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What is the role of covert infection in detrusor overactivity, and other LUTD? ICI-RS 2013

NEUROUROLOGY AND URODYNAMICS (2014)

期刊

NEUROUROLOGY AND URODYNAMICS

卷 33, 期 5, 页码 606-610

出版社

WILEY

DOI: 10.1002/nau.22589

关键词

animal models; bacterial cystitis; covert infection; overactive bladder

类别

Urology & Nephrology

资金

NHMRC [527502]
IUGA
NIH [DK077699, DK097819]

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Protocol

Reagent

摘要

A think tank was convened at the fourth ICI-RS meeting, which took place June 5-7, 2013 in Bristol UK, to consider current evidence and controversies surrounding the possible role of covert infection' in the pathophysiology of refractory detrusor overactivity (DO) and other lower urinary tract disorders (LUTD). The topic was chosen because several authors from different centers worldwide have recently published evidence which supports this concept. However, to date there is inconsistency regarding terminology and microbiological definitions, which were discussed by the participants. The mechanisms whereby infection/inflammation could actually promote aberrant detrusor contractions in the human remain controversial, and are more fully described in this report. Future requirements for research into this topic were outlined. Neurourol. Urodynam. 33:606-610, 2014. (c) 2014 Wiley Periodicals, Inc.

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Figuera Basso, Martin Schulzky, Michael Wittig, Nicole Braun, Tanja Wesse, Wolfgang Albrecht, Xiaoli Yi, Almut Nebel, Anna Peschuck, Sandra May, Banasik Karina, Soren Brunak, Mario Caceres, Jon Lerga-Jaso, Tobias L. Lenz, Ana Teles, Clinton Azuure, Onur Ozer, Agustin Albillos, Beatriz Mateos, Francisco Mesonero, Luis Tellez, Miguel Rodriguez-Gandia, Luis Bujanda, Jesus M. Banales, Manuel Romero-Gomez, Maria Buti, Douglas Maya-Miles, Koldo Garcia-Etxebarria, Laura Izquierdo-Sanchez, Pedro M. Rodrigues, Francisco Rodriguez-Frias, Mar Riveiro-Barciela, Antonio Julia, Adriana Palom, Sara Marsal, Bettina Heidecker, Florian Kurth, Leif Erik Sander, Alena Mayer, Alice Braun, Carsten Skurk, Charlotte Thibeault, Elisa T. Helbig, Julia Kraft, Lena J. Lippert, Phillip Suwalski, Stephan Ripke, Wolfgang Poller, Xiaomin Wang, Zehra Karadeniz, Federico Garcia, Jose Hernandez Quero, Natalia Chueca, Trinidad Gonzalez Cejudo, Frank Hanses, Sibylle Wilfling, Heinz Zoller, Benedikt Schaefer, Jan C. Holter, Johannes R. Hov, Tom H. Karlsen, Trine Folseraas, Aleksander Rygh Holten, Anne Ma Dyrhol-Riise, Kristian Tonby, Andreas Lind, Fredrik Muller, Susanne Dudman, Marit M. Grimsrud, Javier Fernandez, Carlos Ferrando, Enric Reverter, Joan Ramon Badia, Maria Hernandez-Tejero, Pedro Castro, Rafael de Cid, Anna Carreras Nolla, Beatriz Cortes, Ivan Galvan-Femenia, Natalia Blay, Xavier Farre, Rosanna Asselta, Stefano Duga, Alberto Mantovani, Alessandro Protti, Alessio