Epigenetics and ncRNAs in Brain Function and Disease: Mechanisms and Prospects for Therapy

Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma

(2013) N Nohata et al.   BRITISH JOURNAL OF CANCER

MiR-138 Inhibits Tumor Growth Through Repression of EZH2 in Non-Small Cell Lung Cancer

(2013) Huijun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Genetic Markers for PTSD Risk and Resilience Among Survivors of the World Trade Center Attacks

(2013) Casey Sarapas et al.   DISEASE MARKERS

Therapeutic targeting of non-coding RNAs

(2013) Thomas C. Roberts et al.   Essays in Biochemistry

miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

(2013) Liu Qi et al.   FEBS LETTERS

MicroRNA-627 Mediates the Epigenetic Mechanisms of Vitamin D to Suppress Proliferation of Human Colorectal Cancer Cells and Growth of Xenograft Tumors in Mice

(2013) Sathish K.R. Padi et al.   GASTROENTEROLOGY

Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p

(2013) K. Han et al.   GENES & DEVELOPMENT

Transgenerational epigenetic inheritance: how important is it?

(2013) Ueli Grossniklaus et al.   NATURE REVIEWS GENETICS

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA miR-29c Down-Regulation Leading to De-Repression of Its Target DNA Methyltransferase 3a Promotes Ischemic Brain Damage

(2013) Gopal Pandi et al.   PLoS One

Hypermethylation and Post-Transcriptional Regulation of DNA Methyltransferases in the Ovarian Carcinomas of the Laying Hen

(2013) Jin-Young Lee et al.   PLoS One

Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities

(2013) Sheila K. Pirooznia et al.   Frontiers in Cellular Neuroscience

Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer

(2013) Yun Wu et al.   Molecular Therapy-Nucleic Acids

The enhancer of zeste homolog 2 (EZH2), a potential therapeutic target, is regulated by miR-101 in renal cancer cells

(2012) Toshihiko Sakurai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of noncoding RNAs in trinucleotide repeat neurodegenerative disorders

(2012) Huiping Tan et al.   EXPERIMENTAL NEUROLOGY

miR-886-3p Levels Are Elevated in Friedreich Ataxia

(2012) L. H. Mahishi et al.   JOURNAL OF NEUROSCIENCE

Circulating microRNAs involved in multiple sclerosis

(2012) Sue Rutherford Siegel et al.   MOLECULAR BIOLOGY REPORTS

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

(2012) Abed AlFatah Mansour et al.   NATURE

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

(2012) Farzaneh Modarresi et al.   NATURE BIOTECHNOLOGY

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

MicroRNAs in Parkinson's disease

(2012) M. Maral Mouradian   NEUROBIOLOGY OF DISEASE

Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus

(2012) Michael Cowley et al.   NUCLEIC ACIDS RESEARCH

Epigenetic regulation of human cis -natural antisense transcripts

(2012) Andrew B. Conley et al.   NUCLEIC ACIDS RESEARCH

MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc

(2012) Karin Wibrand et al.   PLoS One

Synergetic Cooperation of microRNAs with Transcription Factors in iPS Cell Generation

(2012) Jie Chen et al.   PLoS One

miR-200c Sensitizes Breast Cancer Cells to Doxorubicin Treatment by Decreasing TrkB and Bmi1 Expression

(2012) Florian Kopp et al.   PLoS One

miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the E -miR-155 transgenic mouse model

(2012) S. K. Sandhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death

(2012) K.-M. Noh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-223 is neuroprotective by targeting glutamate receptors

(2012) M. M. Harraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Antisense Makes Sense for Gene-specific Activation in Brain

(2012) Miguel A Varela et al.   Molecular Therapy-Nucleic Acids

Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

(2012) Stuart Knowling et al.   Molecular Therapy-Nucleic Acids

DNA methylation in glioblastoma: impact on gene expression and clinical outcome.

