期刊
NEUROTOXICOLOGY AND TERATOLOGY
卷 33, 期 5, 页码 598-602出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ntt.2011.07.005
关键词
Toll-like receptor; Toluene; Hippocampus; Mice
资金
- Ministry of Education, Culture, Sports, Sciences and Technology, Japan [21390198]
- Grants-in-Aid for Scientific Research [21390198] Funding Source: KAKEN
The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the hippocampi were examined using real-time RT-PCR and an immunohistochemical analysis. In C3H/HeN mice, the relative mRNA expression levels of TLR4 and NF-kappa B activating protein were significantly up-regulated in the groups exposed to toluene, but not in the C3H/HeJ mice. Heat shock protein 70, a possible endogenous ligand for TLR4, mRNA was increased in the C3H/HeN mice exposed to toluene. This is the first report to show that TLR4 may have a role in the neurotoxic effects in mice exposed to toluene. (C) 2011 Elsevier Inc. All rights reserved.
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