Review
Biochemistry & Molecular Biology
Yaqi Hao, Xiumei Zong, Pan Ren, Yuqi Qian, Aigen Fu
Summary: The bHLH transcription factor family in plants is involved in regulating various physiological processes such as biosynthesis, metabolism, and plant hormone signaling by forming dimers. They play important roles in plant growth and development, stress responses, and signaling networks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Sun-Hyung Lim, Da-Hye Kim, Jae-A. Jung, Jong-Yeol Lee
Summary: The study found that the alternative splicing of CmbHLH2 plays a key role in regulating the color changes of chrysanthemum ray florets. The shorter splicing variant CmbHLH2(Short) failed to activate anthocyanin biosynthetic genes and induce pigment accumulation, while the full-length form CmbHLH2(Full) promoted these processes when co-expressed with CmMYB6.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Endocrinology & Metabolism
Yuki Matsushita, Wanida Ono, Noriaki Ono
Summary: Bone marrow contains precursor cells for osteoblasts and adipocytes. Recent studies have identified subsets of bone marrow stromal cells (BMSCs) that can differentiate into marrow adipocytes and possess diverse functions in homeostasis and regeneration. The trajectory of BMSCs towards marrow adipocytes is influenced by multiple modes of cell-autonomous and non-cell autonomous regulations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Entomology
Jie Zhang, Mengyao Zhu, Qilin Li, Ting Tang, Liang Wen, Jielai Zhong, Ruonan Zhang, Xiao-Qiang Yu, Yuzhen Lu
Summary: bHLH transcription factors play crucial roles in various metabolic and developmental processes in eukaryotes, and this study investigated their response to different pathogens in the polyphagous insect, Spodoptera litura. The research identified a new bHLH gene specific to Lepidoptera, analyzed the expression profiles of bHLH genes in response to pathogens, and highlighted the downregulation of SlbHLHs in the midgut of S. litura larvae after Bacillus thuringiensis treatment. These findings provide insights into the host-pathogen interaction mechanism mediated by bHLH members.
Article
Agronomy
Huanhuan Wu, Zhongying Ren, Lei Zheng, Mengzhen Guo, Jingyu Yang, Liyong Hou, Ghulam Qanmber, Fuguang Li, Zuoren Yang
Summary: GhPAS1, a bHLH transcription factor, plays a crucial role in regulating plant development and architecture in cotton by positively regulating the brassinosteroid signaling pathway and promoting cell elongation. This study provides valuable insights for breeders and researchers to develop cotton cultivars with desirable agronomic characteristics.
Article
Biochemistry & Molecular Biology
Hannah L. L. Smith, Juliet C. C. Gray, Stephen A. A. Beers, Janos M. M. Kanczler
Summary: Osteosarcoma, a bone cancer typically found in adolescents, is closely related to the conversion of bone marrow during adolescence. This study compared the differentiation potential of bone marrow cells from different regions with osteosarcoma cell lines. The results showed distinct differences in the differentiation abilities of hematopoietic and adipocyte-rich bone marrow, which correlated with specific characteristics of the osteosarcoma cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xueman Zhou, Jin Liu, Yingcheng Zheng, Zhenzhen Zhang, Yange Wu, Wenke Yang, Jiaqi Liu, Yanmei Huang, Yating Yi, Zhihe Zhao, Hengyi Xiao, Xianming Mo, Jun Wang
Summary: Bone stromal cells are essential for bone homeostasis and regeneration. Non-stem bone niche cells support bone homeostasis and regeneration through paracrine mechanisms. Specifically, SM22α lineage stromal cells expand after bone injury, regulating the process of bone regeneration.
Article
Neurosciences
Kaja Nurm, Mari Sepp, Carla Castany-Pladevall, Jordi Creus-Muncunill, Jurgen Tuvikene, Alex Sirp, Hanna Vihma, Derek J. Blake, Esther Perez-Navarro, Tonis Timmusk
Summary: Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by motor symptoms appearing in midlife, and research suggests that isoform-specific changes in TCF4 expression in HD may contribute to progressive impairment of transcriptional regulation and neuronal function in the disease.
