Article
Clinical Neurology
Clement Hamani, Erich T. Fonoff, Daniella C. Parravano, Valquiria A. Silva, Ricardo Galhardoni, Bernardo A. Monaco, Jessie Navarro, Lin T. Yeng, Manoel J. Teixeira, Daniel Ciampi de Andrade
Summary: Motor cortex stimulation through surgically implanted electrodes has shown a response rate of approximately 40% in treating chronic neuropathic pain. Patients who developed an insertional effect or had specific clinical conditions had a higher likelihood of responding to the treatment.
Article
Clinical Neurology
Vesna Malinova, Tammam Abboud, Veit Rohde, Dorothee Mielke
Summary: Intraoperative ECM and MEPs can confirm the correct position of the MCS-electrode above the motor cortex, allowing the procedure to be performed under general anesthesia, eliminating the need for the patient to be awake during surgery.
ACTA NEUROCHIRURGICA
(2023)
Article
Neurosciences
Jingshan Lu, Lan Yang, Ying Xu, Lijing Ai, Jian Chen, Fangfang Xiong, Lihuan Hu, Huoshu Chen, Jiyuan Liu, Xiongbin Yan, Huihui Huang, Li Chen, Changxi Yu
Summary: The study found that selectively manipulating MCx astrocytes can reduce DNP pain, potentially through the release of cytokines to regulate neuronal activation. These results highlight the pivotal role of MCx astrocytes in DNP pathogenesis and offer new insights into DNP treatment strategies.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Maria F. Bandres, Jefferson L. Gomes, Jacob G. McPherson
Summary: We found that motor-targeted spinal stimulation can modulate spinal nociceptive transmission, suggesting its potential for neuropathic pain-related applications and its ability to provide multi-modal therapeutic benefits for individuals living with SCI.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Urology & Nephrology
Tian Li, Xin Y. Feng, Xiao M. Feng, Jian W. Lv, Ting T. Lv, Si Y. Wang
Summary: This study indicates that EPNS is more effective than II in treating urethral pain syndrome, providing superior pain control and improvement in lower urinary tract symptoms.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Danielle V. Assis, Ana Carolina P. Campos, Amanda F. N. Paschoa, Talita F. Santos, Erich T. Fonoff, Rosana L. Pagano
Summary: In this study, the effectiveness of epidural motor cortex stimulation (MCS) in treating refractory neuropathic pain was investigated. The study found that the effectiveness of MCS depends on the control of inflammatory and neurotrophic changes, as well as the restoration of the opioidergic system observed in neuropathic conditions. Understanding the refractoriness to MCS may lead to improvement in the efficacy of the technique, benefiting patients with persistent neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Cory D. Gloeckner, Jian C. Nocon, Hubert H. Lim
Summary: This study explored the effects of sound and electrical stimulation on the somatosensory cortex, and found that bimodal stimulation can excite or modulate firing activity across a widespread yet targeted population of SC neurons.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Kyeongmin Kim, Guanghai Nan, Leejeong Kim, Minjee Kwon, Kyung Hee Lee, Myeounghoon Cha, Bae Hwan Lee
Summary: This study aimed to investigate the effects of insular cortex stimulation (ICS) on neuropathic pain and determine how ICS modulates pain. The results showed that the most effective pain relief was achieved with ICS at 50 Hz-120 μA in a single trial, and its effects lasted for 4 days after repetitive ICS termination. The expression levels of phosphorylated extracellular signal-regulated kinase (pERK), astrocytes, and microglia were increased in neuropathic rats, but they were decreased after ICS, particularly in layers 2-3 of the insular cortex where pERK and neurons colocalize.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Meng-Fei Zhang, Wei-Zhou Chen, Fub-Biao Huang, Zhi-Yong Peng, Ying-Chan Quan, Zhi-Ming Tang
Summary: The study found that transcranial ultrasound stimulation can decrease hand reaction response time, shorten MEP latency, enhance excitability of the motor cortex, and improve hand motor function in healthy individuals.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Anant Kumar, Bhawna Mattoo, Rohit Bhatia, Senthil Kumaran, Renu Bhatia
Summary: In this study, fMRI-guided neuronavigation was used to target the left motor cortex, and significant reduction in pain ratings, headache frequency, and MIDAS questionnaire were observed in the real rTMS group, with effects maintained at one-month follow-up. Further studies are needed to confirm the long-term pain relief potential of fMRI-based rTMS over the left motor cortex in chronic migraine patients.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Melina Engelhardt, Jana Kimmel, Giovanni Raffa, Alfredo Conti, Thomas Picht
Summary: The study demonstrates that accelerated low-frequency rTMS is a safe and feasible method for stimulating the motor cortex, and may make rTMS protocols more accessible to patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Sascha Freigang, Christian Lehner, Shane M. Fresnoza, Kariem Mahdy Ali, Elisabeth Hlavka, Annika Eitler, Istvan Szilagyi, Helmar Bornemann-Cimenti, Hannes Deutschmann, Gernot Reishofer, Anze Berlec, Senta Kurschel-Lackner, Antonio Valentin, Bernhard Sutter, Karla Zaar, Michael Mokry
Summary: The study found that repetitive transcranial stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) was more effective in treating chronic refractory pain compared to stimulation of the left motor cortex (M1). The DLPFC group showed significant improvements in pain perception, health-related quality of life, and mental state, while the M1 group did not show significant improvements. Further research is needed to determine the optimal cortical target sites and stimulation parameters.
