期刊
STEROIDS
卷 102, 期 -, 页码 101-109出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2015.08.004
关键词
Xylariaceae; Nodulisporium sp.; Endolichenic fungus; 4-Methyl-progesteroid derivatives
资金
- Ministry of Science and Technology of China [2012ZX09301002-003001006]
- National Natural Science Foundation of China [81422054, 81373306]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287]
- Guangdong Special Support Program [2014TQ01R420]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
The fungus Nodulisporium sp. (No. 65-12-7-1), which can produce a rare class of steroids (4-methyl-progesteroids) in rice solid medium, was subjected to a one strain-many compounds (OSMAC) approach. It was found to produce ten new 4-methyl-progesteroid derivatives named nodulisporisteroids C-L (1-10) in potato-dextrose-broth (PDB) medium, which showed that the fungus was a prolific producer of 4-methyl-progesteroids. The structures of 1-10 were elucidated by spectroscopic and X-ray crystallographic analysis. Their cytotoxic activities against five human cancer cell lines had been evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. (C) 2015 Elsevier Inc. All rights reserved.
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