Article
Medicine, General & Internal
Stefan Evers, Alexandra Buchheister, Doris Reichelt, Ingo W. Husstedt, Achim Frese
Summary: This study investigated the efficacy and safety of BTX treatment in HIV-infected patients. The results showed that BTX treatment was effective and well-tolerated in long-term use, with no interaction with antiretroviral treatment. Therefore, BTX treatment can be considered as an additional therapeutic option for HIV-infected patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Food Science & Technology
Andre Lee, Jabreel Al-Sarea, Eckart Altenmuller
Summary: The study found that for patients with musician's dystonia, BoTX dosage and inter-injection intervals show nonlinear changes with treatment duration, while the number of injected muscles continues to increase. Two distinct subgroups were identified, with the low-BoTX group showing improvement in symptoms with continued treatment. This indicates a potential relationship between treatment response and BoTX dosages in patients with task-specific dystonias.
Article
Clinical Neurology
Martina Petracca, Maria Rita Lo Monaco, Tamara Ialongo, Enrico Di Stasio, Maria Luana Cerbarano, Loredana Maggi, Alessandro De Biase, Giulia Di Lazzaro, Paolo Calabresi, Anna Rita Bentivoglio
Summary: Botulinum toxin A (BoNT/A) is a first-line treatment for idiopathic cervical dystonia (ICD), but there is limited data on its effectiveness for acquired cervical dystonia (ACD). This long-term follow-up study showed that all serotypes of BoNT have lasting efficacy and safety in treating ACD, even after 25 years of repeated treatments.
JOURNAL OF NEUROLOGY
(2023)
Article
Food Science & Technology
Harald Hefter, Isabelle Schomaecker, Max Schomaecker, Dietmar Rosenthal, Sara Samadzadeh
Summary: This study investigated the impact of the disease course of idiopathic cervical dystonia (CD) on the long-term outcomes of botulinum toxin therapy before treatment initiation. It found that younger age at onset of symptoms was associated with shorter time to therapy, and there were correlations between disease course and treatment effectiveness.
Review
Food Science & Technology
Urban M. Fietzek, Devavrat Nene, Axel Schramm, Silke Appel-Cresswell, Zuzana Kosutzka, Uwe Walter, Joerg Wissel, Steffen Berweck, Sylvain Chouinard, Tobias Baeumer
Summary: Visualization of the human body, especially through the use of ultrasound (US) imaging, has become a well-established procedure for botulinum toxin therapy in people with cervical dystonia (CD). This technique allows safe injection of relevant muscles under visual US guidance and provides personalized treatment for patients with CD.
Article
Neurosciences
Michal Marciniec, Anna Szczepanska-Szerej, Ewa Papuc, Konrad Rejdak
Summary: Cervical pain is a common non-motor symptom of cervical dystonia (CD) that affects a majority of patients. This study found that cervical pain may increase the severity of muscular symptoms and disease-related disability. Botulinum toxin has a noticeable antinociceptive effect in the long-term treatment of CD.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Lena C. O'Flynn, Kristina Simonyan
Summary: This study investigated the short-term and long-term effects of BoNT treatment on brain function in patients with LD. The results suggest that BoNT-treated patients who benefited from the treatment had reduced activity in the left precuneus compared to untreated patients and patients who did not benefit from the treatment. Additionally, BoNT-treated patients with adductor LD showed decreased activity in the right thalamus, while patients with abductor LD showed reduced activity in the left inferior frontal cortex. There were no significant differences in brain activity between patients with shorter and longer treatment durations. However, patients with intermediate treatment duration of 6-12 years showed reduced activity in the right cerebellum and right prefrontal cortex compared to patients with shorter treatment duration.
