Review
Neurosciences
Nicolas Hernandez Norager, Markus Harboe Olsen, Sarah Hornshoej Pedersen, Casper Schwartz Riedel, Marek Czosnyka, Marianne Juhler
Summary: This study establishes position-dependent reference values for intracranial pressure and lumbar cerebrospinal fluid pressure for the first time. Clinically applicable reference values for normal lumbar cerebrospinal fluid pressure have been established, consistent with previously used reference values. For intracranial pressure, the study emphasizes the scarcity of normal pressure measures and the need for further research in this area.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Clinical Neurology
David E. Bateman, Barbara Wingrove
Summary: This study establishes the normal range of cerebrospinal fluid (CSF) pressure through lumbar puncture measurements and finds that patients with idiopathic intracranial hypertension (IIH) generally have higher CSF pressure. The results suggest that the current upper limit may be too low and should be revised.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ruiqi Pang, Danting Lin, Xiaomeng Di, Xinyu Liu, Lehong Gao, Jia Chen, Yu Jia, Kai Cao, Tianmin Ren, Ying Cheng, Yuping Wang, Jiawei Wang, Ningli Wang
Summary: This study provides reference values of trans-laminar cribrosa pressure difference (TLCPD) and reveals the association of TLCPD with systemic biometric factors. The results show that TLCPD is significantly negatively correlated with body mass index (BMI). This study establishes clinically applicable reference intervals for normal TLCPD.
Article
Ophthalmology
Victoria Sattarova, Alexis Flowers, Sidney M. Gospe, John J. Chen, Leanne Stunkel, M. Tariq Bhatti, Michael Dattilo, Sachin Kedar, Valerie Biousse, Collin M. McClelland, Michael S. Lee
Summary: This retrospective case series investigated the clinical characteristics, outcomes, and management of 19 patients with concomitant malignant arterial hypertension and intracranial hypertension. The majority of patients had pre-existing hypertension and the most common symptom was blurred vision. Treatment included medication for arterial hypertension, medical treatment for raised intracranial pressure, and surgical intervention. Significant improvement was observed in papilloedema, peripapillary retinal nerve fibre layer thickness, and visual field.
Article
Infectious Diseases
Nicolo Girometti, Muhammad H. Junejo, Diarmuid Nugent, Alan McOwan, Gary Whitlock
Summary: This study compared outcomes of patients diagnosed with early neurosyphilis and treated with doxycycline or procaine G penicillin. The results showed similar rates of clinical and serological response and seroreversion in the groups treated with procaine G penicillin versus doxycycline. A randomized controlled trial is needed to establish the effectiveness of doxycycline in the treatment of early neurosyphilis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Emma L. Anderson, Dylan M. Williams, Venexia M. Walker, Neil M. Davies
Summary: Research suggests that CypA and MMP9 may not be effective drug targets for cognitive impairment in human APOE4 carriers, as little evidence was found to support their involvement in Alzheimer's disease or cognitive impairment risk.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Meital Ben-Dov, Avi Fellner, Ophir Keret, Itay Lotan, Lilach Goldstein, Daphna Mezad-Koursh, Israel Steiner, Ainat Klein
Summary: This study characterizes the features of elevated lumbar puncture opening pressure (ELPOP) in aseptic meningitis patients and finds a correlation with body mass index (BMI).
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Andrew L. Callen, Jack Pattee, Ashesh A. Thaker, Vincent M. Timpone, David A. Zander, Ryan Turner, Marius Birlea, Danielle Wilhour, Chantal O'Brien, Jennifer Evan, Fabio Grassia, Ian R. Carroll
Summary: This study investigated the use of the Bern score and calculated craniospinal elastance to diagnose SIH and understand its pathophysiology. Results showed that the Bern score was a better diagnostic tool for CSF leak. Elastance was significantly associated with certain components of the Bern score.
