期刊
STEM CELLS
卷 33, 期 7, 页码 2126-2134出版社
WILEY
DOI: 10.1002/stem.2011
关键词
H2A.Z; Ubiquitination of Nanog; Induced pluripotent stem cells; Differentiation of stem cells
资金
- Chinese Academy of Sciences [XDA01020104]
- Ministry of Science and Technology of China [2011CB966302]
- National Natural Science Foundation of China [81430065, 31371388, 21371174]
The variant histone protein H2A.Z plays a critical role in early development. Likewise, Nanog, a master regulator of embryonic stem cells (ESCs), is essential for proper development in early embryogenesis. In this study, we establish that these two factors work together to maintain pluripotency. It is shown that H2A.Z influences the protein level of Nanog through the ubiquitin-proteasome pathway. Knockdown of H2A.Z causes differentiation of mouse ESCs and disrupts the reprogramming of somatic cells, which can be partially rescued by overexpression of Nanog. We conclude that the H2A.Z-Nanog partnership is involved in ESC pluripotency and reprogramming of somatic cells. Stem Cells 2015;33:2126-2134
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