Review
Environmental Sciences
Nelson T. Peterson, Chad M. Vezina
Summary: Lower urinary tract dysfunction (LUTD) is a common condition in men that imposes significant physical, mental, social, and financial burdens on society. However, research on the influence of environmental chemicals on LUTD is lacking. This review provides toxicologists with an overview of the disease process and the role of environmental chemicals in contributing to LUTD, using both men and male mice as research models.
Article
Biochemistry & Molecular Biology
Matthew M. Ford, Brianna E. George, Victor S. Van Laar, Katherine M. Holleran, Jerusha Naidoo, Piotr Hadaczek, Lauren E. Vanderhooft, Emily G. Peck, Monica H. Dawes, Kousaku Ohno, John Bringas, Jodi L. McBride, Lluis Samaranch, John R. Forsayeth, Sara R. Jones, Kathleen A. Grant, Krystof S. Bankiewicz
Summary: Alcohol use disorder (AUD) causes significant personal, social, and economic burdens worldwide. The recurrence of alcohol use is common in AUD patients despite current pharmacotherapies. However, introducing the GDNF gene into the brain may be a potential therapeutic strategy for preventing relapse in AUD patients.
Review
Biochemistry & Molecular Biology
Arnaud Zuber, Adriana Peric, Nicola Pluchino, David Baud, Milos Stojanov
Summary: The human body is colonised by microorganisms, including the genital tract which has been linked to male infertility and pathological conditions like prostate cancer. However, research on the microbiota of the male genital tract remains lacking due to difficulties in sampling and low abundance of microbiota. This narrative review aims to present the results of studies using next-generation sequencing to examine bacterial colonisation patterns in different anatomical compartments of the male genital tract and highlight their findings and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Vindhya Nawaratne, Sean P. McLaughlin, Felix P. Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvelli
Summary: The dopamine 2 receptors (D2R) play an important role in mediating the effects of amphetamine, which primarily rely on the ability of amphetamine to increase extracellular dopamine. This study found that prolonged exposure to amphetamine can decrease or increase endogenous hD2R at the cellular membrane in HEK293 cells. Moreover, the effects of amphetamine on D2R expression may occur independently of dopamine and DAT.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Virology
Massimiliano Creta, Caterina Sagnelli, Giuseppe Celentano, Luigi Napolitano, Roberto La Rocca, Marco Capece, Gianluigi Califano, Armando Calogero, Antonello Sica, Francesco Mangiapia, Massimo Ciccozzi, Ferdinando Fusco, Vincenzo Mirone, Evangelista Sagnelli, Nicola Longo
Summary: This systematic review identified studies on the involvement of urinary and male genital systems in COVID-19. The findings include various urinary symptoms, bladder hemorrhage, acute urinary retention, as well as male genital symptoms such as scrotal discomfort, swelling, and pain. Additionally, it reported a significant reduction in sperm quality among patients with moderate COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Neurosciences
Bai-Lin Song, Jie Zhou, Yi Jiang, Lai-Fu Li, Ying-Juan Liu
Summary: The dopamine system and the lateral septum play important roles in social hierarchies. Mice living in social groups form linear dominance hierarchies, with subordinates showing increased anxiety. D2 receptors in the intermediate region of the lateral septum are elevated in subordinates, and pharmacological studies show that simultaneous D2 receptor activation in dominants and inhibition in subordinates can switch the original dominant-subordinate relationship.
Article
Multidisciplinary Sciences
Elias Crum, Zubia Merchant, Adriana Ene, Taylor Miller-Ensminger, Genevieve Johnson, Alan J. Wolfe, Catherine Putonti
Summary: Due to its association with UTIs, Escherichia coli is the best characterized constituent of the urobiome. The urobiome also contains a diverse population of bacteriophages, including prophages integrated into bacterial genomes. This study identified and examined the diversity of urinary coliphages, finding that they can infect and lyse urinary E. coli strains, suggesting a role in modulating the E. coli strain diversity of the urobiome.
