Article
Cell & Tissue Engineering
Maria Angeles de Pedro, Esther Lopez, Francisco Manuel Gonzalez-Nuno, Maria Pulido, Veronica Alvarez, Ana Maria Marchena, Christian Preusser, Witold Szymanski, Elke Pogge von Strandmann, Johannes Graumann, Francisco Miguel Sanchez-Margallo, Javier G. G. Casado, Maria Gomez-Serrano
Summary: The study investigates the effects of different preconditioning conditions on the therapeutic potential of extracellular vesicles (EVs) released by menstrual blood-derived stromal cells (MenSCs). The results show that priming MenSCs under proinflammatory and hypoxic conditions alters the cargo proteome of EVs, leading to different therapeutic properties. This highlights the importance of further exploring and defining MSC-derived bioproducts.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Siwen Zhang, Qiyuan Chang, Pingping Li, Xiaoyu Tong, Yi Feng, Xinyao Hao, Xudong Zhang, Zhengwei Yuan, Jichun Tan
Summary: Concentrated MenSC-derived sEVs effectively repaired intrauterine adhesion in rat models, promoting gland and vascular regeneration while reversing endometrial fibrosis. Repeated MenSCs-sEVs transplantations significantly improved endometrial receptivity and pregnancy outcomes without causing hematological or biochemical abnormalities. MenSCs-sEVs safely and effectively enhanced endometrial restoration through inhibition of the TGF beta 1/SMAD3 pathway and upregulation of BMP7 expression.
Review
Immunology
Ali Hazrati, Kosar Malekpour, Zahra Mirsanei, Arezou Khosrojerdi, Nasim Rahmani-Kukia, Neda Heidari, Ardeshir Abbasi, Sara Soudi
Summary: Cancer-associated mesenchymal stem/stromal cells (CA-MSCs) play a crucial role in tumor growth, immune evasion, metastasis, drug resistance, and angiogenesis by interacting with tumor and non-tumor cells in the tumor microenvironment. These cells affect the function of tumor cells and non-tumor cells through the production of cytokines, chemokines, and growth factors. Understanding these interactions is essential for targeted tumor therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Shanshan Li, Junfeng Wang, Bin Jiang, Jiang Jiang, Lilin Luo, Bingrong Zheng, Wei Si
Summary: This study compared the performance of mesenchymal stem cells (MSCs) derived from different sources in the treatment of acute liver failure (ALF). The results showed that MSCs from the fetal placenta and cord-placenta junction significantly improved the syndrome of ALF, making them potential therapeutic options for ALF.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Mariana Robalo Cordeiro, Carlota Anjinho Carvalhos, Margarida Figueiredo-Dias
Summary: The human endometrium contains stem cells called menstrual blood-derived stem cells (MenSC) that have the potential to play a critical role in the development and maintenance of endometriosis. These cells have been studied as biomarkers for the early diagnosis of endometriosis and for the development of targeted therapies. However, further research is needed to ensure their long-term safety and effectiveness before they can be widely implemented in the management of this complex disease.
Review
Cell Biology
Lingling Shang, Jinlong Shao, Shaohua Ge
Summary: MSCs derived from oral tissues have abundant sources and easy accessibility, showing great potential in tissue regeneration and disease therapies. The immunomodulatory effects of oral MSCs during the early immunoinflammatory response stage are crucial for disease recovery and tissue regeneration.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Hematology
Max Hansen, Lilly Stahl, Andreas Heider, Nadja Hilger, Ulrich Sack, Andreas Kirschner, Michael Cross, Stephan Fricke
Summary: This study analyzed the potential beneficial effects of syngeneic versus allogenic treatment, culture expansion of MSCs, and various MSC cell doses and time points of MSC transplantation in a murine GVHD model. The results showed that syngeneic treatment, culture-expanded cells, simultaneous administration, and high doses of UC-MSCs were more effective in reducing CD8(+) T cells, protecting mice from weight loss, and prolonging survival. This animal model of GVHD can be used for further detailed studies on the efficacy of MSCs from alternative sources.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Article
Cell & Tissue Engineering
Yonghai Li, Haiyao Gao, Tobias M. Brunner, Xiaoxi Hu, Yushan Yan, Yanli Liu, Liang Qiao, Peihua Wu, Meng Li, Qing Liu, Fen Yang, Juntang Lin, Max Loehning, Ping Shen