(2011) Amandine Etcheverry et al.   BMC GENOMICS

Overexpression of MBD2 in Glioblastoma Maintains Epigenetic Silencing and Inhibits the Antiangiogenic Function of the Tumor Suppressor Gene BAI1

(2011) D. Zhu et al.   CANCER RESEARCH

Polycomb proteins in mammalian cell differentiation and plasticity

(2011) Carolina Prezioso et al.   FEBS LETTERS

The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2

(2011) Fang Zheng et al.   GUT

Transcriptional gene silencing of HPV16 E6/E7 induces growth inhibition via apoptosis in vitro and in vivo

(2011) Jiansong Zhou et al.   GYNECOLOGIC ONCOLOGY

Plasma Components Affect Accuracy of Circulating Cancer-Related MicroRNA Quantitation

(2011) Dong-Ja Kim et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A specific miRNA signature in the peripheral blood of glioblastoma patients

(2011) Patrick Roth et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1

(2011) Peixin Dong et al.   Molecular Cancer

Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage

(2011) Daniel R. Premkumar et al.   MOLECULAR CARCINOGENESIS

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

Experience-dependent expression of miR-132 regulates ocular dominance plasticity

(2011) Paola Tognini et al.   NATURE NEUROSCIENCE

Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study

(2011) B. B. Friday et al.   NEURO-ONCOLOGY

Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

(2011) Scott T. Younger et al.   NUCLEIC ACIDS RESEARCH

Epigenetic cancer therapy: rationales, targets and drugs

(2011) M Rius et al.   ONCOGENE

Upregulation of MiR-155 in Nasopharyngeal Carcinoma is Partly Driven by LMP1 and LMP2A and Downregulates a Negative Prognostic Marker JMJD1A

(2011) Zi-Ming Du et al.   PLoS One

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

(2011) Mattia Boeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing

(2011) S. Melo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNAs modulate iPS cell generation

(2011) C.-S. Yang et al.   RNA

miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells

(2011) GuoQiang Sun et al.   Nature Communications

Targeting Huntington’s disease through histone deacetylases

(2011) Steven G. Gray   Clinical Epigenetics

Altered microRNA regulation in Huntington's disease models

(2010) Soon-Tae Lee et al.   EXPERIMENTAL NEUROLOGY

Cross talk between microRNA and epigenetic regulation in adult neurogenesis

(2010) Keith E. Szulwach et al.   JOURNAL OF CELL BIOLOGY

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence

(2010) Sujatha Venkataraman et al.   PLoS One

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy

(2010) L Perrone et al.   Cell Death & Disease

RNA regulation of epigenetic processes

(2009) John S. Mattick et al.   BIOESSAYS

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

Transcriptional inhibition of Hoxd4 expression by noncoding RNAs in human breast cancer cells

(2009) Yuliang Tan et al.   BMC MOLECULAR BIOLOGY

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

(2009) J. M. Friedman et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Efficient Regulation of VEGF Expression by Promoter-Targeted Lentiviral shRNAs Based on Epigenetic Mechanism

(2009) Mikko P. Turunen et al.   CIRCULATION RESEARCH

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription

(2009) Makoto Yamagishi et al.   MICROBES AND INFECTION

Mir-214-Dependent Regulation of the Polycomb Protein Ezh2 in Skeletal Muscle and Embryonic Stem Cells

(2009) Aster H. Juan et al.   MOLECULAR CELL

Embryonic stem cell–specific microRNAs promote induced pluripotency

(2009) Robert L Judson et al.   NATURE BIOTECHNOLOGY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms

(2009) Carlos M Loya et al.   NATURE METHODS

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

MicroRNAs: key regulators of stem cells

(2009) Vamsi K. Gangaraju et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular epigenetics and genetics in neuro-oncology

(2009) Raman P. Nagarajan et al.   Neurotherapeutics

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

(2009) E J Noonan et al.   ONCOGENE

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

(2009) J. Kocerha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

MicroRNA Profiling of Human-Induced Pluripotent Stem Cells

(2009) Kitchener D. Wilson et al.   STEM CELLS AND DEVELOPMENT

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

(2008) Huating Wang et al.   CANCER CELL

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells

(2008) Alexander Marson et al.   CELL

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Demethylating agents in myeloid malignancies

(2008) Guillermo Garcia-Manero   CURRENT OPINION IN ONCOLOGY

MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG

(2008) Kok Lian Ho et al.   MOLECULAR CELL

Mobilization-competent Lentiviral Vector–mediated Sustained Transcriptional Modulation of HIV-1 Expression

(2008) Anne-Marie W Turner et al.   MOLECULAR THERAPY

MicroRNAs accurately identify cancer tissue origin

(2008) Nitzan Rosenfeld et al.   NATURE BIOTECHNOLOGY

A small molecule enhances RNA interference and promotes microRNA processing

(2008) Ge Shan et al.   NATURE BIOTECHNOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-148 targets human DNMT3b protein coding region

(2008) A. M. Duursma et al.   RNA

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE

Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells

(2007) F Condorelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

A microRNA-based gene dysregulation pathway in Huntington's disease

(2007) Rory Johnson et al.   NEUROBIOLOGY OF DISEASE