Article
Medicine, Research & Experimental
Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim, Ssang-Goo Cho
Summary: This study investigates the effects of androgen suppression therapy on bladder cancer progression and identifies potential therapeutic targets. It is found that dutasteride, a 5 alpha-reductase inhibitor, can inhibit cell proliferation and migration of bladder cancer cells by regulating the expression of cancer progression proteins. Additionally, the study reveals the role of the target gene SRD5A1 in bladder cancer and its correlation with patient survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rossano Girometti, Gianluca Giannarini, Valeria Panebianco, Silvio Maresca, Lorenzo Cereser, Maria De Martino, Stefano Pizzolitto, Martina Pecoraro, Vincenzo Ficarra, Chiara Zuiani, Claudio Valotto
Summary: This study compared the impact of different PSA density (PSAD) thresholds on the accuracy of the Prostate Imaging Reporting And Data System v.2.1 (PI-RADSv2.1) in diagnosing clinically significant prostate cancer (csPCa). The results showed that PI-RADSv2.1 category four with PSAD >= 0.10 ng/mL ml(-1) was the biopsy-triggering cut-off with the highest net benefit within the expected prevalence range for csPCa.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aleksandar Kuzmanov, Souzan Salemi, Florian A. A. Schmid, Irene A. A. Burger, Daniel Eberli, Benedikt Kranzbuhler
Summary: PSMA-based imaging is a promising diagnostic tool for detecting prostate cancer, but low PSMA expression can limit its effectiveness. Inducing PSMA expression pharmacologically may improve the detection rate. In this study, we found that treatment with low concentrations of dutasteride (Duta) and lovastatin (Lova) significantly upregulated PSMA expression in prostate cancer cells. Combination treatment with lower concentrations of Duta and Lova further enhanced PSMA expression compared to single compound treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Stavros Gravas, Juan Manuel-Palacios, Chandrashekhar Chavan, Claus G. Roehrborn, Matthias Oelke, Marcio Augusto Averbeck, Arunangshu Biswas, Llenalia Maria Garcia, Khadeeja Mohamed, Vanessa Cortes
Summary: Modeling studies using large datasets in men with LUTS/BPE can predict changes in IPSS and risk of acute urinary retention/surgery under different treatment regimens. Combination therapy was found to provide greater predicted benefit than monotherapy for most patients within the CombAT criteria. Predictors such as postvoid residual urine, age, maximum urine flow rate, and nocturia score were significant in predicting outcomes.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Urology & Nephrology
Burcu F. Darst, Xin Sheng, Rosalind A. Eeles, Zsofia Kote-Jarai, David V. Conti, Christopher A. Haiman
Summary: The study revealed that the risk of prostate cancer from rare variants could vary based on an individual's genetic profile of common risk variants. Therefore, to comprehensively assess genetic risk of prostate cancer, it is crucial to consider both rare and common variants.
Article
Oncology
Roderick Clark, Danny Vesprini, Steven A. Narod
Summary: Elderly men with prostate cancer have a lower mortality rate compared to younger men, as they have a higher risk of dying from other causes. For low-grade cancer patients, the annual risk of dying from cancer increases continuously and peaks in men aged 85 and older.
Review
Cell Biology
Dexin Shen, Lingao Ju, Fenfang Zhou, Mengxue Yu, Haoli Ma, Yi Zhang, Tongzu Liu, Yu Xiao, Xinghuan Wang, Kaiyu Qian
Summary: Melatonin, as a potential therapy for prostate cancer, has significant antioxidant and anticancer abilities. Studies have shown that melatonin can inhibit the development of prostate cancer through different pathways, and the synergistic use with other drugs may have better effects.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Medicine, General & Internal
Daisuke Obinata, Ken Nakahara, Tsuyoshi Yoshizawa, Junichi Mochida, Kenya Yamaguchi, Satoru Takahashi
Summary: In this retrospective study, the characteristics of prostate biopsies in patients treated with dutasteride were investigated. The results suggest that dutasteride may have a role in screening for prostate cancer, especially in older patients with abnormal MRI findings.
