Review
Biochemistry & Molecular Biology
Giselle Prunell, Silvia Olivera-Bravo
Summary: This review discusses the role of astrocytes in Parkinson's disease (PD), highlighting the consequences of their loss of normal homeostatic functions and gain in toxic functions for dopaminergic neurons.
Article
Dentistry, Oral Surgery & Medicine
Melis Yilmaz, Ekin Yay, Nur Balci, Hilal Toygar, Basak Bolluk Kilic, Ali Zirh, Carla Alvarez Rivas, Alpdogan Kantarci
Summary: This study found that Parkinson's disease is associated with increased periodontal inflammatory burden and systemic inflammation. Parkinson's patients had higher clinical periodontal parameters and gingival crevicular fluid volume. These findings suggest a link between Parkinson's disease, periodontal inflammation, and neuroinflammation.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Oncology
Louise Emilsson, Cecilia Radkiewicz, Carol E. Semrad, Amit D. Joshi, Jonas F. Ludvigsson
Summary: Gallbladder disease is associated with a slightly increased relative risk of small bowel cancers and adenomas, but the absolute risks are low.
Article
Nutrition & Dietetics
Anne J. Strikwerda, Lisanne J. Dommershuijsen, M. Kamran Ikram, Trudy Voortman
Summary: The Mediterranean diet and the 'Prudent' dietary pattern may be associated with the risk of Parkinson's disease, while no associations were found for the Dutch diet quality score and other dietary patterns. Further research is needed to investigate the effects of different dietary patterns on PD risk.
Article
Clinical Neurology
Tianying Xing, Jinghong Ma, Tongwen Ou
Summary: Lower urinary tract symptoms are common in patients with Parkinson's disease, but neurogenic voiding dysfunction caused by PD remains a knowledge gap. This study evaluated neurogenic bladder outlet obstruction in male PD patients, showing delayed urinary sphincter relaxation without significant voiding difficulty in the patients.
Article
Biochemistry & Molecular Biology
Maria Gevezova, Maria Kazakova, Anastasia Trenova, Victoria Sarafian
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. There is growing evidence suggesting that mitochondrial dysfunction and inflammation play a crucial role in the pathogenesis of PD. This study investigated the metabolic profile of peripheral blood mononuclear cells (PBMCs) from PD patients and found changes in mitochondrial activity and YKL-40 levels in PD patients. The protein levels of YKL-40 were threefold higher in PD and showed a correlation with basal respiration and ATP production. These findings suggest an interplay between YKL-40 and mitochondrial function in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jannik Prasuhn, Ryan L. Davis, Kishore R. Kumar
Summary: Parkinson's disease is complicated and mitochondrial dysfunction plays a key role in its pathophysiology. While there are still gaps in knowledge, targeting various aspects of mitochondrial function and using combined therapeutic approaches may offer the best chance for developing effective novel therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Aksel Berg, Sara Bech, Jan Aasly, Matthew J. Farrer, Maria Skaalum Petersen
Summary: This study aimed to assess the frequency of autonomic symptoms in Parkinson's disease (PD) patients in the Faroe Islands compared to a control group and determine their relationship with motor symptoms. The findings showed that PD patients had a higher frequency of autonomic symptoms in gastrointestinal, urinary, cardiovascular, thermoregulatory, and sexual dysfunction areas compared to the control group. Autonomic symptoms were significantly correlated with motor symptoms, as assessed by the Unified Parkinson Disease Rating Scale.
NEUROSCIENCE LETTERS
(2022)
Article
Geriatrics & Gerontology
Huijia Yang, Song Li, Weidong Le
Summary: There is a significant relationship between the gut environment and Parkinson's disease, with intestinal disorders possibly being the pathological initiators of the disease, which has gained attention from the scientific and medical communities.
Review
Neurosciences
Any Docu Axelerad, Alina Zorina Stroe, Oana Cristina Arghir, Daniel Docu Axelerad, Anca Elena Gogu
Summary: Respiratory dysfunctions are commonly observed in patients with Parkinson's disease, leading to increased morbidity and mortality rates.
