Article
Microbiology
Eduardo Juscamayta-Lopez, Faviola Valdivia, Sara Morales, Luis Fernando Donaires, Victor Fiestas-Solorzano, Marianela Ore, Paul Pachas, Nancy Leon-Janampa, Ronnie Gavilan
Summary: The study demonstrates that asymptomatic carriers may be a source of transmission of ciprofloxacin-resistant Neisseria meningitidis B, with resistance likely acquired through horizontal gene transfer. It recommends the introduction of serogroup B meningococcal vaccines for high-risk populations.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Microbiology
Ryoichi Saito, Jun Nakajima, Isaac Prah, Masatomo Morita, Samiratu Mahazu, Yusuke Ota, Ayuka Kobayashi, Shuji Tohda, Hajime Kamiya, Hideyuki Takahashi, Makoto Ohnishi
Summary: This study assessed the susceptibility profiles of 87 N. meningitidis strains in Japan to various antibiotics and identified sporadic cases of antibiotic-resistant invasive lineages. These findings highlight the importance of monitoring antibiotic resistance in N. meningitidis to prevent the spread of resistant strains and ensure effective treatment.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Freda E-C Jen, Jennifer L. Edwards, Ibrahim M. El-Deeb, Mark J. Walker, Mark von Itzstein, Michael P. Jennings
Summary: The ionophore PBT2, when used alone, has shown potential in killing both N.meningitidis and MDR N. gonorrhoeae, making it a candidate therapy for MDR N. gonorrhoeae infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Jose A. Bazan, David S. Stephens, Abigail Norris Turner
Summary: The emergence of a new clade of Neisseria meningitidis (US_NmUC) causing urethritis in the United States has been linked to acquisition of genetic determinants and phenotypic traits from Neisseria gonorrhoeae, leading to urethra-tropic infection. This pathogen is now spreading to the UK and Southeast Asia, with genomic sequencing defining the clade and development of rapid diagnostic tests for surveillance. The epidemiology and pathogenesis of this urogenital-tropic pathogen are still being studied.
CURRENT OPINION IN INFECTIOUS DISEASES
(2021)
Review
Public, Environmental & Occupational Health
Sandra Guedes, Isabelle Bertrand-Gerentes, Keith Evans, Florence Coste, Philipp Oster
Summary: Neisseria meningitidis, a pathogen causing invasive meningococcal disease (IMD), poses a significant public health burden with high case fatality rates. Older adults are increasingly affected, particularly by serogroups W and Y, which are not usually predominant. Vaccination strategies and public health programs may need to be evaluated to address this shifting epidemiology.
Article
Public, Environmental & Occupational Health
Vittorio Gattini, Marco Napoletano, Alessandra Bonotti, Aldo Mignani, Francesca Cosentino, Giovanni Guglielmi, Poupak Fallahi, Alfonso Cristaudo, Rudy Foddis
Summary: In response to a meningococcal epidemic outbreak, there was a significant increase in demand for antimeningococcal vaccination among healthcare workers at the University Hospital of Pisa. A total of 41.1% of the population received the vaccine, with better compliance observed among women, older healthcare workers, those with lower educational qualifications, doctors, and healthcare workers in specific departments.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Yusuke Ota, Reina Okada, Hideyuki Takahashi, Ryoichi Saito
Summary: This study established a mismatched PCR-restriction fragment length polymorphism (RFLP) assay for detecting mutations in gyrA associated with ciprofloxacin-resistant Neisseria meningitidis. The assay showed correlation with gyrA sequencing and has the potential to contribute to appropriate antibiotic selection for meningococcal chemoprophylaxis and prevent the spread of ciprofloxacin-resistant N. meningitidis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Norman Ducatez, Marine Chancel, Youcef Douadi, Charles Dayen, Remi Suguenot, Emmanuelle Lecuyer, Benoit Brihaye, Houcine Bentayeb
Summary: PMA, a rare disease associated with Neisseria meningitidis, mainly affects young adults and has a better prognosis than usual septic arthritis. This report presents the first case of PMA in a COVID-19 patient, highlighting this rare but serious complication.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Caelin C. Potts, Lorraine D. Rodriguez-Rivera, Adam C. Retchless, Fang Hu, Henju Marjuki, Amy E. Blain, Lucy A. McNamara, Xin Wang
