Article
Anesthesiology
Jiajia Ma, Wei Xiong, Dongze Guo, Anxin Wang, Hui Qiao, Ruquan Han
Summary: The study compares the effect of sevoflurane-propofol-balanced anesthesia with propofol-based total intravenous anesthesia on the amplitude of FVEP during spine surgery. The results show that the effect of sevoflurane-propofol-balanced anesthesia on FVEP amplitude is noninferior to propofol-based TIVA under comparable BIS range.
ANESTHESIA AND ANALGESIA
(2022)
Review
Biochemistry & Molecular Biology
Tibor M. M. Brunt, Wim van den Brink, Jan van Amsterdam
Summary: The recreational use of nitrous oxide (N2O) has been increasing and has resulted in more cases of intoxication. Heavy, frequent, and chronic use of N2O carries significant health risks, including the inactivation of cobalamin and the development of various neurological disorders. The addictive properties of N2O and its underlying mechanism of action remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xia Li, Yali Liu, Chengjun Li, Jiexue Wang
Summary: This study found through meta-analysis that nitrous oxide inhalation is an effective sedative and analgesic treatment during tooth extraction, and oral midazolam can be used as an alternative to nitrous oxide inhalation.
Article
Immunology
Tao Jiang, Shoucai Xu, Yangyang Shen, Yong Xu, Yuwen Li
Summary: Genistein can alleviate isoflurane-induced neuroinflammation and apoptosis in rats and BV2 cells, and exerts protective effects by inhibiting TLR4-mediated microglial inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Neurosciences
Yuanyuan Xiang, Lei Li, Xiaotong Ma, Shan Li, Yuan Xue, Peng Yan, Meijie Chen, Junwei Wu
Summary: Nitrous oxide, also known as laughing gas, is a colorless, nonirritating gas widely used in clinical settings as an anesthetic and analgesic. Recreational abuse of N2O is increasing among young adults, with many unaware of the potential side effects. Abuse of N2O can damage the nervous system, with discontinuation and timely supplementation with vitamin B12 essential for a good prognosis.
NEUROTOXICITY RESEARCH
(2021)
Article
Cell Biology
Yanqiong Wu, Zeyong Yang, Shanchun Su, Xueqin Xu, Yang Li, Xiaohui Li, Yan Gao, Dongsheng Sun, Shengjun Wan, Mingjin Pen, Weiling Jin, Changbin Ke
Summary: This study reveals that repeated early-life exposure to anesthetics can disrupt neurodevelopment and affect social behaviors. The m6A modification plays a crucial role in this process, and anesthetics lead to persistent alterations in protein expression and brain function.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hiroyuki Saito, Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Yoshio Nunoi, Ai Goto, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Kiyotaka Hoshiai, Yasuki Akie, Atsushi Sugiyama
Summary: The study compared the electrocardiographic responses induced by dl-sotalol in intact dogs under different anesthetic states, revealing differences in sympathetic nerve suppression between halothane and isoflurane with nitrous oxide. Both anesthetics exhibited similar effects on ventricular ion channel inhibition, but differed in their influence on the atrioventricular node.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Stefan Maksimovic, Nemanja Useinovic, Nidia Quillinan, Douglas F. Covey, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Summary: Recent research suggests that early exposure to general anesthetics can cause widespread neurodegeneration in the young brain, resulting in neuronal loss and disturbances in neuronal communication. These effects are associated with long-term impairments in cognitive-affective domains. Therefore, finding safe alternatives is an important concern.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hui Gao, Ruihan Wang, Yan Zeng, Linyuan Qin, Hanlin Cai, Dong Zhou, Qin Chen
Summary: A retrospective study of 20 hospitalized patients found that the recreational use of nitrous oxide (N2O) is associated with severe neurological impairments. Common symptoms included unsteady gait, weakness, and limb paresthesia, while decreased deep tendon reflexes, reduced muscle strength, and impaired coordination were frequently observed. Factors such as admission from the emergency room, decreased hemoglobin, decreased red blood cell count, and increased mean corpuscular volume were positively correlated with the degree of neurological impairment.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medicine, General & Internal
Angela L. Chiew, Jacques E. Raubenheimer, Ingrid Berling, Nicholas A. Buckley, Therese Becker, Betty Chan, Jonathan Brett
Summary: This study reports a series of cases with symptomatic chronic N2O use, many of whom experienced ongoing neurological sequelae. The study also found a sharp increase in internet searches for obtaining N2O canisters. Education about the long-term sequelae is important, particularly for high-risk student groups.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Geosciences, Multidisciplinary
Weiyi Tang, Amal Jayakumar, Xin Sun, John C. Tracey, Julia Carroll, Elizabeth Wallace, Jenna A. Lee, Levy Nathan, Bess Ward
Summary: The study found that N2O consumption rates are high in the seasonally anoxic environment of Chesapeake Bay, but generally undetectable in oxygenated waters. However, when the oxygen concentration was reduced in oxygenated samples, N2O consumption rates increased significantly, indicating the potential for N2O consumption in oxygenated environments. These new observations provide insights into N2O cycling processes and can be used to improve the modeling of N2O flux in estuaries.
GEOPHYSICAL RESEARCH LETTERS
(2022)
Article
Behavioral Sciences
Xin-Li Xiao, Jing-Tao Wu, Han-Ze Zhang, Yi-Di Wang, Jing-Qiao Zhang, Le-Fan Liu, Yu-Chen, Min-Li, Peng-Bo Yang, Xiao-Lin Wu, Jian-Xin Liu
Summary: The study showed that isoflurane exposure significantly reduced the numbers of nascent cells (1 day old) and mature neurons (42 days old), but had no effect on the immature (8 days old) and early mature neurons (8 and 21 days old, respectively) originated from the tertiary dentate matrix in mice.