Aghemo, Ana Lleo, Antonio Voza, Elena Azzolini, Elvezia Maria Paraboschi, Ilaria My, Maurizio Cecconi, Paolo Tentorio, Salvatore Badalamenti, Sara Bombace, Claudio Cappadona, Valeria Rimoldi, Siegfried Goerg, Ute Hehr, Emma F. Perez, Ole Bernt Lenning, May Sissel Vadla, Ronny Myhre, Aaron Blandino Ortiz, Raul de Pablo, Adolfo Garrido Chercoles, Beatriz Nafria-Jimenez, Agustin Ruiz, Isabel Hernandez, Itziar de Rojas, Marta Marquie, Merce Boada, Daniele Prati, Guido Baselli, Luca Valenti, Alessandro Cherubini, Antonio Muscatello, Cinzia Hu, Cristiana Bianco, Daniela Galimberti, Elio Scarpini, Ferruccio Ceriotti, Giuseppe Lamorte, Leonardo Terranova, Mahnoosh Ostadreza, Alberto Zanella, Alessandra Bandera, Andrea Gori, Anna Ludovica Fracanzani, Antonio Pesenti, Cinzia Paccapelo, Filippo Martinelli-Boneschi, Flora Peyvandi, Francesco Blasi, Giacomo Grasselli, Giorgio Costantino, Luigi Santoro, Luigia Scudeller, Maria Carrabba, Marina Baldini, Monica Miozzo, Nicola Montano, Roberta Gualtierotti, Serena Pelusi, Silvano Bosari, Stefano Aliberti, Valter Monzani, Pietro Invernizzi, Alessio Gerussi, Chiara Milani, Alfredo Ramirez, Victor Andrade, Ana Barreira, Anders Benjamin Kildal, Andreas Gluck, Thomas Bahmer, Anna Latiano, Orazio Palmieri, Ariadna Rando-Segura, Luisa Roade, Aurora Solier, David Jimenez, Rosa Nieto, Carla Bellinghausen, Carmen Quereda, Enrique Navas, Christoph D. Spinner, Jochen Schneider, Christoph Lange, Jan Heyckendorf, Cristina Sancho, Maider Intxausti, Dag Arne Lihaug Hoff, Jan Egil Afset, Sammra Haider, David Pestana, David Toapanta, Eloisa Urrechaga, Pedro P. Espana, Emanuele Pontali, Lucia Garbarino, Michela Mazzocco, Eunate Arana, Natale Imaz Ayo, Felix Garcia Sanchez, Francesco Malvestiti, Gianni Pezzoli, Holger Neb, Mauro D'Amato, Josune Goikoetxea, Karl Erik Muller, Lars Heggelund, Karoline Gaede, Lauro Sumoy, Manolis Kogevinas, Judith Garcia-Aymerich, Gemma Castano-Vinyals, Carlota Dobano, Victor Moreno, Maria A. Gutierrez-Stampa, Maria J. G. T. Vehreschild, Yascha Khodamoradi, Massimo Castoldi, Tenghao Zheng, Michael J. Seilmaier, Nilda Martinez, Per Hoffmann, Stefanie Heilmann-Heimbach, Petra Bacher, Sandra Ciesek, Ulf Landmesser, Vegard Skogen, Enrique J. Calderon, Francisco J. Medrano, Juan Delgado, Ruben Morilla, Vicente Friaza, Daniel F. Gudbjartsson, Kari Stefansson, Patrick Sulem, Gardar Sveinbjornsson, Pall Melsted, Gudmundur Norddahl, Kristjan Helgi Swerford Moore, Unnur Thorsteinsdottir, Hilma Holm, David Bernardo, Javier Ampuero, Silvia Rojo Rello, Reedik Magi, Lili Milani, Andres Metspalu, Triin Laisk, Kristi Lall, Maarja Lepamets, Tonu Esko, Ene Reimann, Helene Alavere, Kristjan Metsalu, Mairo Puusepp, Paul Naaber, Edward Laane, Jaana Pesukova, Part Peterson, Kai Kisand, Jekaterina Tabri, Raili Allos, Kati Hensen, Joel Starkopf, Inge Ringmets, Anu Tamm, Anne Kallaste, Kati Kristiansson, Sami Koskelainen, Markus Perola, Carlo Rivolta, Mathieu Quinodoz, Dhryata