Article
Multidisciplinary Sciences
Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie Cordonnier, Mark P. Mattson, Deborah L. Croteau, Vilhelm A. Bohr
Summary: Research reveals that levels of NAD* decrease, and inflammation increases in the brains of Alzheimer's disease patients, while treatment with NR can increase brain NAD* levels, reduce inflammation, and improve cellular senescence. NR treatment is beneficial for neuroinflammation and cellular senescence through a cGAS-STING dependent pathway, inducing mitophagy and improving cognitive function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Sonal Dubey, Ekta Singh
Summary: Alzheimer's disease (AD) is a major cause of dementia, affecting millions of people worldwide. Oxidative stress is a crucial factor in the induction and progression of AD. Understanding and managing oxidative stress has proven effective in AD treatment, with various natural and synthetic molecules showing promise. Clinical studies also support the use of antioxidants in preventing neurodegeneration in AD. This review summarizes the development of antioxidants for restricting oxidative stress-induced neurodegeneration in AD.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Traumatic brain injuries are a significant public health issue with long-term consequences such as cerebral atrophy and increased risk of dementia and Alzheimer's Disease. Hidrox (R) treatment has shown benefits in reducing TBI-induced neurodegeneration and improving cognitive function and memory impairment.
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Haleh Barmaki, Alireza Nourazarian, Fatemeh Khaki-Khatibi
Summary: This review examines the impact of impaired autophagy on the progression of Alzheimer's disease pathology. Autophagy plays a crucial role in removing abnormal proteins and damaged organelles, but it weakens with aging and disease progression, leading to the accumulation of toxic proteins and neurodegeneration. There are therapeutic strategies to revitalize autophagy, but they face challenges in clinical practice.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Shruti Shandilya, Sandeep Kumar, Niraj Kumar Jha, Kavindra Kumar Kesari, Janne Ruokolainen
Summary: Recent studies have shown the significant impact of gut microbiota on brain functions, particularly in oxidative stress and neuroprotection. Gut bacteria metabolites play a crucial role in the pathogenesis of neurodegenerative diseases.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
David Vogrinc, Milica Gregoric Kramberger, Andreja Emersic, Sasa Cucnik, Katja Goricar, Vita Dolzan
Summary: Oxidative stress and neuroinflammation are important processes involved in Alzheimer's disease and mild cognitive impairment. This study evaluated the association of polymorphisms in oxidative stress- and inflammation-related genes with cerebrospinal fluid biomarker levels and cognitive test results. The results showed that IL1B rs16944 carriers had higher CSF A beta(1-42) levels, while NFE2L2 rs35652124 carriers had lower CSF A beta(1-42) levels. Several gene variants, including CAT rs1001179, GSTP1 rs1138272, KEAP1 rs1048290 and rs9676881, and NFE2L2 rs35652124, were significantly associated with cognitive test scores.
Article
Biochemistry & Molecular Biology
Ratnakar Jadhav, Yogesh A. Kulkarni
Summary: Alzheimer's disease is a neurodegenerative condition characterized by progressive loss of memory and cognitive dysfunction, particularly in older individuals. The prevalence of the disease has increased due to the global aging population. Current treatments for Alzheimer's disease have limited efficacy and adverse effects. Recent research suggests that natural products, such as baicalein, could be potential treatment options for Alzheimer's disease. Baicalein, a flavonoid from the flavone subclass, has shown neuroprotective properties through its antioxidant, anti-inflammatory, AChE enzyme inhibitory, and anti-amyloid protein aggregation activities.
