Article
Environmental Sciences
Ekrem Sulukan, Alper Baran, Onur Senol, Serkan Yildirim, Ahmet Mavi, Hacer Akgul Ceyhun, Emine Toraman, Saltuk Bugrahan Ceyhun
Summary: The study revealed that a 1-degree temperature increase, combined with exposure to nano-plastics, affected the circadian rhythm of zebrafish, resulted in brain damage, and caused significant changes in the intensity of 18 metabolites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Qiyu Wang, Xueyan Gu, Yu Liu, Shuai Liu, Wuting Lu, Yongming Wu, Huiqiang Lu, Jing Huang, Wenqing Tu
Summary: This study investigated the neurotoxicity and underlying mechanisms of PFOS alternatives, F-53B and OBS, on adult zebrafish's circadian rhythms. The results showed that PFOS affected heat response rather than circadian rhythms by disrupting calcium signaling pathway transduction, while F-53B and OBS altered circadian rhythms through different mechanisms. F-53B interfered with neurotransmitter metabolism and disrupted blood-brain barrier formation, while OBS inhibited Wnt signaling transduction and induced midbrain ventriculomegaly, leading to imbalance in DA secretion and circadian rhythm changes. This study emphasizes the importance of assessing the environmental exposure risks of PFOS alternatives and understanding their multiple toxicities' mechanisms.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Cell Biology
Chin-Chou Wang, Wei-Hsun Lin, Su-Chi Ku, Wan-Jou Shen, Hoang Dang Khoa Ta, Gangga Anuraga, Fang-Wen Liu, Chiu-Fan Shen, Shu-He Wang, Chia-Chen Yang, Chih-Yang Wang, Wei-Jan Wang
Summary: The PER and CRY family members have been found to play critical roles in circadian rhythms and their imbalance may lead to cancer. This study investigated their expressions, genetic variations, molecular mechanisms, and correlations with prognosis and immune infiltration in LUAD patients. The findings showed that PER1 and CRY2 were significantly downregulated in LUAD, while high expression levels of PER2, PER3, CRY1, and CRY2 indicated longer overall survival. The expressions of PER and CRY family members also affected immune cell infiltration.
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Engineering, Environmental
Huiwen Kang, Wei Zhang, Jiaru Jing, Danyang Huang, Lei Zhang, Jingyu Wang, Lin Han, Ziyan Liu, Ziyan Wang, Ai Gao
Summary: The global production of plastic continues to increase, resulting in a rise in plastic particles in the environment. Nanoplastics (NPs) can cross the blood-brain barrier and cause neurotoxicity, but the underlying mechanisms and effective protection strategies are lacking. In this study, mice were exposed to polystyrene NPs (80 nm) for 42 days, leading to neuronal damage in the hippocampus and alterations in neuroplasticity-related molecules. The gut-brain axis and circadian rhythm pathways were found to be involved in the neurotoxicity of NPs, and melatonin or probiotics supplementation showed potential in preventing this toxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Physiology
Jingjing Lin, Xinyue Sun, Xiaofeng Dai, Shaoying Zhang, Xueling Zhang, Qiaosong Wang, Qirong Zheng, Minfang Huang, Yuanyuan He, Rongjin Lin
Summary: This study aimed to investigate the effects of circadian rhythm inversion on proteins, metabolites, and related mechanisms in the hypothalamus of pregnant rats during the whole pregnancy cycle. The results showed that circadian rhythm inversion can affect the number and average weight of offspring in pregnant rats and lead to significant changes in the expression of proteins and metabolites. The integrated analysis between proteins and metabolites found that certain key proteins were closely associated with carbon metabolism and glycerophospholipid metabolism, while differential metabolites were enriched in ATP-binding cassette transporters.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Evan Lloyd, Brian Chhouk, Andrew J. Conith, Alex C. Keene, R. Craig Albertson
Summary: Animals exhibit diverse patterns of rest and activity, influenced by foraging strategies, social behaviors, and predator avoidance. The cichlid species in Lake Malawi provide a unique opportunity to study variation in locomotor behavior, with surprising variability in circadian timing and rest duration. Nocturnal behavior in some species is associated with increased eye size and may be a response to light rather than an internal circadian rhythm.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Entomology
Pedro Henrique Urach Ferreira, Marcelo da Costa Ferreira
Summary: This study evaluated the behavior of the sugarcane weevil, Sphenophorus levis, and found that it is not attracted or repelled by the recommended insecticide dose. The weevils are primarily nocturnal, with increased activity and exposure at night. Therefore, nocturnal insecticide applications may be more effective for controlling S. levis.