Article
Medicine, General & Internal
Hamza Gultekin, Mehmet Guven
Summary: ONSD measured during ICU admission in critical COVID-19 patients can predict in-hospital mortality. ONSD is correlated with ICP and is associated with prognosis.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Paulius Lucinskas, Mantas Deimantavicius, Laimonas Bartusis, Rolandas Zakelis, Edgaras Misiulis, Algis Dziugys, Yasin Hamarat
Summary: This study investigated the possibility of using the ophthalmic artery (OA) as a pressure sensor for continuous ICP monitoring. Numerical modeling and a clinical study showed that non-invasive ICP monitoring using TCD had a systematic error of < 1.0 mmHg, with a high correlation coefficient with invasive microsensor readings. The results suggest that the OA can be used as a linear natural pressure sensor for ICP monitoring.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Yi Kung, Chueh-Hung Wu, Meng-Ting Lin, Wei-Hao Liao, Wen-Shiang Chen, Ming-Yen Hsiao
Summary: Transcranial focused shockwave (FSW) is a noninvasive brain stimulation technique that can open blood-brain barriers and blood-cerebrospinal fluid barriers to facilitate drug delivery to the whole brain. A modified single pulse FSW technique has shown improved safety profiles and can effectively and safely open the blood-cerebrospinal fluid barrier with minimal risk to brain tissue.
Article
Computer Science, Interdisciplinary Applications
Seifollah Gholampour, Mehrnoosh Bahmani
Summary: The study compared the efficiency of shunt placement and endoscopic third ventriculostomy (ETV) in treating adult hydrocephalus patients with varying intensities and obstruction levels in the Sylvius aqueduct.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to analyze the presence of AQP1 and AQP4 in the CSF of iNPH and AD patients as potential biomarkers. However, ELISA analysis showed insufficient sensitivity to detect these proteins, ruling out their use as biomarkers for diagnosing iNPH.
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to investigate the potential of AQP1 and AQP4 proteins in CSF as biomarkers for iNPH, but ELISA analysis showed insufficient sensitivity to detect their presence. The study also revealed differences in vascular risk factors between patients with iNPH and AD.
Review
Medicine, General & Internal
Inga Zerr
Summary: The diagnosis of Creutzfeldt-Jakob disease has evolved to include the detection of 14-3-3 protein and abnormally folded prion protein in cerebrospinal fluid, with nearly 100% sensitivity and specificity.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Emergency Medicine
Ronald F. Marchese, Payal K. Gala, Jeffrey A. Seiden, Richard Scarfone, Robert A. Belfer, Jill Posner
PEDIATRIC EMERGENCY CARE
(2020)
Article
Cardiac & Cardiovascular Systems
Jennifer M. Lynch, Tiffany Ko, David R. Busch, John J. Newland, Madeline E. Winters, Kobina Mensah-Brown, Timothy W. Boorady, Rui Xiao, Susan C. Nicolson, Lisa M. Montenegro, J. William Gaynor, Thomas L. Spray, Arjun G. Yodh, Maryam Y. Naim, Daniel J. Licht
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2018)
Article
Cardiac & Cardiovascular Systems
Jack Rychik, Donna Goff, Eileen Mckay, Antonio Mott, Zhiyun Tian, Daniel J. Licht, J. William Gaynor
PEDIATRIC CARDIOLOGY
(2018)
Review
Obstetrics & Gynecology
Nan Lin, John Flibotte, Daniel J. Licht
SEMINARS IN PERINATOLOGY
(2018)
Article
Critical Care Medicine
Andrew J. Lautz, Ryan W. Morgan, Michael Karlsson, Constantine D. Mavroudis, Tiffany S. Ko, Daniel J. Licht, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton, Todd J. Kilbaugh
CRITICAL CARE MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Kendall M. Lawrence, Patrick E. McGovern, Ali Mejaddam, Avery C. Rossidis, Heron Baumgarten, Aimee Kim, Judith B. Grinspan, Daniel J. Licht, Ryne A. Didier, Arastoo Vossough, Enrico Radaelli, Jack Rychik, Limei Song, William H. Peranteau, Marcus G. Davey, Alan W. Flake, J. William Gaynor