Summary: This study evaluated the therapeutic potential of allogeneic MSCs isolated from menstrual blood in an animal model of experimental autoimmune encephalomyelitis (EAE), showing that MB-MSCs significantly reduced the disease severity of EAE and suppressed Th1 and Th17 cell responses, suggesting their potential as ready-to-use allo-MSCs in MS-related inflammation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Maria Florencia Tellechea, Flavia S. Donaires, Vinicius S. de Carvalho, Barbara A. Santana, Fernanda B. da Silva, Raissa S. Tristao, Lilian F. Moreira, Aline F. de Souza, Yordanka M. Armenteros, Lygia Pereira, Rodrigo T. Calado
Summary: This study used iPSCs to model immune aplastic anemia and found that the differentiation potential of hematopoietic cells in this disease is significantly reduced, suggesting that specific epigenetic changes in HSPCs caused by immune attack may limit cell proliferation and differentiation.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Leticia B. C. Penariol, Carolina H. Thome, Patricia A. Tozetti, Carlos R. K. Paier, Fabiana O. Buono, Kamila C. Peronni, Maristela D. Orellana, Dimas T. Covas, Maria E. A. Moraes, Wilson A. Silva, Julio C. Rosa-e-Silva, Rui A. Ferriani, Vitor M. Faca, Omero B. Poli-Neto, Daniel G. Tiezzi, Juliana Meola
Summary: This study used multi-omics approaches to analyze the transcriptome and proteome data of endometriosis MenSCs, and identified several genes and proteins related to the disease, as well as modulated signaling pathways. The findings suggest that the chronic inflammatory endometrial microenvironment can regulate MenSCs, providing insights into the pathogenesis of endometriosis and its implications for regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jiaqiang Deng, Lijun Zhong, Zihan Zhou, Congwei Gu, Xiaoya Huang, Liuhong Shen, Suizhong Cao, Zhihua Ren, Zhicai Zuo, Junliang Deng, Shumin Yu
Summary: MSCs are promising therapeutic materials with self-renewal, multilineage differentiation, and immunomodulation capabilities. However, external factors like donor age, disease, and environmental pressure may affect their functions. Autophagy, as a critical process in maintaining cellular homeostasis, shows potential in improving MSC functions, making it a promising therapeutic target.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Giedre Skliute, Raminta Bausyte, Veronika Borutinskaite, Giedre Valiuliene, Algirdas Kaupinis, Mindaugas Valius, Diana Ramasauskaite, Ruta Navakauskiene
Summary: The study found that menstrual blood stem cells have good proliferation and regenerative abilities, can perform decidualization through differentiation into epithelial cells, and express genes related to decidualization and angiogenesis, demonstrating the potential for treating reproductive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Matteo Doglio, Rachel E. E. Crossland, Ana C. C. Alho, Olaf Penack, Anne M. M. Dickinson, Georg Stary, Joao F. Lacerda, Gunther Eissner, Marit Inngjerdingen
Summary: This review discusses immunomodulatory approaches for the prevention and treatment of chronic graft-versus-host disease (cGVHD), including T cells, NK cells, ILCs, MSCs, and extracellular vesicles. Clinical studies and pre-clinical research results are presented.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Ying Lv, Liyan Ye, Xiujuan Zheng
Summary: The study found that ATI-2341 TFA enhances the recruitment of MenSCs, promotes the proliferation of endometrial epithelial cells, and facilitates the repair of uterine damage in Asherman's syndrome, suggesting its potential therapeutic role.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2022)
Article
Neurosciences
Diana Quintero-Espinosa, Viviana Soto-Mercado, Catherine Quintero-Quinchia, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
Summary: This study demonstrates that human menstrual blood-derived mesenchymal stromal cells (MenSCs) can be converted into neurons and astrocyte-like cells, providing a valuable resource for investigating neurobiological processes and neurological disorders.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Cell Biology
Masyelly Rojas, Patricia Luz-Crawford, Ricardo Soto-Rifo, Sebastian Reyes-Cerpa, Daniela Toro-Ascuy
Summary: Human immunodeficiency virus type 1 (HIV-1) infection leads to the generation of latent viral reservoirs, associated with chronic immune activation and inflammation, where macrophages play a crucial role in balancing the IFN/ISG signaling network.
