Review
Multidisciplinary Sciences
Kati Tihtonen, Paivi Korhonen, Jaana Isojarvi, Riitta Ojala, Ulla Ashorn, Per Ashorn, Outi Tammela
Summary: The study found that supplementary calcium intake during pregnancy does not have a significant impact on maternal bone density after delivery or offspring bone density, even with low dietary calcium intake. Some data suggest potential long-term harm of the intervention on maternal bone density and growth of female offspring.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Oncology
Dao Li, Kai Wang, Zhuanhong Yang, Hui Li, Suqing Wang
Summary: The study found that advanced maternal age (AMA) in mice has negative effects on the cognitive function of offspring, while vitamin D supplementation before pregnancy can promote offspring development and improve learning and memory abilities. However, it did not have a significant impact on offspring anxiety and depression.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Amelie Le, Amandine Selle, Philippe Aubert, Tony Durand, Carole Brosseau, Philippe Bordron, Erwan Delage, Samuel Chaffron, Camille Petitfils, Nicolas Cenac, Michel Neunlist, Marie Bodinier, Malvyne Rolli-Derkinderen
Summary: Maternal diet plays a crucial role in preventing or contributing to the development of chronic diseases. Supplementation of maternal diet with prebiotics has been shown to reduce the risk of food allergies and affect intestinal permeability in offspring. However, the role of prebiotics in modulating the development of colitis remains unknown.
FRONTIERS IN NUTRITION
(2023)
Article
Pediatrics
Naomi D'souza, Rishikesh V. Behere, Bindu Patni, Madhavi Deshpande, Dattatray Bhat, Aboli Bhalerao, Swapnali Sonawane, Rohan Shah, Rasika Ladkat, Pallavi Yajnik, Souvik K. Bandyopadhyay, Kalyanaraman Kumaran, Caroline Fall, Chittaranjan S. Yajnik
Summary: This study found that pre-conceptional supplementation of vitamin B12 improved maternal B12 status and enhanced offspring neurodevelopment at the age of 2, particularly in cognition and language domains.
FRONTIERS IN PEDIATRICS
(2021)
Article
Food Science & Technology
Nicole Haroun, Imene Bennour, Eva Seipelt, Julien Astier, Lea Sani, Catherine Tardivel, Ljubica Svilar, Jean-Charles Martin, Lourdes Mounien, Jean Francois Landrier
Summary: This study aims to assess the effects of maternal vitamin D deficiency on hepatic lipid accumulation in adult offspring fed a normal or obesogenic diet.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Bianca Arrhenius, Subina Upadhyaya, Susanna Hinkka-Yli-Salomaeki, Alan S. Brown, Keely Cheslack-Postava, Hanna Ohman, Andre Sourander
Summary: This study found no association between low maternal 25(OH)D levels in early pregnancy and offspring specific learning disorders.
Article
Biochemistry & Molecular Biology
Liu Guo, Dongming Zhang, Shuan Liu, Zhenglin Dong, Jian Zhou, Yulong Yin, Dan Wan
Summary: The study found that dietary iron supplementation during pregnancy can improve maternal liver iron, placental iron, hemoglobin, and fetal iron levels, promote reproductive performance, and indicate that the effect of moderate iron supplements on placental function may be achieved by altering the biological processes of ion transport and gland development in the placenta.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lianpeng Zhao, Wei Lu, Zhengyu Mao, Daolin Mou, Long Huang, Min Yang, Dajiang Ding, Hui Yan, Zhengfeng Fang, Lianqiang Che, Yong Zhuo, Xuemei Jiang, Shengyu Xu, Yan Lin, Jian Li, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu, Bin Feng
Summary: Maternal VD3 supplementation during gestation can improve intestinal health and microbiota in suckling piglets, including increasing the length and height of intestinal villi, enhancing the expression levels of intestinal protective proteins, and increasing the abundance of beneficial bacteria and the content of probiotics in the intestine.
Article
Nutrition & Dietetics
Liuqiao Sun, Xuying Tan, Xiaoping Liang, Hangjun Chen, Qian Ou, Qiongmei Wu, Xinxue Yu, Hanqing Zhao, Qiaoli Huang, Zehua Yi, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Summary: Maternal betaine supplementation alleviates NAFLD in offspring through regulating gut microbiota and SCFAs.