Article
Immunology
Yan Gao, Juntong Li, Qinglin Wu, Shasha Wang, Songwei Yang, Xun Li, Naihong Chen, Lin Li, Lan Zhang
Summary: TSG effectively alleviated Aβ-induced cytotoxicity in neuronal cells within APP/PS1 mice by regulating ferroptosis related proteins and enzymes, promoting activation of several antioxidative pathways, and reducing oxidative stress and inflammation levels. These findings highlight a novel mechanism of TSG in reversing Aβ-induced injury, suggesting its potential as a promising candidate in the treatment of neurodegenerative diseases, especially AD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Nyshadham S. N. Chaitanya, Prasad Tammineni, Ganji Purnachandra Nagaraju, Aramati B. M. Reddy
Summary: The cytosolic adaptor protein ECSIT is involved in the toll-like receptor pathway and regulates various biological processes. It interacts with multiple signaling intermediates and its molecular functions in pathophysiology remain unclear.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Amjad Khan, Tae Ju Park, Muhammad Ikram, Sareer Ahmad, Riaz Ahmad, Min Gi Jo, Myeong Ok Kim
Summary: This study demonstrated the neuroprotective effects of kojic acid in an AD mouse model, reversing AD pathology and improving memory function. Kojic acid could serve as a potential novel drug strategy for treating AD-related neurodegenerative conditions.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Davide Decandia, Francesca Gelfo, Eugenia Landolfo, Francesca Balsamo, Laura Petrosini, Debora Cutuli
Summary: Alzheimer's disease (AD) is a growing epidemic with significant social and economic burden. Inflammation and neurodegeneration play a major role in AD pathogenesis. This review focuses on the effects of dietary supplementation in AD-like animal models, specifically in relation to neuroinflammation induced by lipopolysaccharide (LPS) injection. Various compounds, such as curcumin and krill oil, have been found to counteract cognitive decline and neuroinflammatory responses in rodents. Overall, dietary interventions offer potential neuroprotection and immune regulation in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ashly Hindle, Sharda P. Singh, Jangampalli Adi Pradeepkiran, Chhanda Bose, Murali Vijayan, Sudhir Kshirsagar, Neha A. Sawant, P. Hemachandra Reddy
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by synaptic loss, protein accumulation, and oxidative stress. Recent research suggests that reduced levels of Rlip76 may contribute to oxidative stress and mitochondrial dysfunction in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Fatema Yasmin Nisa, Md Atiar Rahman, Md Amjad Hossen, Mohammad Forhad Khan, Md Asif Nadim Khan, Mumtahina Majid, Farjana Sultana, Md Areeful Haque
Summary: This study discussed the mechanisms by which neurotoxicants modulate AD-related gene expressions, highlighting the pathways induced by neurotoxicants that contribute to an increased risk of AD. It emphasized the need for a better understanding of the risk exposure to these neurotoxicants to improve approaches for addressing AD pathogenesis.
ANNALS OF MEDICINE
(2021)
Article
Food Science & Technology
Merle M. Nicolai, Barbara Witt, Sharleen Friese, Vivien Michaelis, Lisa Holz-Armstrong, Maximilian Martin, Franziska Ebert, Tanja Schwerdtle, Julia Bornhorst
Summary: This study characterizes the adverse effects of manganese on genome integrity in dopaminergic-like neurons. The results show that manganese exposure leads to DNA damage and an enhanced DNA damage response, as well as significant alteration of the neuronal network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Physiology
David Walzik, Wiebke Jonas, Niklas Joisten, Sergen Belen, Rob C. I. Wuest, Gilles Guillemin, Philipp Zimmer
Summary: Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme with various cell functions and has been found to be associated with diseases and aging. Exercise is suggested to restore NAD(+) homeostasis through metabolic adaption. This review discusses the impact of acute exercise and exercise training on NAD(+) metabolism and highlights their potential value as NAD(+)-boosting strategies.
Article
Neurosciences
Mariana Ribeiro Costa, Amanda Yasmin Ilario dos Santos, Tais Browne de Miranda, Rogerio Aires, Alex de Camargo Coque, Elizabeth Cristina Perez Hurtado, Maria Martha Bernardi, Vanessa Gallego Arias Pecorari, Denise Carleto Andia, Alexander Birbrair, Gilles J. Guillemin, Alexandra Latini, Rodrigo A. da Silva
Summary: Sonic Hedgehog (Shh) signaling plays a critical role in CNS development and its dysregulation leads to neurological disorders. However, the regulation of Shh signaling in the adult brain is not well understood. This study investigated the effects of DNA methylation on the transcriptional control of Shh signaling pathway members as well as its modulation by inflammation. The findings demonstrate the importance of methylation in the promoter regions of Shh pathway members in determining transcriptional patterns in the adult brain, and reveal the impact of neuroinflammation on the transcriptional control of these genes.
