Article
Virology
Zhaomin Feng, Wenfei Zhu, Lei Yang, Jia Liu, Lijuan Zhou, Dayan Wang, Yuelong Shu
Summary: Eurasian avian-like H1N1 swine influenza viruses in China have shown a genotypic diversity with 11 genotypes, among which genotypes 3 and 5 are predominant in pig population. These viruses continuously reassort with other co-circulated influenza viruses and show different genetic characteristics.
Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Timothy L. Wiemken, Joanne Salas, Daniel F. Hoft, Christine Jacobs, John E. Morley, Jeffrey F. Scherrer
Summary: A large-scale study using data from the Veterans Health Administration in the U.S. found that receiving influenza vaccinations is associated with a lower risk of dementia, especially with repeated vaccinations. This suggests that vaccinations may reduce dementia risk by training the immune system, providing a potentially cost-effective and low-risk intervention for preventing dementia.
Article
Immunology
Anna Parys, Elien Vandoorn, Koen Chiers, Katharina Passvogel, Walter Fuchs, Thomas C. Mettenleiter, Kristien Van Reeth
Summary: The study showed that heterologous prime-boost vaccination induced stronger antibody responses and protection in pigs, especially against heterologous challenges. However, a pan-H1 antibody response was not achieved.
Article
Immunology
Vasilis C. Pliasas, Peter J. Neasham, Maria C. Naskou, Rachel Neto, Philip G. Strate, J. Fletcher North, Stephen Pedroza, Strickland D. Chastain, Ian Padykula, S. Mark Tompkins, Constantinos S. Kyriakis
Summary: This study examined the immunogenicity and protective efficacy of different H1N1 influenza vaccine strategies against an H1N2 swine influenza virus. The results showed that heterologous prime-boost vaccination did not enhance cross-protection and worsened the clinical outcome and pathology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Multidisciplinary Sciences
Carlo De Intinis, Margherita Bodini, Denise Maffione, Laurane De Mot, Margherita Coccia, Duccio Medini, Emilio Siena
Summary: Gene expression data is commonly used in vaccine studies to characterize differences between treatment groups or sampling time points. This study developed a data analysis framework to characterize individual subject response profiles in the context of repeated measure experiments, which are typical of vaccine mode of action studies. Results highlighted a substantial heterogeneity in how different subjects respond to vaccination.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Celeste J. Romano, Clinton Hall, Zeina G. Khodr, Anna T. Bukowinski, Gia R. Gumbs, Ava Marie S. Conlin
Summary: This study examined the association between receiving pandemic H1N1 (pH1N1) vaccines in consecutive influenza seasons and adverse pregnancy outcomes among vaccine-compliant pregnant military women. The results showed no significant association between receiving pH1N1-containing vaccine during pregnancy and spontaneous abortion or birth defects. Therefore, vaccination against pH1N1 in pregnancy is supported regardless of prior influenza season vaccination history.
Article
Microbiology
Lucia Ortiz, Ginger Geiger, Lucas Ferreri, David Moran, Danilo Alvarez, Ana Silvia Gonzalez-Reiche, Dione Mendez, Daniela Rajao, Celia Cordon-Rosales, Daniel R. Perez
Summary: Despite increased surveillance efforts, the epidemiology of FLUAVs circulating in swine in Latin America remains understudied. The study conducted active FLUAV surveillance on a commercial pig farm in Southern Guatemala for 2 years and identified a unique group of H1N1 pdm09 sequences that suggest independent evolution from similar viruses circulating in Central America. These viruses may represent the establishment of a novel genetic lineage with the potential to reassort with other cocirculating viruses and whose zoonotic risk remains to be determined.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Can Chen, Xiaoxiao Liu, Danying Yan, Yuqing Zhou, Cheng Ding, Lu Chen, Lei Lan, Chenyang Huang, Daixi Jiang, Xiaobao Zhang, Zhou Guan, Xiaofang Fu, Yuxia Du, Yushi Lin, Changtai Zhu, Jie Wu, Lanjuan Li, Shigui Yang
Summary: The global influenza vaccination rates are generally low, especially in the general population. High-income countries/regions have significantly higher vaccination rates compared to middle-income countries/regions. Factors such as free vaccination policies, perception of vaccine efficacy, healthcare workers' recommendations, and vaccination history positively influence vaccine uptake.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Lotte Sahin Levison, Reimar Wernich Thomsen, Henning Andersen
Summary: This study found a slightly increased risk of Guillain-Barre syndrome (GBS) within one month after influenza vaccination, based on a retrospective nationwide population-based case-control study in Denmark. However, only 1.5% of GBS cases were associated with recent influenza vaccination. Therefore, the benefits of influenza vaccines in preventing influenza infections and associated morbidity and mortality need to be evaluated against the small absolute risk of GBS.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Letter
Medicine, General & Internal
Andrew M. Parker, Samer Atshan, Matthew M. Walsh, Courtney A. Gidengil, Raffaele Vardavas
Summary: This survey study examines the differences in COVID-19 vaccination based on previous influenza vaccination patterns and investigates whether influenza vaccination changed during the COVID-19 pandemic.
Article
Obstetrics & Gynecology
Fangjun Zhou, Megan C. Lindley, James T. T. Lee, Tara C. Jatlaoui
Summary: A retrospective analysis showed a positive and significant association between influenza vaccination during pregnancy and infant influenza vaccination. Infants born to vaccinated mothers had higher vaccination coverage compared to infants born to non-vaccinated mothers. Increasing influenza vaccination coverage among pregnant individuals may also increase infant vaccination coverage.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Endocrinology & Metabolism
Dong-Hwa Lee, Bumhee Yang, Seonhye Gu, Eung-Gook Kim, Youlim Kim, Hyung Koo Kang, Yeong Hun Choe, Hyun Jeong Jeon, Seungyong Park, Hyun Lee
Summary: This study investigated the yearly trend of influenza vaccination and factors associated with being unvaccinated for influenza in subjects with diabetes over the past decade. The results showed that the prevalence of influenza vaccination in subjects with diabetes tended to increase every year, reaching almost 60% in 2019. Younger age, males, smoking, low-income status, high education level, and poor glycemic control were associated with being unvaccinated.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Astrid Johannesson Hjelholt, Cecilia Bergh, Deepak L. Bhatt, Ole Frobert, Mads Fuglsang Kjolby
Summary: Influenza vaccines not only protect against infection but also potentially induce nonspecific effects, such as immunological memory and modulation of cytokines. This article discusses the possible impacts of influenza vaccination on cardiovascular disease, type 1 diabetes, cancer, and Alzheimer's disease.
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