Review
Cell Biology
Maryam Abrishamdar, Maryam Sadat Jalali, Yaghoob Farbood
Summary: Neurodegeneration is a major challenge affecting millions of patients worldwide, with mitochondrial dysfunction playing a crucial role in the pathophysiology of Parkinson's disease (PD). Specific genes and mitochondrial DNA (mtDNA) have been found to be associated with PD, highlighting the significance of targeting mitochondrial dysfunction as a potential therapeutic approach.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Gary G. Schwartz, Mark R. Williamson
Summary: The prevalence of PD is higher in the Midwest and Northeast regions of the United States, similar to the distribution of acid rain. A study revealed an inverse correlation between PD prevalence and well water use, and positive correlations with industrial releases of sulfuric acid and acid precipitation. This association between PD and acid rain supports the role of metals in the etiology of PD.
Article
Sport Sciences
Camilla Martignon, Fabio Giuseppe Laginestra, Gaia Giuriato, Anna Pedrinolla, Chiara Barbi, Ilaria Antonella Di Vico, Michele Tinazzi, Federico Schena, Massimo Venturelli
Summary: This study investigated the interaction between central and peripheral components of neuromuscular fatigue in patients with Parkinson's disease (PD) compared with healthy controls. The results showed that central neuromuscular fatigue was exacerbated in PD patients, while peripheral fatigue did not differ significantly. This suggests that physical activity may limit fatigue and counterbalance the degenerative effects of PD through peripheral adaptations.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Neurosciences
Yanyan Zhang, Jie Li, Xiao Zhang, Dongdong Song, Tian Tian
Summary: Parkinson's disease is a multifactorial disorder characterized by dopaminergic neurodegeneration, and metabolomics plays a crucial role in identifying biomarkers and improving therapeutic strategies for this disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biology
Priya Rathor, Ratnasekhar Ch
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder, and circadian dysfunction plays an important role in its pathogenesis. Understanding the metabolic basis of circadian dysfunction in PD may provide new therapeutic approaches to restore circadian rhythm, preserve dopaminergic function, and ameliorate disease progression.
Article
Neurosciences
Jumes Leopoldino Oliveira Lira, Carlos Ugrinowitsch, Daniel Boari Coelho, Luis Augusto Teixeira, Andrea Cristina de Lima-Pardini, Fernando Henrique Magalhaes, Egberto Reis Barbosa, Fay B. Horak, Carla Silva-Batista
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Medicine, General & Internal
Cristiano Mendes Gomes, Marcio Augusto Averbeck, Mitti Koyama, Roberto Soler
Review
Neurosciences
Ana Paula Bertholo, Carina Franca, Wilma Silva Fiorini, Egberto Reis Barbosa, Rubens Gisbert Cury
ARQUIVOS DE NEURO-PSIQUIATRIA
(2020)
Article
Clinical Neurology
Carolina de Oliveira Souza, Juliana Goulardins, Daniel Boari Coelho, Sara Casagrande, Juliana Conti, Joao Carlos Papaterra Limongi, Egberto Reis Barbosa, Katia Monte-Silva, Clarice Tanaka
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Carla Silva-Batista, Andrea Cristina de Lima-Pardini, Mariana Penteado Nucci, Daniel Boari Coelho, Alana Batista, Maria Elisa Pimentel Piemonte, Egberto Reis Barbosa, Luis Augusto Teixeira, Daniel M. Corcos, Edson Amaro Jr, Fay B. Horak, Carlos Ugrinowitsch
MOVEMENT DISORDERS
(2020)
Article
Urology & Nephrology
Roberto Iglesias Lopes, Alessandro Tavares, Francisco Tibor Denes, Marcello Cocuzza
Article
Pediatrics
Roberto Iglesias Lopes, Caio Vinicius Suartz, Rubens Pedrenho Neto, Ricardo Haidar Berjeaut, Berenice Mendonca, Madson Q. Almeida, Maria Candida Villares Fragoso, Francisco Tibor Denes
Summary: This study retrospectively analyzed 75 children with hormonally active adrenal tumors who were evaluated at the endocrinology clinic and operated at the institution between 1983 and 2019. The results showed that proper diagnosis and management at the referral center were associated with a high cure rate, even in cases of malignant tumors, highlighting the importance of familial surveillance.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Ricardo Haidar Berjeaut, Bruno Nicolino Cezarino, Roberto Iglesias Lopes, Francisco Tibor Denes
JOURNAL OF PEDIATRIC UROLOGY
(2020)
Article
Pediatrics
Bruno Nicolino Cezarino, Roberto Iglesias Lopes, Ricardo Haidar Berjeaut, Francisco Tibor Denes
Summary: The pure laparoscopic HidES technique proved to be safe, feasible, and not inferior to traditional nephrectomy, with better cosmesis and higher patient satisfaction rates. The shorter operative time and lower blood loss in HidES group indicate its potential advantages over Traditional Ports Placement (TPP) nephrectomy. The study suggests that the location of scars plays a significant role in patient and parental satisfaction, supporting the benefit of HidES procedure.
