Article
Biochemistry & Molecular Biology
Dmitry Troshev, Dmitry Voronkov, Anastasia Pavlova, Denis Abaimov, Alexander Latanov, Tatiana Fedorova, Daniil Berezhnoy
Summary: This study describes the timecourse of motor and non-motor symptoms in a low-dose rotenone mouse model of Parkinson's disease. The study found that the pathology in this model is linked with metabolic changes, rather than with oxidative stress or tonic neurotransmitter release levels.
Article
Immunology
Marwa M. Khalaf, Mahmoud M. El-Sayed, Mohamed A. Kandeil, Sanaa Ahmed
Summary: Parkinson's disease (PD) drugs do not stop disease progression, so finding novel therapeutic medications to halt it is crucial. Research on antidiabetic medicines is valuable for this purpose, and in this study, the neuroprotective benefits of Dulaglutide (DUL) were investigated using the PD model Rotenone (ROT).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Hiroshi Tawarayama, Maki Inoue-Yanagimachi, Noriko Himori, Toru Nakazawa
Summary: Administration of the mitochondrial complex I inhibitor rotenone serves as a model for studying oxidative stress-related neural degeneration diseases. Glial cells play dual roles in retinal cell survival under rotenone-induced oxidative stress conditions, affecting gene expression and cell viability. Intravitreal administration of neurotrophin-5 can prevent rotenone-induced reduction of retinal ganglion cells and inner nuclear layer thickness in rats.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Kondeva-Burdina, Javor Mitkov, Iva Valkova, Lily Peikova, Maya Georgieva, Alexander Zlatkov
Summary: The neurotoxic, neuroprotective, and MAO-B inhibitory effects of a series of N'-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides were evaluated. Compounds N'-(2,3-dimethoxybenzylidene)-3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylthio)propanehydrazide (6k) and N'-(2-hydroxybenzylidene)-3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylthio)propanehydrazide (6l) were identified as the most promising. QSTR analysis revealed that reduced lipophilicity and smaller dipole moments of the molecules contribute to lower neurotoxicity. These findings provide initial information for the further design of (xanthinyl-8-ylthio)propanhydrazides with potential hMAOB inhibitory effect and pronounced neuroprotection.
Review
Cell Biology
Huijing Xue, Abhirami Thaivalappil, Kan Cao
Summary: Methylene blue, the first fully man-made medicine, has a wide range of clinical applications and its anti-oxidative properties have brought new attention to this century-old drug. It can bypass Complex I/III activity in mitochondria and diminish oxidative stress to some degree, making it applicable for treating age-related conditions.
Article
Ophthalmology
Bindu Kodati, Dorota L. Stankowska, Vignesh R. Krishnamoorthy, Raghu R. Krishnamoorthy
Summary: The study found that JNK2 plays a major role in endothelin-mediated loss of retinal ganglion cells in mice. The neuroprotective effects in JNK2(-/-) mice following ET-1 administration occur mainly in the soma and not in the axons of RGCs.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemical Research Methods
Pardis Kaynezhad, Robert Fosbury, Chris Hogg, Ilias Tachtsidis, Sobha Sivaprasad, Glen Jeffery
Summary: Continuous exposure to 420 nm blue light in the environment affects retinal mitochondrial metabolism and blood signals, leading to metabolic instability. The absorption characteristics of blue light may restrict respiration and ATP production.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Biochemistry & Molecular Biology
Matea Juric, Varun Rawat, Radhika Amaradhi, Jacek Zielonka, Thota Ganesh
Summary: In this study, a new Nox2 inhibitor, TG15-132, was discovered to prevent oxygen consumption and reactive oxygen species formation. It also showed inhibitory effects on the expression of inflammatory cytokines and iNOS. TG15-132 has a relatively long plasma half-life and excellent brain permeability, making it a potential neuroprotective agent. Furthermore, it does not exhibit toxicity on vital organs or blood biomarkers.
Article
Biochemistry & Molecular Biology
Lassi Koski, Elina Berntsson, Max Vikstrom, Sebastian K. T. S. Warmlander, Per M. Roos
Summary: This study aimed to investigate if ratios of different metal concentrations in cerebrospinal fluid (CSF) and blood plasma differ between ALS patients and healthy controls. The results showed that 53 metal ratios were significantly elevated in ALS cases, suggesting that metal ratios may be used as biomarkers in ALS diagnosis and guidelines for preventive measures.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Behavioral Sciences
Marta Mendez, Camino Fidalgo, Jorge L. Arias, Natalia Arias
Summary: Mitochondrial dysfunction and brain metabolic decline in hepatic encephalopathy (HE) may involve alterations in enzyme cytochrome c-oxidase (CCO), and can be improved by administering methylene blue (MB) and transcranial photobiomodulation (PBM). Both treatments effectively improved the HE-memory deficit, but PBM had a greater effect on CCO activity compared to MB.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xuan Du, Eimear M. Byrne, Mei Chen, Heping Xu
Summary: The therapeutic potential of minocycline in a chronic model of AMD was investigated. The results showed that long-term minocycline treatment is safe and effective in controlling microglial activation and preserving visual function.
Article
Neurosciences
Elena Stelmashook, Dmitriy N. Voronkov, Alla Stavrovskaya, Svetlana Novikova, Nina G. Yamshikova, Artem S. Olshanskij, Anastasiya S. Guschina, Margarita O. Shedenkova, Elizaveta E. Genrikhs, Nickolay K. Isaev
Summary: Methylene blue (MB) can act as a neuroprotector by stopping the development of neuron damage in neurodegenerative processes. This study found that MB partially mitigates memory impairment caused by streptozotocin (STZ) in rats. MB treatment prevented the STZ-induced increase in microglial and GFAP-positive cells in the brain cortex and prevented the increase in LC3B protein expression in the hippocampus. Additionally, MB reduced NO production and the expression of iNOS in cultured neurons. The findings suggest that MB has neuroprotective and anti-inflammatory effects and could be used in the treatment of neurodegenerative processes.
