Article
Clinical Neurology
Leila Maria Da Roz, Geovanne Pedro Mauro, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar de Souza, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira
Summary: This study retrospectively reviewed AVM patients treated with radiation or a combination of radiation and embolization. The results showed that stereotactic radiosurgery plays an important role in AVM treatment and should be preferred whenever possible.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Geovanne Pedro Mauro, Leila Maria Da Roz, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar de Souza, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira
Summary: This study aimed to evaluate whether fractionated radiotherapy (FRT) is more effective than single-dose radiosurgery (SRS) in the treatment of vestibulocochlear schwannomas in patients with type 2 neurofibromatosis (NF2). The results showed that in the NF2 population, FRT may yield worse control rates than SRS. Therefore, it is preferable to avoid fractionated treatment for these patients whenever possible.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Nicolas Demogeot, J. Salleron, F. Rech, L. Taillandier, P. Royer, G. Vogin
Summary: A larger PTV predicts lower KPS in the treatment of recurrent GBM using fSRT. Initial surgery is associated with better progression-free survival.
RADIATION ONCOLOGY
(2022)
Article
Clinical Neurology
Othman Bin-Alamer, Stylianos Pikis, Georgios Mantziaris, Arif Abdulbaki, Arka N. Mallela, Victor M. Lu, Selcuk Peker, Yavuz Samanci, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M. N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad Eldin, Darrah Sheehan, Kimball Sheehan, Roman Liscak, Tomas Chytka, Manjul Tripathi, Renu Madan, Herwin Speckter, Wenceslao Hernandez, Gene H. Barnett, Yusuke S. Hori, Nisha Dabhi, Salman Aldakhil, David Mathieu, Douglas Kondziolka, Kenneth Bernstein, Zhishuo Wei, Ajay Niranjan, Charles R. Kersh, L. Dade Lunsford, Jason P. Sheehan, Hussam Abou-Al-Shaar
Summary: This study compared the outcomes of adult patients with clival chordomas who received either SRS alone or FRT+SRS treatment. The results showed that adjuvant FRT with subsequent boost SRS did not provide superior overall survival or tumor control rates compared to adjuvant SRS alone. However, the SRS group had a higher rate of freedom from additional treatment compared to the FRT+SRS group.
Article
Oncology
Fabiana Gregucci, Fiorella Cristina Di Guglielmo, Alessia Surgo, Roberta Carbonara, Letizia Laera, Maria Paola Ciliberti, Maria Annunziata Gentile, Roberto Calbi, Morena Caliandro, Nicola Sasso, Valerio Davi', Ilaria Bonaparte, Vincenzo Fanelli, David Giraldi, Romina Tortora, Valeria Interno, Francesco Giuliani, Giammarco Surico, Francesco Signorelli, Giuseppe Lombardi, Alba Fiorentino
Summary: Reirradiation with SRT/FSRT plus regorafenib is a safe treatment for recurrent GBM. Prospective trials are needed to further evaluate its efficacy. Common side effects include asthenia and hand-foot skin reaction, with some cases requiring dose reduction or discontinuation of regorafenib.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Biology
Leonie Johannwerner, Elisa M. Werner, Oliver Blanck, Stefan Janssen, Florian Cremers, Nathan Y. Yu, Dirk Rades
Summary: Based on the study, a maximum biologically effective dose (BED) of 45 Gy(12) is recommended for stereotactic radiosurgery (SRS) of brain metastases measuring 21-30 mm. However, for de novo lesions without prior brain irradiation, the tolerable BED may be higher than 45 Gy(12). This study investigated the occurrence of radiation necrosis (RN) after single-fraction SRS or fractionated stereotactic radiotherapy (FSRT) with a BED greater than 49 Gy(12) for radiotherapy-naive brain metastases. The results showed that FSRT with BED > 49 Gy(12) had a lower risk of RN for metastases larger than 20 mm and appeared to be safer than SRS for such lesions.
