Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. A. Birder, Hann-Chorng Kuo
Summary: The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner's interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The study concluded that IC/BPS patients with frequency and bladder pain complaints have higher levels of urothelial sensory receptors, and inflammatory and pro-apoptotic proteins. The expression levels of these sensory receptors, inflammatory proteins, and pro-apoptotic proteins are not significantly different among IC/BPS bladders with different conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao
Summary: This study used 16S rRNA sequencing and untargeted metabolomics techniques to analyze the urinary microbial and metabolite profiles of IC/BPS patients and healthy controls. The results showed differential genera and metabolites associated with the inflammatory response of IC/BPS, including Lactobacillus as a protective bacterium and Sphingomonas as a pathogenic factor. The metabolite theophylline may also play a role in downregulating the inflammatory response of IC/BPS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi
Summary: Activation of TRPV4 can negatively regulate bladder inflammation induced by LPS and alleviate bladder hypersensitivity. This finding may provide new therapeutic targets for refractory bladder pain syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic bladder disorder characterized by suprapubic pain and discomfort during bladder filling, accompanied by lower urinary tract symptoms. The diagnosis of IC/BPS is still not standardized, but cystoscopy and bladder biopsy can determine the presence of ulcers. The pathophysiology of IC/BPS may involve chronic inflammation, autoimmune disorders, and other factors. Biomarkers in urine and serum specimens could be useful for the diagnosis of IC/BPS.
Article
Pharmacology & Pharmacy
Yuan-Hong Jiang, Jia-Fong Jhang, Teng-Yi Lin, Han-Chen Ho, Yung-Hsiang Hsu, Hann-Chorng Kuo
Summary: The study found that intravesical PRP injection is effective in relieving symptoms of IC/BPS patients, with slightly lower efficacy after a single high-dose PRP injection compared to four low-dose PRP injections. The addition of components and injection site did not significantly affect therapeutic outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jin Li, Xianyanling Yi, Jianzhong Ai
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease with a negative impact on quality of life. Diagnoses and treatments are still unsatisfactory, calling for new approaches. This study aims to provide a comprehensive overview of IC/BPS research, promoting progress in diagnosis, treatment, and prognosis. The complexity of IC/BPS and emerging evidence call for further studies to optimize management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Dan-Yun Chiou, Hann-Chorng Kuo
Summary: Urine oxidative stress biomarkers and inflammatory cytokines play important roles in diagnosing and differentiating clinical subtypes of interstitial cystitis/bladder pain syndrome (IC/BPS).
Article
Medicine, General & Internal
Pedro Abreu-Mendes, Beatriz Araujo-Silva, Ana Charrua, Francisco Cruz, Rui Pinto
Summary: This study suggests that daily silodosin can be an effective and well-tolerated treatment for refractory BPS/IC female patients. Additionally, stress coping levels may be associated with symptom improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Amy M. Ivare, Aneta Obloza, Jonathan C. Goddard
Summary: Bladder pain syndrome (BPS) is often overlooked in pregnancy, despite being a common symptom. This article reviews the current evidence on the impact of BPS on pregnancy and the available options for diagnosis and management, aiming to improve patient experience and outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Food Science & Technology
Wenshuang Li, Zhenming Zheng, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Paierhati Tayier, Yousheng Yao
Summary: This study found that in patients with interstitial cystitis/bladder pain syndrome (IC/BPS), repeated intravesical instillations of Sapylin after botulinum toxin A (BoNT/A) injection can produce significantly better clinical outcomes than BoNT/A alone, with good safety.
Article
Multidisciplinary Sciences
Kun-Lin Hsieh, Hung-Yen Chin, Tsia-Shu Lo, Cheng-Yu Long, Chung-Han Ho, Steven Kuan-Hua Huang, Yao-Chi Chuang, Ming-Ping Wu
Summary: IC/BPS is associated with increased risks of outpatient visits and hospitalizations, with patients having more overall OPD visits and higher IRRs in psychiatry, Chinese medicine, and emergency medicine; IRRs decrease with age, except for gynecology. Similar trends are observed in hospitalizations, with the deductive inference of ulcer type IC/BPS findings to non-ulcer types remaining inconclusive. Adequate recognition of associated factors and proper recommendations for IC/BPS patients can improve healthcare quality.
Article
Biochemistry & Molecular Biology
Yu-Khun Lee, Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Hann-Chorng Kuo
Summary: This study investigated the changes in electron microscopic findings among IC/BPS patients after intravesical PRP injections and found that repeated PRP injections can improve IC/BPS symptoms and promote the recovery of urothelial ultrastructural defects.
Review
Urology & Nephrology
Nadir Osman, David G. Bratt, Alison P. Downey, Francesco Esperto, Richard D. Inman, Christopher R. Chapple
Summary: Surgical interventions show significant efficacy in improving symptoms of bladder pain syndrome/interstitial cystitis, with a notable risk of failure and complications. Further high-quality studies are needed to clarify patient selection and optimal surgical approaches.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Neurosciences
Timothy J. Ness, Cary DeWitte, Alan Randich
Summary: This study investigated the role of CRFR2 in bladder hyperalgesia secondary to neonatal bladder inflammation and acute bladder re-inflammation as an adult, suggesting the therapeutic value of CRFR2 antagonists in the treatment of painful bladder disorders.