Review
Biochemistry & Molecular Biology
Subina Upadhyaya, Tiia Stahlberg, Sanju Silwal, Bianca Arrhenius, Andre Sourander
Summary: Prenatal exposure to vitamin D may have an impact on human brain development and function. Previous epidemiological studies on the association between maternal vitamin D levels and offspring neuropsychiatric outcomes have been inconclusive. This systematic review found limited evidence for a link between prenatal vitamin D deficiency and autism spectrum disorder, and positive associations with attention-deficit/hyperactivity disorder and schizophrenia when considering studies with larger sample sizes and stricter definitions of deficiency. Larger studies with longer follow-up periods and evaluation of prenatal vitamin D at multiple time points are needed for further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Karen M. O'Callaghan, Shaila S. Shanta, Farzana Fariha, Jennifer Harrington, Abdullah Al Mahmud, Abby L. Emdin, Alison D. Gernand, Tahmeed Ahmed, Steven A. Abrams, Daniel R. Moore, Daniel E. Roth
Summary: This study aimed to investigate the potential effects of improving early-life vitamin D status on musculoskeletal health in children. The results showed no significant improvement in bone mass, bone density, or grip strength in four-year-old children with prenatal and postpartum vitamin D supplementation.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Nahal Habibi, Tina Bianco-Miotto, Yan Yin Phoi, Tanja Jankovic-Karasoulos, Claire T. Roberts, Jessica A. Grieger
Summary: Maternal nutrition and nutritional status during pregnancy may affect offspring telomere length, with higher maternal circulating folate and 25-hydroxyvitamin D3 concentrations, along with higher maternal dietary caffeine intakes, associated with longer offspring telomeres. Further research, particularly longitudinal studies involving larger cohorts of pregnant women, is needed in this area.
Article
Environmental Sciences
Xiaotong Ji, Huifeng Yue, Guangke Li, Nan Sang
Summary: The study reanalyzed differentially expressed genes in maternal and offspring lungs, revealing that DEGs in maternal lungs were enriched in immune-related functions, while those in offspring lungs were enriched in cell growth. By screening shared differential genes, maternal genes alone can predict the lung injuries in offspring induced by maternal smoking.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Ling Zhang, Yibin Xu, Xiaoqing Ding, Yongxia Wang, Aikun Fu, Xiuan Zhan
Summary: This study investigated the effects of maternal zinc source and offspring dietary zinc supplementation on the growth performance, antioxidant status, zinc concentration, and immune function of the offspring, and explored their interactions. Maternal zinc-Gly supplementation increased progeny performance, decreased progeny mortality and stress, and improved progeny zinc concentration, antioxidant capacity, and immune function. Simultaneously, zinc supplementation in the offspring's diet was necessary for their growth.
Article
Public, Environmental & Occupational Health
Yanji Qu, Shao Lin, Michael S. Bloom, Ximeng Wang, Bo Ye, Zhiqiang Nie, Yanqiu Ou, Jinzhuang Mai, Yong Wu, Xiangmin Gao, Xiaohua Xiao, Hongzhuan Tan, Xiaoqing Liu, Jimei Chen, Jian Zhuang
Summary: Low maternal socioeconomic status and education level were associated with an increased risk of congenital heart diseases and lower prevalence of folic acid supplementation. Folic acid intake partially mediated the effects of low income and education on the risk of congenital heart diseases.
PREVENTIVE MEDICINE
(2021)
Letter
Critical Care Medicine
David A. Lipson, MeiLan K. Han, Robert Wise, Fernando J. Martinez
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Emily D. Carter, Karen T. Chang, Luke C. Mullany, Subarna K. Khatry, Steven C. LeClerq, Melinda K. Munos, Joanne Katz
Summary: The study assessed the reliability of maternal reports on delivery and immediate newborn care in Sarlahi, Nepal, and found that many interventions were not reliably reported, especially in facility births. This suggests that household surveys relying on maternal reports may not be suitable for collecting data on interventions during the peripartum period.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Critical Care Medicine
Nadia N. Hansel, Nirupama Putcha, Han Woo, Roger Peng, Gregory B. Diette, Ashraf Fawzy, Robert A. Wise, Karina Romero, Meghan F. Davis, Ana M. Rule, Michelle N. Eakin, Patrick N. Breysse, Meredith C. McCormack, Kirsten Koehler
Summary: This is the first environmental intervention study conducted among former smokers with COPD, showing potential health benefits of portable high-efficiency particulate absolute air cleaners in improving respiratory morbidity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Ian M. Adcock, Surya P. Bhatt, Ronald Balkissoon, Robert A. Wise
Summary: Inhaled corticosteroids (ICS) in combination with bronchodilators are commonly used in primary care settings for patients with chronic obstructive pulmonary disease (COPD). However, ICS-containing therapies may be less effective in COPD patients, especially in those who continue to smoke. Studies have shown that the inflammation in COPD is different from asthma, and exposure to cigarette smoke alters the functioning of glucocorticoid receptors and other anti-inflammatory mechanisms. Therefore, ICS treatment may be relatively ineffective in COPD patients, particularly in smokers. Inappropriate use of ICS therapies in COPD patients can increase the risk of side effects such as pneumonia and bone fractures. Careful evaluation and selection of anti-inflammatory/bronchodilatory strategies based on individual patient characteristics and current guidelines are crucial for the treatment of COPD.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Critical Care Medicine
Nirupama Putcha, Han Woo, Meredith C. McCormack, Ashraf Fawzy, Karina Romero, Meghan F. Davis, Robert A. Wise, Gregory B. Diette, Kirsten Koehler, Elizabeth C. Matsui, Nadia N. Hansel
Summary: This study investigated the sensitivity of COPD patients to common indoor allergens and its association with symptoms and exacerbation risk. The results showed a significant correlation between sensitization and exposure with lower lung function, higher respiratory questionnaire scores, and higher exacerbation risk. Allergens are identified as an important home exposure in COPD, which could potentially be addressed through comprehensive home environmental modification strategies to improve outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Meredith C. McCormack, Aparna Balasubramanian, Elizabeth C. Matsui, Roger D. Peng, Robert A. Wise, Corinne A. Keet
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Carolyn M. Boudreau, John S. Burke, Kiel D. Shuey, Caitlin Wolf, Joanne Katz, James Tielsch, Subarna Khatry, Steven C. LeClerq, Janet A. Englund, Helen Y. Chu, Galit Alter
Summary: Seasonal influenza vaccination during pregnancy can provide immunity for infants, and the transfer of selective FCGR-binding antibodies contributes to the protective immune response against influenza in infants.