Article
Oncology
Christopher L. Tinkle, Charu Singh, Shane Lloyd, Yian Guo, Yimei Li, Alberto S. Pappo, Steven G. DuBois, John T. Lucas, Daphne A. Haas-Kogan, Stephanie A. Terezakis, Steve E. Braunstein, Matthew J. Krasin
Summary: The study reviewed the use of stereotactic body radiation therapy (SBRT) in pediatric patients, showing good tolerability and radiographic responses in most cases. Soft tissue lesion type was identified as a predictor of LF, with a 1-year LF rate of 25% serving as a benchmark for further modifications in radiation therapy indications.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Article
Oncology
Matthias Guckenberger, Frederick Mantel, Reinhart A. Sweeney, Maria Hawkins, Jose Belderbos, Merina Ahmed, Nicolaus Andratschke, Indira Madani, Michael Flentje
Summary: The study demonstrates that fractionated SBRT is effective in providing long-term pain relief and improved survival rates for patients with painful spinal metastases. Partial pain response was achieved in some patients at 3 months' follow-up and remained stable up to 5 years. Furthermore, fractionated SBRT resulted in long-term improvements in multiple dimensions of the EuroQol 5-Dimension Questionnaire.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Clinical Neurology
Mandara M. Harikar, Tejas Venkataram, Paolo Palmisciano, Gianluca Scalia, Matias Baldoncini, Salvatore Massimiliano Cardali, Giuseppe E. Umana, Gianluca Ferini
Summary: This study compared the efficacy of fractionated stereotactic radiotherapy (FSRT) with staged stereotactic radiosurgery (SSRS) in patients with brain metastases larger than 2 cm. The results showed that both treatment modalities were comparable, but FSRT was associated with lower 12-month overall survival and higher rate of salvage radiotherapy. Further research is needed to support these findings.
WORLD NEUROSURGERY
(2023)
Article
Oncology
J. A. Crouzen, A. L. Petoukhova, M. L. D. Broekman, M. Fiocco, U. J. Fisscher, J. H. Franssen, C. G. M. Gadellaa-van Hooijdonk, M. Kerkhof, M. Kiderlen, M. E. Mast, C. M. van Rij, R. Nandoe Tewarie, M. A. E. van de Sande, P. P. G. van der Toorn, R. Vlasman, M. J. Vos, N. C. M. G. van der Voort van Zyp, R. G. J. Wiggenraad, L. M. Wiltink, J. D. Zindler
Summary: A multicenter prospective randomized study aims to compare the incidence of adverse local events in patients with brain metastases using fractionated stereotactic radiosurgery (fSRS) versus stereotactic radiosurgery (SRS) in one or three fractions. The study aims to reduce the risk of radionecrosis and improve the effectiveness of brain metastases treatment.
Article
Oncology
Kristin J. Redmond, Chengcheng Gui, Stanley Benedict, Michael T. Milano, Jimm Grimm, J. Austin Vargo, Scott G. Soltys, Ellen Yorke, Andrew Jackson, Issam El Naqa, Lawrence B. Marks, Jinyu Xue, Dwight E. Heron, Lawrence R. Kleinberg
Summary: This study modeled tumor control probability after stereotactic radiosurgery and fractionated stereotactic radiosurgery for brain metastases based on pooled dosimetric and clinical data from published literature. Different dose levels were associated with varying rates of local control for tumors of different sizes, with higher doses recommended for melanoma and fSRS regimens recommended for larger lesions. The need for updated analyses to assess the effectiveness and toxicity of SRS and fSRS in the context of evolving systemic and biologic therapies was highlighted.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Georgios Chatzikon Stantinou, Robert Wolff, Nikolaos Tselis
Summary: The study shows that robotic-based fractionated stereotactic radiotherapy is safe and effective in treating large brainstem metastases, with favorable local control and low toxicity.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Matthew Gallitto, Michelle Savacool, Albert Lee, Tony J. C. Wang, Michael B. Sisti
Summary: This study reports on the feasibility of using GammaKnife ICON for five-fraction SRS in the management of newly diagnosed GBM. Progression free survival was comparable to historical data without significant radiation-induced toxicities.
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Article
Oncology
Antonio Pontoriero, Paola Critelli, Alfredo Conti, Salvatore Cardali, Filippo Flavio Angileri, Antonino Germano, Sara Lillo, Alessandro Carretta, Anna Brogna, Anna Santacaterina, Silvana Parisi, Stefano Pergolizzi
Summary: The results of this study suggest that dose escalation for high-risk WHO grade 2 meningiomas using a Combo-RT approach is safe and particularly effective in patients with subtotal resection. Further studies are needed.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Maria Chiara Lo Greco, Madalina La Rocca, Giorgia Marano, Irene Finocchiaro, Rocco Luca Emanuele Liardo, Roberto Milazzotto, Grazia Acquaviva, Antonello Basile, Stefano Palmucci, Pietro Valerio Foti, Stefano Pergolizzi, Antonio Pontoriero, Silvana Parisi, Corrado Spatola
Summary: Based on literature data suggesting promising advantages of total neoadjuvant therapy (TNT), we conducted a retrospective single-arm, single-center study on 45 patients with locally advanced rectal cancer. The study aimed to analyze the feasibility and short-term efficacy of an integrated intensified treatment in the setting of TNT. At a median follow-up of 30 months, this strategy has shown to be feasible and effective in terms of pathological complete response (pCR) and short-term disease-free survival (DFS).