Kamdar, Pierre-Yves Bochud, Stephanie Bibert, Noemie Boillat, Semira Gonseth Nussle, Werner Albrich, Noemie Suh, Dionysios Neofytos, Veronique Erard, Cathy Voide, P. Y. Bochud, C. Rivolta, S. Bibert, M. Quinodoz, D. Kamdar, D. Neofytos, V Erard, C. Voide, R. Friolet, P. Vollenweider, J. L. Pagani, M. Oddo, F. Meyer zu Bentrup, A. Conen, O. Clerc, O. Marchetti, A. Guillet, C. Guyat-Jacques, S. Foucras, M. Rime, J. Chassot, M. Jaquet, R. Merlet Viollet, Y. Lannepoudenx, L. Portopena, F. Desgranges, P. Filippidis, B. Guery, D. Haefliger, E. E. Kampouri, O. Manuel, A. Munting, M. Papadimitriou-Olivgeris, J. Regina, L. Rochat-Stettler, V Suttels, E. Tadini, J. Tschopp, M. Van Singer, B. Viala, N. Boillat-Blanco, T. Brahier, O. Hugli, J. Y. Meuwly, O. Pantet, Tomas Pumarola, S. Gonseth Nussle, M. Bochud, V D'Acremont, S. Estoppey Younes, W. C. Albrich, N. Suh, A. Cerny, L. O'Mahony, M. Frischknecht, G-R Kleger, M. Filipovic, C. R. Kahlert, H. Wozniak, T. Rochat Negro, J. Pugin, K. Bouras, C. Knapp, T. Egger, A. Perret, P. Montillier, C. di Bartolomeo, B. Barda, Anna Carreras, Josep Maria Mercader, Marta Guindo-Martinez, David Torrents, Marco Gori, Nicola Picchiotti, Mario Umberto Mondelli, Raffaele Bruno, Serena Ludovisi, Francesco Castelli, Eugenia Quiros-Roldan, Melania Degli Antoni, Massimo Vaghi, Stefano Rusconi, Agostino Riva, Matteo Siano, Arianna Gabrieli, Massimiliano Fabbiani, Barbara Rossetti, Ilaria Rancan, Elena Bargagli, Laura Bergantini, Miriana D'Alessandro, Paolo Cameli, David Bennet, Federico Franchi, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Maria Antonietta Mazzei, Susanna Guerrini, Luca Cantarini, Edoardo Conticini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Maria Bandini, Maurizio Spagnesi, Paolo Piacentini, Elena Desanctis, Silvia Cappelli, Gian Piero Caldarelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Agostino Ognibene, Alessandro Pancrazi, Maria Lorubbio, Antonella D'Arminio Monforte, Esther Merlini, Federica Gaia Miraglia, Massimo Girardis, Stefano Busani, Sophie Venturelli, Andrea Antinori, Arianna Emiliozzi, Alessandra Vergori, Daniela Francisci, Elisabetta Schiaroli, Francesco Paciosi, Pier Giorgio Scotton, Francesca Andretta, Sandro Panese, Renzo Scaggiante, Francesca Gatti, Matteo Della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Merla, Giuseppe Fiorentino, Marco Castori, Massimo Carella, Filippo Aucella, Antonio Di Biagio, Matteo Bassetti, Luca Masucci, Alessandra Guarnaccia, Maurizio Sanguinetti, Serafina Valente, Oreste De Vivo, Marco Mandala, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, Ferdinando Giannattasio, Tullio Trotta, Gabriella Coiro, Cristina Mussini, Giancarlo Bosio, Enrico Martinelli, Luisa Tavecchia, Mary Ann Belli, Sandro Mancarella, Lia Crotti, Gianfranco Parati, Marco Rizzi, Franco Maggiolo, Diego Ripamonti, Maria Teresa La Rovere, Simona Sarzi-Braga, Maurizio Bussotti, Sabrina Ravaglia, Ravaglia