Review
Biotechnology & Applied Microbiology
Zimu Mao, Baoshi Fan, Xinjie Wang, Ximeng Huang, Jian Guan, Zewen Sun, Bingbing Xu, Meng Yang, Zeyi Chen, Dong Jiang, Jiakuo Yu
Summary: The use of tissue engineering scaffold, especially biomaterials, has shown significant effectiveness in tendon-bone healing and can be enhanced by biological interventions. Current research is mainly focused on animal models, calling for further clinical trials to explore the full potential of these approaches in clinical practice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Zhiming Zhang, Zijie Rong, Guofeng Wu, Yihan Wang, Zhiwen Tan, Juan Zheng, Yanglei Jin, Zhihao Liang, Chun Liu, Jiasong Guo, Lixin Zhu
Summary: The study introduced a controlled-oxygen-generating composite scaffold to enhance seed cell survival and improve bone defect reconstruction.
APPLIED MATERIALS TODAY
(2021)
Article
Biochemistry & Molecular Biology
Yong Li, JunKai Zhang, LiFu Chen, HaiTao Li, Jian Wang
Summary: In this study, a RADA16-W9 peptide gel scaffold was designed and its effectiveness in bone defect repair was validated through cell experiments and a mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Nanoscience & Nanotechnology
Mingran Zhang, Jiaxue Liu, Tongtong Zhu, Hanxiang Le, Xukai Wang, Jinshan Guo, Guangyao Liu, Jianxun Ding
Summary: Bone adhesives are expected to have significant advantages in treating bone injuries compared to traditional internal fixation devices. Different research directions of bone adhesives, such as liquid scaffold and liquid plate, are summarized. Recent advances in mechanical strength, osseointegration, osteoconductivity, and osteoinductivity of bone adhesives are discussed.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Polymer Science
Mohammad Javad Javid-Naderi, Javad Behravan, Negar Karimi-Hajishohreh, Shirin Toosi
Summary: Damage or loss of bone tissue is a major issue affecting human well-being, and tissue engineering is used to recover and regenerate bone fractures and damage. Polymer biomaterials are the most commonly required materials for synthetic bone scaffolds due to their suitable mechanical properties and degradation rates. Synthetic polymers offer advantages in bone replacement because they can be designed and changed easily, and their biocompatibility has been widely accepted in tissue engineering. This article updates on materials and application usage of scaffolds in bone tissue engineering for hard tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Alireza Shaabani, Roya Sedghi
Summary: The study reported the synthesis of electroactive self-healing polyurethane scaffolds based on aniline trimer and disulfide bonds, showing excellent self-healing and shape memory properties. These scaffolds promoted human adipose-derived mesenchymal stem cell adhesion, proliferation, and differentiation to bone tissue, with good bone defect repair potential shown in vitro and in vivo.
Review
Polymer Science
Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop, Mh Busra Fauzi
Summary: Silicon-based biomaterials have gained significant breakthroughs in various industries, including clinical and biomedical applications. Their highly favorable properties, such as excellent biocompatibility, high surface area, mechanical strength, and selectivity, make them attractive for applications like film, hydrogel, nanoparticles, etc. Exciting results have also been observed in cell culture, cell growth, and tissue engineering. This article provides a simple review of the unique properties of silicon and discusses its future application perspectives in the biomedical field, with the goal of generating broader interest in silicone-based materials for wound healing research.
Article
Biotechnology & Applied Microbiology
Martina Tortorici, Ansgar Petersen, Klara Ehrhart, Georg N. Duda, Sara Checa
Summary: Mechanical and biological factors are known to play key roles in osteochondral defect healing, but the underlying principles and how they can be applied in treatment strategies are still largely unknown. A computational approach was used to investigate the impact of scaffold mechanical and architectural properties on osteochondral defect healing, revealing that scaffold material elastic modulus and structural stability are crucial for supporting the repair process.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Samira Tajvar, Afra Hadjizadeh, Saeed Saber Samandari
Summary: Successful bone tissue engineering requires 3D scaffolds with controllable properties tailored to specific clinical applications. Scaffold degradation, which must match the rate of host tissue regeneration, has been identified as a major challenge. This review focuses on the degradation mechanisms and approaches used to control the degradation rate of bone scaffold materials.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2023)
Review
Engineering, Biomedical
Guanyin Zhu, Tianxu Zhang, Miao Chen, Ke Yao, Xinqi Huang, Bo Zhang, Yazhen Li, Jun Liu, Yunbing Wang, Zhihe Zhao
Summary: Bone-tissue defects are a global issue, with autologous and allogeneic bone grafting failing to achieve ideal therapeutic effects. This has led researchers to explore novel bone-regeneration methods, with the development of BTE scaffolds at the forefront. By delving into bone physiology and healing mechanisms, biomimicking and bioinspired BTE scaffolds are making progress.