Article
Biotechnology & Applied Microbiology
Chang Zhang, Jiahui Xu, Lijun Chen, Xiaojie Lin
Summary: The circadian rhythm pathway exhibited pathological functions in glioma on a single-gene level. By analyzing multi-omics data, it was found that lower grade glioma (LGG) patients showed higher frequencies of mutations and better survival outcomes related to the circadian rhythm pathway. Quantification of the pathway using a pathway index indicated distinctly altered circadian pathway in LGG patients.
Article
Biochemistry & Molecular Biology
Andreas Psomas, Namrata R. Chowdhury, Benita Middleton, Raphaelle Winsky-Sommerer, Debra J. Skene, Menno P. Gerkema, Daan R. van Der Veen
Summary: This study investigated the metabolic rhythms in the plasma metabolome of voles and found that there were both 24-hour circadian rhythms and faster 2-4 hour ultradian rhythms. These ultradian rhythms were synchronized with the circadian rhythms and were not aligned with meal timing, indicating their importance in metabolic regulation.
Article
Biology
D. Cogswell, P. Bisesi, R. R. Markwald, C. Cruickshank-Quinn, K. Quinn, A. McHill, E. L. Melanson, N. Reisdorph, K. P. Wright, C. M. Depner
Summary: Measuring individual circadian phase is important for diagnosing and treating circadian rhythm disorders, and using blood metabolomics to predict DLMO and DLMOff shows promise. Further research is needed to validate these biomarkers for circadian phase.
JOURNAL OF BIOLOGICAL RHYTHMS
(2021)
Article
Biochemistry & Molecular Biology
Amandia R. Batschauer, Tugstenio L. Souza, Patricia E. Manuitt Brito, Francisco Filipak Neto, Ciro A. Oliveira Ribeiro, Claudia F. Ortolani-Machado
Summary: The study found that chronic perinatal exposure to low doses of manganese in mice can lead to neurotoxic effects, including memory impairment and increased anxiety-like behavior. Manganese exposure also affects biochemical markers in different brain regions, indicating that exposure to low doses of manganese may be harmful to a generation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Neurosciences
Yufei Liu, Long Niu, Xinyao Liu, Cheng Cheng, Weidong Le
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by both motor and non-motor symptoms, with circadian rhythm dysregulation emerging as a key feature that may play a pivotal role in the pathogenesis of PD. Recent research progress has focused on understanding altered circadian rhythm in PD, from clinical manifestations to underlying causes of circadian disorders in PD.
NEUROSCIENCE BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Mayur Doke, Jay P. McLaughlin, Hamid Baniasadi, Thangavel Samikkannu
Summary: Disturbances in the circadian rhythm and cocaine abuse have an impact on the human metabolome, potentially providing insights into identifying biomarkers. The study examined the effects of cocaine administration and circadian rhythm sleep disruption (CRSD) on metabolite levels. Analysis revealed alterations in purine and pyrimidine metabolism in relation to chronic exposure to cocaine and CRSD.