Article
Oncology
Robert J. Klein, Emily Vertosick, Dan Sjoberg, David Ulmert, Ann-Charlotte Ronn, Christel Haggstrom, Elin Thysell, Goran Hallmans, Anders Dahlin, Par Stattin, Olle Melander, Andrew Vickers, Hans Lilja
Summary: Polygenic risk scores (PRS) for prostate cancer incidence were evaluated and compared to PSA and a commercialized model in predicting lethal prostate cancer. The study found that PRS was associated with incident prostate cancer, but was not a stronger predictor of lethal disease compared to PSA. The combination of PRS and PSA did not contribute additional risk stratification for lethal prostate cancer.
NPJ PRECISION ONCOLOGY
(2022)
Article
Oncology
Jukka K. Salminen, Viivu Kuoppamaki, Kirsi Talala, Kimmo Taari, Jussi Makinen, Jukka Peltola, Teuvo L. J. Tammela, Anssi Auvinen, Teemu J. Murtola
Summary: The study found that men using antiepileptic drugs had a decreased overall risk of prostate cancer compared to non-users. This risk reduction was similar among users of HDAC inhibitors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Endocrinology & Metabolism
Jordan J. Kramer, Lin Gu, Daniel Moreira, Gerald Andriole, Stephen J. Freedland, Ilona Csizmadi
Summary: In older men, smoking does not increase the risk of developing lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in asymptomatic men, nor does it affect the progression of LUTS in symptomatic men.
Article
Oncology
Jakob Weitzer, Gemma Castano-Vinyals, Nuria Aragones, Ines Gomez-Acebo, Marcela Guevara, Pilar Amiano, Vicente Martin, Ana Molina-Barcelo, Juan Alguacil, Victor Moreno, Claudia Suarez-Calleja, Jose Juan Jimenez-Moleon, Rafael Marcos-Gragera, Kyriaki Papantoniou, Beatriz Perez-Gomez, Javier Llorca, Nieves Ascunce, Leire Gil, Esther Gracia-Lavedan, Delphine Casabonne, Virginia Lope, Marina Pollan, Manolis Kogevinas
Summary: The study found that exercising in the morning reduces the risk of breast and prostate cancer, while evening physical activity specifically has a protective effect on prostate cancer. However, afternoon activity does not seem to affect the risk of breast or prostate cancer. The protective effects of morning activity are more pronounced in intermediate/evening chronotypes for both cancers.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Urology & Nephrology
Sylvia H. J. Jochems, Josef Fritz, Christel Haggstrom, Bengt Jarvholm, Par Stattin, Tanja Stocks
Summary: This study investigated the association between smoking and prostate cancer (PCa) risk and death among 351,448 men in Sweden. Results showed that smoking was associated with a lower risk of PCa incidence, particularly for low-risk PCa. However, smoking was associated with an increased risk of PCa death. Smoking in combination with obesity further affected the risk of PCa.
Article
Oncology
Daimantas Milonas, Zilvinas Venclovas, Gustas Sasnauskas, Tomas Ruzgas
Summary: Persistent prostate-specific antigen after radical prostatectomy can serve as an independent predictor of worse long-term outcomes in high-risk prostate cancer patients, while in intermediate-risk patients, it significantly predicts only biochemical recurrence and has no impact on outcomes in low-risk patients.