BRAIN AND BEHAVIOR
(2021)
Article
Environmental Sciences
Todd S. Rosenstock, Andreas Wilkes
Summary: Improving agricultural activity data is a cost-effective option for reducing the uncertainty of greenhouse gas inventories and monitoring mitigation actions, meeting multiple national data needs, and bolstering investments. It's time to direct effort to this opportunity.
NATURE CLIMATE CHANGE
(2021)
Article
Agronomy
Do-Yeong Hur, Sung-Un Kim, Hyeon-Cheol Park, Keun-Ki Kim, Hong-Ju Son, Kwang-Min Lee, Yu-Jin Kim, Chang-Oh Hong
Summary: The study found that the application of bottom ash (BA) can reduce N2O emissions from upland arable soil and increase crop yield. With increasing BA application rates, N2O emissions decreased significantly and yield-scaled N2O emissions also decreased. The study suggests that an application rate of 200 Mg·ha(-1) of BA can reduce N2O emissions.
Article
Cell Biology
Pengfei Liu, Jing Yuan, Yetong Feng, Xin Chen, Guangsuo Wang, Lei Zhao
Summary: This study reveals that isoflurane induces ferroptosis in a dose-dependent and time-dependent manner in the hippocampus, affecting learning and memory abilities. The ferroptosis induced by isoflurane can be rescued by ferroptosis inhibitor (ferrostatin-1) and mitochondria activator (dimethyl fumarate), showing effective therapeutic action against isoflurane-induced learning and memory impairment.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Guangfu Wang, Genrieta Bochorishvili, Yucai Chen, Kathryn A. Salvati, Peng Zhang, Steve J. Dubel, Edward Perez-Reyes, Terrance P. Snutch, Ruth L. Stornetta, Karl Deisseroth, Alev Erisir, Slobodan M. Todorovic, Jian-Hong Luo, Jaideep Kapur, Mark P. Beenhakker, J. Julius Zhu
GENES & DEVELOPMENT
(2015)
Article
Neurosciences
N. Lunardi, A. Oklopcic, M. Prillaman, A. Erisir, V. Jevtovic-Todorovic
MOLECULAR NEUROBIOLOGY
(2015)
Article
Neurosciences
Wataru Ito, Alev Erisir, Alexei Morozov
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Clinical Neurology
Jacob A. Irwin, Alev Erisir, Inchan Kwon
CURRENT ALZHEIMER RESEARCH
(2016)
Article
Peripheral Vascular Disease
Junlan Yao, David McHedlishvili, William E. McIntire, Nick A. Guagliardo, Alev Erisir, Craig A. Coburn, Vincent P. Santarelli, Douglas A. Bayliss, Paula Q. Barrett
Article
Neurosciences
Rachel W. Schecter, Erin E. Maher, Christina A. Welsh, Beth Stevens, Alev Erisir, Mark F. Bear
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
L. Wang, M. Kloc, E. Maher, A. Erisir, A. Maffei
Article
Neurosciences
Stephen L. Holtz, Anqi Fu, Wyatt Loflin, James A. Corson, Alev Erisir
JOURNAL OF COMPARATIVE NEUROLOGY
(2015)
Article
Neurosciences
Chengsan Sun, Jianli Sun, Alev Erisir, Jaideep Kapur
NEUROBIOLOGY OF DISEASE
(2014)
Article
Neurosciences
Victoria Sanchez, Anousheh Bakhti-Suroosh, Andrew Chen, Darlene H. Brunzell, Alev Erisir, Wendy J. Lynch
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Charles Campbell, Sarah Lindhartsen, Adam Knyaz, Alev Erisir, Marc Nahmani
Article
Neurosciences
Erin E. Maher, McKenzie E. Prillaman, Elif N. Keskinoz, Heywood M. Petry, Alev Erisir
Summary: This study examined the synaptic inputs in the VPMP of tree shrews, finding similarities to nonchemical sensory thalamic nuclei. It revealed that all primary sensory thalamic nuclei in higher mammals share a structural template for processing sensory information. However, significant morphological and molecular differences in taste nuclei between rodents and tree shrews suggest fundamental divergence in cellular processing mechanisms for taste input between these two species.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Aygul Balcioglu, Rebecca Gillani, Michael Doron, Kendyll Burnell, Taeyun Ku, Alev Erisir, Kwanghun Chung, Idan Segev, Elly Nedivi
Summary: This study investigates the synaptic connections between thalamus and visual cortex neurons in mice, revealing sparse, small, and heterogeneous distribution. The findings suggest that a few neurons can reliably decode visual input from the thalamus. The study provides important insights into the processing of sensory information in the brain.
NATURE NEUROSCIENCE
(2023)
Article
Immunology
Chengsan Sun, Shuqiu Zheng, Justin S. A. Perry, Geoffrey T. Norris, Mei Cheng, Fanzhen Kong, Rolf Skyberg, Jianhua Cang, Alev Erisir, Jonathan Kipnis, David L. Hill
Summary: Microglia play a crucial role in the refinement of central gustatory circuits during normal postnatal development. This process can be disrupted by restricting the mother's dietary sodium intake in the early prenatal period, when microglia progenitors migrate from the yolk sac to the brain. The pruning of gustatory terminal fields in the nucleus of the solitary tract (NST) is driven by NaCl-elicited taste activity and involves the complement system. Offspring of mothers with a low NaCl diet fail to prune the gustatory terminal fields, despite normal peripheral taste activity. However, the ability to prune can be rescued by activating myeloid cells postnatally.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Anatomy & Morphology
Angela D. Morris, Alev Erisir, Stacey J. Criswell, Sarah Kucenas
DEVELOPMENTAL DYNAMICS
(2017)