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Romergryko G. Geocadin, Clifton W. Callaway, Ericka L. Fink, Eyal Golan, David M. Greer, Nerissa U. Ko, Eddy Lang, Daniel J. Licht, Bradley S. Marino, Norma D. McNair, Mary Ann Peberdy, Sarah M. Perman, Daniel B. Sims, Jasmeet Soar, Claudio Sandroni
Article
Clinical Neurology
Duriel Hardy, Daniel J. Licht, Arastoo Vossough, Matthew P. Kirschen
Article
Clinical Neurology
Celine Thibault, Maryam Y. Naim, Nicholas S. Abend, Daniel J. Licht, J. William Gaynor, Rui Xiao, Shavonne L. Massey
Article
Engineering, Biomedical
Brian R. White, Jonah A. Padawer-Curry, Tiffany Ko, Wesley Baker, Jake Breimann, Akiva S. Cohen, Daniel J. Licht, Arjun G. Yodh
Summary: Optical neuromonitoring provides insights into neurovascular physiology and brain structure and function by relating light absorption changes to chromophore concentrations. In this study, new methods were developed to perform spectroscopy even with wavelength-dependent spatial variation in data quality. Results showed that accurate calculation of hemoglobin concentrations and functional connectivity network maps was possible even with censoring of some wavelengths, particularly when using changes in total hemoglobin. This rigorous image processing method has the potential to improve the fidelity of functional neuroimaging studies.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Clinical Neurology
T. Feygin, A. E. Goldman-Yassen, D. J. Licht, J. E. Schmitt, A. Mian, A. Vossough, L. Castelo-Soccio, J. R. Treat, A. Bhatia, A. N. Pollock
Summary: The study found that many pediatric patients with segmental infantile hemangiomas, especially those with hemangioma syndromes like PHACE, had neuroaxial hemangiomas, potentially requiring additional clinical evaluation and management.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Melissa L. Hutchinson, Lauren A. Beslow, Evelyn K. Shih, Daniel J. Licht, Alexandra C. Kimmel, Caroline Granath, Rebecca N. Ichord
Summary: This study aimed to describe factors affecting eligibility for and rates of utilization of hyperacute therapy in children with acute ischemic stroke following establishment of an institutional acute stroke treatment pathway in 2005. The results showed that various factors, including delay to presentation, mild neurologic deficits, medical contraindications to IV-tPA, and lack of vessel occlusion on acute neuroimaging, contributed to the low rates of hyperacute treatment in children with acute AIS.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Dieter Bender, Daniel J. Licht, C. Nataraj
Summary: This paper focuses on predicting periventricular leukomalacia (PVL) in neonates after heart surgery using Support Vector Machine (SVM). By incorporating an additional optimization step and utilizing an interactive machine learning (iML) algorithm, the SVM model's predictive accuracy was significantly improved while reducing dimensionality.
APPLIED SCIENCES-BASEL
(2021)
Editorial Material
Critical Care Medicine
Daniel J. Licht
Article
Cardiac & Cardiovascular Systems
Daniel J. Licht, Marin Jacobwitz, Jennifer M. Lynch, Tiffany Ko, Timothy Boorady, Mahima Devarajan, Kristina N. Heye, Kobina Mensah-Brown, John J. Newland, Alexander Schmidt, Peter Schwab, Madeline Winters, Susan C. Nicolson, Lisa M. Montenegro, Stephanie Fuller, Christopher Mascio, J. William Gaynor, Arjun G. Yodh, Juliana Gebb, Arastoo Vossough, Grace H. Choi, Mary E. Putt
Summary: Infants with congenital heart disease (CHD) are at risk for white matter injury (WMI) before neonatal heart surgery. Better knowledge of the causes of preoperative WMI may provide insights into interventions that improve neurodevelopmental outcomes in these patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