Sabrina, Rosangela Artuso, Antonio Perrella, Davide Romani, Paola Bergomi, Emanuele Catena, Riccardo Colombo, Simona Dei, Marco Tanfoni, Maurizio Sanarico, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Mattia Bergomi, Marco Vecchia, Stefania Mantovani, Isabella Zanella, Andrea Cossarizza, Saverio Giuseppe Parisi, Stefano Baratti, Gabriella Maria Squeo, Pamela Raggi, Carmen Marciano, Rita Perna, Elisabetta Menatti, Fabio Lena, Chiara Gabbi, Tiziana Bachetti, Claudia Suardi, Giordano Botta, Paolo Di Domenico, Richard C. Trembath, Qin Qin Huang, Hilary C. Martin, Dan Mason, John Wright, Sarah Finer, Shaheen Akhtar, Mohammad Anwar, Elena Arciero, Samina Ashraf, Gerome Breen, Raymond Chung, Charles J. Curtis, Maharun Chowdhury, Grainne Colligan, Panos Deloukas, Ceri Durham, Chris Griffiths, Matt Hurles, Shapna Hussain, Kamrul Islam, Ahsan Khan, Amara Khan, Cath Lavery, Sang Hyuck Lee, Robin Lerner, Daniel MacArthur, Bev MacLaughlin, Hilary Martin, Shefa Miah, Bill Newman, Nishat Safa, Farah Tahmasebi, Christopher J. Griffiths, Albert Smith, Andrew P. Boughton, Kevin W. Li, Jonathon LeFaive, Aubrey Annis, Sebastian Zollner, Jiongming Wang, Andrew Beck, Cinthia E. Jannes, Jose E. Krieger, Alexandre C. Pereira, Mariliza Velho, Emanuelle Marques, Isabella Ramos Lima, Mauricio Teruo Tada, Karina Valino, Mark McCarthy, Carrie Rosenberger, Diana Chang, Christian Hammer, Julie Hunkapiller, Anubha Mahajan, Sarah Pendergrass, Lara Sucheston-Campbell, Brian Yaspan, Jong Eun Lee, Hyun Soo Lee, Eunsoon Shin, Hye Yoon Jang, Sunmie Kim, Sungmin Kym, Yeon-Sook Kim, Hyeongseok Jeong, Ana Alegria, Ki Tae Kwon, Shin-Woo Kim, Jin Yong Kim, Young Rock Jang, Hyun Ah Kim, Ji Yeon Lee, Jeong Eun Lee, Shinwon Lee, Kang-Won Choe, Yu Min Kang, Sun Ha Jee, Keum Ji Jung, Victoria Parikh, Matthew Wheeler, Karen Dalton, Jeff Christle, John Gorzynski, Hannah de Jong, Shirley Sutton, Nathan Youlton, Ruchi Joshi, David Jimenez-Morales, Christopher Hughes, David Amar, Steve Hershman, Anna Kirillova, Kinya Seo, Yong Huang, Archana Raja, Jimmy Zhen, Euan Ashley, Carlos Bustamante, Manuel Rivas, Alex Ioannidis, Benjamin Pinksy, Massa Shoura, Nathan Hammond, Nathaniel Watson, ChunHong Huang, Malaya Sahoo, Hannah Wang, Phillip Febbo, Kyle Farh, Gary P. Schroth, Francis DeSouza, Christopher Deboever, Sandor Szalma, Simone Rubinacci, Olivier Delaneau, Peter J. McGuigan, Christopher Wasson, Stephanie Finn, Jackie Green, Erin Collins, Bernadette King, Luke Stephen Prockter Moore, Marcela Paola Vizcaychipi, Laura Gomes de Almeida Martins, Jaime Carungcong, Kathryn Hall, Isheunesu Mapfunde, Andy Campbell, Sara Smuts, Joseph Duffield, Oliver Smith, Lewis Mallon, Watkins Claire, Ailstair Nichol, Kathy Brickell, Michelle Smyth, Lorna Murphy, Geraldine Ward, Pamela Bremmer, Valerie Joan Page, Siobhain Carmody, Malcolm G. Semple, Tom Solomon, Lance C. W. Turtle, Hayley Hardwick, Kayode Adeniji, Daniel Agranoff, Chi Eziefula, Ken