Article
Surgery
Tomoaki Yoh, Satoru Seo, Kojiro Taura, Kohta Iguchi, Satoshi Ogiso, Ken Fukumitsu, Takamichi Ishii, Toshimi Kaido, Shinji Uemoto
Summary: The study found that repeat surgery for recurrent hepatocellular carcinoma significantly improves survival rates, especially for patients with intrahepatic and intra plus extrahepatic recurrences. Selecting appropriate patients for repeat surgery can prolong their survival time.
Review
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Mamone, Settimo Caruso, Mariapina Milazzo, Giorgia Porrello, Ambra Di Piazza, Giovanni Gentile, Vincenzo Carollo, Francesca Crino, Gianluca Marrone, Gianvincenzo Sparacia, Luigi Maruzzelli, Roberto Miraglia, Salvatore Gruttadauria
Summary: Liver transplantation provides the best survival benefit for hepatocellular carcinoma (HCC) patients who cannot undergo resection. The Milan criteria have been developed to select suitable candidates for transplantation, aiming to improve survival and reduce the risk of HCC recurrence. However, up to 20% of cases experience HCC recurrence after transplantation, posing a significant challenge due to poor prognosis. Various extended criteria have been proposed to accommodate the increasing demand for organs and the associated higher risk of recurrence. Radiologists need to be aware of the possibility of HCC recurrence involving multiple organs after transplantation. Understanding the location and radiologic appearance of recurrent HCC is crucial for choosing the most appropriate therapy.
INSIGHTS INTO IMAGING
(2023)
Article
Oncology
Lin Wang, Hui Shi, Jia Wei, Wen-Xiu Chen, Yue-Xinzi Jin, Chun-Rong Gu, Yuan Mu, Jian Xu, Shi-Yang Pan
Summary: SP70 is highly expressed in hepatocellular carcinoma (HCC) and can be used as a predictor of early HCC recurrence.
FRONTIERS IN ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Riccardo Nevola, Rachele Ruocco, Livio Criscuolo, Angela Villani, Maria Alfano, Domenico Beccia, Simona Imbriani, Ernesto Claar, Domenico Cozzolino, Ferdinando Carlo Sasso, Aldo Marrone, Luigi Elio Adinolfi, Luca Rinaldi
Summary: Hepatocellular carcinoma (HCC) is the most common liver neoplasm with increasing incidence rates. Long-term outcomes of potentially curative treatments are affected by high recurrence rates, with early recurrence being caused by the spread of the primary neoplasm and related to tumor burden, and late recurrence being independent of the primary neoplasm. Early HCC recurrence has a poorer prognosis than late recurrence, and different predictors exist for each type of recurrence. Understanding predictive factors and recurrence risk stratification is important for guiding treatment strategies and post-treatment surveillance.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Huang, Mei-Qing Cheng, Dan-Ni He, Meng-Fei Xian, Dan Zeng, Shao-Hong Wu, Chao-Qun Li, Si-Min Ruan, Ming-De Li, Man-Xia Lin, Ming-De Lu, Ming Kuang, Wei Wang, Li-Da Chen
Summary: This study investigated the performance of US LI-RADS in surveillance for recurrent hepatocellular carcinoma (RHCC) after curative treatment. Four criteria using US LI-RADS or Alpha-fetoprotein (AFP) as the surveillance algorithm were evaluated. The criterion of US-2/3 or AFP ≥ 20μg/L had higher sensitivity and negative predictive value, but lower specificity.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Ju A. Son, Hye Ri Ahn, Donglim You, Geum Ok Baek, Moon Gyong Yoon, Jung Hwan Yoon, Hyo Jung Cho, Soon Sun Kim, Suk Woo Nam, Jung Woo Eun, Jae Youn Cheong
Summary: Investigating molecular markers for predicting HCC recurrence revealed novel gene signatures, potentially serving as prognostic indicators for patients.
Article
Biochemical Research Methods
Xuanfeng Zhang, Dong Zhang, Xuefeng Bu, Xinhui Zhang, Long Cui
Summary: This study constructed prediction models for postoperative and posttransplantation recurrence in HCC patients using microRNA expression profile data. The results showed that a combination of 10 miRNAs accurately predicted malignancy recurrence and provided prognostic evaluation for HCC patients. This prediction model may assist doctors in offering personalized treatment for HCC patients with a high risk of relapse.
