Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Y. Xu, C. Li, G. Liu, H. Zhang, S. Tian, H. Hao, Y. Hao
Summary: This study found that Ang 1-7 significantly increased NO synthesis in rat VSMCs cultured under high glucose conditions by regulating Cav-1 expression, Cav-1-eNOS interaction, oxidative stress, and intracellular Ca2+ levels.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Article
Physiology
Mutay Aslan, Filiz Basrali, Pinar Ulker, Zerrin Barut, Cagatay Yilmaz, Tugce ceker, Nur Ozen, Aleyna Oztuzun, Ozlem Elpek
Summary: Asperglaucide (ASP), an aurantiamide found in purslane, demonstrated positive effects on endothelial function, eNOS expression, vascular fluidity, and ROS/RNS production in a rat model of renovascular arterial hypertension. In addition, ASP increased eNOS protein expression in human umbilical vein endothelial cells (HUVEC). The results suggest that ASP may have future potential as an anti-hypertensive agent.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Cell Biology
Thomas Dupas, Thomas Pele, Justine Dhot, Melanie Burban, Antoine Persello, Virginie Aillerie, Angelique Erraud, Angela Tesse, David Stevant, Angelique Blangy-Letheule, Celine Menguy, Vincent Sauzeau, Michel De Waard, Bertrand Rozec, Chantal Gauthier, Benjamin Lauzier
Summary: 50% of heart failure patients have preserved ejection fraction (HFpEF). Numerous studies have shown that endothelial dysfunction plays a significant role in HFpEF, but it remains unclear whether it is the cause or consequence. A recent study found that overexpression of human beta(3)-adrenoreceptor in rat endothelial cells leads to the slow development of diastolic dysfunction. This study aims to investigate the involvement of endothelial dysfunction in the development of HFpEF.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yan-Rong Li, Yan Li, Yuan Jin, Mang Xu, Hong-Wei Fan, Qian Zhang, Guo-He Tan, Jing Chen, Yun-Qing Li
Summary: This study investigates the effects of nitric oxide (NO) on colonic motility in a rat model of ulcerative colitis (UC), and the role of the enteric nervous system (ENS) in UC-related colonic motility. The results suggest that changes in the expression of nitric oxide synthase (NOS) in nitrergic neurons can influence colonic motility, and intervention in NOS activity may prevent colonic motor dysfunction in UC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yukio Suga, Yoko Takahashi, Tsutomu Shimada, Shinya Yamada, Eriko Morishita, Hidesaku Asakura
Summary: Our study found that eNOS plays a crucial role in NO production in the TF-induced DIC model, with thrombin serving as a key stimulant of eNOS-mRNA expression in this context.
Article
Biochemistry & Molecular Biology
Divya Seth, Colin T. Stomberski, Precious J. McLaughlin, Richard T. Premont, Kathleen Lundberg, Jonathan S. Stamler
Summary: The aim of this study was to investigate the interactions between nitric oxide synthase (NOS) isoforms and proteins, as well as the mechanisms by which they mediate S-nitrosylation. The results showed that each NOS isoform interacts with and S-nitrosylates many proteins, but a large proportion of S-nitrosylated proteins are not associated with NOS. Additionally, the interactomes and S-nitrosylomes of individual NOS isoforms are largely unique, indicating specific roles for each isoform in S-nitrosylation.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Horticulture
Sitthisak Intarasit, Bualuang Faiyue, Jamnong Uthaibutra, Kobkiat Saengnil
Summary: The research aimed to investigate the impact of chlorine dioxide (ClO2) on the browning of longan pericarp. The findings indicated that ClO2 fumigation reduced the activities of RNS producing enzymes, resulting in lower nitrosative stress levels and reduced pericarp browning.
SCIENTIA HORTICULTURAE
(2022)
Article
Neurosciences
Jafar Vatanparast, Samira Khalili, Maryam Naseh
Article
Neurosciences
Vida Alipour, Fahimeh Hoseinpour, Jafar Vatanparast
Article
Physiology
Maryam Naseh, Amirreza Dehghanian, Sara Keshtgar, Farzaneh Ketabchi
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Atefeh Rahimi, Ali Rafati, Ali Noorafshan, Narges Karbalaei, Saied Karbalay-Doust, Maryam Naseh
Summary: The study revealed that CUR can significantly ameliorate MET-induced cardiotoxicity, prevent structural disorder in cardiac tissues induced by MET, and alleviate the oxidative pathways leading to cardiac damage.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2021)
Review
Behavioral Sciences
Maryam Naseh, Jafar Vatanparast, Ali Rafati, Mahnaz Bayat, Masoud Haghani
Summary: FTY720, as an agonist of S1P receptor, exerts neuroprotective effects in ischemic stroke patients through three mechanisms: functional antagonistic, functional agonistic, and receptor-independent mechanisms.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Gholam Hossein Meftahi, Mahnaz Bayat, Amir Hossein Zarifkar, Somaye Akbari, Afshin Borhani Haghighi, Maryam Naseh, Amirhossein Yousefi Nejad, Masoud Haghani
Summary: The study aimed to investigate the effects of edaravone administration on cellular and electrophysiological properties in a rat model of vascular dementia induced by bilateral carotid artery occlusion. The results showed that vascular dementia led to increased MDA levels, neuronal loss, reduced hippocampal volume, and impaired synaptic plasticity and memory function. However, treatment with edaravone decreased MDA levels, prevented neuronal loss and hippocampal volume reduction, improved synaptic plasticity and memory function.