Agwuh, Dhiraj Ail, Erin L. Aldera, Louise Allen, Eva Beranova, Nikki Crisp, Joanne Deery, Tracy Hazelton, Alicia Knight, Carly Price, Sorrell Tilbey, Salah Turki, Sharon Turney, Brian Angus, Abdul Ashish, Dougal Atkinson, Shahedal Bari, Gavin Barlow, Stella Barnass, Nicholas Barrett, Sam Douthwaite, Marlies Ostermann, Manu Shankar-Hari, Christopher Bassford, Sneha Basude, David Baxter, Michael Beadsworth, Ingeborg Welters, Jolanta Bernatoniene, John Berridge, Nicola Best, Pieter Bothma, Darell Tupper-Carey, David Chadwick, Robin Brittain-Long, Naomi Bulteel, Lee Murphy, Nicola Wrobel, Sarah McCafferty, Kirstie Morrice, Alan MacLean, Tom Burden, Andrew Burtenshaw, Vikki Caruth, Duncan Chambler, Nigel Chee, Jenny Child, Srikanth Chukkambotla, Tom Clark, Paul Collini, Cariad Evans, Gary H. Mills, Norfaizan Ahmad, Joann Barker, Kris Bauchmuller, Sarah Bird, Kay Cawthron, Kate Harrington, Yvonne Jackson, Faith Kibutu, Becky Lenagh, Shamiso Masuko, Ajay Raithatha, Matthew Wiles, Jayne Willson, Helen Newell, Alison Lye, Lorenza Nwafor, Claire Jarman, Sarah Rowland-Jones, David Foote, Joby Cole, Roger Thompson, James Watson, Lisa Hesseldon, Irene Macharia, Luke Chetam, Jacqui Smith, Amber Ford, Samantha Anderson, Kathryn Birchall, Kay Housley, Sara Walker, Leanne Milner, Helena Hanratty, Helen Trower, Patrick Phillips, Simon Oxspring, Ben Donne, Catherine Cosgrove, Jason Cupitt, Maria-Teresa Cutino-Moguel, Paul Dark, Chris Dawson, Samir Dervisevic, Andrew Drummond, Andrew Ustianowski, Ingrid DuRand, Ahilanadan Dushianthan, Tristan Dyer, Christopher Fegan, Adam Finn, Duncan Fullerton, Elijah Matovu, Sanjeev Garg, Atul Garg, Effrossyni Gkrania-Klotsas, Elinoor Moore, Jo Godden, Arthur Goldsmith, Clive Graham, Elaine Hardy, Stuart Hartshorn, Daniel Harvey, Peter Havalda, Andrew Workman, Daniel B. Hawcutt, Maria Hobrok, Luke Hodgson, Anil Hormis, Michael Jacobs, Susan Jain, Paul Jennings, Agilan Kaliappan, Vidya Kasipandian, Stephen Kegg, Michael Kelsey, Caroline Kerrison, Ian Kerslake, Oliver Koch, Rosie Baruah, Sheila Morris, Susie Ferguson, Amy Shepherd, Gouri Koduri, George Koshy, Tamas Leiner, Katherine Mortimore, Shondipon Laha, Steven Laird, Susan Larkin, Patrick Lillie, James Limb, Vanessa Linnett, Jeff Little, Mark Lyttle, Emily MacNaughton, Ravish Mankregod, Huw Masson, Katherine McCullough, Ruth McEwen, Lawrence Wilson, Manjula Meda, Jane Minton, Karl Ward, Mariyam Mirfenderesky, Kavya Mohandas, Quen Mok, James Moon, Nigel Capps, Sanal Jose, Patrick Morgan, Craig Morris, Samuel Moses, Mbiye Mpenge, Rohinton Mulla, Michael Murphy, Megan Nagel, Thapas Nagarajan, Mark Nelson, Matthew K. O'Shea, Christoper A. Green, Igor Otahal, Mark Pais, Selva Panchatsharam, Danai Papakonstantinou, Hollie Bancroft, Mary Bellamy, Margaret Carmody, Jacqueline Daglish, Faye Moore, Joanne Rhodes, Mirriam Sangombe, Salma Kadiri, James Scriven, Hassan Paraiso, Brij Patel, Natalie Pattison, Justin