期刊
NEUROSURGERY CLINICS OF NORTH AMERICA
卷 23, 期 3, 页码 439-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2012.04.006
关键词
Malignant brain tumors; Glioblastoma; Magnetic nanoparticles; Nanoparticles; Convection-enhanced delivery; MRI; EGFR; Thermotherapy
资金
- American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Tumors/Brainlab International Fellowship
- National Institutes of Health [NS053454]
- Georgia Cancer Coalition
- Distinguished Cancer Clinicians and Scientists Program
- Robbins Scholar Award
- Dana Foundation
Glioblastoma remains one of the most difficult cancers to treat and represents the most common primary malignancy of the brain. Although conventional treatments have found modest success in reducing the initial tumor burden, infiltrating cancer cells beyond the main mass are responsible for tumor recurrence and ultimate patient demise. Targeting residual infiltrating cancer cells requires the development of new treatment strategies. The emerging field of cancer nanotechnology holds promise in the use of multifunctional nanoparticles for imaging and targeted therapy of glioblastoma. This article examines the current state of nanotechnology in the treatment of glioblastoma and directions of further study.
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