BMC BIOINFORMATICS
(2022)
Article
Medicine, General & Internal
Indah Jamtani, Kwang-Woong Lee, Yunhee Choi, YoungRok Choi, Jeong-Moo Lee, Eui-Soo Han, Kwangpyo Hong, Gyu-Seong Choi, Jong Man Kim, Nam-Joon Yi, Suk Kyun Hong, Jeik Byun, Su Young Hong, Sanggyeun Suh, Jae-Won Joh, Kyung-Suk Suh
Summary: This study aimed to develop a tailored prediction model of HCC-specific survival after transplantation, validated internally and externally. By combining multiple risk factors, the model showed good accuracy in predicting HCC-specific survival tailored for patients undergoing transplantation. The calculated SALT predictor provided accurate information on expected survival rates based on risk scores and specific characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi Yang, Yi Chen, Feng Ye, Xiaojing Cao, Yujing Xin, Yanan Wang, Yong Lei, Xiao Li, Duiping Feng, Xiang Zhou, Qingsheng Fan
Summary: This study aimed to identify risk factors and develop a model to predict recurrence-free survival after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) within the Milan criteria. Results showed male gender, multiple tumors, and cirrhosis as independent risk factors for late recurrence. Late recurrence is mainly attributed to de novo HCC in the context of cirrhosis.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
Review
Oncology
Filippo Pelizzaro, Martina Gambato, Enrico Gringeri, Alessandro Vitale, Umberto Cillo, Fabio Farinati, Patrizia Burra, Francesco Paolo Russo
Summary: Recurrence of hepatocellular carcinoma after liver transplantation is a major concern, with poor prognosis and uncertainty in management. There is currently lack of specific surveillance strategy and sufficient data to support immunosuppressive drugs and adjuvant therapy.
Review
Gastroenterology & Hepatology
Sang Jin Kim, Jong Man Kim
Summary: Liver transplantation is an effective treatment for hepatocellular carcinoma, but some patients still experience recurrence after transplantation. Prediction models for HCC recurrence after transplantation have been published, but a standard has not been established. This review summarizes the latest prediction models for HCC recurrence after liver transplantation, focusing on radiologic, serologic, and pathologic factors, and includes studies on living donor and deceased donor transplantation.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Oncology
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Summary: Several adjuvant treatments have been evaluated for preventing HCC recurrence after curative liver resection, with antiviral therapy and postoperative adjuvant transarterial chemoembolization showing promising results. However, further large-scale randomized controlled trials are needed to confirm their efficacy in different patient populations.
FRONTIERS OF MEDICINE
(2021)
Article
Health Care Sciences & Services
Yu-Syuan Chen, Shih-Yu Yang, Pei-Ming Wang, Chih-Chi Wang, Chee-Chien Yong, Ding-Wei Chen, Yueh-Wei Liu, Ching-Hui Chuang, Pao-Yuan Huang, Chih-Chien Yao, Yen-Po Lin, Ming-Chao Tsai
Summary: Concurrent cholecystectomy may reduce recurrence in early-stage HCC after curative resection, but does not significantly impact overall survival. Further studies are needed to confirm these results.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Kin-Pan Au, James Yan-Yue Fung, Wing-Chiu Dai, Albert Chi-Yan Chan, Chung-Mau Lo, Kenneth Siu-Ho Chok
Summary: The impact of tumor biology on radical treatment for oligo-recurrence of post-transplant hepatocellular carcinoma (HCC) remains uncertain. This retrospective study found that early recurrence, liver recurrence, and high levels of AFP upon recurrence were predictors of mortality. Radical treatment was associated with improved post-recurrence survival in patients with early and liver recurrence, but not in patients with high AFP levels. The survival benefits of radical therapy were reduced in early recurrence and high AFP, but remained similar among patients with and without liver recurrence. The presence of multiple biological risk factors diminished the survival benefit of radical therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)