Article
Cardiac & Cardiovascular Systems
Nitirut Nernpermpisooth, Charlotte Sarre, Christian Barrere, Rafael Contreras, Patricia Luz-Crawford, Gautier Tejedor, Anne Vincent, Christophe Piot, Sarawut Kumphune, Joel Nargeot, Christian Jorgensen, Stephanie Barrere-Lemaire, Farida Djouad
Summary: Myocardial infarction is a leading cause of death worldwide, and while adult mesenchymal stem cells have shown regenerative properties in preclinical models, their beneficial effects in clinical trials are controversial.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Marine Charrier, Judith Lorant, Rafael Contreras-Lopez, Gautier Tejedor, Christophe Blanquart, Blandine Lieubeau, Cindy Schleder, Isabelle Leroux, Sophie Deshayes, Jean-Francois Fonteneau, Candice Babarit, Antoine Hamel, Armelle Magot, Yann Pereon, Sabrina Viau, Bruno Delorme, Patricia Luz-Crawford, Guillaume Lamirault, Farida Djouad, Karl Rouger
Summary: The study demonstrates that hMuStem cells possess an immunosuppressive phenotype and can inhibit T-cell proliferation and cytotoxic response while promoting the generation of regulatory T cells through both direct contact and secretion of soluble factors. The secretion profile of hMuStem cells is shown to be superior to that of BM-MSCs. These findings reinforce the candidacy of hMuStem cells as therapeutic agents for MDs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Radjiv Goulabchand, Audrey Gabelle, Xavier Ayrignac, Nicolas Malafaye, Pierre Labauge, Daniele Noel, Jacques Morel, Camille Roubille, Lucie Barateau, Philippe Guilpain, Thibault Mura
Summary: A nationwide retrospective study in France using the health insurance database showed that patients with primary Sjogren's syndrome (pSS) have a higher risk of hospitalization for neurological diseases, including dementia, multiple sclerosis (MS), encephalitis, and peripheral neuropathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Reyna Penailillo, Lara J. Monteiro, Stephanie Acuna-Gallardo, Felipe Garcia, Victoria Velasquez, Paula Correa, Pilar Diaz, Patricia P. Valdebenito, Cristina Navarro, Roberto Romero, Mario Sanchez, Sebastian E. Illanes, Gino Nardocci
Summary: This study aimed to identify potential lncRNA biomarkers for preeclampsia by analyzing the expression of lncRNAs in the placentas and plasma of patients. Six lncRNAs were validated and differentially expressed in preeclampsia placentas, two of which were also detected in maternal plasma, indicating their potential use as biomarkers for the disease.
Review
Biochemistry & Molecular Biology
Yujie Song, Christian Jorgensen
Summary: This review highlights the potential of mesenchymal stromal cells (MSCs) in treating osteoarthritis (OA), focusing on their chondrogenic and immunomodulatory potential. The review provides an overview of the effects of MSCs in preclinical and clinical studies of OA treatment, comparing different MSC sources. Furthermore, the review summarizes the current evidence for the assessment of cartilage in OA using magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy.
Article
Biochemistry & Molecular Biology
Reyna Penailillo, Stephanie Acuna-Gallardo, Felipe Garcia, Lara J. Monteiro, Gino Nardocci, Mahesh A. Choolani, Matthew W. Kemp, Roberto Romero, Sebastian E. Illanes
Summary: This study investigated the proliferation, migration, and impact on trophoblast invasion capacity of MenSCs under different physiological conditions. The findings suggest a potential role for MenSCs in the implantation process, implying a communication between maternal MenSCs and invading trophoblast cells that could be implicated in the etiology of PE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
C. Brizuela, George T. -J. Huang, A. Diogenes, T. Botero, M. Khoury
Summary: Endodontics has made significant progress in regenerative approaches, with a clear conceptual shift in therapy. This review provides basic knowledge and practical information on stem cell-based regenerative endodontic therapy and tissue engineering procedures, as well as emerging technologies in biomaterials and signaling molecules.
STEM CELLS INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Article
Obstetrics & Gynecology
Gabriel Cubillos, Max Monckeberg, Alejandra Plaza, Maria Morgan, Pablo A. Estevez, Mahesh Choolani, Matthew W. Kemp, Sebastian E. Illanes, Claudio A. Perez
Summary: This study aims to develop machine learning models for the early prediction of Gestational Diabetes Mellitus (GDM) using widely available variables, allowing for early intervention and application in areas with limited access to complex examinations.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Cell & Tissue Engineering
Noemie Petitjean, Patrick Canadas, Christian Jorgensen, Pascale Royer, Simon Le Floc'h, Daniele Noel
Summary: This study aimed to investigate the impact of mechanical stimulation on chondrocytes derived from mesenchymal stromal cells in their own extracellular matrix.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Claudette Cantin, Andrea Morales, Ramon Serra, Sebastian E. Illanes, Andrea Leiva
Summary: Maternal supraphysiological hypercholesterolemia (MSPH) women present dysfunctional HDL and increased atherogenic cardiovascular risk factors.
Article
Medicine, Research & Experimental
Rafael Contreras-Lopez, Roberto Elizondo-Vega, Noymar Luque-Campos, Maria Jose Torres, Carolina Pradenas, Gautier Tejedor, Maria Jose Paredes-Martinez, Ana Maria Vega-Letter, Mauricio Campos-Mora, Yandi Rigual-Gonzalez, Karina Oyarce, Magdiel Salgado, Christian Jorgensen, Maroun Khoury, Maria de los Angeles Garcia-Robles, Claudia Altamirano, Farida Djouad, Patricia Luz-Crawford
Summary: The study showed that metabolic reprogramming of MSC using oligomycin and other pro-inflammatory factors could significantly enhance their immunosuppressive properties, thereby improving their therapeutic efficacy in inflammatory diseases. Furthermore, the glycolytic reprogramming of MSC also partly depended on the activation of the AMPK signaling pathway.