Article
Endocrinology & Metabolism
Pin-Wen Liao, Jen-Tse Chen, Shih-Ping Liu, Chen-Hsun Ho
Review
Urology & Nephrology
Cheng-Hsing Hsieh, Geng-Long Hsu, Shang-Jen Chang, Stephen Shei-Dei Yang, Shih-Ping Liu, Ju-Ton Hsieh
INTERNATIONAL JOURNAL OF UROLOGY
(2020)
Article
Multidisciplinary Sciences
Yung-Ting Cheng, Chao-Yuan Huang, Chung-Hsin Chen, Shih-Ting Chiu, Jian-Hua Hong, Yeong-Shiau Pu, Shih-Ping Liu, Yu-Chuan Lu, Yi-Kai Chang, Hong-Chiang Chang, Kuo-How Huang, Yuan-Ju Lee, Po-Ming Chow, I-Ni Chiang, Shih-Chun Hung, Chih-Hung Chiang
SCIENTIFIC REPORTS
(2020)
Article
Urology & Nephrology
Budiwan Sumarsono, Jar Jar Jong, Jian-Ye Wang, Limin Liao, Kyu-Sung Lee, Tag Keun Yoo, Shih-Ping Liu, Yao-Chi Chuang
LUTS-LOWER URINARY TRACT SYMPTOMS
(2020)
Article
Oncology
Jui-Ling Hsu, Wohn-Jenn Leu, Lih-Ching Hsu, Chen-Hsun Ho, Shih-Ping Liu, Jih-Hwa Guh
FRONTIERS IN ONCOLOGY
(2020)
Article
Microbiology
Chen-Hsun Ho, Yu-Chuan Lu, Chia-Kwung Fan, Hong-Jeng Yu, Hsin-Tien Liu, Chia-Chang Wu, Kuan-Chou Chen, Shih-Ping Liu, Po-Ching Cheng
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Medicine, General & Internal
Po-Ming Chow, Yao-Chi Chuang, Karina Chin Po Hsu, Yuan-Chi Shen, Ann Wei-Ju Hsieh, Shih-Ping Liu
Summary: The study evaluated the impact of nocturia on quality of life, work productivity, and mental health, finding an association between increasing frequency of nocturia and decreased quality of life. Nocturia was significantly associated with work productivity and anxiety and depression, but patients had low healthcare utilization rates.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Letter
Medicine, General & Internal
Po-Ming Chow, Yao-Chi Chuang, Karina Chin Po Hsu, Yuan-Chi Shen, Ann Wei-Ju Hsieh, Shih-Ping Liu
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Microbiology
Chen-Hsun Ho, Shih-Ping Liu, Chia-Kwung Fan, Kai-Yi Tzou, Chia-Chang Wu, Po-Ching Cheng
Summary: The study found that insulin pretreatment significantly reduced UPEC infection in bladder cells of diabetic individuals in a high-glucose environment, while also inhibiting the JAK/STAT transduction pathway, without affecting the expression of the insulin receptor.
Article
Urology & Nephrology
Ming-Chieh Cheng, Shih-Ping Liu, Yao-Chi Chuang, Karina Chin Po Hsu, Po-Ming Chow
Summary: Male urinary incontinence adversely affects quality of life and mental health, and may cause work limitations. However, many men do not seek any intervention.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chen-Hsun Ho, Pin-Wen Liao, Chia-Kwung Fan, Shih-Ping Liu, Po-Ching Cheng
Summary: RNase 7 is a natural antibiotic that can inhibit urinary tract infection. This study demonstrates its antimicrobial and anti-inflammatory effects on bladder cells infected with Escherichia coli in a high-glucose environment, achieved by regulating the JAK/STAT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Chen-Hsun Ho, Shih-Ping Liu, Chi-Wei Wang, Pin -Wen Liao
Summary: This study analyzed six prospective randomized trials, all of which involved short-term (1-2 weeks) stent placement after uncomplicated ureteroscopic lithotripsy. The meta-analysis showed that CIU-SP significantly reduced stent-related symptoms, with a significant effect on pain relief. CIU-SP is ready for clinical application based on the current evidence, at least for patients requiring short-term stent placement after uncomplicated ureteroscopic lithotripsy.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Oncology
Yung-Ting Cheng, Jian-Hua Hong, Yu-Chuan Lu, Yi-Kai Chang, Shih-Chun Hung, Kuo-Kang Feng, Shih-Ping Liu, Po-Ming Chow, Chung-Hsin Chen, Hong-Chiang Chang, Yeong-Shiau Pu
Summary: This study aimed to investigate the association between post-transurethral enucleation of the prostate nadir prostate-specific antigen level and prostate cancer. The findings suggest that a post-operative nadir prostate-specific antigen level of >= 1.7 ng/ml predicts significant residual cancer, while patients with low post-operative levels can be managed conservatively.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pei-Chi Chen, Chen-Hsun Ho, Chia-Kwung Fan, Shih-Ping Liu, Po-Ching Cheng
Summary: JAK/STAT plays a key role in regulating UPEC infection in urothelial cells, and LCN2 pretreatment can dose-dependently suppress UPEC infections and downregulate TLR-4, STAT1, and STAT3 expression. LCN2 can alleviate UPEC infection by decreasing JAK/STAT pathway activation in a high-glucose environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Po-Ming Chow, Yao-Chi Chuang, Karina Chin Po Hsu, Yuan-Chi Shen, Shih-Ping Liu
Summary: Stress urinary incontinence (SUI) is common among adult women and has negative effects on health-related quality of life, including physical and mental health, as well as work difficulties. The frequency of SUI episodes is associated with a greater reduction in quality of life and an increased risk of anxiety and depression.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)