Article
Cell & Tissue Engineering
Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerden
Summary: The study identifies HSPB7 as a regulator of osteogenic and adipogenic differentiation in bone marrow-derived mesenchymal stromal cells (BMSCs), with a positive role in osteoblastic differentiation and maintaining the balance between osteogenesis and adipogenesis. HSPB7 shows potential as a therapeutic target for bone metabolic diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Plant Sciences
Xueying Chen, Yao-Qian Liu, Man-Ni Wu, Lei Yan, Chun-Yu Chen, Yu-Pei Mu, Yu-Jie Liu, Mu-Yang Wang, Xiao-Ya Chen, Ying-Bo Mao
Summary: The venom-like proteins in caterpillar oral secretion interfere with plant defense by binding to transcription factors, making plants more susceptible to herbivory.
Article
Biochemistry & Molecular Biology
Elena Markina, Elena Andreeva, Ludmila Buravkova
Summary: The rodent hindlimb unloading (HU) model was used to investigate the effects of space weightlessness on bone marrow stromal precursors. Multipotent mesenchymal stromal cells (MMSCs) were isolated from rat femur and tibia and examined after periods of HU and subsequent restoration of load (HU + RL). The study found that HU led to a decrease in osteogenic activity in MMSCs, with more pronounced effects observed in the MMSCs from the tibia. These findings are important for understanding the mechanisms of skeletal disorders in astronauts during long-term space missions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kensuke Toriumi, Yuta Onodera, Toshiyuki Takehara, Tatsufumi Mori, Joe Hasei, Kanae Shigi, Natsumi Iwawaki, Toshifumi Ozaki, Masao Akagi, Mahito Nakanishi, Takeshi Teramura
Summary: In this study, the researchers discovered that the transmembrane protein LRRC15 correlated with the expression of TWIST1 in MSCs, and could be used to estimate the stemness of MSCs. The LRRC15-positive MSC populations expressed stemness-associated transcription factors and therapeutic cytokines, and showed enhanced therapeutic effects in a pulmonary fibrosis mouse model. This study highlights the importance of TWIST1 in MSC stemness and the utility of LRRC15 as a marker for evaluating stem cell quality in MSCs before transplantation.
Article
Biochemistry & Molecular Biology
Shogo Tamura, Masato Mukaide, Yumi Katsuragi, Wataru Fujii, Koya Odaira, Nobuaki Suzuki, Nagaharu Tsukiji, Shuichi Okamoto, Atsuo Suzuki, Takeshi Kanematsu, Akira Katsumi, Akira Takagi, Katsuhide Ikeda, Jun Ueyama, Masaaki Hirayama, Katsue Suzuki-Inoue, Tadashi Matsushita, Tetsuhito Kojima, Fumihiko Hayakawa
Summary: This study found that PDPN-expressing stromal cells are involved in postnatal bone marrow generation and regulate the integrity of primitive vasculatures in the marrow. This is the first comprehensive study on how PDPN-expressing stromal cells contribute to marrow development and homeostasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Immunology
Amanda M. Honan, Emily N. Vazquez, Zhibin Chen
Summary: The study revealed that CD8(+) T cells can convert to CD4(+) T cells in mice, resulting in a unique population of MHC-I-restricted CD4(+) T cells. This conversion process is influenced by MHC-II expression in lymph node stromal cells and involves a specific transcriptional switch. In vitro expansion of CI-T-reg cells using LNSCs showed potential for therapeutic applications in suppressing inflammatory tissue damage.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Boehme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge van de Walle, Stephanie Sontag, Jolien Vandewalle, Bart Vandekerckhove, Georges Leclercq, Pieter Van Vlierberghe, Claude Libert, Filip Van Nieuwerburgh, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Gina Doody, Martin Zenke, Tom Taghon
Summary: The interaction between thymocytes and thymic stromal cells is crucial for T cell development. This study demonstrates that intrathymic development of dendritic cells (DCs) plays a role in supporting early stages of human T cell development. The transcription factor IRF8 and transmembrane TNF are involved in this process. Selective targeting of TNFR2 has the potential to enhance the generation of T cell precursors for clinical applications.