Pepperell, Mandeep Phull, Stefania Pintus, Jagtur Singh Pooni, Frank Post, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O'Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Price, Rachel Prout, Nikolas Rae, Henrik Reschreiter, Tim Reynolds, Neil Richardson, Mark Roberts, Devender Roberts, Alistair Rose, Guy Rousseau, Brendan Ryan, Taranprit Saluja, Aarti Shah, Prad Shanmuga, Anil Sharma, Anna Shawcross, Jeremy Sizer, Victoria Bastion, Daphene Clarke, Beena David, Harriet Kent, Rachel Lorusso, Gamu Lubimbi, Sophie Murdoch, Melchizedek Penacerrada, Alastair Thomas, Jennifer Valentine, Ana Vochin, Retno Wulandari, Brice Djeugam, Richard Smith, Catherine Snelson, Tony Whitehouse, Nick Spittle, Nikki Staines, Shico Visuvanathan, Tom Stambach, Richard Stewart, Pradeep Subudhi, Tamas Szakmany, Kate Tatham, Jo Thomas, Chris Thompson, Ascanio Tridente, Mary Twagira, Nick Vallotton, Lisa Vincent-Smith, Alan Vuylsteke, Sam Waddy, Rachel Wake, Andrew Walden, Paul Whittaker, Ashley Whittington, Padmasayee Papineni, Meme Wijesinghe, Stephen Winchester, Martin Wiselka, Adam Wolverson, Daniel G. Wooton, Bryan Yates, Peter Young, Rupert Beale, Charles Hinds, Elvina Gountouna, David J. Porteous, David Harrison, Kathy Rowan, Gavin Band, Paul Klenerman, Julian Knight, Debby Bogaert, Xia Shen, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Cynthia M. Bulik, Mikael Landen, Bengt Fundin, Yang Wu, Jian Yang, Lisa Norman, Riinu Pius, Thomas M. Drake, Cameron J. Fairfield, Stephen R. Knight, Kenneth A. Mclean, Derek Murphy, Catherine A. Shaw, Annemarie B. Docherty, Ewen M. Harrison, Jo Dalton, Michelle Girvan, Egle Saviciute, Stephanie Roberts, Janet Harrison, Laura Marsh, Marie Connor, Sophie Halpin, Clare Jackson, Carrol Gamble, Chloe Donohue, Gary Leeming, Murray Wham, James Scott-Brown, Beatrice Alex, Benjamin Bach, Colin Begg, Antonia Ying Wai Ho, Peter W. Horby, Lowell Ling, David Maslove, Danny McAuley, Hugh Montgomery, Alistair Nichol, Peter J. M. Openshaw, Ryan S. Thwaites, Shona C. Moore, Charlotte Summers, Lisa Armstrong, Hayley Bates, Emma Dooks, Fiona Farquhar, Brigid Hairsine, C. McParland, Sophie Packham, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, Peter May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Suzanne Wood, Anne Zak, Olivier Zongo, Miranda Forsey, Anne Nicholson, Joanne Riches, Mark Vertue, Lina Grauslyte, Musarat Hussain, Tatiana Pogreban, Lace Rosaroso, Erika Salciute, George Franke, Joanna Wong, Aparna George, Louise Akeroyd, Shereen Bano, Matt Bromley, Lucy Gurr, Tom Lawton, James Morgan, Kirsten Sellick, Deborah Warren, Brian Wilkinson, Janet McGowan, Camilla Ledgard, Amelia Stacey, Kate Pye, Ruth Bellwood, Michael Bentley, Ronda Loosley, Heather McGuinness, Helen Tench, Rebecca Wolf-Roberts, Sian Gibson, Amanda Lyle, Fiona McNeela, Jayachandran Radhakrishnan, Alistair Hughes, Asifa Ali, Megan Brady, Sam Dale, Annalisa Dance, Lisa Gledhill, Jill