JOURNAL OF PEDIATRIC UROLOGY
(2021)
Review
Pediatrics
Roberto I. Lopes, Linda A. Baker, Francisco T. Denes
Summary: Prune belly syndrome is characterized by abdominal flaccidity, urinary tract involvement, and cryptorchidism, predominantly affecting males with normal karyotype. Recent advancements in identifying genetic mutations regulating genitourinary development have improved genetic counseling. A multidisciplinary approach and individualized care are recommended for managing the condition.
JOURNAL OF PEDIATRIC UROLOGY
(2021)
Article
Pediatrics
Marcos Figueiredo Mello, Sabrina Thalita dos Reis, Enzo Yagi Kondo, Jose de Bessa Junior, Francisco Tibor Denes, Roberto Iglesias Lopes
Summary: This study found that urinary ECM proteins can help differentiate the severity of urinary obstruction in children with unilateral UPJO. In the obstructive HN group, the urinary concentrations of uTIMP-1/Cr and uTIMP-2/Cr decreased postoperatively, while uMMP-1/Cr, uMMP-2/Cr, and uMMP-9/Cr increased. Protein analysis in the non-obstructive HN group remained stable after six months of observation. ROC curve analysis showed promising diagnostic values for TIMP-1/Cr, TIMP-2/Cr, and MMP-2/Cr.
JOURNAL OF PEDIATRIC UROLOGY
(2021)
Article
Urology & Nephrology
Roberto Iglesias Lopes, Rodrigo Perrella, Carlos Hirokatsu Watanabe, Fabricio Beltrame, Alexandre Danilovic, Claudio Bovolenta Murta, Joaquim Francisco de Almeida Claro, Fabio Carvalho Vicentini
Summary: This study evaluated 50 patients with retained encrusted ureteral stents who underwent a single session combined endourological approach. The FECal classification was useful for surgical planning, and the stone-free rate was lower in grades III to V. Percutaneous nephrolithotomy was the most common procedure for grades IV and V. The endoscopic combined approach in the supine position was safe and feasible for removal of retained and encrusted stents in a single procedure.
INTERNATIONAL BRAZ J UROL
(2021)
Article
Urology & Nephrology
Bruno Nicolino Cezarino, Roberto Iglesias Lopes, Ricardo Haidar Berjeaut, Francisco Tibor Denes
Summary: Comparative study on two surgical approaches for 44 patients with symptomatic duplex kidneys showed that extended distal ureteral dissection can reduce the risk of distal ureteral stump syndrome and decrease the proportion of patients requiring further surgical treatment.
INTERNATIONAL BRAZ J UROL
(2021)
Article
Urology & Nephrology
Marcos Figueiredo Mello, Jose de Bessa Junior, Sabrina T. Reis, Enzo Yagi Kondo, Luis Yu, Francisco Tibor Denes, Roberto Iglesias Lopes
Summary: In this study, the performance of urinary TIMP-2 and IGFBP7 levels in distinguishing obstructive hydronephrosis from non-obstructive hydronephrosis was evaluated. The results showed that these biomarkers were not reliable in predicting the need for surgical intervention in pediatric patients with UPJO.
INTERNATIONAL BRAZ J UROL
(2022)
Review
Medicine, General & Internal
Fernanda S. Bachega, Caio Suartz, Madson Q. Almeida, Vania B. Brondani, Helaine L. S. Charchar, Amanda M. F. Lacombe, Sebastiao N. Martins-Filho, Ibere C. Soares, Maria Claudia N. Zerbini, Francisco T. Denes, Berenice Mendonca, Roberto Lopes, Ana Claudia Latronico, Maria Candida B. Fragoso
Summary: Pediatric adrenocortical tumors (PACTs) are rare malignancies, but they have a high incidence in the south/southeast regions of Brazil due to a germline pathogenic variant of tumor suppressor gene TP53. This retrospective analysis of PACT patients identified several factors, including age, hormone levels, tumor characteristics, histological features, and genetic factors, that were associated with a poor prognosis. These results can help identify patients who are likely to have an aggressive disease course and guide treatment decisions.
JOURNAL OF CLINICAL MEDICINE
(2022)