BRAIN RESEARCH BULLETIN
(2021)
Article
Cardiac & Cardiovascular Systems
Maryam Rahmanifard, Mahmood Vessal, Ali Noorafshan, Saied Karbalay-Doust, Maryam Naseh
Summary: The study aimed to evaluate the cardioprotective effects of coenzyme Q10 and lisinopril against doxorubicin-induced cardiac toxicity in rats. Results showed that Q10 and LIS were able to prevent some stereological parameters and ECG changes, improve catalase activity, and reduce MDA concentration in the doxorubicin-treated group, indicating their significant cardioprotective effects.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Neurosciences
Mahboobeh Erfanizadeh, Ali Noorafshan, Maryam Naseh, Saied Karbalay-Doust
Summary: The study demonstrated that copper not only negatively impacted the cerebellar structures in rats, but also led to a decrease in neuronal function, thus affecting the animals' motor performance.
IBRO NEUROSCIENCE REPORTS
(2021)
Article
Developmental Biology
Fatemeh Karimi, Hamideh Anari, Amirhossein Yousefi Nejad, Saied Karbalay-Doust, Maryam Naseh
Summary: This study found that exposure to a high dose of Sunset Yellow FCF has negative effects on the structure and behavior of the rat's mPFC, but CoQ10 has a protective effect. However, a low dose of Sunset Yellow FCF does not have a significant impact on the same parameters.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2022)
Article
Neurosciences
Zahra Esmaili, Maryam Naseh, Fatemeh Karimi, Maryam Moosavi
Summary: This study found that ingestion of Al-NP could cause memory impairment, decreased hippocampal volume, reduced cell number, and increased cleaved caspase-3. These results provide new mechanistic insight to understand the impairing effect of Al-NP on hippocampal function and structure.
Article
Surgery
Seyed Reza Mousavi, Majid Reza Farrokhi, Shayan Yousufzai, Maryam Naseh, Fatemeh Karimi
Summary: This study reports a case of anomalous origin of the left vertebral artery and highlights the importance for neurosurgeons and vascular surgeons to be aware of this anomaly.
CASE REPORTS IN SURGERY
(2022)
Article
Psychology, Biological
Maryam Naseh, Mahnaz Bayat, Somayeh Akbari, Jafar Vatanparast, Mohammad Shabani, Afshin Borhani Haghighi, Masoud Haghani
Summary: The study evaluated the therapeutic effect of valproate (VPA) treatment on cognitive impairment, hippocampal neuronal loss, and spatial memory deficits induced by cerebral ischemia. The results showed that VPA treatment significantly reduced the infarct volume and improved spatial learning-memory, fear memory, and anxiety. The induction of long-term potentiation via postsynaptic mechanisms may be responsible for the improvement in cognitive impairment.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Clinical Neurology
Seyed Reza Mousavi, Ali Rafati, Amir Reza Dehghanian, Hossein Nejat, Fatemeh Matin, Mahdi Khorsand Ghaffari, Maryam Naseh
Summary: This study investigated the effects of dexamethasone, nanocurcumin, and coenzyme Q10 on the prevention of epidural fibrosis in a rat laminectomy model. The results showed that nanocurcumin and coenzyme Q10 had the potential to be used for the treatment of epidural fibrosis.
WORLD NEUROSURGERY
(2022)
Article
Developmental Biology
Parisa Yarmohammadi-Samani, Jafar Vatanparast
Summary: This study analyzed the changes in dendritic structure and spine density in CA1 and CA3 neurons in different sexes and age groups. The findings showed that in early adolescence, male rats had more dendritic intersections and spine density in CA1 neurons, while in young adulthood, young female rats had more intersections. The differences in dendritic structure in CA3 neurons also varied between different sexes and age groups.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Maryam Naseh, Amirreza Dehghanian, Farzaneh Ketabchi
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2020)