Article
Clinical Neurology
Harald Hefter, Beyza Urer, Raphaela Brauns, Dietmar Rosenthal, Sven G. Meuth, John-Ih Lee, Philipp Albrecht, Sara Samadzadeh
Summary: The study aims to demonstrate that significant improvement can be observed in patients with STF after switching to incoBoNT/A, and that continuing ABO- or onaBoNT/A treatment in NAB-positive patients without STF does not lead to significant worsening.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
John-Ih Lee, Alexander Jansen, Sara Samadzadeh, Ulrike Kahlen, Marek Moll, Marius Ringelstein, Giulia Soncin, Hans Bigalke, Orhan Aktas, Alexia-Sabine Moldovan, Julia Waskoenig, Sebastian Jander, Michael Gliem, Alfons Schnitzler, Hans-Peter Hartung, Harald Hefter, Philipp Albrecht
Summary: The study aimed to analyze adherence and self-perceived treatment response to long-term BoNT-A treatment in different neurological indications. Results showed that therapy adherence and self-perceived symptom reduction were significantly longer in BSP, HFS, and CD patients compared to ODT and SPAS patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Food Science & Technology
Mariam Hull, Mered Pames, Joseph Jankovic
Summary: Opisthotonus is a condition characterized by abnormal trunk extension and arching due to excessive contractions of the paraspinal muscles. It is most commonly seen in children with dystonia secondary to hypoxic injury or other acquired and genetic causes. Treatment options include oral medications, muscle injections, and deep brain stimulation, although management in the pediatric population has not been systematically reviewed.
Article
Food Science & Technology
Elina Zakin, David M. Simpson
Summary: Task-specific focal dystonia is characterized by abnormal muscle contractions during specific tasks, such as writing or playing music. Treatment options are limited and often involve botulinum toxin injections. Studies show that a majority of patients experience improvement from toxin injections, but targeting specific muscles effectively remains a challenge for ongoing research.
Review
Clinical Neurology
Dirk Dressler, Fereshte Adib Saberi, Raymond L. Rosales
Summary: Botulinum toxin is widely used to treat muscle hyperactivity syndromes, with dystonia being one of the key indications. The peripheral paresis produced by BT injections into dystonic muscles is localized, controllable, and lasts around 3 months. Adverse effects are transient and mild, making long-term application safe and effective.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Review
Food Science & Technology
Supriyo Choudhury, Mark R. Baker, Suparna Chatterjee, Hrishikesh Kumar
Summary: Botulinum toxin has evolved from a treatment for strabismus to the first-line treatment for focal dystonia, with at least six FDA-approved formulations available for diverse indications. These formulations have varying toxo-pharmacological properties and should not be used interchangeably. Synthetic and non-clostridial sources of BoNT are also nearing clinical use, and studies on mutations in natural toxins have led to modifications in the toxo-pharmacokinetic properties of BoNTs.
Review
Food Science & Technology
Bahman Jabbari, Samira Marie Comtesse
Summary: This review provides an up-to-date literature account on the efficacy of Botulinum toxin treatment for common motor disorders of Parkinson Disease. The reviewed disorders include tremor, focal foot dystonia, rigidity, and freezing of gait (FOG) in PD. The Yale method in the USA and Western University method in Canada offer efficacy with low incidence of side effects for Parkinson tremor. Botulinum toxin injections into toe flexors are effective in alleviating foot dystonia of PD. Improvement of Parkinson rigidity after botulinum toxin injection is suggested, but further larger clinical trials are needed for conclusive evidence. Improvement in FOG reported in open label studies needs confirmation in blinded investigations with potential adjustments in injection plan and dosage.
Review
Food Science & Technology
Merete Bakke
Summary: The review discusses the medical treatments using botulinum neurotoxin in the orofacial region, focusing on dystonia and sialorrhea as the most common and safest indications for dentists. It emphasizes the importance of accurate diagnosis, precise injection targeting, measuring treatment effect, and oral health control to prevent side effects.