Article
Multidisciplinary Sciences
William D. Dupont, Joan P. Breyer, Spenser H. Johnson, W. Dale Plummer, Jeffrey R. Smith
Summary: The study found that the G84E germline mutation of HOXB13 predisposes to prostate cancer, and multiple rare genetic variants in European-ancestry case-control study populations have significant effects on prostate cancer risk. Independent risk signals were mainly detected from specific variants within SKAP1 and HOXB13.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Marcin Markuszewski, Magdalena Buszewska-Forajta, Malgorzata Artymowicz, Wojciech Polom, Marek Roslan, Michal Markuszewski
Summary: This study investigated the effect of covalent linking of ICG to a nanocolloid on the time of dye detection as it binds to HSA. The results showed that connecting ICG to a nanocolloid based on human serum albumin improved and prolonged the fluorescence visibility of ICG.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Piotr Zapala, Aleksander Slusarczyk, Pawel Rajwa, Mikolaj Przydacz, Wojciech Krajewski, Bartosz Dybowski, Przemyslaw Kubik, Blazej Kuffel, Maciej Przudzik, Rafal Osiecki, Remigiusz Stamirowski, Lukasz Zapala, Mieszko Kozikowski, Dominik Choragwicki, Magdalena Szymanska, Pawel Kielb, Bartosz Malkiewicz, Jacek Zostawa, Marek Roslan, Joanna Zajaczkowska, Marcin Jarzemski, Bartosz Brzoszczyk, Piotr Petrasz, Piotr Jarzemski, Romuald Zdrojowy, Jakub Dobruch, Andrzej Paradysz, Tomasz Drewa, Piotr Radziszewski, Piotr Chfosta
Summary: In Poland, the COVID-19 pandemic has led to a reduction in urooncological surgeries, specifically for TURBT and PN, while RC surgeries have significantly increased.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Dermatology
John E. Jett, Michael McLaughlin, Mark S. Lee, Lawrence Charles Parish, Janet DuBois, Tooraj Joseph Raoof, Glenn Tabolt, Timothy Wilson, Matthew C. Somerville, Wayne DellaMaestra, Stephen C. Piscitelli
Summary: The study demonstrated that tapinarof cream 1% once daily showed good tolerability and significant efficacy in patients with extensive plaque psoriasis, with 14 patients showing a >= 1-grade improvement in PGA score after 29 days.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Article
Andrology
Kassim Kourbanhoussen, France-Helene Joncas, Christopher J. D. Wallis, Helene Hovington, Francois Dagenais, Yves Fradet, Chantal Guillemette, Louis Lacombe, Paul Toren
Summary: This study evaluates the association between preoperative FSH levels and long-term cardiovascular and oncologic outcomes in men with prostate cancer. The findings suggest that FSH levels are not significantly associated with oncologic outcomes or predictors of long-term cardiovascular risk in these patients.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Urology & Nephrology
Antti Rannikko, Mare Leht, Tuomas Mirtti, Anu Kenttamies, Teemu Tolonen, Irina Rinta-Kiikka, Tuomas P. Kilpelainen, Kari Natunen, Hans Lilja, Terho Lehtimaki, Jani Raitanen, Paula Kujala, Johanna Ronkainen, Mika Matikainen, Anssi Petas, Kimmo Taari, Teuvo Tammela, Anssi Auvinen
Summary: This study evaluated the feasibility of a population-based screening trial using PSA, a kallikrein panel, and MRI. The findings showed that the screening protocol was able to minimize overdiagnosis while retaining mortality benefit, and achieved a substantial detection rate for clinically significant prostate cancer. However, participation rate needs improvement.
Article
Oncology
Lukasz Zapala, Aleksander Slusarczyk, Bartlomiej Korczak, Pawel Kurzyna, Mikolaj Leki, Piotr Lipinski, Jerzy Milow, Michal Niemczyk, Kamil Pochec, Michal Pozniak, Maciej Przudzik, Tomasz Suchojad, Rafal Wolanski, Piotr Zapala, Tomasz Drewa, Marek Roslan, Waldemar Rozanski, Andrzej Wrobel, Piotr Radziszewski
Summary: The study aimed to characterize patients undergoing radical cystectomy (RC) using a prognostic model (modified pentafecta). The achievement rate of pentafecta was found to be low, even in high-volume centers, and was directly influenced by the complexity of the procedure, leading to an increase in cancer-specific mortality among pentafecta failers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Samuel Fradet, Jean-Francois Pelletier, Narcisse Singbo, Louis Lacombe, Paul Toren, Michele Lodde, Thierry Dujardin, Rabi Tiguert, Yves Fradet, Karine Robitaille, Vincent Fradet
Summary: The aim of this study was to determine the effect of long-chain omega-3 (LC omega-3) supplements on perioperative bleeding and complications after radical prostatectomy. The results showed that taking LC omega-3 supplements before the surgery did not increase the risk of surgical bleeding.