Article
Critical Care Medicine
Robert A. Wise, Janet T. Holbrook, Robert H. Brown, Gerard J. Criner, Mark T. Dransfield, Jiaxian He, Robert J. Henderson, David A. Kaminsky, Robert J. Kaner, Stephen C. Lazarus, Barry J. Make, Meredith C. McCormack, Enid R. Neptune, Loretta G. Que
Summary: This study aimed to evaluate the efficacy of losartan in reducing emphysema progression in COPD patients, and the results showed that losartan did not prevent emphysema progression.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Peter M. A. Calverley, Fernando J. Martinez, Jorgen Vestbo, Christine R. Jenkins, Robert Wise, David A. Lipson, Nicholas J. Cowans, Julie Yates, Courtney Crim, Bartolome R. Celli
Summary: Countries participating in COPD trials consistently differ in reporting exacerbations, which may explain why large studies are needed to show differences in exacerbation risk reduction between treatments.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Robert A. Wise, Janet T. Holbrook
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Andrea Gabrio, Necdet B. Gunsoy, Gianluca Baio, Alan Martin, Victoria F. Paly, Nancy Risebrough, David M. G. Halpin, Dave Singh, Robert A. Wise, MeiLan K. Han, Fernando J. Martinez, Gerard J. Criner, Neil Martin, David A. Lipson, Afisi S. Ismaila
Summary: Triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) showed better clinical benefits compared to dual therapy in the treatment of COPD, and also resulted in lower healthcare resource utilization costs related to COPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Allergy
Joan Reibman, Bradley E. Chipps, Robert S. Zeiger, David A. Beuther, Robert A. Wise, William McCann, Ileen Gilbert, James M. Eudicone, Hitesh N. Gandhi, Gale Harding, Katelyn Cutts, Karin S. Coyne, Kevin R. Murphy, Maureen George
Summary: Purpose of this study was to assess the construct validity of the Asthma Impairment and Risk Questionnaire (AIRQ) by comparing it with patient self-perception of asthma status and validated disease-specific patient-reported outcome measures. The results showed significant correlations between AIRQ score and patient self-perception, as well as scores from other validated measures. As the AIRQ control category worsened, scores from other measures also worsened. This study demonstrates that AIRQ can be a useful instrument to raise awareness of the impacts of asthma on patients' lives.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Allergy
Anne M. Mathews, Isaretta Riley, Robert Henderson, Janet T. Holbrook, Jason E. Lang, Anne E. Dixon, Robert A. Wise, Loretta G. Que
Summary: Obesity is an important factor associated with asthma outcomes and may modify the effects of drug treatment. This study aimed to evaluate obesity as a potential treatment effect modifier of enhanced drug messaging or placebos on subjective asthma outcomes.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Cardiac & Cardiovascular Systems
David A. Kaminsky, Jiaxian He, Robert Henderson, Anne E. Dixon, Charles G. Irvin, John Mastronarde, Lewis J. Smith, Elizabeth A. Sugar, Robert A. Wise, Janet T. Holbrook
Summary: The purpose of this study was to determine the relationship between four different definitions of bronchodilator response (BDR) and asthma control and symptom burden in participants with poorly controlled asthma. The study found that there was no association between BDR and asthma control or symptoms, regardless of the definition used. These findings question the clinical utility of BDR in assessing asthma control and symptoms.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Nirupama Putcha, Antonio R. Anzueto, Peter M. A. Calverley, Bartolome R. Celli, Donald P. Tashkin, Norbert Metzdorf, Achim Mueller, Robert A. Wise
Summary: There is an association between body mass index (BMI) and adverse outcomes in COPD, with underweight individuals having higher mortality and exacerbation risk. Overweight and obese individuals are at lower risk or no additional risk. A holistic management approach is needed to improve the general well-being of COPD patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)