Review
Neurosciences
Sara Pietracupa, Matteo Bologna, Silvia Tommasin, Alfredo Berardelli, Patrizia Pantano
Summary: This systematic review highlights the role of MRI in identifying the structural abnormalities associated with motor and non-motor symptoms in essential tremor (ET), particularly focusing on cerebellar damage and connectivity alterations between the cerebellum and various cortical areas. Many studies found an association between MRI findings and non-motor symptoms in ET patients.
Article
Clinical Neurology
Daniele Belvisi, Marco Canevelli, Matteo Costanzo, Margherita Giangrosso, Andrea Fabbrini, Andrea Borraccino, Giuseppe Bruno, Alfredo Berardelli, Giovanni Fabbrini
Summary: The study revealed that frailty in PD patients is associated with both motor and non-motor symptoms, with frail patients exhibiting more severe motor symptoms, higher global burden of non-motor symptoms, and pronounced cognitive deficits. The associations between frailty and symptom severity remained significant even after accounting for traditional predictors of PD severity.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Michele Tinazzi, Mirta Fiorio, Alfredo Berardelli, Bruno Bonetti, Domenico Marco Bonifati, Alessandro Burlina, Annachiara Cagnin, Francesca Calabria, Maurizio Corbetta, Pietro Cortelli, Bruno Giometto, Silvia Vittoria Guidoni, Leonardo Lopiano, Gianluigi Mancardi, Fabio Marchioretto, Maria Pellegrini, Francesco Teatini, Gioacchino Tedeschi, Lucia Tesolin, Emanuele Turinese, Mario Zappia, Angela Marotta
Summary: The study investigated Italian neurologists' knowledge and clinical experience in managing patients with Functional Neurological Disorders (FND). Results showed that neurologists preferred using the term FND over other psychological or descriptive terms when communicating with patients, and were more inclined to refer patients to psychologists rather than psychiatrists. Some believed in the usefulness of physiotherapy and psychiatric interventions, while others thought patients may simulate their symptoms. Overall, the study suggests that understanding of scientific advances in FND is somewhat lacking, and there is a need for professional education to improve patient management.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Gina Ferrazzano, Daniele Belvisi, Maria Ilenia De Bartolo, Viola Baione, Matteo Costanzo, Giovanni Fabbrini, Giovanni Defazio, Alfredo Berardelli, Antonella Conte
Summary: The study found that 75% of patients with isolated head tremor developed cervical dystonia 5 years later, while 25% still only had isolated head tremor. There was no significant change in head tremor severity between baseline and the 5-year follow-up.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Andrea Mastrangelo, Angela Mammana, Simone Baiardi, Dorina Tiple, Elisa Colaizzo, Marcello Rossi, Luana Vaianella, Barbara Polischi, Michele Equestre, Anna Poleggi, Sabina Capellari, Anna Ladogana, Piero Parchi
Summary: The introduction of the Real-Time Quaking-Induced Conversion assay has led to a revision of the diagnostic criteria for sporadic Creutzfeldt-Jakob disease. This study compares the diagnostic value of the old and amended criteria and explores different combinations of clinical variables and biomarker results. The results show that CSF RT-QuIC is highly sensitive and specific for diagnosing CJD, and the Q-CM criteria provide a high diagnostic value.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Giulia Paparella, Martina De Riggi, Antonio Cannavacciuolo, Donato Colella, Davide Costa, Daniele Birreci, Massimiliano Passaretti, Luca Angelini, Andrea Guerra, Alfredo Berardelli, Matteo Bologna
Summary: Through a study involving 33 healthy subjects, it was found that unilateral motor practice leads to improved performance of both the trained and untrained contralateral limbs. The transfer of this skill is asymmetric and relates to the modulation of specific inhibitory interhemispheric connections.
