期刊
NEUROUROLOGY AND URODYNAMICS
卷 34, 期 5, 页码 429-433出版社
WILEY
DOI: 10.1002/nau.22607
关键词
bacteriuria; incontinence; LUTS; OAB; urinary tract infection
资金
- UK Medical Research Council
- National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust
- Imperial College London
- MRC [G1100377] Funding Source: UKRI
- Medical Research Council [G1100377] Funding Source: researchfish
- National Institute for Health Research [ACF-2008-21-040] Funding Source: researchfish
Aims: Previous studies have noted an association between a diagnosis of overactive bladder and bacteriuria, but little is understood about the relationship of bacteriuria to specific LUTS. We hypothesized that bacteriuria in women would be associated with increased self-reported symptom scores for a wide range of LUTS. Methods: Women were recruited from general gynecology and urogynecology outpatient clinics in a secondary care setting. Women completed the 12-item International Consultation on Incontinence Questionnaire for Female Lower Urinary Tract Symptoms and provided a clean-catch mid-stream specimen of urine for microscopy and culture. Women with acute urinary tract infection were excluded. Three statistical approaches (Mann-Whitney U-test, multivariable logistic regression, and receiver operating characteristic curves) were used to assess differences in symptom scores between women with and without bacteriuria. Results: Two hundred forty-seven women were recruited, aged 22-82. Sixteen of 247 urine samples (6.5%) demonstrated significant bacteriuria, growing a different range of organisms. Women with significant bacteriuria were more likely to have nocturia (OR 3.56, 95% CI 1.19-10.6, P=0.02), urgency (OR 6.66, 95% CI 1.47-30.06, P=0.01), bladder pain (OR 2.82, 95% CI 1-7.92, P=0.049), urgency incontinence (OR 2.92, 95% CI 1.02-8.36, P=0.046), nocturnal enuresis (OR 4.21, 95% CI 1.32-13.41, P=0.01). After adjustment for age, parity, symptomatic prolapse, menopausal status and history of mid-urethral sling urinary urgency, bladder pain, nocturia, and nocturnal enuresis remained significantly associated. Conclusions: Bacteriuria is associated with a range of LUTS including nocturia, urgency, and bladder pain supporting a role for bacterial colonization in the pathogenesis of OAB symptoms. (C) 2014 Wiley Periodicals, Inc.
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