Review
Toxicology
Lenka Pulkrabkova, Barbora Svobodova, Jan Konecny, Tereza Kobrlova, Lubica Muckova, Jiri Janousek, Jaroslav Pejchal, Jan Korabecny, Ondrej Soukup
Summary: Organophosphorus compounds are a constant problem in both military and civilian fields, causing acute poisoning and long-term consequences. The key mechanism of their toxicity is the inhibition of acetylcholinesterase, leading to overstimulation of receptors and the activation of the glutamatergic system. This review presents neuroprotection strategies that can slow down nerve cell damage and alleviate neurological and neuropsychiatric disturbance.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Cell Biology
Henry Patrick Oamen, Nathaly Romero Romero, Philip Knuckles, Juha Saarikangas, Marta Radman-Livaja, Yuhong Dong, Fabrice Caudron
Summary: This study found that the natural lipid tripentadecanoin can delay the formation of protein aggregates and extend cellular lifespan, offering a potential treatment for neurodegenerative diseases. Tripentadecanoin can also protect neurons from amyloid toxicity and promote the recovery of retinal cells.
Review
Biochemistry & Molecular Biology
Mohammad Najim Uddin, Mohammad Injamul Hoq, Israt Jahan, Shafayet Ahmed Siddiqui, Chayan Dhar Clinton, Mohammed Ibrahim, Mohammad Safiqul Islam, Md Jakaria
Summary: Thymoquinone (TQ) has shown potential neuroprotective effects in Parkinson's disease (PD) by ameliorating neuroinflammation, oxidative stress, and apoptosis, which could slow down neurodegeneration in PD models. Further mechanistic studies are needed to clarify the exact neuroprotective role of TQ in PD management.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Psychology
Nathaniel J. Blanco, W. Todd Maddox, Francisco Gonzalez-Lima
JOURNAL OF NEUROPSYCHOLOGY
(2017)
Article
Neuroimaging
Pavel Rodriguez, Amar P. Singh, Kristen E. Malloy, Wei Zhou, Douglas W. Barrett, Crystal G. Franklin, Wilson B. Altmeyer, Juan E. Gutierrez, Jinqi Li, Betty L. Heyl, Jack L. Lancaster, F. Gonzalez-Lima, Timothy Q. Duong
BRAIN IMAGING AND BEHAVIOR
(2017)
Article
Neurosciences
Xinlong Wang, Divya D. Reddy, Sahil S. Nalawade, Suvra Pal, F. Gonzalez-Lima, Hanli Liu
Article
Neurosciences
Douglas W. Barrett, F. Gonzalez-Lima
Article
Neurosciences
Jungyun Hwang, Kiyoung Kim, R. Matthew Brothers, Darla M. Castelli, F. Gonzalez-Lima
EXPERIMENTAL BRAIN RESEARCH
(2018)
Article
Medicine, Research & Experimental
Eric D. Zaizar, F. Gonzalez-Lima, Michael J. Teich
CONTEMPORARY CLINICAL TRIALS
(2018)
Meeting Abstract
Neurosciences
Xinlong Wang, Hashini Wanniarachchi, Francisco Gonzalez-Lima, Hanli Liu
BIOLOGICAL PSYCHIATRY
(2019)
Meeting Abstract
Neurosciences
Francisco Gonzalez-Lima, Douglas Barrett, Celeste Saucedo, Courtney Alexander, Hanli Liu, Andreana Haley
BIOLOGICAL PSYCHIATRY
(2019)
Article
Neurosciences
Xinlong Wang, Jacek P. Dmochowski, Li Zeng, Elisa Kallioniemi, Mustafa Husain, F. Gonzalez-Lima, Hanli Liu
Article
Neurosciences
Emma Holmes, Douglas W. Barrett, Celeste L. Saucedo, Patrick O'Connor, Hanli Liu, F. Gonzalez-Lima
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Psychology, Biological
Araceli Vazquez, Andres Hernandez-Oliveras, Juan Santiago-Garcia, Mario Caba, Francisco Gonzalez-Lima, Diana Olivo, Aleph A. Corona-Morales
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Neurosciences
Allison M. Auchter, Douglas W. Barrett, Marie H. Monfils, F. Gonzalez-Lima
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Geriatrics & Gerontology
Courtney M. O'Donnell, Douglas W. Barrett, Latham H. Fink, Erica C. Garcia-Pittman, Francisco Gonzalez-Lima
Summary: This study is the first to investigate the effects of TILS on cognition in older euthymic bipolar patients, showing potential improvements in cognitive flexibility and impulsivity with TILS treatment.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2022)
Review
Cell Biology
Fabrizio dos Santos Cardoso, F. Gonzalez-Lima, Sergio Gomes da Silva
Summary: Longevity is a great triumph of humanity, but it also brings challenges such as age-related cognitive decline and neurological diseases. Photobiomodulation (PBM) has shown promising effects in improving brain functions in aging populations, with studies demonstrating neuroprotective and neuromodulatory capacities in both animals and humans. More controlled studies are needed to further understand the mechanisms and benefits of PBM in older populations.
AGEING RESEARCH REVIEWS
(2021)
Article
Behavioral Sciences
Diana Olivo, Mario Caba, Francisco Gonzalez-Lima, Juan F. Rodriguez-Landa, Aleph A. Corona-Morales
BEHAVIOURAL BRAIN RESEARCH
(2017)