Article
Neuroimaging
Arianna Rustici, Francesca Vari, Carmelo Sturiale, Alfredo Conti, Antonino Scibilia, Carlo Bortolotti, Raffaele Agati, Caterina Tonon, Raffaele Lodi, Diego Mazzatenta, Matteo Zoli, Ciro Princiotta, Massimo Dall'Olio, Luigi Cirillo
Summary: This study aimed to identify the angio-architectural characteristics associated with bleeding in brain arteriovenous malformations (bAVMs). The findings showed that a smaller diameter of the nidus, the absence of venous drainage alterations, and the presence of prenidal aneurysms were significantly related to the risk of bleeding in bAVMs.
NEURORADIOLOGY JOURNAL
(2023)
Article
Oncology
Gueliz Acker, Marcel Nachbar, Nina Soffried, Bohdan Bodnar, Anastasia Janas, Kiril Krantchev, Goda Kalinauskaite, Anne Kluge, David Shultz, Alfredo Conti, David Kaul, Daniel Zips, Peter Vajkoczy, Carolin Senger
Summary: Neoadjuvant stereotactic radiosurgery (NaSRS) is becoming increasingly important in the treatment of brain metastases. Our analysis showed that there was no significant difference in tumor volume pre- and postoperatively, and smaller tumors had a higher risk of volume increase. However, contouring resection cavities remains a challenge.
FRONTIERS IN ONCOLOGY
(2023)
Review
Neurosciences
Alfredo Conti, Nicola Maria Gambadauro, Paolo Mantovani, Canio Pietro Picciano, Vittoria Rosetti, Marcello Magnani, Sebastiano Lucerna, Constantin Tuleasca, Pietro Cortelli, Giulia Giannini
Summary: Modern brain atlases derived from neuroimaging and functional information are crucial for accurate neurosurgical procedures. They help avoid targeting errors caused by imaging artifacts or insufficient anatomical details.
Article
Oncology
Giuseppe Minniti, Sergio Paolini, Manila Antonelli, Francesca Gianno, Paolo Tini, Gaetano Lanzetta, Antonella Arcella, Raffaella De Pietro, Martina Giraffa, Luca Capone, Andrea Romano, Alessandro Bozzao, Vincenzo Esposito
Summary: This study reports the long-term outcomes in adult patients with grade 2 IDH-mutant astrocytoma treated with temozolomide-based chemoradiation, and found that chemoradiation can improve the survival of patients. Delayed chemoradiation can be considered for younger patients after extensive resection, while early treatment should be recommended for high-risk patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Medicine, General & Internal
Alessandro Tel, Marco Zeppieri, Massimo Robiony, Salvatore Sembronio, Shankeeth Vinayahalingam, Antonio Pontoriero, Stefano Pergolizzi, Filippo Flavio Angileri, Leopoldo Spadea, Tamara Ius
Summary: Virtual surgical planning allows for precise preoperative assessment and customized treatment plans. In neck surgery, augmented reality can merge virtual planning with the surgical field in real time, aiding surgeons in locating and preserving vital structures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Edoardo Agosti, Marco Zeppieri, Lucio De Maria, Marcello Mangili, Alessandro Rapisarda, Tamara Ius, Leopoldo Spadea, Carlo Salati, Alessandro Tel, Antonio Pontoriero, Stefano Pergolizzi, Filippo Flavio Angileri, Marco Maria Fontanella, Pier Paolo Panciani
Summary: This study compares and analyzes the clinical and surgical outcomes of different surgical approaches used for the treatment of SOMs. The results show that different surgical approaches have varying rates of gross total resection, complications, and functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Giulia Marvaso, Federico Mastroleo, Giulia Corrao, Mattia Zaffaroni, Maria Giulia Vincini, Paolo Borghetti, Francesco Cuccia, Manuela Federico, Giampaolo Montesi, Antonio Pontoriero, Davide Franceschini, Ciro Franzese, Marta Scorsetti, Barbara Alicja Jereczek-Fossa
Summary: The concept of oligometastatic state has revolutionized our understanding of cancer metastasis and progression, with ongoing research efforts to develop new treatment options. This study presents a bibliometric analysis of the oligometastatic disease/state, providing a comprehensive overview of the topic. A total of 3304 documents from 1995 to 2022 were analyzed, revealing the top keywords used by authors and identifying emerging themes and trends. This analysis serves as a valuable resource for researchers worldwide and highlights the significant scientific progress in the field of oligometastatic state.
