildzukewicz, Reginald Bell, John C. Lipham
Summary: The study demonstrated that there were no significant differences in the outcomes of MSA treatment among normal weight, overweight, and obese patients. All patient groups experienced significant improvements after MSA, including reduced acid suppressive medication use and improved GERD symptoms.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Roberta Neuwald Pauletti, Sidia M. Callegari-Jacques, Laura Fornari, Jr. Iran de Moraes, Fernando Fornari
Summary: This study aimed to assess whether reduced masticatory function can be used as a predictor for gastroesophageal reflux disease (GERD) and esophageal dysphagia. The results showed that reduced masticatory function was associated with GERD and esophageal dysphagia.
DIGESTIVE AND LIVER DISEASE
(2022)
Letter
Gastroenterology & Hepatology
M. J. Koch, P. J. Tanis, W. A. Bemelman, J. B. Tuynman, R. Hompes, H. J. Belgers
COLORECTAL DISEASE
(2020)
Article
Gastroenterology & Hepatology
Karin A. T. G. M. Wasmann, Jojanneke van Amesfoort, Maurits L. van Montfoort, Lianne Koens, Willem A. Bemelman, Christianne J. Buskens
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Surgery
A. S. H. M. van Dalen, M. Jansen, M. van Haperen, S. van Dieren, C. J. Buskens, E. J. M. Nieveen van Dijkum, W. A. Bemelman, T. P. Grantcharov, M. P. Schijven
Summary: The study investigated the satisfaction of the OR team using an MDR for team debriefing, with high satisfaction reported and a strong recommendation for using the OR Black Box in team debriefing.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Esther Z. Barsom, Marilou Jansen, Pieter J. Tanis, Anthony W. H. van de Ven, Marjolein Blusse van Oud-Alblas, Christianne J. Buskens, Willem A. Bemelman, Marlies P. Schijven
Summary: The study compared the attitude and satisfaction with video consultation (VC) among patients with colorectal cancer and their treating surgeons. Results showed that patients who chose VC had a better experience in follow-up consultations, while surgeons were highly satisfied with the use of VC.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
J. K. Schultz, N. Azhar, G. A. Binda, G. Barbara, S. Biondo, M. A. Boermester, A. Chabok, E. C. J. Consten, S. T. van Dijk, A. Johanssen, W. Kruis, D. Lambrichts, S. Post, F. Ris, T. A. Rockall, A. Samuelsson, S. Di Saverio, D. Tartaglia, A. Thorisson, D. C. Winter, W. Bemelman, E. Angenete
COLORECTAL DISEASE
(2020)
Article
Gastroenterology & Hepatology
M. E. Stellingwerf, W. A. Bemelman, M. Lowenberg, C. Y. Ponsioen, G. R. D'Haens, S. vanDieren, C. J. Buskens
Summary: Appendectomy in patients with ulcerative colitis is associated with a decreased risk of colectomy and a delay in surgery, but does not significantly impact the risk of colorectal cancer.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
M. D. M. Bolmers, J. de Jonge, C. C. van Rossem, A. A. W. van Geloven, W. A. Bemelman
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Review
Gastroenterology & Hepatology
Daniel P. Lambrichts, Pim P. Edomskis, Ruben D. van der Bogt, Gert-Jan Kleinrensink, Willem A. Bemelman, Johan F. Lange
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Review
Health Care Sciences & Services
Esther Z. Barsom, Ewout van Hees, Willem A. Bemelman, Marlies P. Schijven
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2020)
Article
Oncology
Louis J. X. Giesen, Wernard A. A. Borstlap, Willem A. Bemelman, Pieter J. Tanis, Cornelis Verhoef, Pim B. Olthof
JOURNAL OF SURGICAL ONCOLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
C. Lansdorp, K. Gecse, C. Buskens, M. Lowenberg, J. Stoker, W. Bemelman, G. D'Haens, R. van Hulst
JOURNAL OF CROHNS & COLITIS
(2020)
Meeting Abstract
Gastroenterology & Hepatology
M. Matheeuwsen, K. Vermeijden, P. Bossuyt, L. Pouillon, F. Baert, N. de Boer, M. Duijvestein, M. Lowenberg, C. Ponsioen, W. Bemelman, G. D'Haens, K. Gecse
JOURNAL OF CROHNS & COLITIS
(2020)
Meeting Abstract
Gastroenterology & Hepatology
F. M. Bloemendaal, M. Becker, P. J. Koelink, J. D. van der Bilt, W. A. Bemelman, G. R. A. M. D'Haens, C. J. Buskens, M. E. Wildenberg
JOURNAL OF CROHNS & COLITIS
(2020)
Meeting Abstract
Gastroenterology & Hepatology
D. C. de Jong, K. Wasmann, C. Buskens, W. Bemelman, M. Lowenberg, K. Gecse, C. Ponsioen, G. D'Haens, R. Hompes, M. Duijvestein
JOURNAL OF CROHNS & COLITIS
(2020)
Correction
Surgery
M. E. Stellingwerf, E. M. van Praag, P. J. Tozer, W. A. Bemelman, C. J. Buskens