Review
Pharmacology & Pharmacy
Carlo Rossi, Nicole Campese, Carlo Colosimo
Summary: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by pathological tau protein build-up, but there is limited consensus on clinical criteria. The clinical features include cognitive, behavioral, and motor symptoms, with similarities to other tauopathies. This narrative review examines possible treatment options for CTE based on similarities with other neurodegenerative disorders.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Matteo Bologna, Alberto J. Espay, Alfonso Fasano, Giulia Paparella, Mark Hallett, Alfredo Berardelli
MOVEMENT DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Marina Giuliano, Dorina Tiple, Piergiuseppe Agostoni, Benedetta Armocida, Ludovico Biardi, Anna Rita Bonfigli, Andrea Campana, Maria Ciardi, Fabiano Di Marco, Marco Floridia, Paola Gnerre, Tiziana Grassi, Ignazio Grattagliano, Paola Kruger, Matilde Leonardi, Rocco Liguori, Elisabetta Pagani, Elisa Perger, Flavia Pricci, Marinella Ruggeri, Andrea Silenzi, Francesco Spannella, Carlo Tascini, Giulia Tete, Matteo Tosato, Simona Vecchi, Marika Villa, Graziano Onder
Summary: A significant number of people experience persistent or new symptoms after acute SARS-CoV-2 infection, known as Long-COVID. In Italy, dedicated health facilities were established for the management of Long-COVID, but there is significant variation in the services provided. To address this, a multidisciplinary panel was formed to create recommendations for the clinical management of Long-COVID.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Luca Marsili, Jennifer Sharma, Tiago Fleming Outeiro, Carlo Colosimo
Summary: Stem cell-based therapies (SCT) have potential in treating neurodegenerative disorders, but clinical trials are just starting and results may take several years. SCTs can provide both symptomatic and disease-modifying effects, and may complement molecular therapies in precision medicine.
Review
Biochemistry & Molecular Biology
Luca Marsili, Samuel Marcucci, Joseph LaPorta, Martina Chirra, Alberto J. Espay, Carlo Colosimo
Summary: Paraneoplastic neurological syndromes (PNS) can manifest as various clinical syndromes of the central nervous system. Early diagnosis and treatment are crucial for improving the long-term outcome of these conditions.
Article
Clinical Neurology
Matteo Costanzo, Carolina Cutrona, Giorgio Leodori, Maria Ilenia De Bartolo, Andrea Fabbrini, Giorgio Vivacqua, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Daniele Belvisi
Summary: This study aimed to characterize the clinical features of upper limb tremor during walking (TW) in Parkinson's disease (PD) patients. TW was found to be a frequent sign in PD patients, and its distribution and severity were similar to rest and re-emergent tremor but different from postural tremor. TW may be considered as a clinical variant of rest tremor.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Katerina Mensikova, John C. Steele, Raymond Rosales, Carlo Colosimo, Peter Spencer, Annie Lannuzel, Yoshikazu Ugawa, Ryogen Sasaki, Santiago Gimenez-Roldan, Radoslav Matej, Lucie Tuckova, Dominik Hrabos, Kristyna Kolarikova, Radek Vodicka, Radek Vrtel, Miroslav Strnad, Petr Hlustik, Pavel Otruba, Martin Prochazka, Martin Bares, Susana Boluda, Luc Buee, Gerhard Ransmayr, Petr Kanovsky
Summary: Endemic parkinsonism refers to diseases that occur in specific locations or populations. Different clusters of endemic parkinsonism exist in different geographic regions, and their persistence or disappearance is determined by genetic or environmental factors. Studying these diseases helps to understand the mechanisms of neurodegenerative diseases and provides direction for future research.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Clinical Neurology
A. Conte, N. De Stefano, A. Nicoletti, V. Caso, M. Mancuso, Alfredo Berardelli, G. Defazio
Summary: According to the analysis, Italian neurological research ranks fifth globally and third in Europe from 2020 to 2023.
NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Clinical Neurology
Richard M. Camicioli, Carlo Colosimo
Summary: This study examined the association between different NPS profiles and the risk of cognitive decline in PD-MCI patients, which is of great importance for the diagnosis and management of PD-MCI patients.