Summary: Antimicrobial susceptibility testing of 695 US meningococcal isolates collected from 2012 to 2016 showed that penicillin- and ampicillin-intermediate isolates were common, but resistance to clinically relevant antibiotics remained rare.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Edwin J. Asturias, Xilian Bai, Julie A. Bettinger, Ray Borrow, Delia Nais Castillo, Dominique A. Caugant, Grettel Chanto Chacon, Ener Cagri Dinleyici, Gabriela Echaniz-Aviles, Luis Garcia, Linda Glennie, Lee H. Harrison, Rebecca L. Howie, Mark Itsko, Jay Lucidarme, Jose Eduardo Oliva Marin, Henju Marjuki, Lucy A. McNamara, Mustapha M. Mustapha, Joan L. Robinson, Belkis Romeu, Manish Sadarangani, Xavier Saez-Llorens, Marco A. P. Safadi, David S. Stephens, James M. Stuart, Muhamed-Kheir Taha, Raymond S. W. Tsang, Julio Vazquez, Philippe De Wals
Summary: This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which focused on meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are monitored through passive and active surveillance networks. While IMD appears to be decreasing in many areas, there are regional variations and outbreaks among high-risk populations. Vaccination practices differ across North America, but overall vaccine uptake remains high.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Daniel P. Morreale, Eric A. Porsch, Brad K. Kern, Joseph W. St. Geme III, Paul J. Planet
Summary: The bacterial genus Kingella includes pathogenic species that secrete a toxin called RtxA, which is absent in commensal species. The evolutionary transition from commensal to pathogen involves horizontal gene transfer, co-option of an existing secretion system, and gene duplication.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Lene Fogt Lundbo, Zitta Barrella Harboe, Hakon Sandholdt, Lars Smith-Hansen, Palle Valentiner-Branth, Steen Hoffmann, Thomas Benfield
Summary: A Danish case-control study found that certain comorbidities increased the risk of invasive meningococcal disease ranging from 2- to 40-fold. These comorbidities included renal disease, immunological disorders, liver disease, cancer, and solid organ transplantation. Vaccination and appropriate medical care may be necessary for these populations with increased risk.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Kathryn A. Matthias, Kristie L. Connolly, Afrin A. Begum, Ann E. Jerse, Andrew N. Macintyre, Gregory D. Sempowski, Margaret C. Bash
Summary: Recent studies have found that Neisseria meningitidis vaccines lacking specific proteins can provide protection against Neisseria gonorrhoeae infections in mice, and the antibodies produced can cross-react with N. gonorrhoeae. This finding supports the development of a cross-protective vaccine against Neisseria infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Chung Pham Van, The Trong Nguyen, Sy Tien Bui, Trong Van Nguyen, Huyen Thi Thanh Tran, Dong Trac Pham, Long Phi Trieu, Manh Dang Nguyen
Summary: This study described the prevalence, clinical features, and treatment outcomes of IMD among young soldiers of the Vietnam People's Army, and identified ceftriaxone resistance in Neisseria meningitidis. New recruits were found to be at higher risk of IMD, with prognostic factors for severity including petechial rash, septicemia, and meningococcemia.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Sara Morselli, Valeria Gaspari, Alessia Cantiani, Melissa Salvo, Claudio Foschi, Tiziana Lazzarotto, Antonella Marangoni
Summary: The study found a negative association between Neisseria meningitidis and Neisseria gonorrhoeae in a cohort of men having sex with men, with meningococcal carriage being more common in younger individuals.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
David K. Kim, Carolyn B. Bridges, Kathleen H. Harriman
ANNALS OF INTERNAL MEDICINE
(2015)
Editorial Material
Public, Environmental & Occupational Health
Claire M. Midgley, Jill K. Baber, Holly M. Biggs, Twila Singh, Michelle Feist, Tracy K. Miller, Kirby Kruger, Susan I. Gerber, John T. Watson, Molly A. Howell
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2017)
Article
Public, Environmental & Occupational Health
Keith LoMurray, Molly Sander
PUBLIC HEALTH REPORTS
(2011)
Article
Public, Environmental & Occupational Health
Curi Kim, Pollyanna Chavez, Abbi Pierce, Andrew Murray, Molly Sander, Cynthia Kenyon, Ruta Sharangpani, Emily Abernathy, Joseph Icenogle, Preeta K. Kutty, Susan B. Redd, Kathleen Gallagher, John Neatherlin, Karen Marienau
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2012)
Article
Public, Environmental & Occupational Health
David K. Kim, Carolyn B. Bridges, Kathleen H. Harriman
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2015)
Article
Public, Environmental & Occupational Health
Carolyn B. Bridges, Tamera Coyne-Beasley
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2014)
Article
Public, Environmental & Occupational Health
Carolyn B. Bridges, LaDora Woods, Tamera Coyne-Beasley
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2013)