CLINICAL NUTRITION ESPEN
(2022)
Article
Oncology
Jukka K. Salminen, Aino Mehtola, Kirsi Talala, Kimmo Taari, Jussi Makinen, Jukka Peltola, Teuvo L. J. Tammela, Anssi Auvinen, Teemu J. Murtola
Summary: The use of anti-epileptic drugs (AEDs) is associated with increased prostate cancer mortality, but the use of HDACi AEDs does not decrease prostate cancer mortality compared to other AEDs.
BRITISH JOURNAL OF CANCER
(2022)
Article
Surgery
German J. Chaud, Louis Lacombe, Francois Dagenais
Summary: Detailed understanding of venous anomalies is crucial for retroperitoneal surgery. This report describes a rare case of successful treatment for a patient with left renal cell carcinoma and level IV IVC thrombus extension using terminal-lateral anastomoses between the left and right IVCs.
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES
(2022)
Article
Oncology
Antti Peltomaa, Kirsi Talala, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen, Teemu J. Murtola
Summary: The study found that there is an inverse association between the use of statins and cancer mortality in men with decreased cholesterol levels. This suggests that the observed reduced cancer mortality associated with statin use is related to cholesterol level. This is the first study to evaluate the separate effects of cholesterol level and statin use on cancer mortality.
Article
Oncology
Idris Olasunmbo Ola, Kirsi Talala, Teuvo Tammela, Kimmo Taari, Teemu Murtola, Paula Kujala, Jani Raitanen, Anssi Auvinen
Summary: PSA-based screening can reduce prostate cancer mortality, but may also lead to overdetection of low-risk disease. The incidence of prostate cancer is associated with PSA levels, with higher PSA values indicating an increased risk of aggressive disease. Risk stratification and appropriate rescreening intervals can help reduce overdetection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Lotta H. Nygard, Kirsi Talala, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen, Teemu J. Murtola
Summary: The use of antidiabetic medication, especially insulin, and untreated hyperglycemia are associated with an elevated risk of BPH surgery in diabetic men. These findings suggest that insulin use and high blood glucose levels may be risk factors for BPH.
Article
Oncology
Michele Rouleau, Flora Nguyen Van Long, Veronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Levesque, Chantal Guillemette
Summary: Naturally occurring germline gene deletions (KO) of UGT2B17 and UGT2B28 genes lead to metabolic rewiring, promoting prostate cancer growth and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Hanane Moussa, Karine Robitaille, Jean-Francois Pelletier, Roxane Tourigny, Yves Fradet, Louis Lacombe, Paul Toren, Michele Lodde, Rabi Tiguert, Thierry Dujardin, Yves Caumartin, Thierry Duchesne, Pierre Julien, Josee Savard, Caroline Diorio, Vincent Fradet
Summary: This study aimed to evaluate the effects of long-chain omega-3 fatty acid supplementation on prostate cancer-specific quality of life in men treated by radical prostatectomy. The results showed that LCn3 supplementation may improve urinary irritation function in men undergoing radical prostatectomy. Larger-scale studies are needed to further investigate this relationship.
Article
Oncology
Mame-Kany Diop, Oscar Eduardo Molina, Mirela Birlea, Helene LaRue, Helene Hovington, Bernard Tetu, Louis Lacombe, Alain Bergeron, Yves Fradet, Dominique Trudel
Summary: The immune infiltrate of intraductal carcinoma of the prostate (IDC-P) is generally reduced compared to the surrounding tissues, especially regarding antigen-presenting cells. These findings could contribute to a better understanding of the immune response to lethal prostate cancer and the development of new therapies.