Review
Geriatrics & Gerontology
Tessa Helman, Nady Braidy
Summary: The role of nicotinamide adenine dinucleotide (NAD+) in aging and its links to chronic diseases are discussed in this review. The mechanisms behind age-associated NAD+ decline are not well understood, but supplements aimed at increasing NAD+ levels are becoming popular. The clinical utility and benefits of NAD+ precursors in attenuating NAD+ decline and age-related disorders are explored.
Article
Pharmacology & Pharmacy
Mael Nicolas, Malia Lasalo, Sharron Chow, Cyril Antheaume, Karl Huet, Edouard Hnawia, Gilles J. Guillemin, Mohammed Nour, Mariko Matsui
Summary: In this study, the anti-inflammatory potential of ethanolic (ePE) and cyclohexane (cPE) extracts from Coleus forsteri on LPS-induced human macrophages models was investigated. The results showed that ePE and cPE extracts significantly inhibited the production of IL-6 and TNF-alpha, two inflammatory cytokines, in PMA-derived THP-1 macrophages. The production of QUIN, an inflammatory marker, was also reduced under ePE and cPE treatment in activated human monocyte-derived macrophages. Additionally, seven abietane diterpenes were identified from the cPE extract of C. forsteri, and their potential contributions to the anti-inflammatory activities were discussed.
FRONTIERS IN PHARMACOLOGY
(2023)
Correction
Multidisciplinary Sciences
Gurkiran Kaur Flora, Ryan S. Anderton, Bruno P. Meloni, Gilles J. Guillemin, Neville W. Knuckey, Gabriella MacDougall, Vance Matthews, Sherif Boulos
Editorial Material
Clinical Neurology
Lucette A. Cysique, Bruce J. Brew
Review
Oncology
Hemaasri-Neya Girithar, Ananda Staats Pires, Seong Beom Ahn, Gilles J. Guillemin, Laurence Gluch, Benjamin Heng
Summary: Breast cancer is the leading cause of cancer incidence and mortality in women worldwide. Metastasis is the main cause of death in breast cancer patients, as current treatment strategies are not effective in treating metastatic tumors. Immunotherapy and the kynurenine pathway (KP) have emerged as potential new approaches for breast cancer metastasis. This review discusses the mechanisms of immune suppression and cancer growth mediated by the KP, and provides an overview of studies and clinical trials targeting KP enzymes in breast cancer.
BRITISH JOURNAL OF CANCER
(2023)
Retraction
Endocrinology & Metabolism
Nady Braidy, Bruce J. Brew, Nibaldo C. Inestrosa, Roger Chung, Perminder Sachdev, Gilles J. Guillemin
METABOLIC BRAIN DISEASE
(2023)
Review
Clinical Neurology
Mona Dehhaghi, Benjamin Heng, Gilles J. Guillemin
Summary: Up to 10 million people per annum experience traumatic brain injury (TBI), 80-90% of which are mild. TBI can cause secondary brain injuries through mechanisms that are not yet fully understood but likely involve neurochemical changes triggered by inflammation, excitotoxicity, and reactive oxygen species. The kynurenine pathway (KP) is an important pathway that is overactivated during inflammation and its metabolites, such as QUIN, may have neurotoxic effects, suggesting a possible mechanism for secondary brain injury. Understanding the changes in KP metabolites during TBI is crucial to prevent or attenuate the severity of secondary brain injuries and develop biomarkers for TBI severity and risk of secondary brain injuries. This review aims to address the knowledge gap regarding the role of KP in TBI and highlight areas for future study.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Lucette A. Cysique, David Jakabek, Sophia G. Bracken, Yasmin Allen-Davidian, Benjamin Heng, Sharron Chow, Mona Dehhaghi, Ananda Staats Pires, David R. Darley, Anthony Byrne, Chansavath Phetsouphanh, Anthony Kelleher, Gregory J. Dore, Gail V. Matthews, Gilles J. Guillemin, Bruce J. Brew