Article
Multidisciplinary Sciences
Rubens Paula, Nathalia Martins Sonehara, Bruna Victorasso Jardim-Perassi, Akos Pal, Yasmin Asad, Luiz Gustavo Almeida Chuffa, Roger Chammas, Florence I. Raynaud, Debora A. P. C. Zuccari
Summary: Human xenografts are useful models for studying human cancers and therapies. This study compared amino acid concentration in breast cancer cells and non-tumorigenic cells, as well as in plasma of tumor-bearing mice. The results showed significant differences in amino acid levels between cancer and non-tumor cells, as well as in the timing of peak amino acid concentrations in tumor-bearing mice.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Xi Li, Yinan Zhang, Lingya Xu, Aoxue Wang, Yejun Zou, Ting Li, Li Huang, Weicai Chen, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang, Joseph Loscalzo, Yi Yang, Yuzheng Zhao
Summary: In this study, a highly sensitive lactate sensor called FiLa was developed, which allows for monitoring subtle lactate fluctuations in living cells and animals. It was found that lactate is highly enriched in mammalian mitochondria and functions as a key hub sensing various metabolic activities. The FiLa sensors also enable direct imaging of elevated lactate levels in diabetic mice and provide a simple, rapid, and sensitive lactate assay for clinical screening. Overall, the FiLa sensors are powerful and broadly applicable tools for studying lactate metabolism in health and disease.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for the quantification of ceramides in liver and small intestine tissues was developed and applied. The method demonstrated good sensitivity and linearity, as well as stable extraction recoveries and precision. The composition of ceramides in the two tissues provides insights for exploring biomarkers and molecular mechanisms of ceramide-related diseases.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Oncology
Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia, Ling Zhao
Summary: This review explores the crucial role of gut microbiota in the metastasis of colorectal cancer (CRC) and elucidates the molecular mechanisms through which gut microbiota contribute to the formation of a tumor-permissive microenvironment, as well as facilitate malignant transformation and dissemination of tumor cells, thus mediating CRC metastasis.
Article
Biotechnology & Applied Microbiology
Jiaxin Li, Yuqi Chen, Rui Li, Xianglong Zhang, Tao Chen, Fengyi Mei, Ruofan Liu, Meiling Chen, Yue Ge, Hongbin Hu, Rongjuan Wei, Zhenfeng Chen, Hongying Fan, Zhenhua Zeng, Yongqiang Deng, Haihua Luo, Shuiwang Hu, Shumin Cai, Feng Wu, Nengxian Shi, Zhang Wang, Yunong Zeng, Ming Xie, Yong Jiang, Zhongqing Chen, Wei Jia, Peng Chen
Summary: Sepsis, a global public health challenge, lacks effective treatment or intervention. This study reveals that hyodeoxycholic acid (HDCA) has excellent anti-inflammatory properties in sepsis. HDCA administration significantly decreases systemic inflammatory responses and improves the survival of septic mice. The mechanism involves the competitive blockade of lipopolysaccharide binding to TLR4 and MD-2 receptor complex by HDCA. These findings highlight the potential value of HDCA as a therapeutic molecule for sepsis.
Review
Pharmacology & Pharmacy
Kenneth Chat Pan Cheung, Ma Jiao, Xingxuan Chen, Jia Wei
Summary: This article discusses the potential of extracellular vesicles in the treatment of osteoporosis, and introduces their characteristics and application prospects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Summary: This study evaluated the effect of cinnamon extract on bowel symptoms in rat models of irritable bowel syndrome with diarrhea (IBS-D). It found that cinnamon extract reduced defecation frequency and visceral hyperalgesia in the rat models, and the efficacy was comparable to a positive drug. Furthermore, cinnamon extract directly inhibited the expression of Tph1 and controlled serotonin synthesis, providing a scientific viewpoint for the traditional use of cinnamon in treating IBS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Yu Pi, Yujun Wu, Xiangyu Zhang, Dongdong Lu, Dandan Han, Jiangchao Zhao, Xiaojiao Zheng, Shiyi Zhang, Hao Ye, Shuai Lian, Yu Bai, Zhenyu Wang, Shiyu Tao, Dongjiao Ni, Xinhua Zou, Wei Jia, Guolong Zhang, Defa Li, Junjun Wang
Summary: In this study, the difference in fecal microbiome and bile acid (BA) profiles between low birth weight (LBW) and normal birth weight (NBW) piglets were investigated. Fecal microbiota transplantation confirmed the link between microbial BA metabolism and intestinal inflammation. The therapeutic potential of ursodeoxycholic acid (UDCA) was evaluated and it was found to alleviate intestinal inflammation through M2 macrophage polarization and suppression of inflammatory cytokines.
