Article
Cell Biology
Hanzhi T. Zhao, Mary Claire Tuohy, Daniel Chow, Mariel G. Kozberg, Sharon H. Kim, Mohammed A. Shaik, Elizabeth M. C. Hillman
Summary: Research has found that in acute brain injuries, CSD can cause vasoconstriction and ischemia, with its effects worsening with repeated CSD occurrences. This feedback loop may explain the variable but potentially devastating effects of CSD in the context of acute brain injury.
Article
Clinical Neurology
Cheng-Ta Li, Chi-Hung Juan, Hui-Ching Lin, Chih-Ming Cheng, Hui-Ting Wu, Bang-Hung Yang, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This study is the first to reveal the underlying molecular mechanisms of the fronto-limbic circuit in individuals with major depressive disorder and demonstrates the differential modulation of neurotransmitter systems by rTMS and iTBS.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, Research & Experimental
Christine Nash, Keren Powell, Daniel G. Lynch, Jed A. Hartings, Chunyan Li
Summary: This review summarizes nonpharmacological techniques for modulating cortical spreading depolarization (CSD), presents their mechanisms of action, and provides insight into future directions. Both pharmacologic and nonpharmacologic interventions can mitigate the pathological impact of CSDs via shared molecular mechanisms, and nonpharmacologic interventions can also target unique mechanisms, which may have broader effects.
Article
Clinical Neurology
Carl Johan Ekman, Katarzyna Popiolek, Robert Boden, Axel Nordenskjold, Johan Lundberg
Summary: This study investigated the effectiveness and tolerability of intermittent Theta-burst stimulation (iTBS) in a clinical setting. The results showed that iTBS was safe and well-tolerated, and the response rate was similar to that reported in clinical trials. Older age and milder illness predicted a better treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Chiho Kudo, Andrea M. Harriott, Michael A. Moskowitz, Christian Waeber, Cenk Ayata
Summary: This study aimed to investigate the effects of sex, gonadectomy, and female hormone supplementation and withdrawal on the susceptibility to cortical spreading depression (CSD). The results showed that female rats had a higher CSD frequency than males and ovariectomized rats. Estrogen withdrawal after prolonged treatment significantly increased CSD susceptibility in gonadectomized females. These findings have implications for estrogen-withdrawal migraine.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Psychiatry
Catherine Toth, Marcie L. King Johnson, Amanda Heinzerling, Nicholas Trapp
Summary: Treatment resistant depression (TRD) is a complex condition associated with disability and suffering. Transcranial magnetic stimulation (TMS) is a well-tolerated treatment for TRD, but lacks predictive biomarkers for treatment response. This study found that treatment responders had higher levels of autonomy and personal growth at baseline, suggesting that assessing psychological well-being might be useful in selecting candidates for TMS treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Ronald E. See, Branon Eusebio, David Agnew, Mark Heatwole
Summary: The study found that steroid hormones may not be reliable biomarkers of treatment response in patients with major depressive disorder undergoing repetitive transcranial magnetic stimulation (rTMS). While rTMS significantly improved symptoms, salivary biomarker levels did not show significant changes during the treatment sessions.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Hannah Ford, Lisa Hahn, Patrick Clarke, Shane Gill, Ben Carnell, Cherrie Galletly
Summary: In this study, it was found that 15-minute and 30-minute rTMS treatments showed no significant difference in partial response, response, and remission rates for treatment resistant depression, indicating that shorter treatment sessions were just as effective as longer sessions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Jeffrey D. Voigt, Andrew F. Leuchter, Linda L. Carpenter
Summary: Through analyzing data from multiple randomized controlled trials, this study found that theta burst stimulation (TBS) is superior to sham treatment in treating major depressive disorder, and is noninferior to standard rTMS therapy (high frequency stimulation over the left prefrontal cortex). These results support the continued development of TBS as a treatment for depression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Andrew M. Fukuda, Jee Won Diane Kang, Asi Polly Gobin, Eric Tirrell, Fatih Kokdere, Linda L. Carpenter
Summary: The study found that TMS treatment significantly improved anhedonia in depressed patients and that the severity of anhedonia was significantly correlated with other depressive symptoms. However, baseline severity of anhedonia was not a significant predictor of clinical outcome.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Goncalo Cotovio, Albino J. Oliveira-Maia, Carter Paul, Francisco Faro Viana, Daniel Rodrigues da Silva, Carolina Seybert, Adam P. Stern, Alvaro Pascual-Leone, Daniel Z. Press
Summary: The study evaluated the daily variability of motor threshold in the treatment of depression using repetitive transcranial magnetic stimulation and found that this variability has a significant impact on treatment intensity. Regular assessments of motor threshold, either daily or weekly, are recommended to improve the effectiveness and safety of therapeutic rTMS practice.
Article
Clinical Neurology
J. O. Lloyd, B. Hill, M. Murphy, A. Al-Kaisy, A. P. Andreou, G. Lambru
Summary: This open label analysis suggests that sTMS may be an effective and well-tolerated treatment option for long-term prevention of difficult-to-treat migraines.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Psychiatry
Noomane Bouaziz, Charles Laidi, Fanny Thomas, Palmyre Schenin-King Andrianisaina, Virginie Moulier, Dominique Januel
Summary: This study did not find any effect of repetitive iTBS targeting the L-DLPFC on cortical excitability, based on a randomized double-blind, sham-controlled trial with 30 healthy volunteers.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Nannan Bian, Yi Yuan, Yingwei Li, Mengyang Liu, Xiaoli Li
Summary: The study demonstrates that low-intensity pulsed ultrasound stimulation (PUS) significantly inhibits cortical spreading depression (CSD) in rats by improving motor activity, reducing CSD propagation speed, and increasing levels of brain-derived neurotrophic factor protein in brain tissue. These findings suggest that PUS has the potential to be a treatment for brain disorders associated with CSD.
Review
Clinical Neurology
Danielle Hett, Jack Rogers, Clara Humpston, Steven Marwaha
Summary: The existing literature suggests that rTMS could be effective in reducing depressive symptoms in adolescents, yet caution is needed due to the lack of sham controlled randomized trials. The studies suffered from multiple biases, limiting the interpretation and generalization of the results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