Summary: The study aims to determine the prevalence and natural history of post-acute COVID-19 objective cognitive impairment and function, as well as their relationship to demographic, clinical factors, post-acute sequelae of COVID-19, and biomarkers. The results showed that mild to moderate cognitive impairment occurred in 16% to 26% of patients during the 12-month study period, and at least 46.5% of patients experienced impairment. Impairment was associated with poorer work capacity and objectively tested anosmia at 2 months.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Hamid Amiri, Gilles J. Guillemin, Vijai Kumar Gupta, Ahmad Rajaei, Yadong Yang, Wanxi Peng, Junting Pan, Mortaza Aghbashlo, Meisam Tabatabaei
Summary: The article introduces the importance of chitosan and its derivative chitin in biomaterials, particularly in terms of their antimicrobial, antioxidant, and anticancer activities. The article also points out some drawbacks in the structure of chitosan and discusses a modification method using lactose and galactose as main raw materials to prepare soluble branched chitosan.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Cell Biology
Marina Ulanova, Lucy Gloag, Andre Bongers, Chul-Kyu Kim, Hong Thien Kim Duong, Ha Na Kim, John Justin Gooding, Richard D. Tilley, Joanna Biazik, Wei Wen, Perminder S. Sachdev, Nady Braidy, Alexander E. Kalyuzhny
Summary: Nanoparticle-based magnetic contrast agents have been developed for early non-invasive diagnosis of Alzheimer's disease (AD) using magnetic resonance imaging (MRI). This study developed a biocompatible magnetic nanoparticle targeted to amyloid beta (A beta) plaques to enhance the sensitivity of T2-weighted MRI for imaging of amyloid pathology in AD. The nanoparticles showed no significant cytotoxicity and were able to bind to amyloid species. The study provides promising preliminary results for the development of a targeted non-invasive method for early AD diagnosis using contrast-enhanced MRI.
Review
Pharmacology & Pharmacy
Mahsa Vaezzadeh, Ehsan Kachooei, Shivani Krishnamurthy, Preeti Manandhar, Annemarie Nadort, Gilles J. Guillemin, Antonio Di Ieva, Marina Santiago, Benjamin Heng, Anna Guller
Summary: Combination drug therapy is a promising strategy to improve treatment outcomes for glioblastoma patients. However, there is a lack of clarity in drug testing using 3D in vitro models of glioblastoma. This review explores the available literature on the application of temozolomide (TMZ) in 3D in vitro models of glioblastoma, providing a roadmap for future combination treatment research.
ADVANCED THERAPEUTICS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Mahsa Vaezzadeh, Benjamin Heng, Anna Guller, Annemarie Nadort, Gilles J. Guillemin
TISSUE ENGINEERING PART A
(2023)
Review
Green & Sustainable Science & Technology
Hossein Shahbeik, Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Gilles J. Guillemin, Alireza Fallahi, Homa Hosseinzadeh-Bandbafha, Hamid Amiri, Mohammad Rehan, Deepak Raikwar, Hannes Latine, Bruno Pandalone, Benyamin Khoshnevisan, Christian Sonne, Luigi Vaccaro, Abdul-Sattar Nizami, Vijai Kumar Gupta, Su Shiung Lam, Junting Pan, Rafael Luque, Bert Sels, Wanxi Peng, Meisam Tabatabaei, Mortaza Aghbashlo
Summary: This review explores the production of biocrude oil from biomass feedstocks through the process of hydrothermal liquefaction (HTL). It discusses the impact of process parameters on the quality, quantity, cost, and environmental impacts of biofuels. The review also highlights the challenges and prospects for the future development of biocrude oil.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2024)