Greig, Kathryn Hanson, Kelly Holdroyd, Marie Home, Diane Kelly, Ross Kitson, Lear Matapure, Deborah Melia, Samantha Mellor, Tonicha Nortcliffe, Jez Pinnell, Matthew Robinson, Lisa Shaw, Ryan Shaw, Lesley Thomis, Alison Wilson, Tracy Wood, Lee-Ann Bayo, Ekta Merwaha, Tahira Ishaq, Sarah Hanley, David Antcliffe, Dorota Banach, Stephen Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Rajeev Jha, Vinodh Krishnamurthy, Lai Lim, Li Lim, Rehana Bi, Barney Scholefield, Lydia Ashton, Alison Williams, Claire Cheyne, Anne Saunderson, Sam Moultrie, M. Odam, Angela Allan, Felicity Anderson, Callum Kaye, Jade Liew, Jasmine Medhora, Teresa Scott, Erin Trumper, Adriana Botello, Petra Polgarova, Katerina Stroud, Eoghan Meaney, Megan Jones, Anthony Ng, Shruti Agrawal, Nazima Pathan, Deborah White, Esther Daubney, Kay Elston, Robert Parker, Amie Reddy, Ian Turner-Bone, Laura Wilding, Peter Harding, Reni Jacob, Cathy Jones, Craig Denmade, Maria Croft, Ian White, Denise Griffin, Nycola Muchenje, Mcdonald Mupudzi, Richard Partridge, Jo-Anna Conyngham, Rachel Thomas, Mary Wright, Maria Alvarez Corral, Joy Dawson, Sweyn Garrioch, Melanie Tolson, Jonathan Aldridge, Sarah Beavis, Katie Dale, Rachel Gascoyne, Joanne Hawes, Kelly Pritchard, Lesley Stevenson, Amanda Whileman, Anne Cowley, Judith Highgate, Rikki Crawley, Abigail Crew, Mishell Cunningham, Allison Daniels, Laura Harrison, Susan Hope, Ken Inweregbu, Sian Jones, Nicola Lancaster, Jamie Matthews, Alice Nicholson, Gemma Wray, Leonie Benham, Zena Bradshaw, Joanna Brown, Melanie Caswell, Sarah Melling, Stephen Preston, Nicola Slawson, Emma Stoddard, Scott Warden, Edward Combes, Teishel Joefield, Sonja Monnery, Valerie Beech, Sallyanne Trotman, Bridget Hopkins, Laura Thrasyvoulou, Heather Willis, Susan Anderson, Janine Birch, Emma Collins, Kate Hammerton, Ryan O'Leary, Eleanor Andrews, Caroline Abernathy, Louise Foster, Andrew Gratrix, Vicky Martinson, Priyai Parkinson, Elizabeth Stones, Llucia Carbral-Ortega, Ritoo Kapoor, David Loader, Karen Castle, Craig Brandwood, Lara Smith, Richard Clark, Katie Birchall, Laurel Kolakaluri, Deborah Baines, Anila Sukumaran, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Manish Chablani, Amy Kirkby, Kimberley Netherton, Michelle Bates, Jo Dasgin, Jaspret Gill, Annette Nilsson, Elena Apetri, Cathrine Basikolo, Bethan Blackledge, Laura Catlow, Bethan Charles, Reece Doonan, Jade Harris, Alice Harvey, Daniel Horner, Karen Knowles, Stephanie Lee, Diane Lomas, Chloe Lyons, Tracy Marsden, Danielle McLaughlan, Liam McMorrow, Jessica Pendlebury, Jane Perez, Maria Poulaka, Nicola Proudfoot, Melanie Slaughter, Kathryn Slevin, Vicky Thomas, Danielle Walker, Angiy Michael, Matthew Collis, Martyn Clark, Martina Coulding, Edward Jude, Jacqueline McCormick, Oliver Mercer, Darsh Potla, Hafiz Rehman, Heather Savill, Victoria Turner, Miriam Davey, David Golden, Rebecca Seaman, Jodie Hunt, Joy Dearden, Emma Dobson, Michelle Mulcahy, ,