Article
Engineering, Biomedical
Qiaosheng Zhang, Sile Hu, Robert Talay, Zhengdong Xiao, David Rosenberg, Yaling Liu, Guanghao Sun, Anna Li, Bassir Caravan, Amrita Singh, Jonathan D. Gould, Zhe S. Chen, Jing Wang
Summary: A closed-loop brain-machine interface (BMI) can modulate sensory-affective experiences in real time by decoding neural codes for nociception and coupling them with therapeutic cortical stimulation. This approach effectively inhibits pain-induced behaviors in rats.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Clinical Neurology
Ming Cheng, Xianwei Che, Yang Ye, Changlin He, Liang Yu, Yating Lv, Paul B. Fitzgerald, Robin F. H. Cash, Bernadette M. Fitzgibbon
Summary: This study evaluated the efficacy of intermittent Theta Burst Stimulation (iTBS) in postoperative pain management. The results showed that iTBS targeting the DLPFC reduced the need for additional anesthesia after surgery. However, due to the continuous administration of opioids at a set speed for each group, DLPFC stimulation did not significantly decrease the total anesthesia volume.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Meng-Xin Wang, Aihaiti Wumiti, Yao-Wen Zhang, Xue-Sheng Gao, Zi Huang, Meng-Fei Zhang, Zhi-Yong Peng, Yoshitaka Oku, Zhi-Ming Tang
Summary: The aim of this study was to investigate the effect of transcutaneous cervical vagus nerve stimulation (tcVNS) on motor cortex excitability in healthy adults. The results showed that after real stimulation, the amplitude of motor-evoked potential (MEP) significantly increased, while MEP latency and rest motor threshold (rMT) significantly decreased. This suggests that tcVNS can improve motor cortex excitability.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
J. Avecillas-Chasin, M. G. Kozoriz, J. R. Shewchuk, M. K. S. Heran, C. R. Honey
AMERICAN JOURNAL OF NEURORADIOLOGY
(2018)
Article
Neurosciences
Josue M. Avecillas-Chasin, Anujan Poologaindran, Murray D. Morrison, Linda A. Rammage, Christopher R. Honey
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2018)
Article
Otorhinolaryngology
Christopher R. Honey, Marie T. Kruger, Murray D. Morrison, Baljinder S. Dhaliwal, Amanda Hu
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2020)
Article
Otorhinolaryngology
Amanda Hu, Murray Morrison, Christopher R. Honey
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2020)
Article
Neurosciences
Marie T. Krueger, Amanda Hu, Christopher R. Honey
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2020)
Article
Medicine, Research & Experimental
Marie T. Kruger, Josue M. Avecillas-Chasin, Mandeep S. Tamber, Manraj K. S. Heran, Mini K. Sandhu, Nancy E. Polyhronopoulos, Natasha Sarai, Christopher R. Honey
Summary: This study compared the ability of standard and directional deep brain stimulation systems to reduce tremor without side-effects and improve quality of life for patients with advanced essential tremor. The results showed a significantly greater reduction in tremor without side-effects when using the directional system, as well as improvements in tremor and voice related quality of life compared to the standard system. The findings suggest that replacing deep brain stimulation with a directional system can significantly improve tremor and quality of life in advanced essential tremor patients who no longer respond well to standard treatments.
Article
Clinical Neurology
Christopher R. Honey, Marie T. Krueger, Timoteo Almeida, Linda A. Rammage, Mandeep S. Tamber, Murray D. Morrison, Anujan Poologaindran, Amanda Hu
Summary: The study confirmed the safety of DBS in patients with SD through a phase I trial, showing a trend towards improved quality of life and voice with blinded DBS despite a small sample size. Secondary outcomes indicated no impact on cognition, but improvements in mood and quality of life.
Article
Clinical Neurology
Marie T. Krueger, Josue M. Avecillas-Chasin, Manraj K. S. Heran, Yashar Naseri, Mini K. Sandhu, Nancy E. Polyhronopoulos, Natasha Sarai, Christopher R. Honey
Summary: This study aimed to determine the optimal thalamic target for improving neuropathic dental pain using directional DBS electrode steering techniques. Results showed promising outcomes with VPM stimulation combined with CM stimulation, demonstrating potential for personalized treatment of NDP.
OPERATIVE NEUROSURGERY
(2021)
Editorial Material
Clinical Neurology
Stephano J. Chang, Alexander D. Rebchuk, Philip Teal, Christopher R. Honey, Thalia S. Field
Review
Neurosciences
Trevor A. Hurwitz, Christopher R. Honey, Amir Ali Sepehry
Summary: This systematic review and meta-analysis aimed to identify the most effective and safest standalone ablative procedure for treatment-resistant depression (TRD). The results indicated that BAC appears to be the most effective and safest among all ablative targets for TRD. However, the conclusion is limited by the small sample sizes and limited number of published case series.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)
Review
Neurosciences
Aisha Alkubaisi, Charles C. J. Dong, Christopher R. Honey
Summary: Understanding the internal anatomy, variations, and relationship of the vagus nerve is crucial for neurosurgeons. This case report demonstrates the location of parasympathetic fibers within the vagus nerve rootlets and provides new insights into the distribution and function of these fibers. The findings may lead to a better understanding and diagnosis of vagal rhizopathies.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)
Article
Neurosciences
Josue M. Avecillas-Chasin, Trevor A. Hurwitz, Nicholas M. Bogod, Christopher R. Honey
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2019)
Article
Neurosciences
Marie T. Krueger, Thomas J. Hirmer, Christopher R. Honey
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2019)
Article
Neurosciences
Marie T. Krueger, Charles C. J. Dong, Christopher R. Honey
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2019)