Article
Environmental Sciences
Dongying Yan, Liang Gao, Jing Lang, Xianhui Gao, Honglin Ma
Summary: Excessive exposure to manganese can lead to neurological diseases characterized by behavioral and motor impairments. Microglia-mediated neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. SIRT1, PGC-1 alpha, NF-kappa B, and STAT3 are important factors in the regulation of neuroinflammatory responses and microglial polarization in mice exposed to manganese.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Immunology
Xiao-Long Wang, Fei Chen, Hui Shi, Man Zhang, Lin Yan, Xiu-Ying Pei, Xiao-Dong Peng
Summary: The study revealed that OMT can regulate the polarization of microglia towards the M2 phenotype by inhibiting the TLR4/NF-Kappa B signaling pathway, effectively attenuating the LPS-induced inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Haijian Wu, Jingwei Zheng, Shenbin Xu, Yuanjian Fang, Yingxi Wu, Jianxiong Zeng, Anwen Shao, Ligen Shi, Jianan Lu, Shuhao Mei, Xiaoyu Wang, Xinying Guo, Yirong Wang, Zhen Zhao, Jianmin Zhang
Summary: Mer plays an important role in regulating microglial/macrophage M1/M2 polarization and neuroinflammation following TBI, potentially serving as a therapeutic target for intervention. Activation of the STAT1/SOCS1/3 pathway by Mer contributes to its regulatory function in this process.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biology
Minna Christiansen Lund, Ditte Gry Ellman, Maiken Nissen, Pernille Sveistrup Nielsen, Pernille Vinther Nielsen, Carina Jorgensen, Ditte Caroline Andersen, Han Gao, Roberta Brambilla, Matilda Degn, Bettina Hjelm Clausen, Kate Lykke Lambertsen
Summary: The neuroinflammatory response is a critical event in spinal cord injury, and tumor necrosis factor (TNF) plays a key role in this process. The expression of TNF and its receptors TNFR1 and TNFR2 were studied in mice after SCI, and it was found that TNF expression increased in both the acute and delayed phases. This study also found that diminishing detrimental immune signaling after SCI could enhance recovery in humans.
Article
Neurosciences
Chin-Hung Hsu, Yi-Ju Pan, Yin-Ting Zheng, Raymond Y. Lo, Feng-Yi Yang
Summary: This study investigated the effects of low-intensity pulsed ultrasound (LIPUS) on M1/M2 polarization of microglial cells and the regulatory mechanisms associated with signaling pathways. The results showed that LIPUS treatment attenuated inflammatory markers and enhanced M2-related markers, switching microglial cells from the M1 to the M2 phenotype.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Geriatrics & Gerontology
Shenrui Guo, Hui Wang, Yafu Yin
Summary: Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases, and microglia can be categorized into M1 and M2 types with opposite functions. Modulating microglia M1/M2 polarization shows promising therapeutic potential in neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Yu Chen, Fu Peng, Chao Yang, Huan Hou, Ziwei Xing, Junren Chen, Li Liu, Cheng Peng, Dan Li
Summary: This study reveals that 2,3,5,6-tetramethylpyrazine mitigates lipopolysaccharide-induced neuroinflammation via the SIRT1/NF-kappa B signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Federica Armeli, Beatrice Mengoni, Elisa Maggi, Cristina Mazzoni, Adele Preziosi, Patrizia Mancini, Rita Businaro, Thomas Lenz, Trevor Archer
Summary: Microglial cell polarization and gut microbial imbalance are associated with neurodegenerative diseases. The gut-brain axis is important, and probiotic treatment can reduce inflammation. Milmed yeast can reverse microglial cell polarization and promote anti-inflammatory response.
Article
Cell Biology
Yicong Wei, Jianxiong Chen, Guo-En Cai, Wei Lu, Wei Xu, Ruiguo Wang, Yu Lin, Chengzi Yang
Summary: The study found that rosmarinic acid can inhibit microglial polarization to the M1 phenotype and promote polarization to the M2 phenotype under conditions of neuroinflammation. An increase in mitochondrial respiration and metabolic reprogramming are necessary for this process. Additionally, the study suggests that regulation of HIF expression through the PDPK1/Akt/mTOR pathway by rosmarinic acid may offer a potential therapeutic approach for inhibiting neuroinflammation by modulating microglial M1/M2 polarization.
Article
Biochemistry & Molecular Biology
Liu Yun-Jia, Chen Xi, Zhang Jie-Qiong, Zhu Jing-Yi, Lin Sen, Ye Jian
Summary: The study found that levels of Sema3A in the retina increased after optic nerve crush (ONC), and inhibition of Sema3A activity may be a novel approach to prevent RGC apoptosis.
CELL AND BIOSCIENCE
(2021)
Article
Food Science & Technology
Ning Zhang, Li Jin, Chunhong Liu, Ruiyan Zhang, Hans-Christian Siebert, Yanhui Li, Gabriele Loers, Athanasios K. Petridis, Zhangyong Xia, Huijun Dong, Xuexing Zheng
Summary: Krill oil (KO) demonstrates neuroprotective effects in mice with CPZ-induced demyelination possibly through modulation of the HDAC3/STAT3/NF-kappa B signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Yehao Zhang, Lan Miao, Qing Peng, Xiaodi Fan, Wenting Song, Bin Yang, Peng Zhang, Guangyu Liu, Jianxun Liu
Summary: The study demonstrates that Parthenolide (PTL) can regulate neuroinflammation and protect against ischemic brain injury by modulating microglial polarization via the RhoA/ROCK pathway.