Summary: The genetic make-up of an individual plays a role in susceptibility and response to viral infections. A global network of researchers identified 13 significant genetic loci associated with SARS-CoV-2 infection and severe COVID-19 cases. Mendelian randomization analyses suggest a causal role for smoking and body-mass index in severe COVID-19. Collaboration among human genetics researchers has allowed for the discovery of novel host genetic factors linked to COVID-19.

NATURE (2021)

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Article Immunology

Bacterial colonization of bladder urothelial cells in women with refractory Detrusor Overactivity: the effects of antibiotic therapy

S. Ognenovska, Z. Chen, C. Mukerjee, K. H. Moore, K. J. Mansfield

Summary: This study found that antibiotic treatment can reduce bacterial colonization within urothelial cells, thereby improving the severity of symptoms in refractory Detrusor Overactivity.

PATHOGENS AND DISEASE (2021)

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Article Physiology

Protective Effect of Purinergic P2X7 Receptor Inhibition on Acrolein-Induced Urothelial Cell Damage

Zhinoos Taidi, Kylie J. Mansfield, Hafiz Sana-Ur-Rehman, Kate H. Moore, Lu Liu

Summary: This study investigated the role of P2X7R in acrolein-induced inflammatory damage in primary cultured porcine bladder urothelial cells. The results showed that blocking P2X7R can alleviate the damage to bladder urothelial cells and reduce the decrease in barrier function caused by acrolein, suggesting that P2X7R blockade may be a possible therapy for bladder cystitis caused by cyclophosphamide treatment.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Physiology

Urinary Tract Infection in Overactive Bladder: An Update on Pathophysiological Mechanisms

Kylie J. Mansfield, Zhuoran Chen, Kate H. Moore, Luke Grundy

Summary: Overactive bladder (OAB) is a clinical syndrome defined by urinary urgency, increased daytime urinary frequency and/or nocturia, with or without urinary incontinence. Despite being clinically characterized in the absence of other organic diseases, including urinary tract infection, research shows that a significant proportion of OAB patients have active bladder infection, with increased pathogenic bacteria and bladder inflammation.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Microbiology

Virulence Mechanisms of Common Uropathogens and Their Intracellular Localisation within Urothelial Cells

Samantha Ognenovska, Chinmoy Mukerjee, Martina Sanderson-Smith, Kate H. Moore, Kylie J. Mansfield

Summary: This study aimed to determine the virulence mechanisms that enable uropathogens to invade urothelial cells. The findings showed that common uropathogens were capable of intracellular colonization and the expression of virulence mechanisms correlated with successful invasion. These findings suggest that bacterial reservoirs within the bladder may contribute to the incidence of recurrent UTIs.

PATHOGENS (2022)

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Article Obstetrics & Gynecology

Does monthly self-management of vaginal ring pessaries reduce the rate of adverse events? A clinical audit

Kate H. Moore, Karin Lammers, Wendy Allen, Katrina Parkin, Nevine te West

Summary: This study aimed to determine the rate of adverse events (AE) in women who self-manage their vaginal ring pessary and compare it with traditional management protocols. The results showed that the rate of AE was lower in women who performed monthly self-management of vaginal ring pessaries compared to those who had ring changes at a clinic every 4-6 months.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X (2022)

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Article Urology & Nephrology

The effect of 12 weeks of estriol cream on stress urinary incontinence post-menopause: A prospective multinational observational study

Nevine I. D. te West, Katie Harris, Steven Jeffrey, Iris de Nie, Katrina Parkin, Jan-Paul Roovers, Kate H. Moore

Summary: This study aimed to quantitate the changes in stress urinary incontinence (SUI) outcome measures after 12 weeks of vaginal estriol cream. The results showed that vaginal estriol cream significantly improved symptoms of stress urinary incontinence, including reducing vaginal pH and alleviating urogenital distress. This is important for postmenopausal women.

NEUROUROLOGY AND URODYNAMICS (2023)

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Article Immunology

N-acetylcysteine prevents catheter occlusion and inflammation in catheter associated-urinary tract infections by suppressing urease activity

Arthika Manoharan, Jessica Farrell, Vina R. Aldilla, Greg Whiteley, Erik Kriel, Trevor Glasbey, Naresh Kumar, Kate H. Moore, Jim Manos, Theerthankar Das

Summary: This study demonstrates the functionality of N-acetyl cysteine (NAC) as a urease inhibitor in preventing catheter occlusion. It also highlights the strong anti-inflammatory and antibiofilm activity of NAC, which can target both bacterial and host factors in the treatment of catheter-associated urinary tract infections (CA-UTIs).

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

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Article Microbiology

Cranberry, but not D-mannose and ibuprofen, prevents against uropathogenic Escherichia coli-induced cell damage and cell death in MDCK cells

Jenane Konesan, Jenny Wang, Kate H. Moore, Kylie J. Mansfield, Lu Liu

Summary: Cranberry has a protective effect against UPEC-induced damage in urinary epithelial cells, while D-mannose and ibuprofen are ineffective in this regard.

FRONTIERS IN MICROBIOLOGY (2023)

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