Letter
Immunology
Mohamed Lamine Keita, Madjid Morsli, Marc Levy, Gregoire Basse, Cecile Verrier, Michel Drancourt
Summary: We characterized an aquatic zoonotic opportunistic pathogen, Mycobacterium angelicum, which belongs to the M. szulgai complex, using a polyphasic approach that included whole-genome sequencing. The pathogen's sequence was obtained from a urine specimen collected from a patient with a urinary tract infection on the island of Tahiti, French Polynesia.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Jie Yu, Sarah L. Berga, Qingying Meng, Mingjing Xia, Trudy A. Kohout, Marcel van Duin, Robert N. Taylor
Summary: The study demonstrated the important regulatory role of dopamine receptor type 2 in endometrial tissue and cells, showing that dopamine agonists like cabergoline can promote decidualization in vitro, potentially serving as therapeutic agents for infertility due to inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Urology & Nephrology
George J. Netto, Mahul B. Amin, Daniel M. Berney, Eva M. Comperat, Anthony J. Gill, Arndt Hartmann, Santosh Menon, Maria R. Raspollini, Mark A. Rubin, John R. Srigley, Puay Hoon Tan, Satish K. Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree, Holger Moch
Summary: This article introduces the latest classification of urinary and male genital tumors by the World Health Organization in 2022, providing a comprehensive update on the diagnosis and prognostic progress of these tumors.
Article
Multidisciplinary Sciences
Han Guo, Jian-Bo Jiang, Wei Xu, Mu-Tian Zhang, Hui Chen, Huan-Ying Shi, Lu Wang, Miao He, Michael Lazarus, Shan-Qun Li, Zhi-Li Huang, Wei-Min Qu
Summary: In this study, the authors found that neurons expressing calretinin in the parasubthalamic nucleus play a key role in the induction and maintenance of wakefulness associated with exploration. They demonstrate that these neurons regulate wakefulness by innervating the ventral tegmental area. These findings provide new insights into the neural circuits regulating wakefulness.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Silvia Colussi, Paolo Pastorino, Marino Prearo, Simona Sciuto, Fabio Bondavalli, Pier Luigi Acutis, Elena Bozzetta, Francesco Amisano, Angelo Salerno
Summary: This paper reports the first human urinary tract infection caused by Lactococcus petauri, highlighting the expected increase in human L. petauri infections and calling for further investigations to understand their role as pathogens and zoonotic agents.
Article
Biochemistry & Molecular Biology
Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study aimed to analyze urinary biomarkers in men with lower urinary-tract symptoms (LUTS) and distinguish interstitial cystitis/bladder pain syndrome (IC/BPS) from other lower urinary-tract dysfunctions (LUTDs) through characteristic urinary biomarker levels. The results showed that urinary TNF-α and eotaxin levels can be used as biomarkers to differentiate IC/BPS from other LUTD subgroups in men with LUTS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Blayne J. Welk, Andrew McClure
Summary: Improvement in male lower urinary tract symptoms is associated with a reduced risk of death, which suggests that symptom treatment may be beneficial regardless of bother.
JOURNAL OF UROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Joachim Neumann, Britt Hofmann, Stefan Dhein, Ulrich Gergs
Summary: Dopamine has various effects on the mammalian heart, including increased contraction force, elevated heart rate, and coronary artery constriction. Dopamine acts on both dopamine receptors and adrenergic receptors in the heart. The role of dopamine receptors in the human heart is clinically relevant and important in understanding cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sandra Sigala, Christina Bothou, David Penton, Andrea Abate, Mirko Peitzsch, Deborah Cosentini, Guido A. M. Tiberio, Stefan R. Bornstein, Alfredo Berruti, Constanze Hantel
Summary: In this study, the genetic and pathophysiological characteristics of three specific adrenocortical carcinoma cell lines were analyzed, revealing their importance in reflecting the heterogeneities of ACC patients. This provides a more accurate model for preclinical studies.