Article
Cell Biology
Esther Camp, Peter J. Anderson, Andrew C. W. Zannettino, Carlotta A. Glackin, Stan Gronthos
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Endocrinology & Metabolism
Yu-Wen Su, Shek Man Chim, Lin Zhou, Mohammadhossein Hassanshahi, Rosa Chung, Chiaming Fan, Yunmei Song, Bruce K. Foster, Clive A. Prestidge, Yaser Peymanfar, Qian Tang, Lisa M. Butler, Stan Gronthos, Di Chen, Yangli Xie, Lin Chen, Xin-Fu Zhou, Jiake Xu, Cory J. Xian
Article
Cell & Tissue Engineering
Esther Camp, Clara Pribadi, Peter J. Anderson, Andrew C. W. Zannettino, Stan Gronthos
STEM CELLS AND DEVELOPMENT
(2018)
Article
Multidisciplinary Sciences
Agnieszka Arthur, Thao M. Nguyen, Sharon Paton, Ana Klisuric, Andrew C. W. Zannettino, Stan Gronthos
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Sally K. Martin, Stephen Fitter, Nadia El Khawanky, Randall H. Grose, Carl R. Walkley, Louise E. Purton, Markus A. Ruegg, Michael N. Hall, Stan Gronthos, Andrew C. W. Zannettino
SCIENTIFIC REPORTS
(2018)
Article
Nanoscience & Nanotechnology
Soraya Rasi Ghaemi, Bahman Delalat, Stan Gronthos, Morgan R. Alexander, David A. Winkler, Andrew L. Hook, Nicolas H. Voelcker
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Hematology
Agnieszka Arthur, Thao M. Nguyen, Sharon Paton, Andrew C. W. Zannettino, Stan Gronthos
EXPERIMENTAL HEMATOLOGY
(2019)
Article
Genetics & Heredity
Dimitrios Cakouros, Sarah Hemming, Kahlia Gronthos, Renjing Liu, Andrew Zannettino, Songtao Shi, Stan Gronthos
EPIGENETICS & CHROMATIN
(2019)
Article
Cell & Tissue Engineering
Dongqing Yang, Stan Gronthos, Sandra Isenmann, Howard A. Morris, Gerald J. Atkins
STEM CELLS INTERNATIONAL
(2019)
Review
Clinical Neurology
Maria R. Gancheva, Karlea L. Kremer, Stan Gronthos, Simon A. Koblar
FRONTIERS IN NEUROLOGY
(2019)
Review
Biochemistry & Molecular Biology
Nicholas Smith, Suzanna Shirazi, Dimitrios Cakouros, Stan Gronthos
Summary: Many important epigenetic changes occur during early skeletal development and throughout life, influenced by factors such as aging, disease, and lifestyle. Epigenetics explores the heritable changes in gene expression resulting from environmental changes without any alterations in DNA sequence. Cellular epigenetic profiles are dynamic and regulated through mechanisms including histone modifications, non-coding RNA-associated gene silencing, and DNA methylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Dimitrios Cakouros, Stan Gronthos
Meeting Abstract
Endocrinology & Metabolism
Esther Camp, Peter Anderson, Andrew Zannettino, Stan Gronthos
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Biotechnology & Applied Microbiology
Thao M. Nguyen, Agnieszka Arthur, Stan Gronthos
JOURNAL OF GENE MEDICINE
(2018)
Meeting Abstract
Biotechnology & Applied Microbiology
Dimitrios Cakouros, Sarah Hemming, Clara Pribadi, Andrew Zannettino, Stan Gronthos
JOURNAL OF GENE MEDICINE
(2018)