Review
Health Care Sciences & Services
Antonio Pontoriero, Paola Critelli, Federico Chillari, Giacomo Ferrantelli, Miriam Sciacca, Anna Brogna, Silvana Parisi, Stefano Pergolizzi
Summary: Tumor behavior is influenced by the tumor microenvironment. Chimeric antigen receptor (CART) cell therapy is a new form of cellular immunotherapy. Immune cells have different sensitivity to radiation therapy. Radiation therapy can modify the tumor microenvironment, induce DNA damage, and promote the expression of CART cells.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giovanna Mantello, Elena Galofaro, Luciana Caravatta, Clelia Di Carlo, Sabrina Montrone, Donatella Arpa, Giuditta Chiloiro, Antonino De Paoli, Vittorio Donato, Maria Antonietta Gambacorta, Domenico Genovesi, Marco Lupattelli, Gabriella Macchia, Giampaolo Montesi, Rita Marina Niespolo, Elisa Palazzari, Antonio Pontoriero, Melissa Scricciolo, Francesca Valvo, Pierfrancesco Franco
Summary: Radical resection is the best treatment for local recurrence rectal cancer, and re-irradiation can increase the rate of successful resection. However, there is a lack of guidelines on re-irradiation for these patients. A national survey conducted by the Italian Association of Radiation and Clinical Oncology for Gastrointestinal Tumors (AIRO-GI) study group aimed to investigate the current clinical practice of external beam radiation therapy in LR rectal cancer patients.
Review
Medicine, General & Internal
Maria Chiara Lo Greco, Giulia Marletta, Giorgia Marano, Alessandro Fazio, Emanuele Buffettino, Arianna Iudica, Rocco Luca Emanuele Liardo, Roberto Milazzotto, Pietro Valerio Foti, Stefano Palmucci, Antonio Basile, Francesco Marletta, Francesco Cuccia, Giuseppe Ferrera, Silvana Parisi, Antonio Pontoriero, Stefano Pergolizzi, Corrado Spatola
Summary: At the time of diagnosis, most prostate carcinoma patients have a localized form of the disease, with low- or intermediate-risk prostate cancer being the most common. Treatment options for localized prostate cancer include surgery, external beam radiotherapy, and brachytherapy. Moderate hypofractionated radiotherapy has been shown to be a valid alternative strategy. High-dose-rate brachytherapy can be administered in different schedules. Proton beam radiotherapy shows promise, but further research is needed to improve affordability and accessibility. New technologies like MRI-guided radiotherapy have great potential.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Francesca Carbonara, Tiziana Feola, Francesca Gianno, Michela Anna Polidoro, Rosa Maria Di Crescenzo, Antonietta Arcella, Michelangelo De Angelis, Roberta Morace, Dario de Alcubierre, Vincenzo Esposito, Felice Giangaspero, Marie-Lise Jaffrain-Rea
Summary: The study concludes that hormone-negative gonadotroph tumors tend to occur in older patients and do not significantly differ from other gonadotroph tumors in terms of invasion or proliferation. It also highlights the current limitations of D2R immunostaining in such tumors.
ENDOCRINE PATHOLOGY
(2023)
Article
Oncology
Giuseppe Minniti, Sergio Paolini, Manila Antonelli, Francesca Gianno, Paolo Tini, Gaetano Lanzetta, Antonella Arcella, Raffaella De Pietro, Martina Giraffa, Luca Capone, Andrea Romano, Alessandro Bozzao, Vincenzo Esposito
Summary: TMZ-based chemoradiation is associated with survival benefit in adult patients with grade 2 IDH-mutant astrocytoma. For this group of patients, chemoradiation can be deferred until time of progression in younger patients receiving extensive resection, while early treatment should be recommended in high-risk patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)