Article
Microbiology
Lepeng Zhou, Wen Qiu, Jie Wang, Aihua Zhao, Chuhui Zhou, Tao Sun, Ziyu Xiong, Peihua Cao, Wei Shen, Jingfen Chen, Xiaolu Lai, Liu-hong Zhao, Yue Wu, Meng Li, Feng Qiu, Yanhong Yu, Zhenjiang Zech Xu, Hongwei Zhou, Wei Jia, Yan Liao, Ravi Retnakaran, Daniel Krewski, Shi Wu Wen, Jose C. Clemente, Tianlu Chen, Ri-hua Xie, Yan He
Summary: The microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related micro biome disturbances. In this study, VMT was found to be safe and had positive effects on infant neurodevelopment, gut microbiota maturation, and fecal metabolites.
CELL HOST & MICROBE
(2023)
Review
Immunology
Kenneth C. P. Cheung, Jiao Ma, Rodrigo Azevedo Loiola, Xingxuan Chen, Wei Jia
Summary: Bile acid-activated receptors have important roles in regulating microbiota-host immunity and may influence the development of metabolic disorders. This perspective provides a summary of regulatory pathways and mechanisms of these receptors, their impact on immune system, cell proliferation, and signaling in inflammatory diseases. It also discusses new therapeutic approaches and clinical projects on bile acids for disease treatment.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D'Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Summary: An essential function of the epidermis is to provide a physical barrier that prevents water loss. Alteration of ceramides, cholesterol, and very long chain fatty acids, mediators of this barrier function, causes human pathologies. A study shows that genetic deletion of ZFP750 in mice leads to the loss of epidermal barrier function due to a reduction in ceramides. ZFP750 directly and/or indirectly regulates the expression of enzymes involved in ceramide biosynthesis, contributing to our understanding of skin disease pathogenesis.
Article
Biochemistry & Molecular Biology
Keith M. Erikson, Kristina El-Khouri, Radmila Petric, Chenhao Tang, Jinlan Chen, Delicia Esther Cardenas Vasquez, Steve C. Fordahl, Zhenquan Jia
Summary: The effectiveness of carbon nanodots in preventing brain lipid peroxidation was evaluated in this study. The results showed that carbon nanodots performed well in preventing oxidative stress and lipid peroxidation, without any negative effects on normal mice. This suggests that carbon nanodots may be a safe and effective nanomaterial for combating the harmful effects caused by lipid peroxidation.
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Article
Biochemistry & Molecular Biology
Siu Leung Chau, Aihua Zhao, Wei Jia, Lu Wang
Summary: This study presents a method for rapidly detecting pesticide residues and mycotoxins in Pu-erh tea. The results showed no pesticide residues and mycotoxins detected in the collected samples, all of which were below the legal limits.
Article
Nutrition & Dietetics
Hung N. Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E. Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E. Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C. Clemente, Jian-Min Yuan
Summary: The study found that colorectal advanced adenoma is associated with alterations in ileal juice bile acids. The concentrations of hyodeoxycholic acid (HCA) species in ileal juice were significantly higher in advanced adenoma patients compared to controls. The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for quantifying ceramides and dihydroceramides in animal tissues has been developed. The results indicate significant differences in ceramide and dihydroceramide levels between liver and small intestine tissues, which may be related to the compositional features of ceramides.
ANALYTICAL BIOCHEMISTRY
(2023)
