Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Vinod Khetarpal, Mette Skinbjerg, Longbin Liu, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, Steven Staelens
Summary: The study demonstrated that the novel radioligand [C-11]CHDI-626 is suitable for mHTT PET imaging. Longitudinal quantification revealed genotype differences, with an increase in signal in HET mice associated with mHTT aggregate load progression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Mathematical & Computational Biology
Pierre-Emmanuel Poulet, Stanley Durrleman
Summary: Disease modeling is crucial for understanding disease progression and heterogeneity among patients. This study presents a disease progression model that can handle ordinal and categorical data, providing a more detailed description of progression and improved predictions. The application to Parkinson's disease patients demonstrates the usefulness of this approach.
STATISTICS IN MEDICINE
(2023)
Article
Oncology
Adriana V. F. Massicano, Patrick N. N. Song, Ameer Mansur, Sharon L. White, Anna G. Sorace, Suzanne E. Lapi
Summary: Triple-negative breast cancers (TNBCs) have limited treatment options, but PD-L1 can be used as an indicator for immunotherapy susceptibility. Currently, PD-L1 assessment is limited to biopsy samples, but molecular imaging can overcome these limitations. This study demonstrates the potential of [Zr-89]-Atezolizumab PET/CT imaging for the noninvasive detection of PD-L1-positive TNBC tumors, allowing for quantitative and longitudinal assessment. It also provides insights into tumor heterogeneity and early expression changes in PD-L1 induced by therapy.
Article
Rheumatology
Chiara Bellocchi, Lorenzo Beretta, Xuan Wang, Marka A. Lyons, Maurizio Marchini, Maurizio Lorini, Vincenzo Carbonelli, Nicola Montano, Shervin Assassi
Summary: This study investigated the global gene expression profile of peripheral blood cells (PBCs) in the preclinical stage of systemic sclerosis (PreSSc), and found that there are molecular differences at the transcriptomic level already present in the preclinical stages of SSc. The reduced NK cell signature in PBCs is related to the progression of SSc over time.
Article
Public, Environmental & Occupational Health
Ville-Petteri Makinen, Mari Karsikas, Johannes Kettunen, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Jarvelin, Olli T. Raitakari, Mika Ala-Korpela
Summary: This study investigated metabolic ageing trends in two large cohorts using new methods, revealing that women gained more weight but showed milder metabolic changes compared to men. Temporal sex differences were observed for certain metabolic markers, and individuals with different weight changes exhibited divergent patterns in certain metabolic measures.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fan Ding, Chen Huang, Chenyi Liang, Cheng Wang, Jianjun Liu, Dewei Tang
Summary: The study indicates that (68)Ga-FAPI-04 is more sensitive in detecting early tumor metastasis, while it becomes less sensitive than F-18-FDG at the late stage of metastasis. There is no direct correlation between uptake or S/B ratios of (68)Ga-FAPI-04 and F-18-FDG during this dynamic process.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ming Zhou, Shijun Xiang, Yajie Zhao, Yongxiang Tang, Jinhui Yang, Xiaoqin Yin, Jie Tian, Shuo Hu, Yang Du
Summary: [(68) Ga]Ga-AUNP-12 was developed as a PD-L1-specific PET imaging tracer, which showed high specificity and sensitivity in evaluating PD-L1 expression in tumors. It can effectively guide immunotherapy for PD-L1 blockade.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Heejune So, Hyunjong Lee, Seung Hyup Hyun, Young Seok Cho, Seung Hwan Moon, Joon Young Choi, Kyung-Han Lee
Summary: This study found that the metabolic bulk volume (MBV) obtained from the single largest lesion can be used to stratify the risk in follicular lymphoma (FL) patients. High total metabolic tumor volume (TMTV) and MBV were independent predictors of worse progression-free survival (PFS).
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caroline Guglielmetti, Jelena Levi, Tony L. Huynh, Brice Tiret, Joseph Blecha, Ryan Tang, Henry VanBrocklin, Myriam M. Chaumeil
Summary: The combination of F-18-FAraG PET imaging and MRI in an MS mouse model successfully detected inflammatory demyelination and T cell infiltration, providing a new tool for evaluating lesion heterogeneity during disease progression and after treatment.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Genetics & Heredity
Hua-Song Liu, Qiang Guo, Heng Yang, Min Zeng, Li-Qiang Xu, Qun-Xian Zhang, Hua Liu, Jia-Long Guo, Jun Zhang
Summary: This study found that SPDL1 is upregulated in ESCA and is associated with clinical features, PET/CT results, and prognosis of ESCA patients. Additionally, silencing SPDL1 can inhibit the proliferation and migration of ESCA cells. These findings suggest that SPDL1 may serve as a biomarker for ESCA prognosis.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Summary: Longitudinal imaging studies in adults with Down syndrome identified A beta accumulation trajectories and early accumulation sites; A beta(-) group, A beta converters, and A beta (+) group showed differences in A beta(L) change; Model images and A beta(L) change values can better identify subthreshold A beta accumulation in DS.
Article
Oncology
Shama Jaswal, Vanessa Sanders, Priyanka Pullarkat, Stephanie Teja, Amber Salter, Marcus P. Watkins, Norman Atagu, Daniel R. Ludwig, Joyce Mhlanga, Vincent M. Mellnick, Linda R. Peterson, Nancy L. Bartlett, Brad S. Kahl, Todd A. Fehniger, Armin Ghobadi, Amanda F. Cashen, Neha Mehta-Shah, Joseph E. Ippolito
Summary: In many cancers, including lymphoma, males have higher incidence and mortality than females. One mechanism underlying this phenomenon is sex differences in metabolism, both with respect to tumor nutrient consumption and systemic alterations in metabolism, i.e., obesity. This study found that visceral fat and tumor glucose uptake can predict outcomes in DLBCL patients in a sex-specific fashion.
Article
Public, Environmental & Occupational Health
Eun Sun Yu, Kwan Hong, Byung Chul Chun
Summary: The study aimed to estimate the incidence of and period of progression to stage 2 hypertension from normal blood pressure. Participants were followed up for a median of 12.23 years, with over 60 years old having a higher incidence of stage 2 hypertension. Different strategies may be needed to prevent progression to stage 2 hypertension based on the individual's progression path from normal blood pressure.
Article
Oncology
Justin Ferdinandus, Anne Zaremba, Lisa Zimmer, Lale Umutlu, Robert Seifert, Francesco Barbato, Selma Ugurel, Eleftheria Chorti, Viktor Gruenwald, Ken Herrmann, Dirk Schadendorf, Wolfgang Peter Fendler, Elisabeth Livingstone
Summary: This study aimed to determine the potential added value of FDG-PET in identifying melanoma patients at higher risk of relapse following discontinuation of ICB therapy. The results showed that FDG-PET was more effective in evaluating complete metabolic response compared to CT imaging. These findings may have clinical relevance for patients with residual tumor burden.
Article
Public, Environmental & Occupational Health
E. Ma, T. Ohira, M. Fukasawa, S. Yasumura, M. Miyazaki, T. Suzuki, A. Furuyama, M. Kataoka, M. Hosoya
Summary: This study aimed to evaluate the long-term metabolic risk profiles of Fukushima residents after the Great East Japan Earthquake. The prevalence of metabolic factors in Fukushima was higher than the country average, with an increasing trend in metabolic syndrome, overweight, and diabetes. Control measures for metabolic syndrome in Fukushima residents, particularly in subareas affected by the earthquake, are necessary.