Article
Biochemistry & Molecular Biology
Mariangela Tamburello, Andrea Abate, Elisa Rossini, Ram Manohar Basnet, Daniela Zizioli, Deborah Cosentini, Constanze Hantel, Marta Lagana, Guido Alberto Massimo Tiberio, Salvatore Grisanti, Maurizio Memo, Alfredo Berruti, Sandra Sigala
Summary: This study reveals that progesterone can inhibit the growth and metastasis of adrenocortical cancer (ACC) by reducing MMP2 levels and cellular invasion. Furthermore, progesterone induces apoptosis and changes in cell cycle distribution. These findings provide support for the application of progesterone in the treatment of ACC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Reproductive Biology
Carlo Giulioni, Valentina Maurizi, Virgilio De Stefano, Giordano Polisini, Jeremy Yuen-Chun Teoh, Giulio Milanese, Andrea Benedetto Galosi, Daniele Castellani
Summary: The effect of lead exposure on semen parameters in healthy men was evaluated in this study. The results showed that lead exposure was significantly associated with a reduction in semen volume, sperm concentration, total sperm count, sperm vitality, and total sperm motility. These findings are important for both workers exposed to lead and the general population.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Oncology
Andrea B. Galosi, Giulio Milanese, Lorenzo Montesi, Alessia Cimadamore, Carmine Franzese, Erika Palagonia, Giuseppe Chiacchio, Daniele Castellani
Summary: The prognostic significance of different patterns of isolated seminal vesicle invasion (SVI) in patients undergoing radical prostatectomy (RP) was evaluated. It was found that patients with type 3 SVI had a shorter time to biochemical recurrence compared to other patterns.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Review
Urology & Nephrology
Vineet Gauhar, Carlo Giulioni, Nariman Gadzhiev, Virgilio De Stefano, Jeremy Yuen-Chun Teoh, Ho Yee Tiong, Kazumi Taguchi, Giulio Milanese, Andrea Benedetto Galosi, Bhaskar Kumar Somani, Daniele Castellani
Summary: A systematic review was conducted to examine the application, outcomes, and limitations of using artificial intelligence and robotics for kidney puncture in percutaneous nephrolithotomy (PCNL). The review found that 3D printing and virtual reality technologies can improve anatomical understanding and accuracy, leading to a shorter learning curve and higher stone-free rate. Robotic-assisted access improves the accuracy of ultrasound- and fluoroscopic-guided punctures, reducing the number of punctures and radiation exposure.
CURRENT UROLOGY REPORTS
(2023)
Article
Medicine, General & Internal
Giulio Milanese, Edoardo Agostini, Maria Vittoria De Angelis, Eugenio Pretore, Andrea Benedetto Galosi, Daniele Castellani
Summary: The study aimed to evaluate the impact of Cavacurmin(R) on prostate volume (PV), lower urinary tract symptoms (LUTS), and micturition parameters in men after 1 year of therapy. The retrospective comparison of 20 men receiving alpha 1-adrenoceptor antagonists plus Cavacurmin(R) with 20 men receiving only alpha 1-adrenoceptor antagonists revealed that the combination therapy led to significantly lower PV, PSA, and IPSS levels, as well as higher Qmax values.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Valentina Schiavoni, Roberto Campagna, Valentina Pozzi, Monia Cecati, Giulio Milanese, Davide Sartini, Eleonora Salvolini, Andrea Benedetto Galosi, Monica Emanuelli
Summary: The aim of this review is to discuss novel prognostic and therapeutic markers for clear cell renal cell carcinoma (ccRCC), the most common variant of renal cell carcinoma. ccRCC is characterized by high aggressiveness, invasiveness, and metastatic potential, leading to poor prognosis and high mortality rate. This review provides an overview of the epidemiology, risk factors, established prognostic markers, and recent advances in treatment and biomarker discoveries for ccRCC.