BIOACTIVE MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Jian Li, Jiaxing Wei, Ang Li, Hongyu Liu, Jingxue Sun, Hong Qiao
Summary: A novel BVHP66 scaffold was developed to enhance osteogenesis and angiogenesis in diabetic fracture healing, showing excellent biocompatibility and bioactive properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
C. Ruiz-Aguilar, L. Gaytan-Tocaven, R. G. Paredes
Summary: Beta-TCP is a promising bioceramic with similar composition to bones and teeth, which stimulates the formation of bone tissue. It can be used in various ways in the human body, mainly for the regeneration and stimulation of cortical and trabecular bone tissue. In a skull implant experiment on rats, the beta-TCP scaffold showed excellent bioactivity, stimulating new bone formation without affecting the animals' motor and cognitive abilities.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biophysics
Banafsheh Safari, Ayuob Aghanejad, Jamileh Kadkhoda, Marziyeh Aghazade, Leila Roshangar, Soodabeh Davaran
Summary: This study successfully fabricated a biofunctional magnetic scaffold with well-developed porous morphology and stable structure, showing no toxicity on dental pulp stem cells and improved osteoconductivity. The use of phosphorylated polymer and magnetic nanoparticles enhanced bone mineralization and expression of osteogenic biomarkers in the scaffold. The phosphorylation also increased the osteoinductivity of the scaffold and upregulated specific genes related to bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Ceramics
Mojtaba Mansoorianfar, Khashayar Shahin, Mariam Marlen Mirstrom, Dagang Li
Summary: This study developed a bioglass nanoparticle composite fabric with BG nanoparticles embedded between CNF layers. By enhancing osseoconductivity and increasing the Young's modulus of the fabric, it showed superior osteogenic potential and improved mechanical strength and structural stability.
CERAMICS INTERNATIONAL
(2021)
Review
Cell Biology
Venkata Suresh Venkataiah, Yoshio Yahata, Akira Kitagawa, Masahiko Inagaki, Yusuke Kakiuchi, Masato Nakano, Shigeto Suzuki, Keisuke Handa, Masahiro Saito
Summary: Bone tissue engineering involves combining MSCs with a biocompatible scaffold to aid in bone regeneration and recovery. While promising results have been seen in clinical trials, regenerating large bone defects remains a challenge.
Article
Surgery
Z-Hye Lee, David A. Daar, John T. Stranix, Lavinia Anzai, Vishal D. Thanik, Pierre B. Saadeh, Jamie P. Levine
Article
Surgery
David A. Daar, Salma A. Abdou, Joshua A. David, David J. Kirby, Stelios C. Wilson, Pierre B. Saadeh
ANNALS OF PLASTIC SURGERY
(2020)
Article
Surgery
Z-Hye Lee, Salma A. Abdou, Elie P. Ramly, David A. Daar, John T. Stranix, Lavinia Anzai, Pierre B. Saadeh, Jamie P. Levine, Vishal D. Thanik
Article
Surgery
Rami S. Kantar, Allyson R. Alfonso, Elie P. Ramly, Oriana Cohen, William J. Rifkin, Samantha G. Maliha, J. Rodrigo Diaz-Siso, Bradley S. Eisemann, Pierre B. Saadeh, Roberto L. Flores
PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Article
Surgery
John T. Stranix, Said C. Azoury, Z-Hye Lee, Geoffrey Kozak, Natalie Plana, Vishal D. Thanik, Pierre B. Saadeh, Jamie P. Levine, L. Scott Levin, Stephen J. Kovach
PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Article
Surgery
Z-Hye Lee, David A. Daar, John T. Stranix, Lavinia Anzai, Jamie P. Levine, Pierre B. Saadeh, Vishal D. Thanik
JOURNAL OF SURGICAL RESEARCH
(2020)
Review
Surgery
Michael Sosin, Kareem M. Termanini, Cara K. Black, Vishal Thanik, Pierre B. Saadeh, Jamie P. Levine
PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Article
Surgery
Oriana D. Cohen, Salma A. Abdou, Ian T. Nolan, Pierre B. Saadeh
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2020)
Editorial Material
Surgery
Jordan D. Frey, Adam Jacoby, Steven M. Cohen, Pierre B. Saadeh, Jamie P. Levine
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Editorial Material
Surgery
Carter J. Boyd, Shivani Ananthasekar, Rebecca Vernon, Timothy W. King, Pierre B. Saadeh
ANNALS OF PLASTIC SURGERY
(2021)
Letter
Surgery
Kshipra Hemal, Carter J. Boyd, Nicholas G. Cuccolo, Pierre B. Saadeh
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Review
Surgery
David A. Daar, Jonathan M. Bekisz, Michael V. Chiodo, Evellyn M. DeMitchell-Rodriguez, Pierre B. Saadeh
Summary: This study conducted a comprehensive review on factors contributing to hematoma after non-oncologic breast surgery, finding inconclusive evidence on the association between specific factors and hematoma rate. Hematomas after breast surgery should not be underestimated, and further high-quality research is needed to explore potential risk factors.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Surgery
Z-Hye Lee, Elie P. Ramly, Allyson R. Alfonso, David A. Daar, Christodoulos Kaoutzanis, Rami S. Kantar, Vishal Thanik, Pierre B. Saadeh, Jamie P. Levine
Summary: A systematic review was conducted to derive evidence-based recommendations for dangling protocols after lower extremity microvascular reconstruction, revealing significant heterogeneity in practice. Patient comorbidities and flap characteristics appear to influence tolerance to dangling, suggesting the need for tailored protocols based on risk factors to ensure clinical vigilance.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Michael Sosin, Isabel S. Robinson, Gustave K. Diep, Allyson R. Alfonso, Samantha G. Maliha, Daniel J. Ceradini, Jamie P. Levine, David A. Staffenberg, Pierre B. Saadeh, Eduardo D. Rodriguez
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Article
Surgery
Ira L. Savetsky, Michael J. Cammarata, Rami S. Kantar, J. Rodrigo Diaz-Siso, Yash J. Avashia, Rod J. Rohrich, Pierre B. Saadeh
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)