Prostatic α1-adrenoceptors: New concepts of function, regulation, and intracellular signaling

Small Interfering RNA Transfection Against Serum Response Factor Mediates Growth Inhibition of Benign Prostatic Hyperplasia Fibroblasts

(2015) Andrea Nolte et al.   Nucleic Acid Therapeutics

EAU Guidelines on the Treatment and Follow-up of Non-neurogenic Male Lower Urinary Tract Symptoms Including Benign Prostatic Obstruction

(2013) Matthias Oelke et al.   EUROPEAN UROLOGY

Noradrenaline induces binding of Clathrin light chain A to α1-adrenoceptors in the human prostate

(2013) Martin Hennenberg et al.   PROSTATE

Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3

(2012) F Strittmatter et al.   BRITISH JOURNAL OF PHARMACOLOGY

Silodosin: a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia

(2012) Nadir I Osman et al.   EXPERT OPINION ON PHARMACOTHERAPY

Activation of protein kinase B/Akt by alpha1-adrenoceptors in the human prostate

(2012) Frank Strittmatter et al.   LIFE SCIENCES

Silodosin Inhibits Noradrenaline-Activated Transcription Factors Elk1 and SRF in Human Prostate Smooth Muscle

(2012) Martin Hennenberg et al.   PLoS One

Phenotype pharmacology of lower urinary tract α1-adrenoceptors

(2011) A Nishimune et al.   BRITISH JOURNAL OF PHARMACOLOGY

What makes the α1A-adrenoceptor gene express the α1L-adrenoceptor functional phenotype?

(2011) S Ventura   BRITISH JOURNAL OF PHARMACOLOGY

Up-Regulation of α1a and α1d-Adrenoceptors in the Prostate by Administration of Subtype Selective α1-Adrenoceptor Antagonist Tamsulosin in Patients With Benign Prostatic Hyperplasia

(2011) Yoshiyuki Kojima et al.   JOURNAL OF UROLOGY

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Coupling of α1-Adrenoceptors to ERK1/2 in the Human Prostate

(2011) Ricarda M. Bauer et al.   UROLOGIA INTERNATIONALIS

Alpha1-adrenoceptor Signaling in the Human Prostate Involves Regulation of p38 Mitogen-activated Protein Kinase

(2011) Frank Strittmatter et al.   UROLOGY

Expression and Alpha1-adrenoceptor Regulation of Caldesmon in Human Prostate Smooth Muscle

(2011) Sebastian Walther et al.   UROLOGY

Beta-arrestin-2 is expressed in human prostate smooth muscle and a binding partner of α1A-adrenoceptors

(2011) Martin Hennenberg et al.   WORLD JOURNAL OF UROLOGY

Correlation between expression of α1-adrenoceptor subtype mRNA and severity of lower urinary tract symptoms or bladder outlet obstruction in benign prostatic hyperplasia patients

(2010) Yoshiyuki Kojima et al.   BJU INTERNATIONAL

Thromboxane A2 induces contraction of human prostate smooth muscle by Rho kinase- and calmodulin-dependent mechanisms

(2010) Frank Strittmatter et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Silodosin Therapy for Lower Urinary Tract Symptoms in Men with Suspected Benign Prostatic Hyperplasia: Results of an International, Randomized, Double-Blind, Placebo- and Active-Controlled Clinical Trial Performed in Europe

(2010) Christopher R. Chapple et al.   EUROPEAN UROLOGY

The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: α-Blockers in the Treatment of Male Voiding Dysfunction — How Do They Work and Why Do They Differ in Tolerability?

(2010) Martin C. Michel   JOURNAL OF PHARMACOLOGICAL SCIENCES

Identification of Cysteine-Rich Epidermal Growth Factor–Like Domain 1α (CRELD1α) as a Novel α1A-Adrenoceptor–Down-Regulating Protein and Establishment of an α1L-Adrenoceptor–Expressing Cell Line

(2010) Atsushi Nishimune et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The Modulation of Vascular ATP-Sensitive K+ Channel Function via the Phosphatidylinositol 3-Kinase-Akt Pathway Activated by Phenylephrine

(2010) M. Haba et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis

(2009) Yu-xi Zhang et al.   BIOCHIMIE

The Effects of Combination Therapy with Dutasteride and Tamsulosin on Clinical Outcomes in Men with Symptomatic Benign Prostatic Hyperplasia: 4-Year Results from the CombAT Study

(2009) Claus G. Roehrborn et al.   EUROPEAN UROLOGY

The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells

(2009) Ka-Kei Ho et al.   FEBS Journal

Potential for control of detrusor smooth muscle spontaneous rhythmic contraction by cyclooxygenase products released by interstitial cells of Cajal

(2009) Clinton Collins et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway

(2009) Hong-Zhi Sun et al.   JOURNAL OF ENDOCRINOLOGY

Effect of long-term partial bladder outlet obstruction on caldesmon isoforms and their correlation with contractile function

(2008) Lin YANG et al.   ACTA PHARMACOLOGICA SINICA

The α1L-adrenoceptor is an alternative phenotype of the α1A-adrenoceptor

(2008) C P Nelson   BRITISH JOURNAL OF PHARMACOLOGY

Native profiles of α1A-adrenoceptor phenotypes in rabbit prostate

(2008) T-H Su et al.   BRITISH JOURNAL OF PHARMACOLOGY

The α1A-adrenoceptor gene is required for the α1L-adrenoceptor-mediated response in isolated preparations of the mouse prostate

(2008) K T Gray et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of α1L-adrenoceptor in mice and its abolition by α1A-adrenoceptor gene knockout

(2008) I Muramatsu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lower Urinary Tract Symptoms Revisited: A Broader Clinical Perspective

(2008) Christopher R. Chapple et al.   EUROPEAN UROLOGY

α1-Adrenoceptor subtypes and lower urinary tract symptoms

(2008) Debra A Schwinn et al.   INTERNATIONAL JOURNAL OF UROLOGY

Smooth muscle signalling pathways in health and disease

(2008) H. R. Kim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Expression of α1-Adrenoceptor Subtype mRNA as a Predictor of the Efficacy of Subtype Selective α1-Adrenoceptor Antagonists in the Management of Benign Prostatic Hyperplasia

(2008) Yoshiyuki Kojima et al.   JOURNAL OF UROLOGY

Terazosin Therapy for Patients With Female Lower Urinary Tract Symptoms: A Randomized, Double-Blind, Placebo Controlled Trial

(2008) Bee Yean Low et al.   JOURNAL OF UROLOGY

Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific

(2008) Brian C. Jensen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Silibinin Impairs Constitutively Active TGFα-EGFR Autocrine Loop in Advanced Human Prostate Carcinoma Cells

(2008) Alpna Tyagi et al.   PHARMACEUTICAL RESEARCH

Thromboxane A2: Physiology/pathophysiology, cellular signal transduction and pharmacology

(2008) Norimichi Nakahata   PHARMACOLOGY & THERAPEUTICS

The proliferative effect of estradiol on human prostate stromal cells is mediated through activation of ERK

(2008) Zhisong Zhang et al.   PROSTATE

Intracellular Signaling by Akt: Bound to Be Specific

(2008) T. F. Franke   Science Signaling

Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis

(2008) Shu-Fen Liou et al.   TOXICOLOGY

Do α1-adrenoceptor antagonists improve lower urinary tract symptoms by reducing bladder outlet resistance?

(2007) Maurits M. Barendrecht et al.   NEUROUROLOGY AND URODYNAMICS