Article
Oncology
Antonella Turla, Marta Lagana, Andrea Abate, Valentina Cremaschi, Manuel Zamparini, Matteo Chitto, Francesca Consoli, Andrea Alberti, Roberta Ambrosini, Mariangela Tamburello, Salvatore Grisanti, Guido Alberto Massimo Tiberio, Sandra Sigala, Deborah Cosentini, Alfredo Berruti
Summary: This study investigated the feasibility and tolerability of combining megestrol acetate with EDP-M in ACC patients with a low PS, and found that this combination therapy was feasible and well tolerated. The efficacy of this combination therapy appeared to be non-inferior to EDP-M administered to patients with a good PS.
Correction
Cell Biology
Sandra Sigala, Christina Bothou, David Penton, Andrea Abate, Mirko Peitzsch, Deborah Cosentini, Guido A. M. Tiberio, Stefan R. Bornstein, Alfredo Berruti, Constanze Hantel
Review
Urology & Nephrology
Edoardo Agostini, Antonio Vinci, Dorian Bardhi, Fabio Ingravalle, Mario Muselli, Giulio Milanese
Summary: The purpose of this study was to define the typical clinical presentation of false penile fractures (FPF) and determine the diagnostic indicators for distinguishing them from true penile fractures (TPF), providing clinicians with more useful tools for decision-making.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Medicine, General & Internal
Giuseppe Chiacchio, Mattia Beltrami, Andrea Cicconofri, Carlotta Nedbal, Lucia Pitoni, Demetra Fuligni, Martina Maggi, Giulio Milanese, Andrea Benedetto Galosi, Daniele Castellani, Carlo Giulioni
Summary: This study retrospectively reviewed 452 patients who underwent robotic-assisted radical prostatectomy (RARP), with 73 patients undergoing simultaneous inguinal hernia repair (IHR). The surgery was successfully performed in all cases, with short operative time and few postoperative complications.
MEDICINA-LITHUANIA
(2023)
Article
Urology & Nephrology
William Ong Lay Keat, Bhaskar Kumar Somani, Amelia Pietropaolo, Ben Hall Chew, Chu Ann Chai, Takaaki Inoue, Deepak Ragoori, Sarvajit Biligere, Andrea Benedetto Galosi, Maria Pia Pavia, Giulio Milanese, Thomas Ahn, Sumit More, Kemal Sarica, Olivier Traxer, Jeremy Yuen-Chun Teoh, Vineet Gauhar, Daniele Castellani
Summary: This study evaluates the effectiveness of flexible ureteroscopy for treating renal stones by comparing the outcomes of hard and soft stones based on their density on CT scans. The results show that stone density is associated with the occurrence of residual fragments and the need for further treatment.
WORLD JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Oncology
Edoardo Agostini, Andrea Cicconofri, Giulio Milanese, Andrea Benedetto Galosi
ANTICANCER RESEARCH
(2022)
Meeting Abstract
Urology & Nephrology
Simone Scarcella, Angelo Mottaran, Carlo Andrea Bravi, Luca Sarchi, Pietro Piazza, Marco Paciotti, Marco Amato, Stefano Puliatti, Paolo Umari, Carlo Giuloni, Giulio Milanese, Lucio Dell'Atti, Daniele Castellani, Edward Lambert, Jonathan Vollemaere, Dries Develtere, Ralf Veys, Marijn Goossens, Jolien Van der Jeugt, Andrea Galosi, Alexandre Mottrie
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Andrea Benedetto Galosi, Lucio Dell'Atti, Daniele Castellani, Marco Tiroli, Maria Pia Pavia, Eugenio Pretore, Lorenzo Montesi, Mariella Donati, Paolo Cerchiara, Elisabetta Cerutti, Giulio Milanese
Summary: This study compared the outcomes of retrograde intrarenal surgery (RIRS) performed under general anesthesia (GA) and spinal anesthesia (SA). The results showed that there were no significant differences in stone-free rate (SFR) and postoperative complications between the two anesthesia methods.
ARCHIVOS ESPANOLES DE UROLOGIA
(2022)