Article
Biochemistry & Molecular Biology
Chaoming Liu, Song Liu, Lijiao Xiong, Limei Zhang, Xiao Li, Xingling Cao, Jinhua Xue, Liangdong Li, Cheng Huang, Zhihua Huang
Summary: The study demonstrated that GSS protected against brain injury in ischemic stroke by reducing microglial M1 depolarization to suppress neuroinflammation in peri-infarcted brain regions through upregulating alpha 7nAChR and thereby inhibition of NF-KB signaling. This finding reveals a potential molecular mechanism for GSS treatment in ischemic stroke.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Fatima El Idrissi, Bernard Gressier, David Devos, Karim Belarbi
Summary: The study identified 94 proteins significantly associated with neuroinflammation in Alzheimer's disease, with IL4, IL10, and other signaling pathways playing key roles. Key regulators such as IL10 and TLR4 were found to control immune processes, regulated by 63 microRNAs dysregulated in Alzheimer's disease, and targetable by various compounds. This research may help prioritize diagnostic biomarkers and develop effective therapeutic strategies against neuroinflammation in Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Manuela Leri, Marzia Vasarri, Federica Carnemolla, Francesco Oriente, Serena Cabaro, Maria Stio, Donatella Degl'Innocenti, Massimo Stefani, Monica Bucciantini
Summary: In Alzheimer's disease, microglia become chronically inflammatory and neurotoxic. Genetic variants of molecules like TREM2 increase the risk of developing AD. This study explored the protective effects of extra virgin olive oil polyphenols on neuronal and microglial cells, finding that they reduce pro-inflammatory cytokines, activate the anti-inflammatory pathway, and enhance microglial activity. These findings offer important insights into the mechanisms by which olive polyphenols alleviate neuroinflammation and neuronal impairment.
Review
Pharmacology & Pharmacy
Ruben Orihuela, Christopher A. McPherson, Gaylia Jean Harry
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Toxicology
Steven T. Szabo, G. Jean Harry, Kathleen M. Hayden, David T. Szabo, Linda Birnbaum
TOXICOLOGICAL SCIENCES
(2016)
Article
Neurosciences
Andrew D. Kraft, Christopher A. McPherson, G. Jean Harry
NEUROTOXICITY RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Valeria Avdoshina, Seamus P. Caragher, Erin D. Wenzel, Francesca Taraballi, Italo Mocchetti, Gaylia Jean Harry
JOURNAL OF NEUROCHEMISTRY
(2017)
Retraction
Immunology
Jagadeesh Sridhara Rao, Hyung-Wook Kim, Matthew Kellom, Dede Greenstein, Mei Chen, Andrew David Kraft, Gaylia Jean Harry, Stanley Isaac Rapoport, Mireille Basselin
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Neurosciences
David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, G. Jean Harry
Article
Behavioral Sciences
David R. Goulding, Viktoriya D. Nikolova, Lopa Mishra, Lisheng Zhuo, Koji Kimata, Sandra J. McBride, Sheryl S. Moy, G. J. Harry, Stavros Garantziotis
GENES BRAIN AND BEHAVIOR
(2019)
Article
Neurosciences
Christopher A. McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S. Brar, Ralph Wilson, Amy Brix, Catherine Picut, G. Jean Harry
NEUROTOXICITY RESEARCH
(2018)
Article
Multidisciplinary Sciences
Kelvin Yen, Junxiang Wan, Hemal H. Mehta, Brendan Miller, Amy Christensen, Morgan E. Levine, Matthew P. Salomon, Sebastian Brandhorst, Jialin Xiao, Su-Jeong Kim, Gerardo Navarrete, Daniel Campo, G. Jean Harry, Valter Longo, Christian J. Pike, Wendy J. Mack, Howard N. Hodis, Eileen M. Crimmins, Pinches Cohen
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
David R. Goulding, Andrew Kraft, Peter R. Mouton, Christopher A. McPherson, Valeria Avdoshina, Italo Mocchetti, G. Jean Harry
NEUROTOXICITY RESEARCH
(2019)
Article
Environmental Sciences
Christine Bowen, Gabrielle Childers, Caroline Perry, Negin Martin, Christopher A. McPherson, Tatlock Lauten, Janine Santos, G. Jean Harry
Review
Biochemistry & Molecular Biology
Gaylia Jean Harry
Summary: Changes in microglia are commonly associated with neurodegeneration, but it is not clear if they initiate the process. Communication between microglia and neurons helps maintain the cells in a surveillance state, suggesting a partnership role rather than an initiating one in neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Gabrielle M. Childers, Caroline A. Perry, Barbara Blachut, Negin Martin, Carl D. Bortner, Stella Sieber, Jian-Liang Li, Michael B. Fessler, G. Jean Harry
Summary: The study investigated the role of mitochondrial toxicants in inflammasome activation and IL-1β processing in murine macrophages. Results showed that mitochondrial toxicants induced inflammasome activation, suppressed mitochondrial bioenergetics and ROS production, and impacted the transcriptional response of macrophages, potentially leading to suppressed host defense.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Meeting Abstract
Neurosciences
G. J. Harry
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
G. J. Harry, C. Perry, C. McPherson
JOURNAL OF NEUROCHEMISTRY
(2017)